Clinical trials: Total Knee Arthroplasty
Arthroplasty, Overweight and Obesity
Healthy Living After Knee Replacement
The purpose of this study is to examine if a weight loss program designed for adults after knee replacement improves weight loss, physical activity, pain, and function, as well as if the program is cost effective, as compared to…
- Trial name
- NCT05190666
- Testing
- PACE Weight Loss program, Chronic Disease Self-Management
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Osteoarthritis
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement
The aim of the study is to determine whether the AQUACEL™ Ag SURGICAL cover dressing is successful in reducing the incidence of wound infection in high risk patients following total knee replacement.
- Trial name
- NCT02217202
- Testing
- Aquacel Ag dressing
- Sponsor
- Golden Jubilee National Hospital
Knee Osteoarthritis
The Influence of Coronally Knee Alignment on the Tibial Tuberosity Rotation
The primary aim of this study is to find a possible correlation between tibial tuberosity rotation and coronal leg alignment. If correlation exists, a more individual tibial component rotation might be proposed during a total…
- Trial name
- NCT05295602
- Testing
- CT scan
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- Valdoltra Orthopedic Hospital
Arthroplasty, Replacement, Knee
Outcome Study of Highly-cross Linked Polyethylene vs. Standard Polyethylene for Primary Posterior Stabilized (PS) Total Knee
Polyethylene wear and osteolysis remain a concern with the use of modular, fixed bearing total knee arthroplasty. A variety of highly cross-linked polyethylenes have been introduced to decrease this problem, but there is little…
- Trial name
- NCT02178020
- Testing
- knee arthroplasty, standard polyethylene, knee arthroplasty, XLP polyethylene
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Chapel Hill Orthopedics Surgery & Sports Medicine
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Arthroplasties, Knee Replacement, Revision Arthroplasty
Patient Outcomes With Robotic-Assisted Total Knee Arthroplasty
This is a post-market multicentre study that has been implemented to confirm safety and performance of cemented CR/UC and PS Apex Knee implants in primary or revision Robotic Assisted Total Knee Arthroplasty up to 10-year follow…
- Trial name
- NCT06203756
- Testing
- Omnibotics Robotic-assisted Total Knee Arthroplasty with Apex UC, Omnibotics Robotic-assisted Total Knee Arthroplasty with Apex PS, Omnibotics Robotic-assisted Total Knee Arthroplasty with Apex Revision
- Where
- 6 sites in United States
- Volunteers
- 713 people
- Sponsor
- Corin
Knee Replacement, Knee Replacement Revision
Prevalence and Incidence of Multiple Revisions Following Knee Arthroplasty in Denmark 1998-2021: A Nationwide Population-based Study
The purpose of this study is to investigate the incidence and prevalence rates of multiply revised knee arthroplasty patients in Denmark from 1998-2021.
- Trial name
- EMKAR ONE (NCT06064318)
- Testing
- Revision
- Where
- Denmark
- Volunteers
- 161,384 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stress
Effect of Audio Book applıcatıon on patıents Blood Pressure, Pulse Rate and anxıety Levels Before Total Knee Replacement Surgery
Before the TDP surgery, the anxiety levels of the patients in the experimental group will be measured by listening to an audio book.
- Trial name
- NCT06905899
- Testing
- audiobook app
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Beyza Yilmaz
Venous Thromboembolism (VTE), Total Joint Arthroplasty
Efficacy of Aspirin in Preventing Venous Thromboembolism
Efficacy of aspirin and enoxaparin in preventing venous tromboembolism was compared after total knee or hip arthroplasty.
- Conditions
- Venous Thromboembolism (VTE), Total Joint Arthroplasty, Total Hip Arthroplasty (THA)
- Trial name
- NCT06635317
- Testing
- Aspirin, enoxaparin
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Total Knee Replacement
Prediction of Leg Length Discrepancy After Unilateral Total Knee Replacement in Varus Deformity
To What degree total knee replacement (TKA) affects leg length discrepancy in patients with varus deformity? Varus deformity, the most commonly encountered deformity in patients undergoing TKA is associated with limb alignment…
- Trial name
- NCT03502382
- Testing
- x-ray
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Pain
Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Knee Arthroplasty
The purpose of this study is to examine whether local infiltration analgesia (LIA) with Ropivacaine and adrenaline is effective in the treatment of postoperative pain after total knee arthroplasty.
- Trial name
- NCT00408707
- Testing
- local infiltration analgesia
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Hvidovre University Hospital
Venous Thromboembolism
Comparative Study of Prophylactic Agent for Venous Thromboembolism After Total Knee Arthroplasty
The purpose of this study is to compare the efficacy of two prophylactic agent(aspirin 300mg/day and rivaroxaban 10mg/day) for venous thromboembolism after total knee arthroplasty.
- Trial name
- NCT02271399
- Testing
- acetylsalicylic acid, rivaroxaban
- Where
- South Korea
- Volunteers
- 156 people
- Sponsor
- Hanyang University Seoul Hospital
Arthroplasty, Replacement
Knee Connect: Physiotherapy Exercise Performance With Visual Feedback After Total Knee Arthroplasty
The main objective of this pilot study is to determine if using a portable, accelerometer based, visual feedback system improves exercise quality.
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT03738384
- Testing
- Knee Connect + Visual Feedback System
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Surgery, Cataract
Routine Surgical Procedures During COVID-19 Pandemic: a French Nationwide Cohort Study
Determine the consequences of COVID-19 pandemic on routine targeted surgeries. Five surgical procedures were considered : cataract surgery, hip and knee arthoplasties, coronary revascularisation by angioplasty and definitive…
- Conditions
- Surgery, Cataract, Hip Arthroplasty, Knee Arthroplasty
- Trial name
- NCT05197660
- Testing
- surgical procedures
- Where
- France
- Volunteers
- 2,000,000 people
- Sponsor
- EPI-PHARE
Osteoarthritis, Knee
Outcome Comparison of Two Total Knee Arthroplasty Systems: e.Motion-Pro Versus Genesis II
Recently, E.Motion-PS-Pro (B.Braun-Aesculap, Tuttlingen, Germany), a new mobile bearing knee system with a unique ball and socket post-cam mechanism was developed for use in total knee arthroplasty.
- Trial name
- NCT02276118
- Testing
- device: e.motion PS Pro, device : Genesis II
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Seoul National University Hospital
Postoperative Pain, Analgesic Efficacy
Local Anesthetic in Total Knee Arthroplasty (TKA): Volume Versus Concentration
In a randomized, double-blind, cross-over trial, 48 patients scheduled for total knee arthroplasty with placement of an intracapsular catheter will be randomized to receive bolus injection of ropivacaine in high volume/low…
- Trial name
- NCT01012232
- Testing
- 20 mL ropivacaine 5 mg/mL, 10 mL ropivacaine 10 mg/mL
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Lundbeck Foundation
Knee Osteoarthritis
Custom Guides for Total Knee Arthroplasty (TKA)
The goal of the study is to know if the reconstruction of the lower limb mechanical axis and the patient knee function is improved after Total Knee Arthroplasty (TKA) using patient specific instruments.
- Trial name
- NCT01573208
- Testing
- Custom guides
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Lausanne Hospitals
Osteoarthritis
Intrathecal Diamorphine Versus Femoral Nerve Block in Primary Total Knee Arthroplasty
Primary total knee arthroplasty (TKA) is commonly associated with moderate to severe early post-operative pain. The primary aim of this study was to investigate the impact of either a single-shot femoral nerve block (FNB) or…
- Trial name
- NCT01931332
- Testing
- Femoral Nerve Block with levobupivicaine, Intrathecal injection of diamorphine
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Arthroplasty Complications, Inflammatory Response
Effects of Navigation Versus Conventional Total Knee Arthroplasty on the Levels of Inflammation Markers
Total knee arthroplasty (TKA) is a well-established modality for the treatment of advanced knee osteoarthritis with high satisfaction rate.
- Trial name
- NCT03163888
- Testing
- Navigation TKR
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Total Knee Arthroplasty
Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery
Intra-articular Posteromedial Surgeon Administered (IPSA) Block in this study describes a new type of medical procedure where a surgeon provides anesthetic medication directly into a specific area inside a knee joint to numb the…
- Trial name
- NCT06946368
- Testing
- Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL, Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL, Local Infiltration Analgesia (LIA) of EXPAREL
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic