Clinical trials: Total Knee Replacement Surgery
Knee Osteoarthritis
Validation of a New Technique for the Evaluation of the Patello-femoral Joint Kinematics
The objective of this study is to validate a new technique for intraoperative quantification of the patello-femoral joint kinematics in patients undergoing total knee replacement, and for postoperative quantification of implanted…
- Trial name
- CINE-FEMORO (NCT03448198)
- Testing
- Total knee replacement
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Blood Loss
The Use of FLOSEAL to Reduce Bleeding in Total Knee Replacement Surgery
The purpose of this study is to determine if the agent, Floseal, can decrease the amount of blood patients lose after total knee replacement (TKR) surgery.
- Trial name
- NCT00990288
- Testing
- Hemostatic Matrix
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis
A Post-Market Retrospective Study on Revision Total Knee Arthroplasty Using Medacta GMK® Revision Prosthesis
This is a retrospective, single-site observational study, designed to assess the clinical outcomes and collect safety data of GMK Revision knee system used for primary or revision total knee arthroplasty at minimum two years…
- Trial name
- NCT02912351
- Testing
- Patient record review, Radiographs, and questionaires.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Edema
Lower Leg Edema Evaluation After Total Knee Arthroplasty Using Bioimpedance
The purpose of this study is to evaluate the applicability and measurement properties of bioimpedance spectroscopy for postsurgical edema assessment after total knee arthroplasty
- Trial name
- NCT00627770
- Testing
- bioimpedance spectroscopy ImpediMed SFB7 Brisbane Australia
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Haute Ecole de Santé Vaud
Same-day Surgery
Is Partial Knee Replacement as Same-day Surgery Generalizable?
Fast-track/rapid recovery/Enhanced Recovery After Surgery (ERAS) programs have proven both safe and effective in joint replacement surgery, to the degree where same-day surgery have been tested in selected cases.
- Trial name
- NCT04790591
- Testing
- Same-day surgery
- Where
- 2 sites in Sweden
- Volunteers
- 33 people
- Sponsor
- Region Skane
Osteoarthritis
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement
The aim of the study is to determine whether the AQUACEL™ Ag SURGICAL cover dressing is successful in reducing the incidence of wound infection in high risk patients following total knee replacement.
- Trial name
- NCT02217202
- Testing
- Aquacel Ag dressing
- Sponsor
- Golden Jubilee National Hospital
Osteoarthritis, Osteoarthritis, Knee
The Effectiveness of Resistance Training for Patients With Degenerative Arthritis After Surgery
Osteoarthritis is a common degenerative disease that significantly impacts mobility and disability in older adults. This pilot randomized controlled study aimed to examine the effects of a three-month resistance training program…
- Trial name
- Arthritis (NCT07696195)
- Testing
- Progressive Lower Extremity Resistance Exercise, Routine Postoperative Rehabilitation Care
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Tzu Chi University
Total Knee Arthroplasty, Telehealth
The Effect of Tele-Health Application on Functional Status, Self-Care Ability and Activities of Daily Living in Individuals Undergoing Total Knee Arthroplasty Surgery
Osteoarthritis, defined as a degenerative joint disease, is a chronic, non-inflammatory condition characterized by deterioration of joint cartilage and new bone formation on joint surfaces and margins.
- Conditions
- Total Knee Arthroplasty, Telehealth, Self-Care Ability
- Trial name
- (TKA-TELECARE) (NCT07380724)
- Testing
- tele health
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Sakarya Applied Sciences University
Arthropathy, Incision, Surgical
Approach Modification for Total Knee Arthroplasty in Morbidly Obese Patients
The study provides a detailed description of a smaller incision with better visualization in total knee arthroplasty operations
- Conditions
- Arthropathy, Incision, Surgical, Obesity, Morbid
- Trial name
- NCT05840705
- Testing
- Small curved incision with apex lateral
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Degenerative Arthritis of Knee
Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)
The objective of this study is to assess outcomes following TKA, utilizing two surgical techniques. Patients will be randomized to one of two arms: TKA with standard instrumentation and TKA with VISIONAIRE™ patient-matched…
- Trial name
- NCT01084772
- Testing
- VISIONAIRE Total Knee Arthroplasty, Standard Total Knee Arthroplasty
- Where
- 7 sites in United States, Australia
- Volunteers
- 134 people
- Sponsor
- Smith & Nephew, Inc.
Arthroplasty, Replacement, Knee
The Association of Gait Kinematics, Instability and Patient Reported Outcomes in Patients With Total Knee Replacement
It is unclear why 20% of patients with total knee replacements (TKR) are dissatisfied. Few studies have specifically assessed the way people walk ('gait') with an 'unhappy' or unstable knee or following re-do ('revision') TKR…
- Trial name
- NCT03896191
- Testing
- Revision TKR surgery, No intervention.
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Bath
Bilateral Total Knee Chronic Pain Following Arthroplasty
Risk of Chronic Post-surgical Pain After TKA
Chronic post-surgical pain (CPSP) is a common surgical complication. The role of timing in the development of CPSP after bilateral total knee arthroplasty (BTKA) is not well studied.
- Trial name
- NCT06079749
- Testing
- Simultaneous BTKA, Staged BTKA
- Volunteers
- 403 people
- Sponsor
- Gangnam Severance Hospital
Joint Replacement Surgery
Reversal of Spinal Anesthesia Residual Motor Block Via Intrathecal Catheter
The purpose of this study is to determine the feasibility of administering a predetermined amount of normal saline into the intrathecal or subarachnoid space via a small spinal catheter to reduce or eliminate the effects of…
- Trial name
- IT-Cath (NCT07404982)
- Testing
- Normal Saline 10 mL Injection
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Beth Israel Deaconess Medical Center
Osteoarthritis, Knee
Conventional Alignment System Versus Surgical Navigation System in Total Knee Arthroplasty
This is a randomized, controlled, blinded prospective study comparing the use of the usual cutting guides with a palm-sized digital surgical navigation system in unilateral total knee arthroplasty.
- Trial name
- NCT01797731
- Testing
- Digital hand-held surgical navigation system, Conventional tibial extramedullary alignment system
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hospital for Special Surgery, New York
Arthroplasty; Replacement; Knee, Radiotherapy; Image-Guided
Surgical Outcomes of the Accelerometer-based Navigation System for Total Knee Arthroplasty
Osteoarthritis (OA) is a very common condition in the elderly population. Treatment for end-stage OA is total knee Replacement (TKR)
- Trial name
- NCT04037228
- Testing
- KneeAlign 2 system (OrthAlign Inc, Aliso Viejo, California)
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Surgical Glove, Total Knee Arthroplasty
Comparison of Surgical Glove Contamination During Total Knee Arthroplasty Procedure : a Randomized Controlled Trial
Total knee arthroplasty post-op surgical site infection rate about 0.5- 5% Pre-operative , perioperative and post-operative prevention are importance for reduce surgical site infection The prevention of surgical-site infections…
- Conditions
- Surgical Glove, Total Knee Arthroplasty, Contamination Rate
- Trial name
- NCT04308798
- Testing
- Surgical glove changing
- Where
- Thailand
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Surgery, Total Knee Arthroplasty
Enhanced Recovery After Surgery for Total Knee Arthroplasty, Left Colectomy and Hysterectomy
The objective of the study is to assess retrospectively the effect of an awareness-raising phase in favour of Enhanced Recovery After Surgery across the Assistance Publique-Hopitaux Paris institution and to explore the…
- Conditions
- Surgery, Total Knee Arthroplasty, Colectomy, Hysterectomy
- Trial name
- RAAC-AP (NCT03552913)
- Testing
- One year before awareness-raising phase in favour of Enhanced Recovery After Surgery, One year after awareness-raising phase in favour of Enhanced Recovery After Surgery, No specific program toward improving practices
- Where
- France
- Volunteers
- 1,710 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Knee Replacement Surgery
Anatomic Reconstruction of the Patellofemoral Joint
The investigators posit that it would be advantageous to reproduce the height of the entire patellofemoral joint in order to maintain the lever arm of the quadriceps mechanism at its preoperative level.
- Trial name
- NCT01375231
- Testing
- Measured Resection of patellofemoral joint, Measured resection of patella
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Total Knee Arthroplasty, Reinfection
Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies
A single-center retrospective cohort study was conducted in the Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University.
- Conditions
- Total Knee Arthroplasty, Reinfection, Aseptic Loosening, Revision
- Trial name
- NCT07232771
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Total Knee Arthroplasty
Interferential Current Therapy After Total Knee Arthroplasty
Interferential current is widely used as a popular treatment in painful musculoskeletal disorders. And total knee arthroplasty patients present with extreme pain immediately after surgery.
- Trial name
- NCT03542981
- Testing
- Interferential Current
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- Ege University