Clinical trials: Transmission Vertical
Vertical Transmission of Infectious Disease, HIV Infections
Community Health Workers and Prevention of Mother-to-Child HIV Transmission in Tanzania
The investigators implemented and evaluated a pilot program in Shinyanga Region, Tanzania to bring prevention of HIV services to communities using community health workers (CHWs).
- Trial name
- NCT03058484
- Testing
- Community Health Worker intervention
- Volunteers
- 1,830 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
HIV Infections
Evaluating the Safety and Pharmacokinetics of Maraviroc in HIV-1-Exposed Infants at Risk of Acquiring HIV-1 Infection
This study aimed to evaluate the safety, tolerability, and pharmacokinetics of maraviroc in infants at risk for mother-to-child HIV transmission, and to determine an appropriate dose of maraviroc during the first six weeks of…
- Trial name
- NCT02778204
- Testing
- Maraviroc
- Where
- 9 sites in United States, Kenya and 2 more
- Volunteers
- 47 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatitis C, Transmission
Vertical Transmission of Hepatitis C Virus
Vertical HCV Transmission has been extensively studied, with a risk around 5% (range: 3 to 10%). Spontaneous viral clearance in infected children during childhood can occur, but data about this phenomenon are scarse, justifying…
- Trial name
- NCT02044042
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hopital Lariboisière
SARS-CoV-2, Covid19
Assessing the Mother-to-infant Transmission Capabilities of COVID-19 Infection Among Pregnant Women in Ontario, Canada
In order to assess the mother-to-infant and potential vertical transmission of SARS-CoV-2 infection in pregnant women, maternal and neonatal biological samples were prospectively collected from women with confirmed or suspected…
- Conditions
- SARS-CoV-2, Covid19, Corona Virus Infection, Infectious Disease Transmission, Vertical
- Trial name
- COPE (NCT04913948)
- Testing
- No intervention
- Where
- 12 sites in Canada
- Volunteers
- 246 people
- Sponsor
- Ottawa Hospital Research Institute
Human Immunodeficiency Virus
Evaluation of Problem Management Plus in Pregnant Women With HIV in Kenya
This study includes secondary quantitative analysis, qualitative methods, and hybrid type 2 implementation-effectiveness pilot trial.
- Trial name
- Tatua (NCT05841797)
- Testing
- In-Person Program Management Plus (PM+), Mobile Program Management Plus (mHealth PM+)
- Where
- Kenya
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
COVID-19, Neonatal Disease
Characteristics of Neonatal Covid-19 in Turkey
The investigators aimed to investigate the clinical and epidemiological characteristics of neonates who will be born to Covid-19 positive mothers in Turkey.
- Conditions
- COVID-19, Neonatal Disease, Healthy
- Trial name
- NCT04401540
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
HIV Infections, Pregnancy
Study of Perinatal Transmission of Zidovudine-Resistant HIV Among Pregnant Women Treated With Zidovudine
To identify patterns of zidovudine ( AZT ) susceptibility among mother/infant pairs with perinatal HIV transmission. Most HIV-infected infants acquire their disease via perinatal transmission.
- Trial name
- NCT00000828
- Where
- 29 sites in United States, Puerto Rico
- Volunteers
- 250 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Immune Globulin, Prophylaxis, Telbuvidine, Vaccine
Efficacy of Antiviral Therapy in Pregnancy in Preventing Vertical Transmission of HBV in Mothers With a High Viral Load
Mother-to-child transmission (MTCT) is the most common route of hepatitis B virus (HBV) infection. After given standard immunoprophylaxis, MTCT still occurred in some infants born to a HBsAg positive mothers with high HBV DNA…
- Trial name
- NCT02253485
- Testing
- telbivudine
- Volunteers
- 600 people
- Sponsor
- Beijing Ditan Hospital
Hepatitis C, Infection Transmission, Maternal-Fetal
The Pathogenesis of Hepatitis C Virus Vertical Transmission
To evaluate for the presence of HCV Core protein, HCV RNA and SPP in the placenta and fetal membranes using paraffin-embedded sections and post-delivery specimens respectively.
- Trial name
- NCT01921400
- Where
- 2 sites in United States, Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Neonate, Maternal Transmission
Phase 3 Maternal Safety & Immunogenicity Trial of MVA-BN® in DRC
This Phase 3 open-label study aims to assess the safety and immune response of the MVA-BN mpox vaccine when administered subcutaneously to pregnant and postpartum women in the Democratic Republic of the Congo (DRC), a population…
- Conditions
- Neonate, Maternal Transmission, Mpox, Vaccination
- Trial name
- PregInPoxVac (NCT06844500)
- Testing
- MVA-BN standard regimen, MVA-BN standard regimen (Administered as PEP)
- Where
- Democratic Republic of the Congo
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- Jean-Pierre Van geertruyden
Hepatitis B, Chronic
Study of Antiretroviral Therapy to Prevent HBV Intrauterine Infection
500 pregnant patients with HBeAg-positive and HBV-DNA≥ 106copies /ml who will do their pregnant check in the First Affiliated Hospital of Xi'an Jiaotong University will be enrolled into the study.
- Trial name
- NCT02719808
- Testing
- Tenofovir1, Tenofovir2, Tenofovir3
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
HIV Infections
Nevirapine (NVP) Use to Prevent Mother-to-Child Transmission of HIV
HIV can be transmitted from an HIV infected mother to her infant through her breast milk. The purpose of this study is to determine whether giving infants of HIV infected mothers the anti-HIV drug nevirapine (NVP) for six weeks…
- Trial name
- NCT00074399
- Testing
- Nevirapine
- Where
- Ethiopia
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus Transmission, Human Immunodeficiency Virus
Validation of Rapid Tests for the Serological Diagnosis of HIV in 9 to 24 Months Old Children
Antiretroviral therapy of the mother and of the newborn associated with alternative schemes of breastfeeding can reduce these transmission rates to 1%.
- Conditions
- Human Immunodeficiency Virus Transmission, Human Immunodeficiency Virus, Diagnoses, Syndromes, and Conditions
- Trial name
- NCT03984552
- Testing
- This was an observational study of medical devices (rapid tests) used for the HIV diagnosis in children up to 2 years
- Where
- Brazil
- Volunteers
- 502 people
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Human Papilloma Virus (HPV), Cervical Carcinoma
Transmission of Oncogenic HPV Infection Among Families
The goal of the Transmission of Oncogenic HPV Infection Among Families (TREVINO) study is to improve understanding of how high-risk human papillomavirus (HPV) infections are transmitted within families.
- Conditions
- Human Papilloma Virus (HPV), Cervical Carcinoma, Oropharyngeal Carcinoma, Transmission Vertical
- Trial name
- TREVINO (NCT07036211)
- Where
- 2 sites in Finland
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Pregnant Women, Covid19
Exploratory Study: COVID-19 and Pregnancy
The SARS-CoV-2 infection may behave differently in pregnant and postpartum women in the short and long term. Several risk factors or medication use can interfere on disease' evolution and vertical transmission.
- Trial name
- NCT04647994
- Testing
- SARS-CoV-2 serology
- Where
- Brazil
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Hiv, Transmission Vertical
Differentiated Service Delivery for Pregnant and Postpartum Women Living With HIV and Their Infants
Differentiated service delivery (DSD) is an evidence-based HIV care and treatment model endorsed by the World Health Organization (WHO) that simplifies HIV services for clients who are clinically stable, improving the quality and…
- Conditions
- Hiv, Transmission Vertical, Viremia, Health Care Acceptability
- Trial name
- NCT06629753
- Testing
- Differentiated service delivery model
- Where
- Kenya
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pathogen Transmission, Vertical, Nosocomial Infection
Use of Disposable Cuff Cover to Prevent Carriage of Pathogen Microorganisms Originated by Cuffs
Introduction: Pathogen Microrganisms (PM) colonized on the Blood Pressure Cuff (BPC) are transported from one patient to another by health professionals, which is leading an increase in Health Care Associated Infections (HCAI).
- Conditions
- Pathogen Transmission, Vertical, Nosocomial Infection, Cross Infection, Cuff
- Trial name
- DCC (NCT05326945)
- Testing
- Presence or Absence of a Blood Pressure Cuff Sheath
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people
- Sponsor
- Hasan Kalyoncu University