Clinical trials: Transfusions
Cardiac Arrest
Goal-orientated Coagulation Management in Hypothermic Cardiac Arrest Surgery
Cardiac surgery including hypothermic cardiac arrest (HCA) commonly involves perioperative transfusion of allogeneic blood products which is associated with increased morbidity and mortality.
- Trial name
- NCT01446354
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Transfusions
Impact of Feeding on Pro-Inflammatory Cytokine Response in Neonates Receiving a RBC Transfusion
Prior to a non-urgent blood transfusion, subjects will be randomized to either stopping feeds or continuing feeds. The intervention group will be the placement of a subject in the NPO group.
- Trial name
- NCT01949896
- Testing
- NPO, Control group: continue feedings
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Ewing's Sarcoma, Neuroblastoma
New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma
The prognosis for patients with metastatic Ewing's sarcoma family of tumors (ESF), rhabdomyosarcoma (RMS), and neuroblastoma (NBL) remains dismal, with less than 25% long-term disease-free survival.
- Conditions
- Ewing's Sarcoma, Neuroblastoma, Rhabdomyosarcoma
- Trial name
- NCT00001335
- Testing
- ADR-529, Topotecan, G-CSF
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute (NCI)
Transfusional Iron Overload, β-thalassemia Major
A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload.
In this 4-year extension study the safety, efficacy and and pharmacokinetics of deferasirox in regularly transfused pediatric patients with β-thalassemia major was assessed.
- Conditions
- Transfusional Iron Overload, β-thalassemia Major, Pediatric Rare Anemia
- Trial name
- NCT00390858
- Testing
- Deferasirox
- Where
- 4 sites in France, Italy
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Anemia
The Study on Umbilical Cord Milking to Prevent and Decrease the Severity of Anemia in Preterms
The overall objective of the present study is to examine the effects of umbilical cord milking at birth in preterm infants to prevent and decrease anemia using a multi-center prospective randomized controlled trial comparing…
- Trial name
- NCT03023917
- Testing
- umbilical cord milking, umbilical cord clamping immediately
- Where
- China
- Volunteers
- 284 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Infant Development
Measurements of Anemia and Physiologic Tissue Response to Blood Transfusions in VLBW Infants Using Quantitative NIRS
The study quantified functional measures of red blood cell mass and oxygen in neonatal tissues using a non-invasive optical technique: near infrared optical spectroscopy .
- Trial name
- NCT00544375
- Testing
- Optical measurement
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Blood Coagulation, Disorders, Surgical Procedures, Minimally Invasive
Is Plasma Transfusion Beneficial Prior to Low-Risk Procedures in Hospitalized Patients With Blood Clotting Abnormalities?
Blood clotting abnormalities or problems that happen during surgery ? even minor surgery ? are serious because of the possibility of serious bleeding that cannot be stopped.
- Trial name
- NCT00953901
- Testing
- Fresh Frozen Plasma Transfusion
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Surgery, Blood Loss
Epidemiology of Severe Peroperative Bleeding During Scheduled Surgery
Peroperative bleeding has been studied in specific populations exposed to bleeding (i.e. cardiac surgery, orthopedic surgery). Epidemiology of peroperative bleeding and transfusion remain poorly studied in the whole cohort of…
- Trial name
- NCT02311309
- Testing
- Control, Unanticipated bleeding
- Volunteers
- 1,439 people
- Sponsor
- University Hospital, Caen
E-Aminocaproic Acid, Bilateral Varus Rotational Osteotomy
The Effect of Intravenous EACA on Blood Loss and Transfusion Requirements After Bilateral VRO
E-Aminocaproic acid (EACA) is an anti-fibrinolytic agent that is used to decrease blood loss and transfusion requirements after several orthopedic procedures.
- Trial name
- NCT02257580
- Testing
- E-Aminocaproic acid
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Hospital for Special Surgery, New York
Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion
Trial of Indication-Based Transfusion of Red Blood Cells in ECMO
TITRE - Trial of Indication-based Transfusion of Red Blood Cells in ECMO, is a multicenter, prospective, randomized clinical trial.
- Conditions
- Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion, Organ Failure, Multiple
- Trial name
- TITRE (NCT05405426)
- Testing
- Red blood cell transfusion
- Where
- 22 sites in United States, Australia and 1 more
- Volunteers
- 228 people
- Sponsor
- Boston Children's Hospital
Iron Overload
MRI T2* Mapping of Myocardium, Liver, Pancreas and Pituitary Gland
All patients were investigated using a 3T MRI and 1,5 T MRI scanners. For myocardium, pancreas and pituitary gland iron overload quantification in children we have used special sequences for T2*-mapping.
- Trial name
- NCT04835285
- Testing
- Npf.
- Where
- Russia
- Volunteers
- 152 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Premature, Placental Transfusion
Evaluation of Placental Transfusion Techniques in Prevention of Prematurity Related Complications and Effect on Their Hematological Profile
The objective of this study is to evaluate the general course and prognosis associated with different methods of placental transfusion (Intact umbilical cord milking, cut- umbilical cord milking and delayed cord clamping) in…
- Trial name
- NCT06812507
- Testing
- intact umbilical milking, cut umbilical milking, Delayed cord clamping
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Iron Overload Due to Repeated Red Blood Cell Transfusions
Study for Transfusionally Iron Overloaded Children, Adolescents and Adults Using FBS0701 (SSP-004184)
The purpose of this extension study is to evaluate SSP-004184AQ in patients with transfusional iron overload and to provide data on long term safety and efficacy.
- Trial name
- NCT01671111
- Testing
- SSP-004184AQ
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 30 people
- Sponsor
- Shire
Metastases to Bone
Tranexamic Acid After Pathological Fracture Treated With Modular Arthroplasty
This study assesses the safety and efficacy of TXA for patients treated for pathological femur fractures using modular prosthetics.
- Trial name
- NCT06244498
- Testing
- Tranexamic acid injection
- Where
- Poland
- Volunteers
- 110 people
- Sponsor
- Piotr Biega
Blood Transfusion
Developing, Implementing and Evaluating Effective Community-facility Interactions to Improve Blood Availability and Transfusion in Three Distinct County Settings in Kenya
The strategy of the CoBAnK study is to establish and enable the function of Community-Facility Transfusion Committees (CFTCs) incorporating diverse representation involving hospital, community, and county leadership, to improve…
- Trial name
- CoBAnK (NCT06142825)
- Testing
- Community-Facility Transfusion Committee (CFTC)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Necrotizing Enterocolitis
The Impact of Different Feeding Strategies During Packed Red Cell Transfusion on Intestinal Oxygenation
This study aims to compare the differences between three different feeding regimens on intestinal oxygenation during packed red blood cell (PRBC) transfusion in premature babies.
- Trial name
- NCT02733718
- Testing
- NIRS (near-infrared spectroscopy)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Marmara University
Necrotizing Enterocolitis
SMA Flow Patterns in Neonatal Transfusion
This study aims to measure the changes induced by packed red blood cell (PRBC) transfusion in the superior mesenteric artery (SMA) flow velocity and intestinal oxygenation indices in premature neonates.
- Trial name
- SPARTAN (NCT02347475)
- Testing
- Observational Study
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University of Calgary
Transfusion-dependent Beta-Thalassemia
Safety and Efficacy of the Lentiviral Vector in Gene Therapy of Beta-thalassemia Patients
This is a non-randomized, open-label, single-dose study. The aim of this study is to evaluate the safety and efficacy of the treatment with lentiviral vector encoding βA-T87Q-globin gene transduced autologous hematopoietic stem…
- Trial name
- NCT06219239
- Testing
- KL003 cell injection Drug Product
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Haemolysis Neonatal
Efficacy of Intravenous Immunoglobulin in Management of Rh and ABO Incompatibility Disease
hemolytic disease of newborn is an important cause of hyperbilirubinemia with significant morbidity and mortality in neonatal period. intravenous immunoglobulin has widely used in management of hemolytic disease of new born
- Trial name
- IVIG (NCT03130517)
- Testing
- intravenous immunoglobulin
- Volunteers
- 30 people
- Sponsor
- Assiut University
Lymphoproliferative Disorders
Transfusion-related EBV Infection Among Allogeneic Stem Cell Transplant Pediatric Recipients
In many countries, numerous steps are taken to minimize the risk of infection from transfused blood products. Typically, blood banking organisations will screen for an array of infectious pathogens as part of their quality…
- Trial name
- TREASuRE (NCT02505789)
- Testing
- Determining the source of EBV in severe EBV infections
- Where
- 3 sites in Canada
- Volunteers
- 324 people
- Sponsor
- St. Justine's Hospital