Clinical trials: Vascular Function
Acquired Brain Injury
Effect of Methylphenidate on Ecologic Function in Paediatric Acquired Brain Injury Population
The purpose of this study is to investigate the influence of Methylphenidate in pediatric acquired brain injury population, regarding ecologic (every day) function.
- Trial name
- NCT02227056
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 34 people
- Sponsor
- Loewenstein Hospital
Cardiovascular Diseases, Coronary Disease
Hostility and Coronary Risk--Role of Weak Vagal Function
To determine whether deficient vagal antagonism of sympathetic nervous system (SNS) actions on the heart contributed to increased coronary heart disease risk in hostile persons.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Ischemia
- Trial name
- NCT00005337
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Physical Activity, Obesity
Effectiveness of MOVI Interventions on Adiposity, Cognition and Subclinical Atherosclerosis: MOVI-daFit!
Project which objective is to test the effectiveness of an extracurricular physical activity intervention based on high intensity interval training (MOVI-daFit!) on improving cardiorespiratory fitness (CRF), cardiometabolic risk…
- Conditions
- Physical Activity, Obesity, Children, Cardiovascular
- Trial name
- NCT03236337
- Testing
- MOVI intervention
- Where
- 2 sites in Spain
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Cystic Fibrosis
Investigation of Relationship Between Vascular Functions, Exercise Capacity, and Respiratory Functions in CF
In the literature, there is no study that evaluates the endothelial function and arterial stiffness together and investigates its relationship with exercise capacity and respiratory functions in children with CF of different…
- Trial name
- NCT04259983
- Testing
- Maximal exercise test, Endothelial dysfunction assessment, Arterial stiffness assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Fabry Disease
Fabry: Renal Function During Long-term ERT by 51Cr-EDTA Clearance
The aim of this study was to investigate renal function decline by measured glomerular filtration rate (mGFR) in patients with FD during enzyme replacement therapy, and to explore the influence of age on renal function in FD.
- Trial name
- NCT02969200
- Testing
- Enzyme replacement therapy
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- Ulla Feldt-Rasmussen
Motor Disorders, Neurodevelopmental Disorders
Neuromotor Development and Motor Related Health Care in Children with a High Risk Neonatal Period
The overall aim of the study is to evaluate the prevalence of motor- and neurological disorders (cerebral pares and other less severe motor disorders) in Swedish infants with a high-risk neonatal period and to elucidate whether…
- Conditions
- Motor Disorders, Neurodevelopmental Disorders, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT06645717
- Volunteers
- 2,900 people
- Sponsor
- Karolinska Institutet
Asthma, COPD
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- NCT04624490
- Testing
- Hyperpolarized Xe129
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Mario Castro, MD, MPH
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Thrombosis
Antiaggregation in Primary Prevention of Vascular Access for Hemodialysis
This is a prospective study consisting in testing whether systematic use of aspirin is beneficial for primary prevention of vascular access for hemodialysis attested by doppler ultrasound exam.
- Trial name
- NCT02055131
- Testing
- aspirin
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- Tunis University
Fabry Disease
A Study of Migalastat in Fabry Disease
Fabry disease is a rare metabolic condition characterised by the widespread deposition of sphingolipids in multiple organ systems.
- Trial name
- GALAFAB (NCT03949920)
- Testing
- Migalastat
- Where
- 2 sites in United Kingdom
- Volunteers
- 21 people
- Sponsor
- Manchester University NHS Foundation Trust
Cystic Fibrosis
Fitness, Body Composition, Physical Activity and Sleep Patterns in People With Cystic Fibrosis on Modulator Therapy.
Cystic fibrosis (CF) is the most common inherited condition in the United Kingdom, affecting approximately 10,837 people. It is well recognised that regular exercise is clinically important for people with CF.
- Trial name
- Understand-CF (NCT05857709)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Ischemic Heart Disease, Microvascular Coronary Artery Disease
Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function
The DIAST-CMD registry (Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function) is prospective registry which enrolled patients who underwent echocardiography, cnically-indicated invasive coronary…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction
- Trial name
- DIAST-CMD (NCT05058833)
- Testing
- Echocardiography, Coronary flow reserve and index of microcirculatory dysfunction
- Where
- 4 sites in United States, South Korea
- Volunteers
- 800 people
- Sponsor
- Samsung Medical Center
Stroke
Effect of Qigong on Balance, Fall Efficacy, Wellbeing of People With Stroke in Hong Kong
The purpose of this study is to compare the effects of qigong practice with fitness exercise on balance, fall-efficacy, physical functions, psychological wellbeing and quality of life of stroke survivors.
- Trial name
- NCT02999464
- Testing
- Qigong, Fitness exercise
- Where
- Hong Kong
- Volunteers
- 58 people
- Sponsor
- The Hong Kong Polytechnic University
Normal and Abnormal Cardiovascular Physiology
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs.
- Trial name
- NCT03581318
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Multiple Myeloma
Health-Related Quality of Life (QOL), Physical and Respiratory Function in Patients With Myeloma Affecting the Spine
The purpose of this study is to create a prospective database of patients with myeloma affecting the spine. This database will define changes in health-related quality of life over time, and the effect of incident fractures and…
- Trial name
- NCT01006070
- Testing
- kyphoplasty
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Endothelial Function (Reactive Hyperemia)
MOVING - MOtiVation, INtervention and Vascular chanGe
Background: The impact of demographic changes on workplace has increased the importance of effective occupational preventive health programs.
- Trial name
- MOVING (NCT01919632)
- Testing
- health-behavior seminar and endurance exercise
- Where
- 2 sites in Germany
- Volunteers
- 330 people
- Sponsor
- Technical University of Munich
Abdominal Aortic Aneurysm, Cardiovascular Events
Tonometry and Duplex Ultrasound to Predict AAA Progression and CV Events in Aneurysm Patients (1-2-3 Trial)
Abdominal aortic aneurysm (AAA) is a common vascular disease and associated with risk of rupture, but also with a high cardiovascular (CV) event rate.
- Trial name
- NCT03989011
- Testing
- Carotid Artery Reactivity test (CAR test), Arterial stiffness
- Where
- 3 sites in Netherlands
- Volunteers
- 167 people
- Sponsor
- Rijnstate Hospital
Mitral Regurgitation, Coronary Artery Disease
Randomised Ischaemic Mitral Evaluation (RIME) Trial
The study is a randomised controlled trial comparing two treatment strategies for patients with moderate functional ischaemic mitral regurgitation undergoing coronary artery bypass grafting (CABG).
- Trial name
- RIME (NCT00413998)
- Testing
- CABG + Mitral valve annuloplasty, CABG
- Where
- 9 sites in Poland, United Kingdom
- Volunteers
- 73 people
- Sponsor
- Imperial College London
Ataxia, Cerebrovascular Accident
PET Scan to Study Brain Control of Human Movement
Positron Emission Tomography (PET) is a technique used to investigate activity in areas of the brain. The PET technique allows researchers to study the normal processes in the brain (central nervous system) of normal individuals…
- Conditions
- Ataxia, Cerebrovascular Accident, Healthy, Movement Disorder
- Trial name
- NCT00001324
- Where
- United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hypoxic-Ischemic Encephalopathy
ANS Function in HIE Infants Treated With Therapeutic Hypothermia
After birth, babies that have suffered from oxygen deprivation may develop hypoxic-ischemic encephalopathy (HIE). Moderate or severe HIE has been associated with death or disability.
- Trial name
- NCT06730490
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre