Clinical trials: Ventilatory Failure
Acute Respiratory Failure
Noninvasive NAVA Versus Flow-triggered Noninvasive Pressure Support in Pediatric Respiratory Failure
Acute Hypoxemic Respiratory Failure (AHRF) is a leading cause of admission in Pediatric Intensive Care Unit (PICU). Traditional treatment includes endotracheal intubation and mechanical ventilation, that are invasive and not free…
- Trial name
- NCT03697863
- Testing
- Noninvasive Respiratory Support
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Distress Respiratory Syndrome, Weaning Failure
Pressure Support Ventilation Versus Neurally Adjusted Ventilatory Assist in Difficult to Wean Pediatric Patients
This study assessed the effects of NAVA versus Pressure Support Ventilation (PSV) on patient-ventilator interaction in pediatric patients with difficult weaning from mechanical ventilation after moderate Pediatric Acute…
- Trial name
- NCT04360590
- Testing
- pressure support ventilation versus neurally adjusted ventilatory assist
- Volunteers
- 12 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sleep Disorder; Breathing-Related, Central Apnea
Transcutaneous CO2 Monitoring at Home for Children With Neuromuscular Disease
There is an unmet demand for the evaluation of nocturnal hypoventilation in children with NMD. An ambulatory screening tool that can reliably facilitate timely diagnosis and treatment in these children would be invaluable.
- Conditions
- Sleep Disorder; Breathing-Related, Central Apnea, Neuromuscular Diseases, Obstructive Sleep Apnea
- Trial name
- NCT03478566
- Testing
- Transcutaneous CO2 monitoring
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- The Hospital for Sick Children
Acute Respiratory Failure With Hypoxia
NAVA Helmet in Pediatric Respiratory Failure
Neurally Adjusted Ventilatory Assist (NAVA) is a new form of partial support wherein the machine applies positive pressure throughout inspiration in proportion to the electrical activity of the diaphragm (EAdi), Because…
- Trial name
- NCT02050217
- Testing
- Neurally Adjusted Ventilatory Assist
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ondine Syndrome, Congenital Central Hypoventilation Syndrome (CCHS)
Relationship Between Breathing and Attention in Children With Ondine Syndrome
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that alters oxygen delivery to the brain. CCHS patients are at risk for broad neurocognitive deficits.
- Trial name
- OndineCo (NCT06337149)
- Testing
- neuropsychological tests used usually in clinical practice (TEA-ch, NEPSY, BRIEF) and research (Conners 3, K-CPT II or CPT III, Flankers Task)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypercapnic Respiratory Failure
Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure
The purpose of the study is to determine the optimal method to withdraw non-invasive ventilation after an episode of hypercapnic respiratory failure.
- Trial name
- NCT00775710
- Testing
- Nocturnal non-invasive ventilation
- Where
- 3 sites in Spain
- Volunteers
- 128 people
- Sponsor
- Hospital Clinic of Barcelona
Ondine Syndrome
Assessment of Desogestrel in Ondine Syndrome
The congenital central hypoventilation syndrome (CCHS), also known as the Ondine syndrome, is a very rare genetic disorder. In contrast with healthy people, patients do not increase breathing in response to an excess of carbon…
- Trial name
- RESPIRONDINE (NCT01243697)
- Testing
- desogestrel
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anxiety, Stress
Breathing for Adolescent Stress Reduction Feasibility RCT
The purpose of this study was to test a simple slow breathing curriculum for reducing stress among high school students. The curriculum was developed by the Health and Human Performance Foundation and implemented for this study…
- Trial name
- NCT05266833
- Testing
- Slow diaphragmatic breathing
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Health and Human Performance Foundation
Respiratory Failure
Comparison Between IMV and SIMV/PS for Ventilatory Support of Children: a Randomized Clinical Trial
Objectives: to compare intermittent mandatory ventilation (IMV) with synchronous intermittent mandatory ventilation associated with pressure support (SIMV/PS) related to duration of mechanical ventilation/weaning and length of…
- Trial name
- NCT00549809
- Testing
- Intermittent mandatory ventilation (IMV) and synchronous IMV
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Acute Mechanical Ventilatory Failure
Rescue High Frequency Oscillatory Ventilation in Newborns Who Do Not Respond to Conventional Ventilation
Although High Frequency Oscillatory Ventilation (HFOV) has been used in case of unresponsive to conventional mechanical ventilation both in children and newborns, there is no data on its success and the factors that affect its…
- Trial name
- RescueHFO (NCT02752438)
- Testing
- HFOV
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Ankara University
Oxygen Deficiency, Desaturation of Blood
THRIVE Use in Pediatric Populations- Multi Site
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT04322994
- Testing
- Transnasal Humidified Rapid-Insufflation Ventilatory Echange
- Where
- 5 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Stanford University
ROHHAD Syndrome
Treatment of Rapid Onset Obesity, Hypoventilation, Hypothalamic Dysfunction, and Autonomic Dysregulation (ROHHAD )
ROHHAD (rapid onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation) syndrome is a rare pediatric disorder associated with a cancer called neuroblastoma and presumed to be driven by an attack of…
- Trial name
- NCT02441491
- Testing
- Cyclophosphamide
- Where
- United States
- Sponsor
- Johns Hopkins University
Childhood Obesity, Morbid Obesity
Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation.
- Trial name
- NCT02602769
- Testing
- Transcriptome profiling
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Central Alveolar Hypoventilation Syndrome
PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood
Detect the PHOX2B Mutation-confirmed congenital central hypoventilation syndrome
- Trial name
- NCT00652964
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Cystic Fibrosis
Sleep in Patients With Cystic Fibrosis
The aim of the study is to identify the parameters that are associated with nocturnal hypoventilation in children and adults with cystic fibrosis.
- Trial name
- Sommeil (NCT00804661)
- Testing
- SENTEC device
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sleep Apnea Syndromes in Children, Obesity in Children
Overview: Use of Respiratory Support At Home in Children
the primary outcome is to describe the perceived success of the use of the respiratory support from the parent's point of view
- Conditions
- Sleep Apnea Syndromes in Children, Obesity in Children, Bronchopulmonary Dysplasia (BPD), Neuromuscular Disease
- Trial name
- ELIPSE (NCT06692660)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea, Hypoventilation
The IPAd Study: Exploring the Association Between Insomnia and Positive Airway Pressure Adherence in Children
Sleep-disordered breathing (SDB) is prevalent in children and adolescents and untreated SDB impacts key indicators of physical and psychosocial health.
- Conditions
- Obstructive Sleep Apnea, Hypoventilation, Central Sleep Apnea
- Trial name
- IPAd (NCT05949164)
- Testing
- Insomnia
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- The Hospital for Sick Children
Nutrition
Individualized Metabolic Assessment and Nutritional Optimization in Children With Chronic Respiratory Insufficiency
The investigators aim to examine the feasibility of individualized diet intervention in children dependent on long-term mechanical ventilator support at home.
- Trial name
- NutriCAPE (NCT02354495)
- Testing
- Changes in energy and protein intake
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
WorldwidE AssessmeNt of Separation of pAtients From Ventilatory assistancE
WEAN SAFE (WorldwidE AssessmeNt of Separation of pAtients From ventilatory assistancE) is a multi-centre, prospective, observational, 4-week inception cohort study being carried out by the Acute Respiratory Failure section of…
- Trial name
- WEAN SAFE (NCT03255109)
- Where
- Belgium
- Volunteers
- 11,000 people
- Sponsor
- European Society of Intensive Care Medicine
Respiratory Failure
Regional Distribution Differences Between Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation
Neurally adjusted ventilatory assist (NAVA) is an FDA approved mode of mechanical ventilation. This mode of ventilation is currently in routine use in adult, pediatric and neonatal intensive care units.
- Trial name
- NCT01504373
- Testing
- Neurally Adjusted Ventilatory Assist (NAVA)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Children's Hospital