Clinical trials: Treatment
Pulmonary Alveolar Proteinosis
Evaluation and Treatment Planning of Patients With PAP Using Thrive Ultra Short Echo Time MRI and CT
The purpose of this study is twofold: to assess routine cat scan (CT) imaging as a biomarker for removal of lipoprotein surfactant via lung lavage (where CT is the gold-standard imaging technique for density quantification), and…
- Trial name
- PAP (NCT02081092)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Noninvasive Ventilation, Child, Only
Custom Non-invasive Ventilation Masks in Children
One significant challenge to non-invasive ventilation (NIV) use in children is finding masks to fit a wide range of growing shapes and sizes.
- Conditions
- Noninvasive Ventilation, Child, Only, Adherence, Patient
- Trial name
- NCT05336136
- Testing
- Custom mask, Current commercial mask
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Alberta
Patent Ductus Arteriosus
Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates
To compare the effectiveness of rectal vs. intravenous paracetamol in the medical treatment of significant PDA in neonates.
- Trial name
- NCT06256211
- Testing
- Paracetamol
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soha mahmoud Hussien mahdy
COVID-19
Mesenchymal Stem Cell Infusion for COVID-19 Infection
Since the outbreak of coronavirusdisease2019(COVID-19), many researchers in China have carried out/published clinical trials on treatment based on Western medicine, traditional Chinese medicine or a combination of the two.
- Trial name
- NCT04444271
- Testing
- Mesenchymal stem cells
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Dr. Zaineb Akram
mHealth, PMTCT
Mobile Strategies for Women's and Children's Health: Optimizing Adherence and Efficacy of PMTCT/ART
The investigators are conducting a 3-arm randomized trial comparing the effects of unidirectional SMS (ie: "push" messaging to participant) vs. bidirectional SMS dialogue between participant and provider vs.
- Conditions
- mHealth, PMTCT, Adherence, Medication, SMS
- Trial name
- Mobile WAChx (NCT02400671)
- Testing
- SMS messaging
- Where
- 6 sites in Kenya
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- University of Washington
Heart Rate Determination, Patient Participation
Promoting Children's Participation in Conventional X-ray Examinations
The goal of this explorative observational study is to map the procedure and child centered approach in the examination for children that undergo conventional X-ray examinations.
- Trial name
- NCT06322264
- Testing
- Measurement of variation in heart rate
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Lund University
Compliance
Compliance With Once Daily Glaucoma Medication
A study to examine patient compliance with once daily glaucoma medication
- Trial name
- NCT00333463
- Testing
- Intervention
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Alcon Research
Sports Physical Therapy, Multi-Tasking Behavior
A New Dual Task Test Method for Football Players
Multitasking (Dual Task) is a measurement method to evaluate cognitive ability to execute multiple functions at the same time. To perform this test, while participant/patient performing a main skill (for example, walking), a…
- Conditions
- Sports Physical Therapy, Multi-Tasking Behavior, ACL Injury, Kinesiophobia
- Trial name
- NCT05218993
- Testing
- A new dual-task measurement method with images, A new dual-task measurement method with cards
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Duchenne Muscular Dystrophy
A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD)
The study will evaluate the safety and efficacy of gene transfer therapy in boys with DMD. It is a randomized, double-blind, placebo-controlled study.
- Trial name
- EMBARK (NCT05096221)
- Testing
- delandistrogene moxeparvovec
- Where
- 42 sites in United States, Belgium and 7 more
- Volunteers
- 126 people
- Sponsor
- Sarepta Therapeutics, Inc.
Dental Caries
Effect of aPDT on Deep Caries in Permanent Tooth
The aim of this study is to assess the clinical effect of aPDT on deep caries in permanent teeth. Half of the deep caries will receive aPDT disinfect in restorative treatment procedure, while the other half will receive sodium…
- Trial name
- NCT02929914
- Testing
- Local anesthesia and rubber dam isolation, Incomplete caries removal and microbiological samples collection, Dentin washed with sodium 0.9% saline
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University
Acute Liver Failure, Fulminant Hepatic Failure
TReatment for ImmUne Mediated PathopHysiology
TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) is a multi-center, three arm, randomized, controlled trial of immunosuppressive therapy for children with acute liver failure.
- Conditions
- Acute Liver Failure, Fulminant Hepatic Failure, Hepatic Encephalopathy, Acute Liver Injury
- Trial name
- TRIUMPH (NCT04862221)
- Testing
- High-dose methylprednisolone, Equine anti-thymocyte globulin, Prednisolone
- Where
- 17 sites in United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Prostate Cancer
Liposomal Doxorubicin in Treating Patients With Prostate Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of liposomal doxorubicin in treating patients with…
- Trial name
- NCT00004014
- Testing
- pegylated liposomal doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Case Comprehensive Cancer Center
Hemophilia A
Russian Kogenate Pediatric Study
A prospective study to evaluate the effect of rFVIII-FS in different prophylactic regimens on bleeding events frequency and development of arthropathy in Previously Treated and Minimally treated Hemophilia A pediatric population.
- Trial name
- NCT00632814
- Testing
- rFVIII-FS (Kogenate FS, BAY14-2222) 70 IU/kg, dosing once per week, rFVIII-FS (Kogenate FS, BAY14-2222), 70 IU/kg twice per week (30 IU/kg + 40 IU/kg), rFVIII-FS (Kogenate FS, BAY14-2222) 75 IU/kg, dosing three times per week (3 x 25 IU/kg)
- Where
- 4 sites in Russia
- Volunteers
- 32 people
- Sponsor
- Bayer
Malignant Pericardial Effusion, Malignant Pleural Effusion
Genetic Sequencing-Informed Targeted Therapy in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer
This randomized clinical trial studies how well genetic sequencing-informed targeted therapy works in treating patients with stage IIIB-IV non-small cell lung cancer.
- Conditions
- Malignant Pericardial Effusion, Malignant Pleural Effusion, Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer
- Trial name
- NCT02132884
- Testing
- cytology specimen collection procedure, therapeutic procedure, targeted therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Fox Chase Cancer Center
Periodontal Inflammation, Orthodontic Appliance Complication
Effects of Social Media on Oral Hygiene With Orthodontic Patients
The aim of this study was to compare the efficacy of traditional and social media motivation strategies in improving oral hygiene with fixed orthodontic treatment.
- Trial name
- NCT06886984
- Testing
- Social media motivation
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Gastroparesis
Idiopathic Gastroparesis Registry Using a Predominant-Symptom Classification
The diagnosis of "gastroparesis" suggests that delayed gastric emptying is the underlying cause of symptoms, but this description fails to explain the variable presentation.
- Trial name
- NCT01173484
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Louisville
Hematological Diseases, Allogeneic Stem Cell Transplantation
Long-term Versus Short-term Sequential Therapy (Intravenous Itraconazole Followed by Oral Solution) of Itraconazole as Primary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation
The primary objective of this study is to evaluate the efficacy and safety profile of itraconazole as in primary prophylaxis The second objective of this study is to find the difference between long-term versus short-term…
- Trial name
- NCT01160952
- Testing
- itraconazole
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Acute Leukaemia
Leukemia Cell Cultures for Research of New Anti-Cancer Therapies
The main objective of this project is not only a better understanding of the human leukemic disease but also to find new anti-leukemic or improve existing ones.
- Trial name
- NCT00993538
- Testing
- Blood sampling, Bone marrow aspiration
- Where
- 2 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Strasbourg, France
Autism, Intellectual Disabilities With Other Behavioral Symptoms
Regulating Together for Intellectual Disability and Autism: A Group Behavioral Therapy for for Emotion Dysregulation
The goal of this study is to help children with autism and a co-occurring intellectual disability and their families learn practical strategies for managing issues like irritability, aggression, and other challenging behaviors.
- Conditions
- Autism, Intellectual Disabilities With Other Behavioral Symptoms, Intellectual Disability
- Trial name
- RT-ID (NCT07624448)
- Testing
- Regulating Together group therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Mercy Hospital Kansas City
Selective Mutism
The Efficacy of Integrated Behavioral Therapy for Selective Mutism
This study examines the efficacy of the Integrated Behavioral Therapy for Selective Mutism protocol (Bergman et al., 2013). Participants are 60 children, aged 4-8 years, diagnosed with Selective Mutism (SM).
- Trial name
- NCT04585048
- Testing
- Integrated Behavioral Therapy for Selective Mutism
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
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