Clinical trials: Transfusions
Hip Fractures, Intertrochanteric Fractures
Does Early Administration of Tranexamic Acid Reduce Blood Loss and Perioperative Transfusion Requirement
Intertrochanteric hip fractures typically result in blood loss from the fracture and require surgery that can cause further blood loss.
- Trial name
- NCT03182751
- Testing
- Tranexamic Acid (TXA)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Mayo Clinic
Traumatic Intracranial Hemorrhage
Platelet Transfusion and Repeat TEG-PM in Patients With Severe TBI on Antiplatelet Therapy (Repeat TEG-PM)
The aim of this study is to see if administering platelets (cells in our blood that stop or prevent bleeding) results in improved platelet function and slows/stops the progression of a head bleed for patients who have a traumatic…
- Trial name
- NCT06433622
- Testing
- Repeat Thromboelastography with Platelet Mapping
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Lancaster General Hospital
Neonatal Hyperbilirubinemia, Treatment Decisions
Bilirubin Thresholds in Preterm Infants on Neonatal Intensive CarE Units: The B-NICE Trial
Rationale: Neonatal hyperbilirubinemia is highly prevalent in very preterm infants born <30 weeks. Since 2008, uniform Dutch phototherapy thresholds for preterm infants have been used nationwide, largely based on consensus.
- Conditions
- Neonatal Hyperbilirubinemia, Treatment Decisions, Neurodevelopmental Outcome, Phototherapy
- Trial name
- B-NICE (NCT07674537)
- Testing
- Phototherapy, Exchange Transfusion
- Where
- Netherlands
- Volunteers
- 680 people
- Sponsor
- University Medical Center Groningen
Transfusion-dependent α-Thalassemia
A Study Evaluating the Safety and Efficacy of the GMCN-508A Drug Product in Transfusion-dependent α-Thalassemia Participants
This is a non-randomized, open label, single-site, single-dose, phase 1 study in up to 5 participants (between 5 and 35 years of age, inclusive) with Transfusion-dependent α-thalassemia.
- Trial name
- NCT05757245
- Testing
- GMCN-508A Drug Product
- Where
- China
- Volunteers
- 5 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Hereditary Anemias
Utility of Fibroscan in Estimating Hepatic Iron Concentration
In patients with hereditary anemias (e.g. thalassemias), defective red blood cells are produced due to an error in the genes, or DNA, that provide the instructions for their synthesis.
- Trial name
- NCT02067130
- Testing
- Fibroscan
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Blood Transfusion; Hemoglobinemia, Hypoxia
The Role of Central Venous Oxygen Saturation (ScvO2) as an Indicator of Blood Transfusion in the Critically Ill
Transfusion of red blood cells is an everyday practice in critical care with the primary aim of restoring adequate tissue oxygenation.
- Conditions
- Blood Transfusion; Hemoglobinemia, Hypoxia, Anemia
- Trial name
- NCT03138200
- Testing
- Blood transfusion
- Where
- 2 sites in Hungary
- Volunteers
- 160 people
- Sponsor
- Szeged University
Chimerism, Blood Transfusion
Transfusion-Associated Microchimerism in Individuals Receiving a Blood Transfusion After a Traumatic Injury
Individuals who experience a traumatic injury often have a significant amount of blood loss and may require a blood transfusion.
- Conditions
- Chimerism, Blood Transfusion, Wounds and Injuries
- Trial name
- NCT00400192
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Vitalant Research Institute
Transfusion-dependent Anemia
Study to Evaluate Treatment Compliance, Efficacy and Safety of an Improved Deferasirox Formulation (Granules) in Pediatric Patients (2-<18 Years Old) With Iron Overload
This was a randomized, open-label, multicenter, two arm, phase II study to evaluate treatment compliance and change in serum ferritin of a deferasirox granule formulation and a deferasirox dispersible tablet (DT) formulation in…
- Trial name
- NCT02435212
- Testing
- Deferasirox granule formulation, Deferasirox DT formulation
- Where
- 43 sites in United States, Belgium and 15 more
- Volunteers
- 224 people
- Sponsor
- Novartis Pharmaceuticals
α-thalassemia
the Safety and Efficacy Evaluation of HGI-002 Injection in Patients With Transfusion-Dependent α-Thalassemia
This is an open label study to evaluate the safety and efficacy of α-globin Restored Autologous Hematopoietic Stem Cells in α-Thalassemia Major Patients
- Trial name
- NCT05851105
- Testing
- α-globin restored autologous hematopoietic stem cells
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Shenzhen Hemogen
Autism Spectrum Disorder, Autism
Safety and Efficacy of the Transfusion of UCB in Patients With an ASD Depending on the Degree of HLA Compatibility.
Autism is one of those disorders in Autism spectrum disorders (ASD), which characterized by social interaction abnormalities, impaired verbal and non-verbal communication, and repetitive, obsessive behavior, while the therapeutic…
- Trial name
- ASD-HLA2019 (NCT04099381)
- Testing
- ASD CB-MNC infusion low level HLA compatibility., ASD CB-MNC infusion high level HLA compatibility., Standard therapy.
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- State-Financed Health Facility "Samara Regional Medical Center Dinasty"
The Focus is on the Detection of the Consequences of Autologous Blood Transfusion in Healthy Volunteers
Biological Parameters Changes After Autologous Blood Transfusion of Red Blood Cells (200 ml) in Healthy Volunteers.
The purpose of this study is to evaluate if differences between samples of subjects obtained before autologous blood transfusion or samples of non-transfused subjects and samples of subjects after autologous blood transfusion can…
- Trial name
- AUTOT-SPORT (NCT03889834)
- Testing
- Autologous Blood Transfusion, No transfusion
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Malaria
Clinical and Biological Efficacy of Mirasol-treated Fresh Whole Blood for the Prevention of Transfusion-transmitted Malaria
The trial will evaluate the efficacy of the Mirasol Pathogen Reduction Technology for Whole Blood to prevent Malaria transmission by transfusion of whole blood.
- Trial name
- AIMS (NCT02118428)
- Testing
- Mirasol-treated Whole Blood, Untreated Whole Blood
- Where
- Ghana
- Volunteers
- 227 people
- Sponsor
- Terumo BCTbio
Fetal Anemia as Antepartum Condition (Diagnosis), Rh Incompatible Blood Transfusion Nos
Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion
INTRODUCTION Circulatory changes associated with fetal anemia have an important role in maintaining sufficient tissue oxygenation. With fetal anemia, hyperdynamic circulation and increased cardiac output occurred.
- Trial name
- NCT03169907
- Testing
- Mid trimesteric fetal ultrasonography
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Hematological Malignancies, Thrombocytopenia
PRevention Of BLeeding in hEmatological Malignancies With Antifibrinolytic (Epsilon Aminocaproic Acid)
STUDY BACKGROUND AND PURPOSE: Patients with hematological malignancies (blood-related cancers) often develop thrombocytopenia (low platelet count), which can be made worse by cancer treatment.
- Trial name
- PROBLEMA (NCT02074436)
- Testing
- EACA, Platelet transfusion
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Emory University
Hip Fracture, Blood Loss
The Effect of Tranexamic Acid on Transfusion Rates in Intertrochanteric Hip Fractures
The goal of this study is to determine if the use of tranexamic acid, a safe and effective antifibrinolytic, in patients with intertrochanteric hip fractures will result in a reduction in blood transfusion rates.
- Trial name
- NCT01940536
- Testing
- Tranexamic Acid
- Where
- United States
- Sponsor
- Hospital for Special Surgery, New York
Cardiac Disease, Blood Transfusion
Predicting CSA-AKI With ACTA-PORT Score
In the scope of this study, it will be determined whether the ACTA-PORT (Association of Cardiothoracic Anesthetists perioperative risk of blood transfusion) scoring system can predict the incidence of events in other organ…
- Conditions
- Cardiac Disease, Blood Transfusion, Acute Kidney Injury
- Trial name
- NCT06484907
- Where
- Turkey (Türkiye)
- Volunteers
- 467 people
- Sponsor
- Ankara City Hospital Bilkent
Red Blood Cells Transfusion, Oncologic Surgery
Transfusion Requirements in Surgical Oncologic Patient
Blood transfusion during perioperative period in patients undergoing to major surgery has been associated to several postoperative complications.
- Trial name
- TRISOP (NCT01502215)
- Testing
- Red blood cell transfusion
- Where
- Brazil
- Volunteers
- 198 people
- Sponsor
- University of Sao Paulo
Platelet Transfusion Refractoriness (PTR), Thrombocytopenia
The SOLID Platelet Study
Background: Platelets are cell fragments in the blood that help it clot. Some people get very low platelet counts during a disease or treatment. Low platelet counts can cause severe bleeding.
- Trial name
- NCT03712618
- Testing
- Platelet Transfusion - LONG Platelet Transfusion, Platelet Transfusion - SHORT Platelet Transfusion
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Anemia, Surgery
Anemia and Red Blood Cells Transfusion in Oncological Surgery
Oncologic patients experience anemia and anemia is associated with poor prognosis. Transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical…
- Conditions
- Anemia, Surgery, Oncology
- Trial name
- IMPACT (NCT04101240)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Massive Transfusion, Trauma
Australian and New Zealand Massive Transfusion Registry
Severe and un-stopped blood loss can occur for a number of different reasons including after a serious injury, delivery of a baby and following other medical and surgical emergencies.
- Conditions
- Massive Transfusion, Trauma, Cardiothoracic Surgery, Gastrointestinal Bleeding
- Trial name
- ANZ-MTR (NCT02863250)
- Where
- Australia
- Volunteers
- 50,000 people
- Sponsor
- Monash University
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