Clinical trials: Topical Administration
Acne
Comparison Study of Topical Acne Regimens
The purpose of this study is to compare the effectiveness of two over the counter acne products in subjects with moderate severity acne vulgaris.
- Trial name
- NCT00913185
- Testing
- Acne Free, Proactiv
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- MedDerm Associates
Plasminogen Deficiency
Treatment of Ligneous Conjunctivitis in Children With Plasminogen Deficiency
Congenital plasminogen deficiency causes impaired wound healing and growth of pseudomembranous lesions over multiple parts of the body. The most common lesions involve eyes and are known as Ligneous conjunctivitis.
- Trial name
- NCT05404932
- Testing
- Aliquoted allogeneic donor plasma in patient's conjunctiva
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Saskatchewan
Alopecia Areata
Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata
Alopecia areata (AA) is an autoimmune disease that involves the hair follicles. Topical corticosteroids are the established agents for treating this disorder.
- Trial name
- COLA (NCT02350023)
- Testing
- Topical latanoprost 0.005%, Topical betamethasone 0.05%
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Tinea Cruris
Topical Antifungal Treatment for Tinea Cruris
To determine if a topical antifungal cream is safe and effective for the treatment of tinea cruris
- Trial name
- NCT01342315
- Testing
- 33525
- Where
- 21 sites in United States, Belize and 3 more
- Volunteers
- 483 people
- Sponsor
- Medicis Global Service Corporation
Toxic Epidermal Necrolysis
Topical Clobetasol for the Treatment of Toxic Epidermal Necrolysis
The primary objectives of this study are to investigate the efficacy and safety of topical steroid ointment (clobetasol 0.05%) for the treatment of the cutaneous manifestations of toxic epidermal necrolysis (TEN).
- Trial name
- TEN (NCT02319616)
- Testing
- Clobetasol 0.05% ointment
- Where
- United States
- Sponsor
- University of California, Davis
Vernal Keratoconjunctivitis
Topical Immuonosuppressant Drugs in Spring Catarrh
Spring catarrh is a prevalent type of conjunctival allergic disorder in temperate countries. Topical steroids are the cornerstone management of spring catarrh beside other anti allergic drugs.
- Trial name
- NCT04705584
- Testing
- Prednisolone (as Acetate), CycloSPORINE Ophthalmic Suspension, LTacrolimus Topical
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Assiut University
Hemangioma
Topical Timolol Gel for the Treatment of Infantile Hemangiomas
We plan to conduct a study, to see how safe and effective timolol maleate 0.5% gel-forming solution is for infantile hemangiomas (IH) and the response of hemangiomas to timolol maleate 0.5% .
- Trial name
- NCT02145884
- Testing
- timolol maleate 0.5% gel
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Rady Children's Hospital, San Diego
Hand Dermatitis
A Study for a Topical Medication Versus Placebo in Patients With Hand Dermatitis
This is a double-blind, pilot study with 20 subjects to determine the tolerability and efficacy of topical AFX 5931 in the treatment of mild to moderate hand dermatitis.
- Trial name
- AFX5931 (NCT03703895)
- Testing
- Topical AFX5931
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Center for Clinical and Cosmetic Research
Epidermolysis Bullosa (EB), Dystrophic Epidermolysis Bullosa
A Phase 2 Study of TCP-25 Gel in Patients With Epidermolysis Bullosa, STEP-study
This is a Phase 2, double-blind, randomized, vehicle-controlled study designed to evaluate efficacy, safety, and tolerability of topically applied TCP-25 gel in patients with confirmed DEB or JEB.
- Conditions
- Epidermolysis Bullosa (EB), Dystrophic Epidermolysis Bullosa, Junctional Epidermolysis Bullosa
- Trial name
- STEP (NCT06594393)
- Testing
- TCP-25 gel
- Where
- 13 sites in United States, France and 5 more
- Volunteers
- 32 people
- Sponsor
- Xinnate AB
Molluscum Contagiosum
Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum Contagiosum
The purpose of this study is to determine if cantharidin is a safe and effective treatment for molluscum contagiosum in kids
- Trial name
- NCT02665260
- Testing
- Cantharidin, Gauze occlusion bandage
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Onychomycosis of Toenail
Study to Evaluate the Efficacy and Safety of P-3058 Nail Solution in the Treatment of Onychomycosis
The aim of this phase III study is to establish the efficacy and safety of P-3058 (terbinafine 10% nail solution) topically administered once weekly in patients with onychomycosis in comparison to the Vehicle in a double-blind…
- Trial name
- NCT03094468
- Testing
- P-3058 (terbinafine hydrochloride 10%), Vehicle of P-3058
- Where
- 26 sites in United States, Canada
- Sponsor
- Polichem S.A.
Osteoarthritis of the Hand
Compassionate Use of Pennsaid Topical Lotion (Diclofenac) in Osteo or Rheumatoid Arthritis
This was a compassionate use, open treatment safety study of Pennsaid topical lotion (diclofenac) for osteo or rheumatoid arthritis.
- Trial name
- NCT01579890
- Testing
- Diclofenac
- Sponsor
- Mallinckrodt
Acute Otitis Media
Safety and Efficacy of Moxidex Otic
The purpose of this study is to determine if Moxidex otic solution is safe and effective in treating middle ear infections in patients with ear tubes.
- Trial name
- NCT01071902
- Testing
- Moxidex otic solution, Moxifloxacin otic solution, Vehicle
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Alcon Research
Burn
Use of Amnion on Partial Thickness Burns
To determine if Amnion, used on partial thickness burn injuries would provide an improvement in rate of healing, pain control and scarring as compared to standard medical treatments.
- Trial name
- Amnion (NCT00674999)
- Testing
- Amnion, Polysporin/Bacitracin/Mycostatin
- Sponsor
- The University of Texas Medical Branch, Galveston
Atopic Dermatitis
A Study of Lebrikizumab (LY3650150) With/Without Topical Corticosteroid Treatment in Participants With Moderate-to-Severe Atopic Dermatitis
The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab with/without Topical Corticosteroid Treatment in Participants with Moderate-to-Severe Atopic Dermatitis.
- Trial name
- NCT06280716
- Testing
- Lebrikizumab, Topical Corticosteroid
- Where
- 46 sites in China, South Korea
- Volunteers
- 301 people
- Sponsor
- Eli Lilly and Company
Dermatitis Herpetiformis
Use of Dapsone Gel, 5% for Treating Dermatitis Herpetiformis
The primary objective of this study is to evaluate the efficacy of dapsone gel, 5% in the treatment of dermatitis herpetiformis.
- Trial name
- NCT01115244
- Testing
- Dapsone gel, 5%
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University Medical Center
Pityriasis Alba
Efficacy of Topical Pimecrolimus in the Treatment of Pityriasis Alba
Pityriasis alba (PA) is a common benign skin disorder, that usually affects children and adolescents of darker phototypes. A history of atopic dermatitis is a well-known risk factor, and PA may be a minor manifestation of atopic…
- Trial name
- NCT03834935
- Testing
- Elidel (pimecrolimus 1%), Cold Cream
- Where
- Lebanon
- Volunteers
- 40 people
- Sponsor
- St Joseph University, Beirut, Lebanon
Cutaneous Leishmaniasis
Topical Treatment of Cutaneous Leishmaniasis With WR 279,396: A Phase 2 Study in the Old World
This study is to determine the effectiveness and safety of WR 279,396, a topical cream for the treatment of cutaneous leishmaniasis.
- Trial name
- NCT00703924
- Testing
- WR 279,396
- Where
- 2 sites in France, Tunisia
- Volunteers
- 92 people
- Sponsor
- U.S. Army Medical Research and Development Command
Warts Flat
Efficacy of Tazarotene in Treatment of Verruca Plana
Verruca plana is a common skin infection with worldwide distribution. Approximately 10% of general population is infected with flat warts and it represents up to 18 % of the patients seeking treatment for warts.
- Trial name
- NCT05314127
- Testing
- Tazarotene 0.1% Gel,Top, Imiquimod, Fluorouracil Cream
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zagazig University
Pain Management
Pain Management in Pediatric Adenotonsillectomy
Tonsillectomy is considered one of the most frequent minor surgeries conducted on a day-case basis on children, and usually associated with pain and sore throat.
- Trial name
- AZU (NCT05928520)
- Testing
- Tramadol 5%, Lidocaine 2%
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University