Clinical trials: Transfusions
Hypoxic-Ischemic Encephalopathy, Sepsis
Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants
Historically, CKRT and hemodialysis were performed in small infants and newborns with devices developed for adults with high rates of complications and mortality.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Sepsis, Kidney Diseases, Metabolic Disease
- Trial name
- NCT05495607
- Testing
- CARPEDIEN
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Type 1 Diabetes, Children
Cord Blood Infusion for Type 1 Diabetes Mellitus (T1DM)
Type 1 diabetes (T1D) is still associated with tremendous morbidity and premature mortality. Patients require multiple daily insulin injections throughout their lives as well as close monitoring of their diet and blood sugar…
- Trial name
- NCT00989547
- Testing
- Umbilical Cord Blood VITA 34
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Technical University of Munich
Hutchinson-Gilford Progeria Syndrome
Umbilical Cord Blood Transfusion in Progeria Syndrome
This is a pilot study on safety and efficacy of umbilical cord blood therapy for patients with Hutchinson Gilford Progeria syndrome (HGPS).
- Trial name
- NCT03871972
- Testing
- Umbilical Cord Blood Unit
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Bundang CHA Hospital
Aplastic Anemia, Platelet Transfusion Refractoriness
Efficacy of Daratumumab to Overcome Platelet Transfusion Refractoriness in Patients with Aplastic Anemia
This is a phase 1, prospective, single-arm, open-label study. The aim of this study is to evaluate the transfusion responses of platelet increment by using Daratumumab among aplastic anemia patients with platelet transfusion…
- Trial name
- NCT05832216
- Testing
- Daratumumab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Blood Transfusion Complication
Blood Transfusion Education Using Blended Virtual Reality and Simulation for Nursing Undergraduate Students
Nurse-administered blood transfusion (BT) is a common form of medical treatment, but nursing students are often excluded from participating in and observing BTs during clinical placements.
- Trial name
- NCT05922163
- Testing
- Evidence-based VR simulation
- Where
- Hong Kong
- Volunteers
- 151 people
- Sponsor
- The University of Hong Kong
Pediatric Cardiac Surgery, Transfusion
Is Redo Pediatric Cardiac Surgery a Risk Factor for Transfusion?
In pediatric cardiac surgery, transfusion requirements are associated with age, development status, pathology, type of surgical intervention and extracorporeal bypass.
- Trial name
- NCT04456751
- Testing
- Redo op
- Where
- Belgium
- Volunteers
- 2,439 people
- Sponsor
- Brugmann University Hospital
Allergy, Transfusion Reaction
Allergic Transfusion Reactions in Plasma Transfusion
Allergic transfusion reactions are a common complication of transfusion by blood components containing plasma. This study aims to investigate passive transfer of Immunoglobin E antibodies as a risk factor of allergic reactions to…
- Trial name
- NCT02200692
- Where
- Norway
- Volunteers
- 38 people
- Sponsor
- Haukeland University Hospital
Blood Component Transfusion
Appropriateness of Frozen Plasma Use in Canada
There is little evidence to guide the current use of Frozen Plasma. Despite this, over 260,000 units of frozen plasma are transfused in Canada annually.
- Trial name
- NCT01187030
- Volunteers
- 2,580 people
- Sponsor
- Ottawa Hospital Research Institute
MDS-EB
Allogenic NK Cell Transfusion Azacitidine MDS-EB
The aim of this investigation was to assess safety and efficacy of allogenic NK cells therapy for refractory MDS-EB.
- Trial name
- NCT04599426
- Testing
- Allogeneic NK cell regimen group
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Second Hospital of Shandong University
Patient Blood Management
Impact of Patient Blood Management (PBM) at the Schulthess Clinic
Aim of this study is to analyze the transfusion requirements of allogenic blood products at the Schulthess Clinic for patients that had major orthopedic or major spine surgery between 2019 and 2024 order to identify patients at…
- Trial name
- PBM (NCT06363214)
- Testing
- Patient blood management
- Volunteers
- 16,000 people
- Sponsor
- Schulthess Klinik
Blood Loss, Anatomic Total Shoulder Arthroplasty
Investigation of Intravenous Tranexamic Acid With Anatomic and Reverse Total Shoulder Arthroplasty
To compare intravenous Tranexamic Acid (TXA) versus normal saline placebo to determine whether or not TXA administration reduces blood loss, decrease in hemoglobin, and rate of transfusions following anatomic and reverse total…
- Conditions
- Blood Loss, Anatomic Total Shoulder Arthroplasty, Reverse Total Shoulder Arthroplasty, Transfusion
- Trial name
- NCT02569658
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Platelet Transfusion Refractoriness, Acute Leukemia in Remission
Sequential Infusion of CD19 and BCMA CAR-T Cells to Improve PTR in Patients With AL
Alloimmune-mediated platelet transfusion refractoriness(PTR) was usually caused by repeated blood transfusions and pregnancy and accounts for about 20-25% of PTR patients.
- Trial name
- NCT04846439
- Testing
- CAR-T infusion
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
α-thalassemia
the Safety and Efficacy Evaluation of HGI-002 Injection in Patients With Transfusion-Dependent α-Thalassemia
This is an open label study to evaluate the safety and efficacy of α-globin Restored Autologous Hematopoietic Stem Cells in α-Thalassemia Major Patients
- Trial name
- NCT05851105
- Testing
- α-globin restored autologous hematopoietic stem cells
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Shenzhen Hemogen
Sickle Cell Disease
Utilizing A Single Session Problem-Solving Intervention With Caregivers of Pediatric Patients Receiving Chronic Transfusion to Treat Sickle Cell Disease
This study seeks to utilize an innovative approach of a single session problem-solving intervention to address psychosocial factors affecting patient outcomes within the pediatric sickle cell population.
- Trial name
- NCT04606160
- Testing
- Single Session Problem-Solving Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Anemia of Prematurity
The Effect of Blood Transfusion on Blood Flow to the Intestines of Premature Infants
The purpose of the study is to see if a blood transfusion changes how fast blood flows to the intestines of a premature baby. Blood flow is measured by an ultrasound test.
- Trial name
- NCT00167388
- Testing
- feed during blood transfusion
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pittsburgh
Beta-Thalassemia, Non-transfusion-dependent Thalassemia
Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Preliminary Efficacy of VIT-2763 in β-thalassaemia
This is a randomised, double-blind, placebo-controlled parallel group trial to investigate the safety, tolerability and efficacy of multiple doses of VIT-2763 versus placebo in participants with non-transfusion-dependent…
- Trial name
- VITHAL (NCT04364269)
- Testing
- VIT-2763 once a day (QD), VIT-2763 twice a day (BID)
- Where
- 16 sites in Greece, Israel and 3 more
- Volunteers
- 35 people
- Sponsor
- Vifor (International) Inc.
β-thalassemia
Safety and Efficacy of Gene Modified Autologous Hematopoietic Stem Cells to Treat Transfusion-dependent Beta-thalassemia
This study will be intented to evaluate the safety, tolerability, and engraftment efficacy after myeloablative preconditioning and transplantation of autologous CD34+ hematopoietic stem cells transduced with a lentiviral vector…
- Trial name
- NCT05773729
- Testing
- BD211
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai BDgene Co., Ltd.
Scoliosis
Transfusion Requirements During Spinal Surgery for Severe Scoliosis
Corrective surgery for scoliosis can result in prolonged operating room time and significant blood loss. The investigators goal is to determine what the transfusion requirements are for young adults undergoing spinal surgery for…
- Trial name
- NCT01490164
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rutgers, The State University of New Jersey
Transfusion Related Complication
Impact of Transfusional Practice on the Morbidity and Mortality of Patients in Intensive Care Unit
This study will allow correlating transfusion monitoring and patients' prognostic according to the chosen outcome criteria. These data could thus represent a basis for transfusion recommendations, except for intensive care and…
- Trial name
- PATMORE (NCT03934112)
- Where
- France
- Volunteers
- 150,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Myeloid Leukemia
A Trial Comparing a Prophylactic With a Therapeutic Platelet Transfusion Strategy in Two Groups
The purpose of this study is to show that a therapeutic platelet transfusion strategy (i.e. platelet transfusion only in case of bleeding) needs minimally a quarter less of transfusions compared to the standard prophylactic…
- Trial name
- NCT00521664
- Testing
- Prophylactic platelet transfusion, Therapeutic platelet transfusion
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Technische Universität Dresden