Clinical trials: Transmission Vertical
Covid19, Vertical Transmission of Infectious Disease
Clinical Outcomes of Newborns Born to Pregnant Women With and Without COVID-19
A case-control trial was conducted to test the early postpartum period clinical outcomes of newborns born to pregnant women with and without COVID-19.
- Conditions
- Covid19, Vertical Transmission of Infectious Disease, Neonatal Infection, Pregnancy Related
- Trial name
- NCT04883801
- Testing
- Reviewed clinical records and laboratory results
- Where
- Turkey (Türkiye)
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Pathogen Transmission, Vertical, Nosocomial Infection
Use of Disposable Cuff Cover to Prevent Carriage of Pathogen Microorganisms Originated by Cuffs
Introduction: Pathogen Microrganisms (PM) colonized on the Blood Pressure Cuff (BPC) are transported from one patient to another by health professionals, which is leading an increase in Health Care Associated Infections (HCAI).
- Conditions
- Pathogen Transmission, Vertical, Nosocomial Infection, Cross Infection, Cuff
- Trial name
- DCC (NCT05326945)
- Testing
- Presence or Absence of a Blood Pressure Cuff Sheath
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people
- Sponsor
- Hasan Kalyoncu University
COVID-19, Neonatal Disease
Characteristics of Neonatal Covid-19 in Turkey
The investigators aimed to investigate the clinical and epidemiological characteristics of neonates who will be born to Covid-19 positive mothers in Turkey.
- Conditions
- COVID-19, Neonatal Disease, Healthy
- Trial name
- NCT04401540
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Hepatitis B, Vertical Transmission of Infectious Disease
The COMBAT HBV Feasibility Trial
This is a double-blind, randomized placebo-controlled trial (RCT) of a prophylaxis-for-all approach to prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) in the Democratic Republic of Congo (DRC).
- Trial name
- COMBAT-HBV (NCT05705427)
- Testing
- Tenofovir Disoproxil Fumarate 300 MG, Hepatitis B monovalent vaccine
- Where
- Democratic Republic of the Congo
- Volunteers
- 317 people
- Sponsor
- University of North Carolina, Chapel Hill
Hepatitis C, Infection Transmission, Maternal-Fetal
The Pathogenesis of Hepatitis C Virus Vertical Transmission
To evaluate for the presence of HCV Core protein, HCV RNA and SPP in the placenta and fetal membranes using paraffin-embedded sections and post-delivery specimens respectively.
- Trial name
- NCT01921400
- Where
- 2 sites in United States, Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Blood Loss, Repeat Cesarean Section
Cesarean Scar Pregnancy and Clinical Outcomes
This study is a prospective cohort study, led by Prof. Zhao Yangyu, from the Department of Gynecology \& Obstetrics, Peking University Third Hospital.
- Conditions
- Blood Loss, Repeat Cesarean Section, Maternal Transmission, Hysterectomy
- Trial name
- NCT05481606
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Human Immunodeficiency Virus
Mother and Infant Visit Adherence and Treatment Engagement Study
This is a 2x2 factorial cluster randomized trial of two interventions to improve retention and adherence for women and infants on Option B+.
- Trial name
- MOTIVATE! (NCT02491177)
- Testing
- cMM, Text Messaging
- Where
- Kenya
- Volunteers
- 1,338 people
- Sponsor
- University of Colorado, Denver
Lactation
Dietary Sugars Found In Breast Milk
The majority of pregnant women in the United States are either overweight or obese at conception with their offspring having greater adiposity at birth, a 2-fold greater risk of later obesity and neonatal insulin resistance.
- Trial name
- NCT02940795
- Testing
- Coke, Diet Rite
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
HIV Infections, Herpes Simplex
HSV-2 Suppression to Reduce Maternal HIV-1 RNA Levels During Pregnancy and Breastfeeding
In this study, we will determine whether treating pregnant and breastfeeding women co-infected with human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 2 (HSV-2) with daily valacyclovir will reduce HIV-1…
- Trial name
- VIP (NCT00530777)
- Testing
- valacyclovir
- Where
- Kenya
- Volunteers
- 148 people
- Sponsor
- University of Washington
HIV Infections, Pregnancy
Study of Perinatal Transmission of Zidovudine-Resistant HIV Among Pregnant Women Treated With Zidovudine
To identify patterns of zidovudine ( AZT ) susceptibility among mother/infant pairs with perinatal HIV transmission. Most HIV-infected infants acquire their disease via perinatal transmission.
- Trial name
- NCT00000828
- Where
- 29 sites in United States, Puerto Rico
- Volunteers
- 250 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Vertical Human Immunodeficiency Virus Transmission, HIV Infection Pediatric
Increasing Neonatal HIV Test and Treat to Maximize the Long-Term Impact on Infant Health and Novel Infant Antiretroviral Treatment
This study aims to improve HIV healthcare services for mothers living with HIV and their newborns in Tanzania and Mozambique. The main questions it aims to answer are: 1) does enhancing screening with maternal HIV viral load…
- Conditions
- Vertical Human Immunodeficiency Virus Transmission, HIV Infection Pediatric, Infant Death, Infant Morbidity
- Trial name
- LIFE2Scale (NCT06267508)
- Testing
- Maternal HIV viral load testing at delivery for VHT risk assessment
- Where
- 2 sites in Mozambique, Tanzania
- Volunteers
- 6,000 people
- Sponsor
- Michael Hoelscher
HIV
Vertical Transmission Study
Short courses of drugs can be given to HIV-infected pregnant women to reduce the chance of HIV infection being passed to her child either during pregnancy or during the labour process.
- Trial name
- VTS (NCT01948557)
- Testing
- Infant feeding counselling and support
- Where
- 2 sites in South Africa
- Volunteers
- 3,465 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
COVID-19
Coronavirus Disease 2019 (COVID-19) During Pregnancy: Prevalence of Seroconversion, Effect on Maternal and Perinatal Outcomes and Risk of Vertical Transmission (COVID-MAP)
The objectives of this proposal are to: 1) determine the rate of SARS-CoV-2 seroconversion in unselected pregnant women in Hong Kong; 2) determine the rate of SARS-CoV-2 infection in women presenting with miscarriage and…
- Trial name
- NCT04465474
- Testing
- Non Intervention
- Where
- 10 sites in China, Hong Kong and 1 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Human Immunodeficiency Virus, Acquired Immune Deficiency Syndrome
Mentor Mothers: A Sustainable Family Intervention in South African Townships
The purpose of this study is to test a mother-to-mother intervention during pregnancy and after delivery with Mothers Living with HIV (MLH)in South Africa.
- Conditions
- Human Immunodeficiency Virus, Acquired Immune Deficiency Syndrome, Tuberculosis
- Trial name
- NCT00972699
- Testing
- Peer support and mentoring
- Where
- South Africa
- Volunteers
- 1,200 people
- Sponsor
- University of California, Los Angeles
Preterm Labor
Extended-spectrum β-lactamase -Producing Enterobacteriaceae (ESBL) Vertical Transmission in Women With Preterm Labor Versus Those in Term Pregnancy
The aims of the study are to evaluate the rate of ESBL-producing Enterobacteriaceae colonization among women in preterm labor and term labor, the incidence of maternal vertical transmission of ESBL, and the clinical significance…
- Trial name
- NCT03251885
- Testing
- swabs
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Western Galilee Hospital-Nahariya
HIV Infections
A Study of Chlorhexidine in the Prevention of HIV-1 Transmission From Mothers to Their Babies
The purpose of this study is to find the best strength of chlorhexidine (a solution that kills germs), for washing the mother's vagina during labor and the newborn baby, that may reduce the chance of HIV being passed from an…
- Trial name
- NCT00006075
- Testing
- Chlorhexidine gluconate
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Covid19, Pregnancy Related
Evaluation of the Possible Vertical Transmission of SARS-CoV-2 Through Study of Amniotic Fluid and Chorionic Villi of Affected Pregnant Women for the COVID-19
Longitudinal prospective study in pregnant women withpositive serology or PCR for SARS-CoV-2 and indicationinvasive technique (amniocentesis or chorionic biopsy) that has the objective to evaluate the possible vertical…
- Trial name
- NCT04598347
- Where
- Spain
- Volunteers
- 225 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Methicillin-resistant Staphylococcus Aureus
Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus
The prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) colonization and infections have been increasing in the general population, including the pediatric population.
- Trial name
- NCT01141101
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Medical Center
Hepatitis B Infection, Congenital Malformation
Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission
Immunoprophylaxis with two hepatitis B vaccinations following the hepatitis B immune globulin (HBIg) and hepatitis B vaccine at birth is largely effective in protecting infants from hepatitis B virus (HBV) infection.
- Conditions
- Hepatitis B Infection, Congenital Malformation, Birth Defect, Viremia
- Trial name
- NCT03476083
- Testing
- Tenofovir Disoproxil Fumarate (TDF) 300 mg oral daily.
- Where
- 7 sites in China
- Volunteers
- 280 people
- Sponsor
- New Discovery LLC
Vertical Disease Transmission, HBV
Hepatitis B Virus Vertical Transmission From HIV-HBV Co-infected Women
Vertical HIV transmission has been dramatically reduced by the use of combined antiretroviral therapy in HIV-infected pregnant women.
- Trial name
- NCT02044068
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Hopital Lariboisière