Clinical trials: Tuberculosis in Children
Tuberculosis Diagnosis, HIV
Optimizing Clinical Outcomes in HIV-Infected Adults & Children
This is a study to evaluate Xpert MTB/RIF as the first-line TB diagnostic test in HIV-infected adults and pediatric patients as a means to obtain faster, more accurate TB diagnosis.
- Trial name
- NCT02043080
- Testing
- Xpert MTB/RIF Tuberculosis diagnostic tool
- Where
- Zambia
- Volunteers
- 1,436 people
- Sponsor
- University of North Carolina, Chapel Hill
Tuberculosis, Human Immunodeficiency Virus
Adequacy of the New Pediatric Isoniazid/Rifampin/Pyrazinamide (HRZ) Tablet
Lack of quality-assured pediatric formulations of the first-line antituberculosis (anti-TB) drugs is barrier to optimized tuberculosis (TB) treatment outcome in children.
- Conditions
- Tuberculosis, Human Immunodeficiency Virus, Coinfection
- Trial name
- NCT03800381
- Testing
- Observational PK study
- Where
- Ghana
- Volunteers
- 92 people
- Sponsor
- University of Florida
Tuberculosis, HIV
Optimal Dosing of 1st Line Antituberculosis and Antiretroviral Drugs in Children (a Pharmacokinetic Study)
The aims of this project are to: 1. To evaluate the pharmacokinetics of first line antituberculosis drugs (isoniazid, rifampicin, pyrazinamide and ethambutol) when applying the 2010 WHO/IUATLD dosing guidelines across pediatric…
- Trial name
- DATiC (NCT01637558)
- Testing
- 8 hourly LPV/r during TB treatment, Nevirapine, Lopinavir/Ritonavir
- Where
- 4 sites in Malawi, South Africa
- Volunteers
- 200 people
- Sponsor
- University of Cape Town