Clinical trials: Tooth Disorder
Dental Caries
Radiographic Progression of Infiltrated Caries Lesions In-vivo
This study is investigating the efficacy of caries lesion infiltration therapy as compared to the current preventative approach for early caries lesions.
- Trial name
- ICON (NCT01496456)
- Testing
- Resin infiltration, Caries management
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Michigan
Carious and Non-carious Lesions of the Teeth
Comparative Evaluation of Dental Disease Prevention Programs
Relevance. The dental health of the Chapaevsk children's population and the risk factors for dental caries and periodontal disease were well studied in 1995-2009.
- Trial name
- NCT05767281
- Testing
- prevention program
- Where
- Russia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samara State Medical University
Dental Caries, Dental Fluoroses
Iowa Fluoride Study/Iowa Bone Development Study
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries.
- Conditions
- Dental Caries, Dental Fluoroses, Bone Density
- Trial name
- (IFS/IBDS) (NCT03547128)
- Volunteers
- 1,882 people, healthy volunteers welcome
- Sponsor
- Steven M Levy
Healthy
Collection of Dental Plaque and Saliva for Studies of Bacterial Colonization of Teeth
This study will explore how bacteria colonize human teeth and how this process changes over the lifetime of individuals. It will include an investigation of transmission of bacteria that initiate colonization between adults and…
- Trial name
- NCT00098267
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dental Caries
Edulcorants Effect in Caries Risk Schoolchildren
This double-blind RCT aimed to evaluate the effect of sugar-free snacks on caries risk in 6-9 years-old schoolchildren. Considering a 20% difference among groups, the number of subjects needed per group was set in 87.
- Trial name
- STEVIA (NCT03724864)
- Testing
- delivery of snacks
- Where
- Italy
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Dental Pain, Anesthesia, Local
Self-Reported Pain in Children Submitted to Single Infiltration of Articaine During Primary Molar Extraction
The aim of this study is to analyze the effectiveness of articaine in controlling self-reported pain compared with conventional lidocaine anesthesia in children requiring extraction of deciduous maxillary molars.
- Trial name
- NCT05443009
- Testing
- Lidocaine, Articaine
- Where
- 4 sites in Brazil
- Volunteers
- 76 people
- Sponsor
- Universidade Federal de Santa Catarina
Class II Division 1 Malocclusion
Mechanism of Class II Correction With Fixed Lingual Mandibular Growth Modificator (FLMGM)
The aim of the current controlled trial was to assess the possible net skeletal and dental effects of FLMGM treatment in relation to growth with emphasis on the contribution of skeletal and dental changes to sagittal correction…
- Trial name
- FLMGM (NCT01853995)
- Testing
- Fixed Lingual Mandibular Growth Modificator (FLMGM)
- Where
- Syria
- Volunteers
- 43 people
- Sponsor
- Damascus University
Charcot-Marie-Tooth Disease, Type IA, Charcot-Marie-Tooth Disease Type 2A
Muscle MRI in Charcot Mary Tooth Disease: a Prospective Cohort Study
This cohort study (participants with CMT and control participants) has two parts (Part 1: CMT1A cohort; Part2: CMT1B, CMT2A and CMTX1 cohort) and is proposed to take place over 3 years across three sites.
- Conditions
- Charcot-Marie-Tooth Disease, Type IA, Charcot-Marie-Tooth Disease Type 2A, Charcot-Marie-Tooth Disease, Type IB, Charcot-Marie-Tooth Disease, Type X
- Trial name
- NCT03550300
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- University College, London
Dental Caries
Clinical Evaluation and Antimicrobial Effect of Papain Based Chemo-mechanical Caries Removal Agents
Minimally invasive dentistry continues to gain importance, especially in the treatment of permanent teeth with deep caries lesions and immature roots.
- Trial name
- NCT05983900
- Testing
- BRIX3000, papacarie, hand excavation
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Dental Caries in Children, Dental Diseases
Information and Communication Technologies (ICTS) in Dentistry for SUS
At the time of the COVID-19 pandemic, thousands of children had their dental care interrupted or postponed, generating a pent-up demand for primary care.
- Trial name
- NCT04798599
- Testing
- Telemonitoring and teleorientation, Control Group - Waiting list
- Where
- Brazil
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Maxillary Anomaly
Evaluation of the Hybrid Rapid Maxillary Expander Assisted With Micro-osteo Perforation (MOPs) in Adult.
This study will be directed for Evaluation of the hybrid rapid maxillary expander assisted with Micro-osteo perforation (MOPs) in adults
- Trial name
- NCT06467240
- Testing
- hybrid rapid maxillary expander assisted with Micro-osteo perforation (MOPs)
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Al-Azhar University
Malocclusion of Anterior Teeth, Malocclusion; Displaced Teeth
Effects of Three Orthodontic Archwire Protocols on Root and Bone Changes
This randomized controlled clinical trial compares the effects of three orthodontic archwire protocols used during the alignment phase on anterior tooth roots and the supporting alveolar bone.
- Trial name
- NCT07688655
- Testing
- Square-shaped cross-sectional archwire, Rectangular-shaped cross-sectional archwire, Traditional sequence of archwires
- Where
- Syria
- Volunteers
- 53 people
- Sponsor
- Damascus University
Dental Caries, Primary Teeth
Non-Restorative Versus Conventional Caries Treatment in Primary Teeth: A Randomized Controlled Trial
Dental caries is common in young children, and treatment of cavities in primary teeth can be challenging. Conventional treatment usually involves removal of carious tooth tissue and placement of a restoration.
- Trial name
- NRCT (NCT07866755)
- Testing
- Non-restorative caries treatment (NRCT), CT
- Where
- Slovenia
- Volunteers
- 96 people
- Sponsor
- Lenka Likar Ostrc, DMD
Molar Hypomineralization, Incisor
Resin Infiltration vs Ionomer-Based Fluoride Varnish for the Prevention of Post-Eruptive Breakdown in Molars With Mild MIH
round/Objective: The objective of this clinical trial is to evaluate the clinical efficacy of a resin infiltrant (Icon®, DMG) compared to an ionomer-based fluoride varnish (Clinpro XT®, 3M) in preventing post-eruptive enamel…
- Trial name
- MIH (NCT07443878)
- Testing
- Resin Infiltrant (Icon®, DMG), Varnish-Modified Glass Ionomer (Clinpro XT®, 3M)
- Where
- Mexico
- Volunteers
- 17 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Masseter, Ultrasonography
Masseter Muscle Thickness and Craniofacial Skeletal Patterns
Facial morphology is influenced by hard and soft tissues, including bone and muscle. While numerous factors can lead to changes in bone tissue, soft tissues such as muscle also have an important influence.
- Conditions
- Masseter, Ultrasonography, Malocclusions, Cephalometry
- Trial name
- NCT06870084
- Testing
- Ultrasonography, Lateral cephalometric radiography, Facial photograph
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Pit and Fissure Sealant Retention, Dental Caries
Clinical Evaluation of the Retention of Fissure Sealants Applied Following Guided Biofilm Therapy and Conventional Polishing
This randomized split-mouth clinical trial will compare two methods of occlusal surface cleaning before pit and fissure sealant placement in children aged 6-10 years.
- Trial name
- NCT07725133
- Testing
- Device: Guided Biofilm Therapy with erythritol, Device: Conventional Polishing
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Tooth, Impacted
Oral Health Related Quality of Life and Clinical Outcomes in Patients Undergoing Canine Disimpaction
To test the null hypothesis that there are no differences in the OHRQOL and clinical outcomes in patients undergoing palatal canine disimpaction using either open or closed surgical method.
- Trial name
- NCT01917604
- Testing
- open exposure, closed exposure
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jamia Millia Islamia
Pulp Necrosis, Immature Permanent Teeth
PRF and CGF Scaffolds With EDTA in Regeneration
This study evaluated the regenerative outcomes of immature permanent teeth with necrotic pulps treated using three scaffold types-blood clot, platelet-rich fibrin (PRF), and concentrated growth factor (CGF)-combined with either…
- Conditions
- Pulp Necrosis, Immature Permanent Teeth, Open Apex, Periapical Periodontitis
- Trial name
- RET-EDTA-CGF (NCT07265804)
- Testing
- Blood Clot + 5% EDTA, Blood Clot + 17% EDTA, PRF + 5% EDTA
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Deep Bite, Skeletal Class I Malocclusion
Effects of Anterior Bite Raisers Combined With Fixed Orthodontic Appliances in Deep Bite Treatment
This clinical study evaluated the treatment outcomes of fixed orthodontic appliances combined with anterior bite raisers in patients with skeletal Class I malocclusion and deep bite.
- Conditions
- Deep Bite, Skeletal Class I Malocclusion, Anterior Bite
- Trial name
- NCT07907263
- Testing
- Fixed Orthodontic Appliance With Composite Anterior Bite Raiser
- Where
- Vietnam
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Dental Caries, White Spot Lesions
QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment
This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS…
- Conditions
- Dental Caries, White Spot Lesions, Caries Lesion Activity, Post-Orthodontic Enamel Demineralization
- Trial name
- NCT07608471
- Volunteers
- 30 people
- Sponsor
- Universidad El Bosque, Bogotá
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