Clinical trials: Transfusions
Transfusion-dependent Beta-Thalassemia
Gene-Modified Stem Cell Therapy for Subjects With Transfusion-dependent Beta-thalassemia
This is a prospective, dual-centre, single dose, Phase IIb, single arm, open label study. The proposed clinical trial involves a single infusion of autologous HSPCs genetically modified with the GLOBE lentiviral vector, using an…
- Trial name
- NCT07680803
- Testing
- FT007
- Where
- 2 sites in Italy
- Volunteers
- 9 people
- Sponsor
- Fondazione Telethon
Acquired Factor XIII Deficiency Disease
Impact of Acquired FXIII Deficiency on Morbidity and Mortality
Observational prospective study aiming to assess acquired FXIII deficiency implications in morbidity and mortality
- Trial name
- NCT04416594
- Testing
- Data collection
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Patricia Duque González
Patient Blood Management
Impact of Patient Blood Management (PBM) at the Schulthess Clinic
Aim of this study is to analyze the transfusion requirements of allogenic blood products at the Schulthess Clinic for patients that had major orthopedic or major spine surgery between 2019 and 2024 order to identify patients at…
- Trial name
- PBM (NCT06363214)
- Testing
- Patient blood management
- Volunteers
- 16,000 people
- Sponsor
- Schulthess Klinik
Pediatric Cancer
Granulocyte Transfusions After Umbilical Cord Blood Transplant
Although most children with leukaemia are cured using drugs (chemotherapy) alone, for some children additional treatments are needed. Stem cell transplant can cure children where chemotherapy and other drugs have failed.
- Trial name
- NCT05425043
- Testing
- Granulocytes
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Manchester
Transfusion Dependent Beta-Thalassaemia
A Study to Evaluate the Safety and Efficacy of ET-01 Transplantation in Subjects with Transfusion Dependent Β-Thalassaemia.
This is an open label, single site study to evaluate the safety and Efficacy of ET-01 Transplantation in subjects with Transfusion Dependent β-Thalassaemia.
- Trial name
- NCT05752123
- Testing
- ET-01
- Where
- China
- Volunteers
- 2 people
- Sponsor
- EdiGene (GuangZhou) Inc.
Anemia
RBC Transfusion in Severe Anemia With Lactic Acidosis
The hypothesis of this study is that prolonged-storage RBCs are not inferior to short-storage RBCs for the time required to clear elevated blood lactate levels in children with severe anemia.
- Trial name
- TOTAL (NCT01586923)
- Testing
- RBC transfusion
- Where
- Uganda
- Volunteers
- 290 people
- Sponsor
- Massachusetts General Hospital
Metastases to Bone
Tranexamic Acid After Pathological Fracture Treated With Modular Arthroplasty
This study assesses the safety and efficacy of TXA for patients treated for pathological femur fractures using modular prosthetics.
- Trial name
- NCT06244498
- Testing
- Tranexamic acid injection
- Where
- Poland
- Volunteers
- 110 people
- Sponsor
- Piotr Biega
Erythrocyte Transfusion, Percutaneous Coronary Intervention
Bare Metal Stents and Drug Eluting Stents in Patients Who Underwent Blood Transfusion
Retrospective cohort study of Korean National Healthcare Insurance Database. To investigate clinical outcomes of bare metal stents versus drug eluting stents in patients who underwent periprocedural red blood cell transfusion.
- Conditions
- Erythrocyte Transfusion, Percutaneous Coronary Intervention, Revascularization
- Trial name
- TFPCI2 (NCT03788148)
- Testing
- Stent, red blood cell transfusion
- Where
- South Korea
- Volunteers
- 28,322 people
- Sponsor
- Samsung Medical Center
Beta-Thalassemia, Thalassemia
Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease
This is a single-dose, open-label study in participants with transfusion-dependent β-thalassemia (TDT) or severe sickle cell disease (SCD).
- Conditions
- Beta-Thalassemia, Thalassemia, Hematologic Diseases, Genetic Diseases, Inborn
- Trial name
- NCT05477563
- Testing
- CTX001
- Where
- 6 sites in United States, Germany and 2 more
- Volunteers
- 26 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Iron Overload Due to Repeated Red Blood Cell Transfusions, Thalassemia Majors (Beta-Thalassemia Major)
Evaluate the Efficacy and Safety of Irochel for the Management of Iron Overload in Thalassemia Patients in Comparison With Deferoxamine
This research study was an experimental, randomized, controlled clinical trial to evaluate the safety and efficacy of coded Unani formulation Irochel for the management of IOL due to repetitive blood transfusion in comparison…
- Trial name
- NCT07782931
- Testing
- Irochel, Deferoxamine
- Where
- Pakistan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hamdard University
Plasmodium Falciparum Malaria
The Cytoadherence in Pediatric Malaria (CPM) Study
The purpose of this study is to determine the importance of key blood group molecules in the clinical outcome of Plasmodium falciparum malaria infection in children.
- Trial name
- CPM (NCT00707200)
- Where
- Uganda
- Volunteers
- 2,000 people
- Sponsor
- University Health Network, Toronto
Anemia, Neonatal, Intracranial Hemorrhages
Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates
The purpose of this study is to test the safety and effectiveness of a whole own (autologous) umbilical cord blood transfusion in the first 5 days after birth if the baby is born premature <34 weeks and developed anemia of…
- Conditions
- Anemia, Neonatal, Intracranial Hemorrhages, Necrotizing Enterocolitis, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT02050971
- Testing
- Umbilical Cord Blood Infusion, Intravenous Infusion of Peripheral Blood or its Components
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Pomeranian Medical University Szczecin
Anemia of Prematurity (AOP)
Combining Restrictive Guidelines and a NIRS SCORE to Decrease RBC Transfusions
The primary aim of this study is to determine the mean number of red blood cell (RBC) transfusions received by preterm infants cared for using restrictive Hgb guidelines in combination with splanchnic to cerebral oxygenation…
- Trial name
- NCT02535208
- Testing
- Restrictive transfusions based on SCOR assessment, Liberal transfusions
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Hypoxic-Ischemic Encephalopathy, Hypoxia Neonatal
Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and Anemia
The study is to investigate the feasibility and safety of autologous umbilical cord blood transfusion to treat the newborn infants with presence of clinical indications of neonatal hypoxic-ischemia encephalopathy (HIE) and…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Hypoxia Neonatal, Cerebral Ischemia of Newborn, Anemia, Neonatal
- Trial name
- NCT03352310
- Testing
- autologous umbilical cord blood (UCB), standard care
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Mononuclear Therapeutics Ltd.
Anemia, Low Birth Weight
Treatment and Prevention of Severe Anemia in Pregnant Zanzibari Women
The purpose of this research is to compare the efficacy of two low-cost low intervention packages to prevent and treat severe anemia in pregnant women in Zanzibar, Tanzania.
- Conditions
- Anemia, Low Birth Weight, Neonatal Mortality
- Trial name
- NCT00148629
- Testing
- multivitamin, mebendazole
- Where
- Tanzania
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Cornell University
β-thalassemia Major
Safety and Efficacy of Gene Modified Autologous Hematopoietic Stem Cells to Treat Transfusion-dependent β-thalassemia
This study will be intented to evaluate the safety, tolerability, and engraftment efficacy after myeloablative preconditioning and transplantation of autologous CD34+ hematopoietic stem cells transduced with a lentiviral vector…
- Trial name
- NCT05776173
- Testing
- BD211
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai BDgene Co., Ltd.
Extreme Prematurity, Anemia of Prematurity
Folic Acid Supplementation to Reduce Anemia in Extremely Preterm Infants
Anemia of Prematurity (AOP) is very common in extremely preterm infants and often leads to blood transfusions. Folic acid, essential for growth and DNA synthesis, is deficient in premature infants.
- Trial name
- FASCINATE (NCT06220461)
- Testing
- Folic acid
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Calgary
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Iron, Abnormal Blood Level
PICU Transfusion Study: Harmful Effects of Red Blood Cell Transfusions
The investigators hypothesize that the storage-damaged red cells are responsible for some of the adverse effects of transfusion.
- Trial name
- NCT02087553
- Testing
- Transfusion of red blood cells, Infusion of albumin/saline
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Columbia University
Congenital Cardiac Defect, Acute Renal Injury
Investigation of the Relationship Between Blood Transfusion Volume and Development of Renal Failure in Pediatric Patients Undergoing Cardiovascular Surgery
Blood transfusion strategies in cardiac surgery are a research topic that has been studied more for adults. There is not enough data on this subject for children in studies.
- Conditions
- Congenital Cardiac Defect, Acute Renal Injury, Blood Transfusion Complication
- Trial name
- NCT06889272
- Testing
- blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 205 people
- Sponsor
- Hacettepe University