Clinical trials: Trauma, Multiple
Trauma Chest, Rib Fracture Multiple
Surgical Stabilization for Rib Fractures
The purpose of this study is to compare the usual care alone to usual care plus early surgical stabilization in adult trauma patients who have been admitted with rib fractures, to evaluate for heterogeneity of treatment effect in…
- Trial name
- SSRF (NCT04081233)
- Testing
- surgical stabilization, Usual care
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- The University of Texas Health Science Center, Houston
Acquired Bleeding Disorder, Trauma
Efficacy and Safety of Activated Recombinant Human Factor VII in Severely Injured Trauma Patients
This trial is conducted in Africa, Asia, Europe, Oceania and North America. The aim of this trial is to evaluate the efficacy of activated recombinant human factor VII given in conjunction with standard therapy in the treatment…
- Trial name
- NCT01563523
- Testing
- activated recombinant human factor VII
- Where
- 9 sites in Australia, Austria and 7 more
- Volunteers
- 283 people
- Sponsor
- Novo Nordisk A/S
Nonspecific Pain Post Traumatic Injury
MAST Trial: Multi-modal Analgesic Strategies in Trauma
This is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. Two different multi-modal, opioid minimizing analgesic strategies will be compared [original multimodal pain…
- Trial name
- MAST (NCT03472469)
- Testing
- Acetaminophen IV/PO, Acetaminophen PO, Ketorolac
- Where
- United States
- Volunteers
- 1,561 people
- Sponsor
- The University of Texas Health Science Center, Houston
Brain Injuries, Brain Edema
Non-contact DCS-Speckle Multi-parameter Imaging for Neurological Diseases
This study aims to evaluate brain injuries and brain edema with non-contact DCS-Speckle multi-parameter imager.
- Conditions
- Brain Injuries, Brain Edema, Optical Imaging
- Trial name
- NCT04623307
- Testing
- Non-contact DCS-Speckle multi-parameter imaging
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ting Li
Intervention Effectiveness, Practice-based Evidence
Strengthening Family Coping Resources Open Trials
Strengthening Families Coping Resources (SFCR) Open Trials completes the second stage of the National Institute on Drug Abuse's intervention development model by testing a new family, skills-based intervention involving pre-post…
- Conditions
- Intervention Effectiveness, Practice-based Evidence, Posttraumatic Stress Disorder
- Trial name
- SFCR (NCT01754610)
- Testing
- Strengthening Family Coping Resources (SFCR)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Limb Fracture
Impact of Continuous Regional Analgesia in Severe Trauma Patients
Regional analgesia, based on its physiological effects and efficacy, is used for optimal perioperative pain relief. However, for acute pain in multiple trauma patients in a critical condition, it has not been prospectively…
- Trial name
- ALRréa (NCT04546503)
- Testing
- Continuous Regional analgesia, Control Group
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Bone Fractures, Dislocations
Intranasal Ketamine for Procedural Sedation
This study will examine the effectiveness of intranasal (IN) ketamine compared to standard intravenous (IV) ketamine administration for simple reductions of orthopaedic injuries in the paediatric population.
- Trial name
- INK (NCT02828566)
- Testing
- IN ketamine, IV ketamine, IN saline 0.9%
- Volunteers
- 470 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Trauma Centers/Statistics & Numerical Data, Trauma Blunt
Medical,Nursing Record,PE, Blood Test and Radiological Examination ,Morality and Mobility of Multiple Trauma Patient
This study aims to analyze statistical data on physiological examination values, blood test results, and radiological findings in patients admitted to the emergency department for severe trauma.
- Conditions
- Trauma Centers/Statistics & Numerical Data, Trauma Blunt, Trauma (Including Fractures), Trauma Abdomen
- Trial name
- trauma (NCT07903727)
- Testing
- Collect results of trauma patients
- Volunteers
- 700 people
- Sponsor
- St. Martin De Porress Hospital
Hemorrhagic Shock, Trauma
A Comparison of Two Target Mean Arterial Pressures in the Resuscitation of Hypotensive Trauma Patients
The goal of this study will be to determine if a lower than normal blood pressure during surgery for bleeding in the abdomen or chest will result in decreased bleeding and decreased chance of death.
- Conditions
- Hemorrhagic Shock, Trauma, Wounds, Penetrating, Shock, Traumatic
- Trial name
- NCT00459160
- Testing
- Intraoperative Hypotensive Resuscitation
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Baylor College of Medicine
Ureter Injury
IS-001 Injection in Patients Undergoing Robotic-Assisted Colorectal Surgery
This study evaluates the safety and efficacy of intravenous injection of IS-001 to aid in intraoperative ureter structure delineation
- Trial name
- NCT07346066
- Testing
- filricianine
- Where
- 9 sites in United States
- Volunteers
- 146 people
- Sponsor
- Intuitive Surgical
Ultrasonography, Multiple Trauma
Keller Prehospital Ultrasound Study
The study is based on the premise that ultrasound is not commonly used in an ambulance. There are some departments that do deploy it into the field, but of those departments there is almost no data collected about its use.
- Conditions
- Ultrasonography, Multiple Trauma, Kidney Calculi, Aortic Aneurysm, Abdominal
- Trial name
- NCT01074112
- Testing
- EFAST exam, Pelvic Ultrasound, Ultrasound Guided Vascular Access
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Keller Fire Rescue
Neonatal Encephalopathy
Follow-up of Inflammatory Responses and Multiorgan Outcomes FoLlowing Neonatal Brain injurY
Babies who have brain injury also frequently have involvement of their kidneys, lung and heart. Although clinical care in the neonatal period is well defined there are few guidelines and evidence for developmental, heart and…
- Trial name
- FIREFLY (NCT04816331)
- Testing
- Medical records and clinical measurements
- Where
- 5 sites in Ireland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Burns
Relationship Between Neutrophil Function and Sepsis in Adults and Children With Severe Thermal Injuries
The study aims to validate neutrophil function, immature granulocyte and plasma free DNA levels as predictive diagnostic biomarkers of sepsis in burn patients.
- Trial name
- SIFTI-2 (NCT04693442)
- Testing
- taking of blood, urine and blood samples and objective scar assessment
- Where
- United Kingdom
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Respiratory Disorder, Diabetes
The Measurement of VItal SIgns by Lifelight® Software in comparisON to the Standard of Care - Multi-site Development
AIM: To advance the development and accuracy of the Lifelight® app for the measurement of vital signs, therefore developing a non-invasive and easy-to-perform means of measuring vital signs which can be implemented across a wide…
- Conditions
- Respiratory Disorder, Diabetes, Cardiovascular Diseases, Critical Care
- Trial name
- VISION-MD (NCT04763746)
- Testing
- Lifelight Data Collect Sub-protocol 1, Lifelight Data Collect Sub-protocol 2, Lifelight Data Collect Sub-protocol 3
- Where
- United Kingdom
- Volunteers
- 1,869 people, healthy volunteers welcome
- Sponsor
- Xim Limited
Trauma
The WikiTrauma Interrupted Time Series Protocol
The purpose of this study is to study the combined effect of WikiTrauma, a free collaborative database of clinical decision support tools, and Wiki101, a training course teaching participants how to use WikiTrauma, on the quality…
- Trial name
- WikiTrauma (NCT04035772)
- Testing
- Wiki101 and WikiTrauma
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Laval University
Multiple Trauma
Importance of Forces and Safety Features in Car Crash Multitrauma
The pupose of the study is a prospective evaluation of external and internal factors/causes of importance for the trauma and final outcome experienced by persons inside motor vehicles in serious car accidents.
- Trial name
- NCT00204204
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University of Oslo
Drug-induced Liver Injury
A Prospective Cohort Study on Drug-induced Liver Injury in China（DILI-P）
This is a multi-center, prospective, non-interventional cohort study . Its primary objectives are: 1. assess DILI patients' clinical characteristics, disease progression and influencing factors in clinical practice; 2.
- Trial name
- DILI-P (NCT02961413)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Drug Induced Liver Disease Study Group
Traumatic Hemorrhage, Coagulopathy
Factor In the Initial Resuscitation of Severe Trauma 2 Patients
Injury is the leading cause of death for people between the ages of 1-44. This is especially true in trauma patients who have bleeding complications.
- Conditions
- Traumatic Hemorrhage, Coagulopathy, Massive Hemorrhage
- Trial name
- FiiRST-2 (NCT04534751)
- Testing
- Fibrinogen + PCC, Frozen Plasma
- Where
- 6 sites in Canada
- Volunteers
- 142 people
- Sponsor
- University Health Network, Toronto
Hemorrhage, Coagulopathy
Implementing Treatment Algorithms for the Correction of Trauma Induced Coagulopathy
This trial compares the haemostatic effect of viscoelastic haemostatic assay (VHA)-guided transfusion strategy versus non-VHA guided transfusion strategy in haemorrhaging trauma patients.
- Conditions
- Hemorrhage, Coagulopathy, Trauma
- Trial name
- iTACTIC (NCT02593877)
- Testing
- VHA algorithm
- Where
- 7 sites in Denmark, Germany and 3 more
- Volunteers
- 412 people
- Sponsor
- Queen Mary University of London
Wounds
A Post-marketing Observational Study of Cell Therapy for Chronic Wounds
A post-marketing multi-center observational study to provide data describing the safety and effectiveness of CUREXCELL™ as it is applied in a real-life setting for treatment in patients with chronic and/or refractory wounds.
- Trial name
- NCT01038986
- Testing
- CureXcell
- Where
- 3 sites in Israel
- Volunteers
- 70 people
- Sponsor
- Macrocure Ltd.