Clinical trials: Transfusions
Transfusion-dependent Thalassemia
Safety & Efficacy of Thalidomide in Children With Transfusion Dependent Thalassemia
Transfusion Dependent Thalassemia (TDT) is emerging as a global public health concern. Hemopoietic stem cell transplantation (HSCT) is the only curative treatment.
- Trial name
- NCT06098014
- Testing
- Thalidomide Capsules
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Acute Myeloid Leukemia
Transfusion in Adult Acute Myeloid Leukemia
Acute myeloid leukaemia (AML) is a haematological malignant disease characterized by an uncontrolled proliferation of immature hematopoietic cells.
- Trial name
- NCT02899767
- Volunteers
- 1,067 people
- Sponsor
- Hospices Civils de Lyon
Venous System, Venous Access
A Retrospective, Observational, Monocenter, Study to Describe the Utilization and Overall Safety and Performance of POLYSITE®/SEESITE® Implantable Ports
This study is a retrospective, observational, monocenter case series. The purpose of this study is to collect clinical data to describe the use of POLYSITE® and SEESITE® devices and verify overall safety and performance.
- Conditions
- Venous System, Venous Access, Chemotherapy, Antibiotics
- Trial name
- NCT05519787
- Testing
- Central Veinous access devices' insertion
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Perouse Medical
Massive Hemorrhage, Massive Blood Loss
Recombinant Activated Factor VII in the Management of Massive Bleeding in Hospital Universiti Sains Malaysia
This is a retrospective descriptive study, to study the treatment indications, changes in transfusion need, coagulation profiles changes and clinical outcome (survival, complication) of non-haemophiliac patients who received…
- Conditions
- Massive Hemorrhage, Massive Blood Loss, Massive Blood Transfusion; Thrombocytopenia
- Trial name
- NCT03251547
- Testing
- NovoSeven
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Universiti Sains Malaysia
Placental Transfusion
Short-Delay Cord Clamping Compared to Extended- Delay Cord Clamping in Term Neonates That Require Resuscitation.
To determine whether performing extended delayed cord clamping in term neonates that require resuscitation improves early transition as compared to short-delayed cord clamping.
- Trial name
- Term-NRIC (NCT02827409)
- Testing
- Short Delay Cord Clamping, Extended Delay Cord Clamping
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Anup Katheria, M.D.
Infant, Newborn, Infant, Low Birth Weight
The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants
This study tested the safety and efficacy of transfusing erythropoietin (Epo) and iron in infants of <1,250g birth weight. For infants 401-1,000g birth weight, we tested whether early erythropoietin (Epo) and iron therapy would…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- EPO (NCT01203514)
- Testing
- Erythropoietin
- Where
- 9 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Blood Transfusion, Hip Fracture Surgeries
Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs
This study looks at patients with hip fractures who are taking direct oral anticoagulants (DOACs), a type of blood thinner. In many hospitals, surgery for these patients is delayed because of concerns about bleeding, but waiting…
- Conditions
- Blood Transfusion, Hip Fracture Surgeries, Geriatric, Bleeding Complications
- Trial name
- OPTIMIZEDOAC (NCT07309848)
- Where
- 7 sites in Netherlands
- Volunteers
- 374 people
- Sponsor
- St. Antonius Hospital
Thalassemia, Beta
Long-term Follow-up Study of BRL-101 for TDT
Observe long-term safety risk and long-term efficacy after intravenous infusion of BRL-101 in TDT subjects.
- Trial name
- NCT06298630
- Testing
- Assessments
- Where
- 7 sites in China
- Volunteers
- 45 people
- Sponsor
- Bioray Laboratories
Postoperative Hemorrhage
Antithrombin III Supplementation for Cardiopulmonary Bypass in Neonates
A prospective, randomized, placebo-controlled, double-blinded pilot study is planned. Neonates undergoing surgeries requiring cardiopulmonary bypass will receive antithrombin III (ATIII) supplementation or placebo in addition to…
- Trial name
- NCT01158729
- Testing
- Antithrombin (Recombinant)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical College of Wisconsin
Blood Component Transfusion, Cardiac Surgical Procedures
Plasma Utilization Following Cardiac Surgery
In Canada, 218,000 units of fresh frozen plasma and frozen plasma were transfused in 2005.Cardiac surgery patients are the largest recipient group for FP transfusions.
- Trial name
- PUCS (NCT01187394)
- Where
- Canada
- Volunteers
- 970 people
- Sponsor
- Ottawa Hospital Research Institute
Transfusion
Intraoperative Transfusion Practice in Children
The purpose of this study is to examine factors, impact and outcome on perioperative blood transfusion for pediatric patients.
- Trial name
- NCT04282382
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Beta Thalassemia Transfusion Dependent
Effect of Deferasirox on Patients With Cardiac MRI T2* < 20 Msec
This study will assess the safety and efficacy of deferasirox in patients with cardiac MRI T2* < 20 msec.
- Trial name
- NCT00879242
- Testing
- Deferasirox
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Novartis Pharmaceuticals
Cardiac Disease, Cardiac Surgery
Platelet Transfusion During Neonatal Open Heart Surgery
Hypothesis: Dilutional thrombocytopenia after cardiopulmonary bypass (CPB) is universal and administration of donor apheresis platelets just prior to termination of bypass will assist in early correction of coagulopathy, early…
- Conditions
- Cardiac Disease, Cardiac Surgery, Cardiopulmonary Bypass, Platelet Transfusion
- Trial name
- CPB (NCT03045068)
- Testing
- Platelet Transfusion, FFP and Cryoprecipitate, PRBC and cell saver Transfusion
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The University of Texas Health Science Center, Houston
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Thalassemia in Children
Efficacy of Transdermal Microneedle Patch for Topical Anesthesia Enhancement in Paediatric Thalassemia Patients
Microneedle (MN) is the mimic of a hypodermic needle, composed of hundreds of micron-sized, out-of-plane protrusions, typically arranged in arrays on a patch that can be applied onto the skin.
- Trial name
- NCT05078463
- Testing
- Microneedle, 1 Finger Tip Unit (FTU) EMLA Cream (30-minute application time), 1 Finger Tip Unit (FTU) EMLA (15-minute application time)
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Blood Transfusion, Cardiac Surgery
ICU Cell Saver to Reduce Blood Transfusions in Cardiac
PURPOSE: Autotransfusion devices may be employed in cardiac surgery to decrease allogenic blood requirements. Limitations of previous trials include the use of cell saver systems in selected high risk patients only or the lack of…
- Trial name
- NCT00950547
- Testing
- CARDIOPAT, Traditional Chest Drains
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Cardiochirurgia E.H.
Osteoarthritis, Hip, Joint Deformities, Acquired
Efficacy of Aquamantys for Reducing Transfusions With Anterior Supine Intermuscular Approach Total Hip Arthroplasty
The purpose of this study is to establish whether or not there is a clinical advantage to the use of Aquamantys® System from Medtronic Advanced Energy (formerly Salient Surgical Technologies) in patients undergoing primary total…
- Conditions
- Osteoarthritis, Hip, Joint Deformities, Acquired, Hip Dislocation, Congenital, Osteonecrosis
- Trial name
- Aquamantys (NCT01583465)
- Testing
- Aquamantys, standard electrocautery (Bovie)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Joint Implant Surgeons, Inc.
Preterm Birth, Blood Transfusion Complication
Blood Warming in Preterm Infants to Decrease Hypothermia
Background/significance: Over 100,000 early preterm infants are born annually in the United States and suffer morbidity and mortality during hospitalization in a neonatal intensive care unit. One such condition is hypothermia.
- Conditions
- Preterm Birth, Blood Transfusion Complication, Hypothermia
- Trial name
- NCT05170633
- Testing
- Ranger blood warmer (3M Healthcare, Oakdale, Minnesota)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Surgical Blood Loss, Surgical Hemorrhage
TEG Use in Children Undergoing Procedures With High Anticipated Blood Loss
The research team proposes a prospective, observational study to better understand how TEG can be useful in guiding clinical practice in the Main OR for subject's undergoing high transfusion risk surgeries.
- Conditions
- Surgical Blood Loss, Surgical Hemorrhage, Post Operative Hemorrhage
- Trial name
- NCT05379530
- Testing
- Thromboelastography (TEG), Anesthesia Provider Survey
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Trauma
Unmet Need for Massive Transfusion in Indian Trauma Patients
This study aims to estimate the difference between predicted and provided massive transfusion in adult trauma patients admitted to university hospitals in urban India.
- Trial name
- NCT03068104
- Testing
- No intervention
- Volunteers
- 16,047 people
- Sponsor
- Karolinska Institutet