Clinical trials: Tissue Damage
Cerebral Palsy
Functional and Neuroplastic Effects of HABIT-ILE in Children With Bilateral Cerebral Palsy
This randomized controlled trial will compare the effects of neuroplastic and functional changes of Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) when presented in two periods (2HG; n=24) versus a…
- Trial name
- FuN HABIT-ILE (NCT06428032)
- Testing
- Hand-Arm Bimanual Intensive Therapy Including Lower Extremities
- Where
- Chile
- Volunteers
- 48 people
- Sponsor
- Universidad Nacional Andres Bello
Diplegic Spastic Cerebral Palsy
Effects OF NMES With and Without Dynamic Bracing on Spasticity and Movement Quality in CP
The study aims at comparing Neuromuscular electrical Stimulation with and without dynamic bracing on spasticity and movement quality of lower limb in Children with Cerebral Palsy
- Trial name
- NCT06303336
- Testing
- NMES with Dynamic Bracing, NMES without Dynamic Bracing, Dynamic Bracing Only
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Disorders of Consciousness
mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness
The goal of this clinical trial is to test how effective the mindBEAGLE device is in allowing people who are unconscious (due to a brain injury or other condition) to communicate using brain waves to answer Yes/No questions.
- Trial name
- NCT06426602
- Testing
- mindBEAGLE daily device use
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Amy Wagner
Cerebral Palsy (CP)
Virtual Hand-Arm Assessments for Children With Cerebral Palsy
Cerebral palsy (CP) affects approximately 1 in 500 Canadian children, and the majority experience hand and arm limitations that impact independence, participation in daily activities, and overall quality of life.
- Trial name
- NCT07383753
- Testing
- Upper-Limb Virtual and In-Person Assessment
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Spastic Diplegia
Action Observation Therapy in Children With Spastic Diplegia
The aim of this study is to compare the effect of live versus video action observation training (AOT) on balance and gait in children with spastic diplegia.
- Trial name
- AOT/CP (NCT07651111)
- Testing
- A selected physical therapy program, Live action observation training (AOT), Video action observation training (AOT)
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Cerebral Palsy
A Study of UCB and MSCs in Children With CP: ACCeNT-CP
The main purpose of this study is to estimate change in motor function 12 months after treatment with a single dose of allogeneic umbilical cord blood (AlloCB) or repeated doses of umbilical cord tissue-derived mesenchymal…
- Trial name
- ACCeNT-CP (NCT03473301)
- Testing
- Infusion of allogeneic umbilical cord blood, Infusion of MSCs
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Joanne Kurtzberg, MD
Child, Hemiplegic Cerebral Palsy
Video Game for Home-based Rehabilitation for Children With Hemiplegia
This study evaluates the feasibility of a low-cost, movement tracking video game (Bootle Blast) to 1) sustain engagement in children with cerebral palsy (CP) during a 12-week intervention; and 2) generate changes in upper limb…
- Trial name
- NCT04009031
- Testing
- Bootle Blast
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Cerebral Palsy
Biomechanical Properties and Their Association With Balance and Functional Mobility in Children With Cerebral Palsy
This study aimed to investigate the differences in the biomechanical properties of the dorsal trunk and lower extremity muscles of children with unilateral spastic cerebral palsy compared with their typically developing peers…
- Trial name
- NCT05818839
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ilke KARA
Cerebral Palsy
Individualized Neurodevelopmental Treatment
The purpose of the study was to evaluate this therapeutic intervention by expressing functional level with valid quantitative data.
- Trial name
- NCT00922077
- Testing
- standard physical therapy program with emphasis on dynamic balance exercises
- Where
- Greece
- Volunteers
- 1 people
- Sponsor
- Hellenic Society for Disabled Children
Cerebral Palsy (CP), Drooling
Effectiveness of Neuromuscular Electrical Stimulation Added to Oral Motor Therapy in Cerebral Palsy
This randomized, controlled, single-blind trial aims to investigate the effectiveness of neuromuscular electrical stimulation (NMES) combined with oral motor therapy in reducing drooling severity among children with cerebral…
- Trial name
- NOMES-CP (NCT07069257)
- Testing
- Oral Motor Therapy, Neuromuscular Electrical Stimulation (NMES)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Aslinur Keles Ercisli, MD, PhD
Cerebral Palsy, Muscle Contracture
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.
Cerebral palsy (CP) is a motor impairment due to a brain malformation or a brain lesion before the age of two. Spasticity, hypertonus in flexor muscles, dyscoordination and an impaired sensorimotor control are cardinal symptoms.
- Conditions
- Cerebral Palsy, Muscle Contracture, Spasticity, Muscle
- Trial name
- CPMuscleSL (NCT05518565)
- Testing
- No intervention
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Eva Ponten
Cerebral Palsy
Orofacial Dysfunction in Cerebral Palsy Patients and Its Association With Oral Health Status and Quality of Life
The objective of this study is to analyze prevalence of orofacial dysfunction in children with cerebral palsy by using Nordic Orofacial Test screening (NOT-S) and its association with oral health status and quality of life.
- Trial name
- NCT03608969
- Testing
- NOT-S
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Health-Related Quality-of-Life, Adolescent
HEALTH-RELATED QUALITY OF LIFE IN CEREBRAL PALSY: AGREEMENT BETWEEN ADOLESCENTS, CAREGIVERS AND PHYSIOTHERAPISTS
Health-related quality of life (HRQoL) has recently become a widely used outcome measure. Although self-reporting is considered the gold standard, proxy reports are commonly used for adolescents with cerebral palsy (CP).
- Conditions
- Health-Related Quality-of-Life, Adolescent, Cerebral Palsy (CP)
- Trial name
- NCT07211594
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Hacettepe University
Cerebral Palsy (CP)
Local Vibration for Drooling in Children With Cerebral Palsy
This randomized-controlled trial evaluates local vibration therapy for drooling and orofacial muscle biomechanics in children with cerebral palsy.
- Trial name
- NCT07626424
- Testing
- Local Vibration Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Bitlis Eren University
Cerebral Palsy
FES in Young Children With Perinatal Stroke
Every year about 1 out of every 1,600-5,000 infants has a stroke around the time of birth. Many of these children will have lifelong physical problems. For example, the arm muscles are often paralyzed.
- Trial name
- NCT02975180
- Testing
- FES, Conventional
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University Health Network, Toronto
Cerebral Palsy
Gait Training Program With Blood Flow Restriction in Children With Cerebral Palsy - EMBRIN: Pilot Study
This is a single-center prospective experimental pilot study to assess the feasibility, tolerability and effect of a 10-week gait training program combined with simultaneous blood flow restriction (BFR) on the walking speed of…
- Trial name
- EMBRIN (NCT06533956)
- Testing
- 10-week gait training program combined with simultaneous blood flow restriction (BFR).
- Where
- 2 sites in France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Angers
Spastic Cerebral Palsy
Cuevas Medek Exercises on Balance and Postural Control in Children With Spastic Cerebral Palsy
Cerebral palsy (CP) is a disorder characterized by abnormal tone, posture and movement and clinically classified based on the predominant motor syndrome-spastic hemiplegia, spastic diplegia, spastic quadriplegia, and…
- Trial name
- NCT05719623
- Testing
- CUEVAS MEDEK EXERCISES, BALANCE AND POSTURAL
- Where
- Pakistan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Cerebral Palsy (CP)
Effects of Dry Needling on Spasticity and Functional Ability
This study investigates the effects of dry needling on spasticity and its impact on functional ability in individuals with neuromuscular disorders.
- Trial name
- NCT06856473
- Testing
- Traditional Physical Therapy, Dry Needling
- Where
- Saudi Arabia
- Volunteers
- 48 people
- Sponsor
- Batterjee Medical College
Cerebral Palsy, Acquired Brain Injury
Safety and Usability of a Robotic Gait Device for Children and Adolescents With Neurological or Neuromuscular Disease in Their Natural Environment
The goal of this clinical trial is to analyze the usability and safety of the robotic gait device EXPLORER in children with cerebral palsy, acquired brain injury and spinal muscular atrophy.
- Conditions
- Cerebral Palsy, Acquired Brain Injury, Spinal Muscular Atrophy
- Trial name
- NCT06167954
- Testing
- EXPLORER
- Where
- 5 sites in Spain
- Volunteers
- 50 people
- Sponsor
- MarsiBionics
Cerebral Palsy
Study in Children Who Have Switched to Isosource Junior Mix Formula
A Retrospective study In Children who have switched to Isosource Junior Mix formula (RICIMIX study) will review paediatric children > 12 months of age who require Isosource Junior Mix as an enteral tube feeding formula and have…
- Trial name
- NCT05020756
- Testing
- Isosource Junior Mix
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Société des Produits Nestlé (SPN)
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