Clinical trials: Tissue Oxygenation
Diabetic Foot, Diabetes Mellitus
The Role of Extrinsic Foot Muscles Chances in Determining the Risk of Diabetic Foot Ulcer
Many foot and lower limb disorders resulting from diabetes, such as deformity, muscle weakness, reduced range of motion, stiffness of connective tissue, amount of oxygenation, functional capacity, poor balance and coordination…
- Trial name
- NCT06736210
- Testing
- Muscle Elastic Properties Measurement, Muscle Oxygen Saturation (SmO2), Plantar Pressure Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Vascular Disease, Critical Lower Limb Ischemia
Pilot Study of Hemospan® in Patients With Chronic Critical Limb Ischemia
The purpose of this study is to evaluate the effects of Hemospan infusion on vascular reactivity, regional perfusion and oxygenation of ischemic tissue in patients with chronic critical lower limb ischemia.
- Trial name
- NCT00633659
- Testing
- Hemospan (MP4OX), Voluven (HES 130/0.4)
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Sangart
Lower Abdominal Surgery
Erector Spinae Plane Block for Peroperative Analgesia and Intraabdominal Tissue Oxygenation
Brief summary: Regional anesthesia decreases the need for intravenous analgesia in the peri-operative period. Erector spinae plane (ESP) is a regional anesthesia technique shown to be effective at the dorsal and ventral rami of…
- Trial name
- ESPB (NCT03808129)
- Testing
- Bupivacaine and Lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Neonatal Respiratory Distress
Tolerance of nHFPV Versus nCPAP in Neonatal Respiratory Distress
Respiratory distress is the main cause of morbimortality in preterm and term neonates. In most of the case, these babies required the use of positive end expiratory pressure (PEEP) delivered by a non invasive device.
- Trial name
- TONIPEP (NCT02030691)
- Testing
- Nasal continuous airway positive pressure (nCPAP), Nasal high frequency percussive ventilation (nHFPV)
- Where
- France
- Volunteers
- 49 people
- Sponsor
- University Hospital, Bordeaux
Cerebral Oxygenation
Cerebral Tissue Oxygenation Values in Newborns Measured Using Laser and LED NIRS Oximeters
The aim of the study is to compare the values of cerebral tissue oxygenation measured simultaneously using laser light (FORE-SIGHT) and LED (INVOS) cerebral oximeters.
- Trial name
- NCT01496027
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Neonates and Preterm Infants, Infant Respiratory Distress Syndrome
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA)…
- Conditions
- Neonates and Preterm Infants, Infant Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Surfactant
- Trial name
- SurfStab I (NCT07261787)
- Testing
- Poractant alfa (Curosurf®) - 1-minute administration, Poractant alfa (Curosurf®) - 5-minute administration
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Tourette's Syndrome, Chronic Motor Tic Disorder
Brain Activation in Vocal and Motor Tics
This study will investigate the brain areas that are activated by vocal and motor tics in patients with Tourette's syndrome and other tic disorders. Tics are involuntary repetitive movements similar to voluntary movements.
- Conditions
- Tourette's Syndrome, Chronic Motor Tic Disorder, Chronic Motor Vocal Disorder
- Trial name
- NCT00026000
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Necrotizing Enterocolitis
Early Predictors of Necrotizing Enterocolitis in Neonates
The goal of this project is to identify neonates who are predisposed to Necrotizing Enterocolitis (NEC). the investigators will determine the effectiveness of non-invasive measures as well as biochemical markers to identify…
- Trial name
- NCT03210831
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Pediatric Obstructive Sleep Apnea
Development of a Wearable Point of Care Monitoring Device for Pediatric Obstructive Sleep Apnea
Background: Obstructive sleep apnea (OSA) occurs when the blockage of the airway causes a person to stop breathing involuntarily for 10 seconds or more throughout the night during sleep.
- Trial name
- NCT05052216
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Tissue Oxygenation Measurement
OxyPrem Validation Study
The precision of the novel diagnostic near-infrared spectroscopy (NIRS) device for the measurement of tissue oxygenation and hemoglobin concentration (OxyPrem) is assessed by repeated measurements.
- Trial name
- NCT04860401
- Testing
- Measurement of tissue oxygenation with novel diagnostic near-infrared spectroscopy device (OxyPrem) (no clinical decisions based on oxygenation levels)
- Where
- Switzerland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Hans Ulrich Bucher
Tissue Oxygenation
Tissue Oxygen Deprivation as Detected With Raman in Association With Umbilical Artery Catheters
Umbilical artery catheters (UACs) are associated with significant morbidity in preterm neonates however are necessary for the management of this high risk population.
- Trial name
- NCT04038203
- Testing
- Resonance Raman Spectroscopy (RPS)
- Where
- United States
- Sponsor
- University of Florida
Prematurity of Fetus, Patent Ductus Arteriosus
Influence of Treatment for Patent Ductus Arteriosus on Cerebral Oxygenation in Preterm Infants
The purpose of this study is to examine the influence medical or surgical treatment for patent ductus arteriosus in preterm infants on cerebral and renal tissue oxygenation and on cardiac output.
- Trial name
- NCT01428180
- Testing
- Indomethacin, Surgical Ligation, Ibuprofen
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University of Ulm
Cleft Palate, Cleft Lip and Palate
Assessment of the Influence of Cleft Repair on Microcirculation of the Palate
Investigators aim to evaluate the influence of cleft surgery on the tissue microcirculation of the palate with a non-invasive measurement.
- Trial name
- NCT03877666
- Where
- Switzerland
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Heart Defects, Congenital
Congenital Heart Defects and NIRS
Congenital Heart Defects and NIRS
- Trial name
- NCT03411512
- Where
- Slovenia
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Petja Fister, MD, PhD
Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
Study on the Effects of Different Premedication for LISA on Stress and Cerebral Tissue Oxygenation in Preterm Infants
Given the popularity that LISA technique has gainig in worldwide neonatal units, the lack of evidence regarding its premedication is becoming even more relevant to provide the best care to premature infants.
- Conditions
- Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Near Infrared Spectroscopy
- Trial name
- SAFE LISA (NCT03718507)
- Testing
- Fentanyl, Sucrose 24% Oral Solution
- Sponsor
- ASST Fatebenefratelli Sacco
Blood Pressure, Cerebral Tissue Oxygenation
Bloodpressure and NIRS During the Immediate Transition
Blood pressure will be measured in min. 5/10/15 after birth. Cerebral tissue oxygenation (crSO2) monitoring with NIRS in addition to routine arterial oxygen saturation (SpO2) monitoring with pulse oximetry will be performed…
- Trial name
- RR (NCT06168045)
- Testing
- Cerebral tissue oxygenation and blood pressure measurement
- Where
- Austria
- Volunteers
- 104 people
- Sponsor
- Medical University of Graz
Tissue Oxygenation
The Correlation Between Tissue Oxygenations Using NIRS and Clinical Outcomes in Very Preterm Infants.
With the development of neonatal critical medicine, the survival rate of premature infants has gradually increased, and the incidence of late complications has significantly decreased, but preterm delivery is still the main cause…
- Trial name
- TCBTOUNACOIVPI (NCT06483867)
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Sepsis, Shock
Noninvasive Assessment of Tissue Perfusion Status in Critically Ill Pediatric Patients
Investigators are conducting research about oxygen levels in the body and whether it is possible to use a device to measure oxygen in the body's tissues noninvasively, without blood draws or a catheter (a plastic tube placed in a…
- Trial name
- NCT01760044
- Testing
- Tissue oxygenation monitoring
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Cardiac Catheterization
Validation of Brain Oxygenation Monitor on Pediatric Patients
The aim of this study is calibrate (adjust and tune) the CAS FORE-SIGHT Near-Infrared Spectroscopy (NIRS) monitor when used to measure the tissue oxygen saturation of internal organs (StO2).
- Trial name
- NCT00849940
- Testing
- CAS NIRS FORE-SIGHT oximeter
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Duke University
Preterm Birth, Oxygen Toxicity
Fetal Haemoglobin and Cerebral and Peripheral Oxygenation.
The aim of this study is to investigate the relationship between cerebral and peripheral oxygenation and oxygen extraction, as measured by NIRS (near-infrared spectroscopy ), and the FHbF (fraction of fetal hemoglobin) and…
- Conditions
- Preterm Birth, Oxygen Toxicity, Fetal Hemoglobin
- Trial name
- HbFIN (NCT04802629)
- Testing
- Near-infrared spectroscopy
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz