Clinical trials: Tuberculosis in Children
Tuberculosis
Effects of the Active Cycle of Breathing Technique With and Without Balloon Blowing Therapy in Tuberculosis
The study design will be a randomized controlled trial. The data will be collected from Gulab Devi Teaching Hospital, Lahore. 34 kids aged 8 to 14 years will be randomly assigned either to an experimental group or a control…
- Trial name
- NCT07484490
- Testing
- Active cycle of breathing with Balloon therapy, Active Cycle of breathing
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Latent Tuberculosis, HIV Infections
Improving Latent Tuberculosis (TB) Diagnosis in Thai Children
The study is a prospective study to improve the diagnosis and management of latent TB in HIV-infected and HIV uninfected children in Thailand.
- Trial name
- TB Px (NCT00947609)
- Where
- 2 sites in Thailand
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- SEARCH Research Foundation
Tuberculosis, Polio
Mobile Phone SMS Messages and Automated Calls in Improving Vaccine Coverage Among Children in Pakistan
Routine childhood immunization (RCI) in Pakistan is well below the recommended coverage of 90% with rates as low as 16% in certain regions (Pakistan DHS 2012-3).
- Conditions
- Tuberculosis, Polio, Diphtheria, Pertussis
- Trial name
- NCT03341195
- Testing
- SMS messages and automated calls
- Volunteers
- 3,850 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Tuberculosis, Diagnostics
Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and Assessing Diagnostics At POC for TB in Children (ADAPT for Kids)
Every year there are an estimated 230,000 childhood deaths from TB. There is an urgent need for novel tests for TB diagnosis in children under 15 years.
- Conditions
- Tuberculosis, Diagnostics, Global Health
- Trial name
- NCT05989802
- Testing
- Oral swab molecular testing, Automated Cough Sound Analysis, Automated Lung Sound Analysis
- Where
- 3 sites in Mozambique, South Africa and 1 more
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tuberculosis, Hiv
Pharmacokinetics of Twice or Once Daily DTG (50mg) in Children With HIV and TB
Stage 1 proposed study will provide evidence to support the use of twice-daily dose 50mg DTG in children (20-35kgs) co-treated with RIF.
- Trial name
- ORCHID (NCT04746547)
- Testing
- Dolutegravir 50 MG, Dolutegravir 10 MG
- Where
- South Africa
- Volunteers
- 20 people
- Sponsor
- University of KwaZulu
HIV Infections, Tuberculosis
Efavirenz (EFV) in HIV-Infected and HIV/Tuberculosis (TB) Coinfected Children
Efavirenz (EFV) is an anti-HIV medicine that is commonly used to treat HIV infection in adults and children older than 3 years of age.
- Trial name
- NCT00802802
- Testing
- Efavirenz (EFV), Rifampin-containing anti-TB therapy
- Where
- 7 sites in India, South Africa and 2 more
- Volunteers
- 67 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Latent Tuberculosis
Tuberculosis Clinical Trials Consortium Study 35
Hypotheses: Rifapentine (given as water-dispersible monolayer and/or fixed dose combination with isoniazid) dosing in HIV-infected and uninfected children ≤ 12 years of age with latent TB infection (LTBI) or with exposure to…
- Trial name
- NCT03730181
- Testing
- Rifapentine, Isoniazid
- Where
- South Africa
- Volunteers
- 69 people
- Sponsor
- Centers for Disease Control and Prevention
Tuberculosis
Population Pharmacokinetics of Anti-tuberculosis Drugs in Children With Tuberculosis
This study is based on the hypothesis that the pharmacokinetics of anti-tuberculosis drugs in TB children are different from adults.
- Trial name
- NCT03625739
- Testing
- anti-tuberculosis drug
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Beijing Children's Hospital
Maternal and Child Health
Impact of Vitamin D Supplementation on Fetomaternal Outcomes in LTBI Pregnant Females
The goal of this randomized controlled trial is to see the effect of vitamin D supplementation on fetomaternal outcomes in pregnant females with Latent Tuberculosis infection The main question[s] it aims to answer are: If Vitamin…
- Trial name
- RCT (NCT06354621)
- Testing
- Vitamin-D supplementation
- Where
- Pakistan
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of the Punjab
Tuberculosis
Re-evaluating the Duration in Children of TB Treatment
Current tuberculosis (TB) treatment is effective (works well), but it takes a long time to cure TB. This study will evaluate if TB treatment with a higher dose of rifampicin, one of the TB medicines, and shorter TB treatment…
- Trial name
- REDUCE TB (NCT07656012)
- Testing
- Rifampicin, Isoniazid, Pyrazinamide
- Where
- Peru
- Volunteers
- 230 people
- Sponsor
- University of Wisconsin, Madison
COVID-19
INTEGrating Ag-RDTs for COVID-19 in MNCH,HIV and TB Services in Cameroon and Kenya
Integration of antigen-detecting rapid diagnostic tests (Ag-RDT) for COVID-19 into services that provide care for vulnerable populations such as pregnant women, children, people with HIV infection, and patients with tuberculosis…
- Trial name
- INTEGRATE (NCT05382130)
- Testing
- Test all
- Where
- 2 sites in Cameroon, Kenya
- Volunteers
- 152,082 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Children LTBI
A Multicentre, Cohort Study of Screening and Preventive Intervention for Latent Tuberculosis Infection in Children
The management of latent Mycobacterium tuberculosis infection is a new priority action for the WHO End Tuberculosis (TB) Strategy.
- Trial name
- NCT04156568
- Testing
- INH、RFT
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Children's Hospital
Tuberculosis Infection
Tuberculosis In Children Visiting Friends and Relatives
In countries with a low incidence of Tuberculosis (TB), the incidence remains higher among the immigrant population than among the autochthonous population beyond the first years after arrival in the host country.
- Trial name
- NCT04236765
- Testing
- TB infection-screening benefiting group
- Where
- Spain
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Tuberculosis, Pulmonary
Childhood TB Sequel
This study aims to describe the long-term adverse outcomes associated with PTB in children, to describe the evolution of these sequelae, and to determine the epidemiological risk factors associated with these sequelae.
- Trial name
- NCT05325125
- Where
- The Gambia
- Volunteers
- 100 people
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV/AIDS, Tuberculosis
Pharmacokinetics of Atazanavir in Special Populations
The lack of data relating to the DDI between ATV and RIF is a major limitation to the use of ATV in patients who require treatment for TB.
- Trial name
- VirTUAL WP5 (NCT03923231)
- Testing
- Atazanavir 300mg/ Ritonavir 100 mg once daily, Atazanavir 250 mg / ritonavir 80 mg
- Where
- 4 sites in South Africa, Uganda
- Volunteers
- 32 people
- Sponsor
- University of Liverpool
Latent Tuberculosis Infection
Vitamin A Supplementation for Modulation of Mycobacterium Tuberculosis Immune Responses in Latent Tuberculosis
In populations with high prevalence of latent tuberculosis infection (LTBI), malnutrition (PEM) may influence incident rates of TB.
- Trial name
- NCT00558480
- Testing
- Vitamin A
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical Research Council Unit, The Gambia
Tuberculosis
Epidemiological Study In Tuberculosis-Endemic Urban Area in Senegal
A cross-sectional childhood M. tuberculosis infection survey of age-specific rates (defined by positivity to the test QuantiFERON-TB Gold Plus) will be conducted in Senegal to collect information on the local TB endemic to inform…
- Trial name
- MTBVAC-EPI (NCT03767946)
- Testing
- Quantiferon Gold Plus Test
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Biomedical Research Center EPLS
Pulmonary Tuberculosis
Epidemiological Study of Hospitalized Children for Pulmonary Tuberculosis at Strasbourg University Hospitals
Pulmonary tuberculosis is the most common form of tuberculosis in children; According to the WHO, tuberculosis pulmonary tuberculosis in children represents approximately 80% of all cases of tuberculosis in children.
- Trial name
- TPE (NCT06110533)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Tuberculosis, Human Immunodeficiency Virus
Adequacy of the New Pediatric Isoniazid/Rifampin/Pyrazinamide (HRZ) Tablet
Lack of quality-assured pediatric formulations of the first-line antituberculosis (anti-TB) drugs is barrier to optimized tuberculosis (TB) treatment outcome in children.
- Conditions
- Tuberculosis, Human Immunodeficiency Virus, Coinfection
- Trial name
- NCT03800381
- Testing
- Observational PK study
- Where
- Ghana
- Volunteers
- 92 people
- Sponsor
- University of Florida
Tuberculosis, Human Immunodeficiency Virus
Contributing Factors for Poor HIV Treatment Response in Children With TB/HIV Coinfection
Efavirenz (EFV)-based antiretroviral therapy (ART) remains the preferred regimen in human immunodeficiency virus (HIV)-infected children aged 3 years or older on rifampin-containing antituberculosis (anti-TB) therapy.
- Conditions
- Tuberculosis, Human Immunodeficiency Virus, Coinfection
- Trial name
- NCT03800407
- Testing
- Observational study
- Where
- Ghana
- Volunteers
- 213 people
- Sponsor
- University of Florida