Clinical trials: Trauma Chest
Injury, Spinal Cord
Study of Probable Benefit of the Neuro-Spinal Scaffold™ in Subjects With Complete Thoracic AIS A Spinal Cord Injury as Compared to Standard of Care
This is a randomized, controlled, single-blind, multicenter, two Arm (Treatment or "Scaffold" Arm; Standard of Care or "Comparator" Arm) of a Neuro-Spinal Scaffold to evaluate whether the Scaffold is safe and demonstrates…
- Trial name
- INSPIRE 2 (NCT03762655)
- Testing
- Neuro-Spinal Scaffold
- Where
- 16 sites in United States
- Volunteers
- 20 people
- Sponsor
- InVivo Therapeutics
Blunt Injury of Thorax, Flail Chest
Treatment of Acute, Unstable Chest Wall Injuries
Unstable chest injuries are common in poly trauma patients. They can lead to severe pulmonary restriction, loss of lung volume, difficulty with ventilation and can render the patient to require intubation and mechanical…
- Conditions
- Blunt Injury of Thorax, Flail Chest, Chest Wall Injury Trauma, Rib Fracture
- Trial name
- NCT01367951
- Testing
- Surgical fixation
- Where
- Canada
- Volunteers
- 207 people
- Sponsor
- Unity Health Toronto
Chest Trauma
Thorax Trauma Severity Score in Chest Trauma: A Study in Iraq
This prospective observational study aims to evaluate the predictive utility of the Thorax Trauma Severity Score (TTSS) in determining morbidity and mortality in patients presenting with chest trauma at a tertiary hospital in…
- Trial name
- TTSS-Iraq (NCT06744959)
- Where
- Iraq
- Volunteers
- 166 people
- Sponsor
- Al-Nahrain University
Rib Fractures, Spirometry
Evaluation of Serratus Plane Block on the Respiratory Pattern in Patients With Multiple Rib Fractures
In patients admitted following a trauma, the incidence of multiple rib fractures is reported to be 9,7%, and this can be even higher in high energy trauma like motor vehicle accidents (1).
- Trial name
- NCT05105399
- Testing
- Serratus plane block (continuous or single-shot)
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Niguarda Hospital
Breast Cancer, Glioma
A Study of Gene Polymorphisms and Normal Tissue Radiation Injury in Patients Treated for Breast, Prostate, Brain, Lung, and Head and Neck Cancers
This study will examine, for the first time, the independent contribution of a patient's own genetic makeup to the development of post-radiation complications, permitting the future development of predictive tests to avoid…
- Conditions
- Breast Cancer, Glioma, Prostate Cancer, Carcinoma, Squamous Cell
- Trial name
- NCT00122239
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- AHS Cancer Control Alberta
Radiotherapy Side Effect, Radiation Toxicity
Curatively Intended Thoracic Reirradiation
The number of long-term lung cancer (LC) survivors increases, however many patients are diagnosed with recurrent or new thoracic cancers. High-dose reirradiation (reRT) is promising but associated with high severe toxicity rates.
- Conditions
- Radiotherapy Side Effect, Radiation Toxicity, Oncology, Lung Cancer
- Trial name
- CureLung (NCT06950073)
- Testing
- Radiotherapy
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- University of Aarhus
Cancer Therapy-related Cardiovascular Toxicity, Childhood Cancer
Early Diagnosis and Cardiovascular Risk Stratification in Children Exposed to Cancer Therapies
The goal of this prospective interventional study is to improve the detection of subclinical chronic Cancer Therapy-Related Cardiovascular Toxicity (CTRCT) and evaluate the added value of advanced cardioechography…
- Conditions
- Cancer Therapy-related Cardiovascular Toxicity, Childhood Cancer, Chemotherapeutic Toxicity, Radiotherapy Side Effect
- Trial name
- CTRCT-pedia (NCT07408362)
- Testing
- Ergospirometry
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Paraquat Poisoning, Lung Injury
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Paraquat Poisoning Induced Lung Injury
Phase I-II Clinical Trial-Safety and efficacy of umbilical-cord-derived mesenchymal stem cell (UC-MSC) in patients with paraquat poisoning induced lung injury, randomized,single blind, controlled prospective study.
- Trial name
- UCMSC-PQLI (NCT02444858)
- Testing
- UCMSC group, Control group(Normal saline)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Blunt Injury of Thorax
Abg in Blunt Chest Trauma
This study aims to determine the value of ABG measurments in patients with blunt chest trauma and its role in prognosis of different outcomes and the results would aid the emergency physicians to speed up the management and…
- Trial name
- NCT05886946
- Testing
- ABG
- Volunteers
- 150 people
- Sponsor
- Assiut University
Pelvic Fracture, Prostate Cancer
A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial
The objective of this prospective multicentre study that recruits altogether 1500 older patients from the university hospitals of Tampere, Kuopio, and Oulu is to explore the clinical significance and detection of causes of…
- Conditions
- Pelvic Fracture, Prostate Cancer, Lung Cancer, Brain Metastasis
- Trial name
- COSMOS-I (NCT07740239)
- Testing
- Test set to determine vulnerability
- Where
- Finland
- Volunteers
- 2,050 people
- Sponsor
- Tampere University Hospital
Iatrogenic Injury, Iatrogenic Disease
A Novel Technique to Remove Iatrogenic Pulmonary Parenchymal Chest Tube (PPcT): A Retrospective Analysis From a Tertiary Care Thoracic Surgery Centre
Iatrogenic Pulmonary Parenchymal chest Tube (PPcT) placement is a recognized but underreported complication of tube thoracostomy, described both in the subcontinent and worldwide.
- Trial name
- PPcT (NCT07148661)
- Testing
- Removal of PPcT
- Where
- Pakistan
- Volunteers
- 163 people
- Sponsor
- University of Health Sciences Lahore
Pulmonary Embolism, Deep Vein Thrombosis
Non-Interruptive Alerts for Improving Use of Clinical Decision Rules
This study is an extension of a planned quality improvement project that aims to promote standard of care by increasing the use of evidence-based clinical decision rules amongst emergency medicine providers in the University of…
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Minor Head Injury, Chest Pain
- Trial name
- NCT04702308
- Testing
- Clinical Decision Rule Alerts
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Utah
Congenital Heart Disease, Postoperative Pulmonary Complications
Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery
Cardiopulmonary bypass-associated pulmonary injury is a common complication after infant cardiac surgery and may contribute to impaired oxygenation, prolonged mechanical ventilation, and longer intensive care stay.
- Conditions
- Congenital Heart Disease, Postoperative Pulmonary Complications, Acute Lung Injury
- Trial name
- PLICS (NCT07499154)
- Testing
- Lidocaine %2 ampoule, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 320 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury (ALI)
Trial of Steroids in Pediatric Acute Lung Injury/ARDS
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are devastating disorders associated with lung inflammation, low oxygen levels and respiratory failure in children.
- Trial name
- SPALIT (NCT01274260)
- Testing
- methylprednisolone, Normal Saline (0.9%)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Tennessee
Acute Coronary Syndrome, Myocardial Infarction
High-Sensitivity Troponin in the Evaluation of Patients With Acute Coronary Syndrome
In patients with chest pain the diagnosis of a heart attack (myocardial infarction) is made where there is evidence of heart muscle damage using a blood test to measure the heart muscle protein troponin.
- Trial name
- High-STEACS (NCT01852123)
- Testing
- High-sensitivity troponin I assay
- Where
- United Kingdom
- Volunteers
- 48,282 people
- Sponsor
- University of Edinburgh
Acute Traumatic Spinal Cord Injury
Safety and Preliminary Efficacy of FAB117-HC in Patients With Acute Traumatic Spinal Cord Injury
The main objective of the study is the evaluation of the safety and tolerability of FAB117-HC (a medicinal product containing human allogeneic adipose derived adult mesenchymal stem cells expanded and pulsed with H2O2, HC016…
- Trial name
- SPINE (NCT02917291)
- Testing
- FAB117-HC, Control group
- Where
- 9 sites in Spain
- Volunteers
- 48 people
- Sponsor
- Ferrer Internacional S.A.
Preparation of Internal Thoracic Artery
Low Thermal Electrosurgical Device for Atraumatic Internal Thoracic Artery Harvesting
Electrosurgery is fundamental to the precise, fast and bloodless preparation of internal thoracic artery grafts in cardiac surgery.
- Trial name
- NCT03510026
- Testing
- Low thermal device preparation
- Volunteers
- 20 people
- Sponsor
- Triemli Hospital
Burst Thoracic Spine Fractures
The Influence of the Ribs on the Gravity of Burst Thoracic Spine Fractures
The purpose of this study is to analyse the anatomic influence of the ribs related to the incidence and severity of burst spine fractures.
- Trial name
- NCT01544933
- Where
- Brazil
- Volunteers
- 2 people
- Sponsor
- Universidade de Passo Fundo
Bronchopulmonary Dysplasia
Follow-Up Study of Safety and Efficacy of Pneumostem® in Premature Infants With Bronchopulmonary Dysplasia
This is a long term follow-up study of the open label, single-center, phase I clinical trial to evaluate the safety of Pneumostem® in premature infants with BPD.
- Trial name
- NCT01632475
- Testing
- Pneumostem®
- Where
- 2 sites in South Korea
- Volunteers
- 9 people
- Sponsor
- Samsung Medical Center
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane