Clinical trials: Uncomplicated Pregnancy
Fetal Growth Retardation, Stillbirth
Prediction of Late Fetal Growth Restriction Using Cerebroplacental Ratio
To investigate the screening performance of CPR and biophysical profile score for the prediction of composite of adverse neonatal morbidity and mortality and operative delivery (CS or instrumental) for intrapartum fetal distress…
- Conditions
- Fetal Growth Retardation, Stillbirth, Neonatal Respiratory Failure, Neonatal Death
- Trial name
- NCT04640467
- Testing
- Biophsical profile, Cerebroplacental ratio
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Urinary Tract Infections
A Study in Adolescent and Adult Female Participants to Evaluate Clinical Symptom Improvement and the Safety of Gepotidacin During Treatment of Uncomplicated Urinary Tract Infections (Acute Cystitis)
The study will be conducted to evaluate the clinical symptom improvement and safety of oral gepotidacin for treatment of uncomplicated UTI (acute cystitis) in adolescent and adult female participants.
- Trial name
- SIS (NCT06597344)
- Testing
- Gepotidacin
- Where
- 22 sites in United States
- Volunteers
- 97 people
- Sponsor
- GlaxoSmithKline
Malaria, Pregnancy, Malaria, Antepartum
Safety of Antimalarials in the FIRst trimEster
The SAFIRE study aims to find effective treatments with acceptable safety for malaria in early pregnancy, a particularly sensitive time for the adverse consequences of malaria in pregnancy for both mother and baby.
- Conditions
- Malaria, Pregnancy, Malaria, Antepartum, Malaria (Uncomplicated)
- Trial name
- SAFIRE (NCT06962319)
- Testing
- dihydroartemisinin-piperaquine (DP), Pyronaridine-artesunate (PA), Artemether-lumefantrine
- Where
- 3 sites in Burkina Faso, Kenya and 1 more
- Volunteers
- 1,510 people
- Sponsor
- Liverpool School of Tropical Medicine
Malaria
Efficacy of Artemisinin Combination Therapies for the Treatment of Uncomplicated P. Falciparum in Pregnancy in Brazil
Data on the burden of MIP in low transmission areas, such as Latin America, are very limited; there is even less information on the efficacy of case management of MiP.
- Trial name
- PAACT-PF (NCT01082731)
- Testing
- Artemether-Lumefantrine, Mefloquine- Artesunate
- Where
- 2 sites in Brazil
- Volunteers
- 6 people
- Sponsor
- Centers for Disease Control and Prevention
Urinary Tract Infections
A Study to Investigate the Efficacy and Safety With Gepotidacin in Japanese Female Participants With Uncomplicated Urinary Tract Infection (Acute Cystitis)
The purpose of this study is to evaluate the consistency of therapeutic response of gepotidacin in female participants with acute uncomplicated cystitis with qualifying bacterial uropathogen(s) at baseline that all are…
- Trial name
- EAGLE-J (NCT05630833)
- Testing
- Gepotidacin, Nitrofurantoin
- Where
- 27 sites in Japan
- Volunteers
- 380 people
- Sponsor
- GlaxoSmithKline
Malaria, Falciparum, Hookworm Infections
Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma
The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
- Conditions
- Malaria, Falciparum, Hookworm Infections, Schistosoma Haematobium
- Trial name
- NCT01163877
- Testing
- Fe-57 orally, Fe-58 intravenously
- Where
- Côte d’Ivoire
- Volunteers
- 43 people
- Sponsor
- Swiss Federal Institute of Technology
Pelvic Inflammatory Disease
Moxifloxacin Versus Ofloxacin Plus Metronidazole in Uncomplicated Pelvic Inflammatory Disease: Multicenter Randomized Controlled Trials
We aimed to compare efficacy and safety of combination therapy with oral ofloxacin, 400 mg twice daily, plus oral metronidazole, 500 mg twice daily, for 14 days, with moxifloxacin monotherapy, 400 mg once daily, for 14 days
- Trial name
- NCT01799356
- Testing
- Moxifloxacin, Ofloxacin, Metronidazole
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 1,303 people, healthy volunteers welcome
- Sponsor
- Istanbul Bakirkoy Maternity and Children Diseases Hospital
Labor Complication
Traditional WHO Partograph and Korle-Bu Modified WHO Partograph for Uncomplicated Labour
Brief Background: The partograph is a graphical representation of the events in the first stage of labour. It is an instrument used in monitoring the well being of both the pregnant woman and her fetus (es) as they go through the…
- Trial name
- NCT05837559
- Testing
- Korle-Bu Modified WHO Partograph for Uncomplicated Labour
- Where
- Ghana
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Ghana Medical School
Urinary Tract Infections
A Study to Evaluate Efficacy and Safety of Gepotidacin in the Treatment of Uncomplicated Urinary Tract Infection (UTI)
The study will be conducted to evaluate the therapeutic response (combined per participant microbiological and clinical response) of oral gepotidacin compared to oral nitrofurantoin for treatment of uncomplicated UTI (acute…
- Trial name
- NCT04020341
- Testing
- Gepotidacin, Nitrofurantoin
- Where
- 103 sites in United States, Bulgaria and 10 more
- Volunteers
- 1,531 people
- Sponsor
- GlaxoSmithKline
Pregnancy Complicated by Malaria as Antepartum Condition
Efficacy,Safety and Tolerability of Dihydroartemisinin-Piperaquine for Uncomplicated Malaria in Pregnancy in Ghana
Malaria in pregnancy poses enormous public health challenges, contributing to significant maternal and infant deaths yearly. Adverse outcomes include maternal anaemia and low birthweight.
- Trial name
- DHAPPQ/MIP (NCT01231113)
- Testing
- artesunate-amodiaquine, Dihydroartemisinin-piperaquine
- Where
- Ghana
- Volunteers
- 417 people
- Sponsor
- Kwame Nkrumah University of Science and Technology
Urinary Tract Infections
Single Dose Amikacin for Uncomplicated Cystitis in the ED: A Feasibility Study
The purpose of this study is to determine if a single dose of amikacin (a type of antibiotic) can be used to effectively treat emergency department patients with uncomplicated cystitis (inflammation of the bladder).
- Trial name
- NCT05227937
- Testing
- Amikacin
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Antonios Likourezos
Plasmodium Vivax Malaria
Efficacy of Artemisinin Combination Therapies for the Treatment of Uncomplicated P. Vivax in Pregnancy in Brazil (PAACT-PV)
The current treatment recommendations for P. vivax in pregnant and non-pregnant individuals are to use chloroquine; in non-pregnant patients this is followed by primaquine to prevent relapse.
- Trial name
- PAACT-PV (NCT01107145)
- Testing
- Mefloquine- Artesunate, Artemether-Lumefantrine, Chloroquine
- Where
- 3 sites in Brazil
- Volunteers
- 16 people
- Sponsor
- Centers for Disease Control and Prevention
Urinary Tract Infections in Children
Oral Antibiotics Alone in Children Aged 4 Weeks to 2 Months With a Urinary Tract Infection
The goal of this prospective study is to investigate whether oral antibiotic therapy alone is feasible and safe in clinically stable children aged 4 weeks to 2 months without any past high-risk medical history with a suspected or…
- Trial name
- NCT05819229
- Testing
- Oral antibiotic therapy
- Where
- 4 sites in Denmark
- Volunteers
- 125 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Malaria
Quinine vs. Artemether/Lumefantrine in Uncomplicated Malaria During Pregnancy
A) for the treatment of uncomplicated malaria during second and third trimester pregnancy to oral Quinine hydrochloride. The PCR-corrected adequate clinical and parasitological response (ACPR) on day 42 is considered as the…
- Trial name
- NCT00495508
- Testing
- Quinine, artemether / lumefantrine
- Where
- Uganda
- Volunteers
- 300 people
- Sponsor
- Epicentre
Urinary Tract Infections
Comparative Study to Evaluate Efficacy and Safety of Gepotidacin to Nitrofurantoin in Treatment of Uncomplicated Urinary Tract Infection (UTI)
The study will be conducted to evaluate the therapeutic response (combined per participant microbiological and clinical response) of oral gepotidacin compared to oral nitrofurantoin for treatment of uncomplicated UTI (acute…
- Trial name
- NCT04187144
- Testing
- Gepotidacin, Nitrofurantoin
- Where
- 113 sites in United States, Australia and 4 more
- Volunteers
- 1,606 people
- Sponsor
- GlaxoSmithKline