Clinical trials: Transfusions
Self-regulation, Forethought
Exploring Self-regulatory Processes in Anesthesiologists During Massive Transfusion
The purpose of the project is to investigate the function of self-regulatory processes in anesthesiologists and how application of these processes influence performance in a crisis situation.The investigators intend to explore…
- Conditions
- Self-regulation, Forethought, Performance
- Trial name
- NCT02199210
- Testing
- Prompting forethought
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Neonatal Jaundice, Hyperbilirubinemia
Compassionate Use of Stanate (TM) [Stannsoporfin]
The purpose of this protocol is to make Stanate (TM) [stannsoporfin, tin-mesoporphyrin] available to infants who meet the following criteria: 1.
- Trial name
- NCT00076960
- Testing
- Stanate (TM) [stannsoporfin, tin-mesoporphyrin]
- Where
- United States
- Sponsor
- InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company
Anaphylaxis, Allergy
Mechanisms of Anaphylaxis
The purpose of this study is to explore different mechanisms for anaphylaxis and find novel biomarkers for this hypersensitivity syndrome.
- Conditions
- Anaphylaxis, Allergy, Transfusion Reaction, Febrile Transfusion Reaction
- Trial name
- ANAMEK (NCT03182491)
- Testing
- Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Severe Anaemia
Study of Safe Blood Transfusion Volumes to Correct Acute Severe Anaemia
Greater volume of whole blood(30mls/kg compared to 20mls/kg) following standard calculations, given to children with severe anaemia will be beneficial in haematological correction and can be given safely since respiratory…
- Trial name
- Tx30 (NCT01461590)
- Testing
- Whole blood
- Where
- 2 sites in Uganda
- Volunteers
- 160 people
- Sponsor
- Prof Kathryn Maitland
COVID-19, Hematopoietic Stem Cell Transplantation
A Study to Evaluate the Safety and Efficacy of COVID-19 Convalescent Plasma (CCP) Transfusion to Prevent COVID-19 in Adult Recipients Following Hematopoietic Stem Cell Transplantation
The study is to evaluate the safety and efficacy of COVID-19 convalescent plasma (CCP) transfusion to prevent COVID-19 in adult recipients following hematopoietic stem cell transplantation.
- Trial name
- NCT05904067
- Testing
- COVID Convalescent Plasma
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
5q Minus Syndrome, Myelodysplastic Syndrome
Leucovorin for the Treatment of 5 q Minus Syndrome
The 5 q minus syndrome is a condition that occurs due to a missing segment of chromosome 5 in the normal genetic make-up of the cells responsible for forming blood cells.
- Trial name
- NCT00004997
- Testing
- Leucovorin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Thalassemia, Iron Overload
Combined Chelation Therapy in Patients With Transfusion Dependent Thalassemia and Iron Overload
This is a pilot study looking at the safety and efficacy of giving combination chelation with deferasirox and deferoxamine. The hypothesis is that combination chelation is safe in decreasing overall iron in patients with…
- Trial name
- NCT00901199
- Testing
- Combo Chelation with Deferasirox (Exjade) and Deferoxamine (DFO)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Elliott Vichinsky
Total Hip Replacement, Blood Loss
An Algorithm for Predicting Blood Loss and Transfusion Risk in Fast Track Total Hip Arthroplasty
Aim of these study is to create an algorithm, using data from patients that undergoing total hip arthroplasty, to predict blood loss after surgery and permit a safe domestic discharge.
- Trial name
- NCT02750852
- Testing
- Total hip arthroplasty, blood loss analysis
- Volunteers
- 124 people
- Sponsor
- Azienda Ospedaliera Bolognini di Seriate Bergamo
Hypoxia Neonatal, Premature
Pulse Oximetry Measurement and Transfusions
The primary purpose of this observational study was to determine if pRBC transfusions decrease the frequency of intermittent hypoxia events in very low birth weight infants (VLBW) during the first six weeks of life.
- Conditions
- Hypoxia Neonatal, Premature, Blood Transfusion
- Trial name
- POMAT (NCT04249193)
- Testing
- Transfusion
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Christiana Care Health Services
Blood Transfusion, Cardiac Surgery
Brain Tissue Oxygen Saturation and Blood Transfusion in Cardiac Surgery
In cardiac operations under cardiopulmonary bypass(CPB), monitoring of brain tissue oxygen saturation with infrared spectrophotoscopy leads to a reduction of the number of packed red cell(PRC) transfusions during the period of…
- Trial name
- INVOS (NCT00879463)
- Testing
- Brain tissue oxygen saturation monitoring, Transfusion according to the anesthesiologist's judgement
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Larissa University Hospital
Refractory Immune-mediated Platelet Transfusion Refractoriness, Relapsed or Refractory Immune Thrombocytopenia
RN1201 Injection in the Treatment of Antibody-Mediated Diseases
This single-arm, open-label exploratory trial aims to evaluate the safety, feasibility, and preliminary efficacy of RN1201 Injection in patients with antibody-mediated diseases, including refractory immune-mediated platelet…
- Trial name
- NCT07072247
- Testing
- CD19 and BCMA-targeted allogeneic CAR-T cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- The First Affiliated Hospital of Soochow University
TTTS
Neonatal Outcome for Laser Coagulation in Twin-to-twin-transfusion Syndrome
Twin-twin transfusion syndrome is one of the most severe complication in monochorionic twin pregnancies and can cause severe impairment of fetal and neonatal outcome.
- Trial name
- NCT03151915
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Michael Tchirikov MD, PhD
Ewing's Sarcoma, Neuroblastoma
New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma
The prognosis for patients with metastatic Ewing's sarcoma family of tumors (ESF), rhabdomyosarcoma (RMS), and neuroblastoma (NBL) remains dismal, with less than 25% long-term disease-free survival.
- Conditions
- Ewing's Sarcoma, Neuroblastoma, Rhabdomyosarcoma
- Trial name
- NCT00001335
- Testing
- ADR-529, Topotecan, G-CSF
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute (NCI)
Hepatitis C, HIV Infection
Nucleic Acid Amplification Testing (NAT) of Blood Donors for HCV and HIV
This study will evaluate the accuracy of an experimental test method called nucleic acid amplification technology (NAT) in detecting human immunodeficiency virus (HIV) and hepatitis C virus (HCV).
- Trial name
- NCT00004846
- Testing
- ABC/Gen-Probe/Chiron HIV-1/HCV 001
- Where
- United States
- Volunteers
- 30,000 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Prematurity Complications, Anemia
Personalizing Preterm Neonatal Transfusions With Fetal Hemoglobin-Enriched Cord Blood
Long-term morbidities among very low birth weight infants remain a significant challenge. Oxidative stress is a key factor in the pathogenesis of 'free radical (FR) diseases of prematurity,' including retinopathy of prematurity…
- Trial name
- ANH-Prestige (NCT07636473)
- Testing
- Cord Blood Red Blood Cell Transfusion (CB-RBC), Adult Donor Red Blood Cell Transfusion (A-RBC)
- Volunteers
- 200 people
- Sponsor
- University of Parma
Transfusion-dependent Hemachromatosis, Thalassemia Major
Pilot Study for Patients With Poor Response to Deferasirox
This purpose of this study is to understand the differences between people who have a good response to deferasirox (exjade) compared to people who have a poor response to this medication when used for transfusion-dependent iron…
- Conditions
- Transfusion-dependent Hemachromatosis, Thalassemia Major, Sickle Cell Disease
- Trial name
- NCT00749515
- Testing
- Deferoxamine, Deferasirox, HIDA
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Children's Hospital
Neonatal Thrombocytopenia, Intraventricular Hemorrhage
PRedicting OutcomeS in Preterm nEonates With thromboCyTopenia
Preterm neonates often receive platelet transfusions when their platelet count is low to prevent bleeding. However, it is currently unclear which infants benefit from such transfusions.
- Conditions
- Neonatal Thrombocytopenia, Intraventricular Hemorrhage, Platelet Transfusion
- Trial name
- PROSPECT (NCT06043050)
- Testing
- Platelets
- Where
- 12 sites in Germany, Netherlands and 1 more
- Volunteers
- 1,042 people
- Sponsor
- Leiden University Medical Center
Preterm Infants, Anemia of Prematurity
Hepcidin Levels in Preterm Infants
A recently isolated peptide hormone, hepcidin, is thought to be the principal regulator of iron homeostasis. Hepcidin acts by limiting intestinal iron absorption and promoting iron retention in reticuloendothelial cells.
- Conditions
- Preterm Infants, Anemia of Prematurity, Neonatal Sepsis
- Trial name
- NCT01539356
- Where
- Israel
- Volunteers
- 62 people
- Sponsor
- Meir Medical Center
Anemia
RBC Transfusion in Severe Anemia With Lactic Acidosis
The hypothesis of this study is that prolonged-storage RBCs are not inferior to short-storage RBCs for the time required to clear elevated blood lactate levels in children with severe anemia.
- Trial name
- TOTAL (NCT01586923)
- Testing
- RBC transfusion
- Where
- Uganda
- Volunteers
- 290 people
- Sponsor
- Massachusetts General Hospital
Trauma, Hemorrhage
Transfusion for Major Haemorrhage in Trauma - Characteristics and Outcomes
Background: Trauma is the leading cause of death in young adults worldwide and the most common causes of mortality are haemorrhage and brain injury.
- Conditions
- Trauma, Hemorrhage, Shock, Traumatic, Acute Coagulopathy
- Trial name
- NCT05573841
- Where
- Sweden
- Volunteers
- 161 people
- Sponsor
- Karolinska University Hospital