Clinical trials: Wasting Syndrome
Acute Malnutrition, Severe, Malnutrition, Child
Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia
The R-SWITCH intervention aims to address the low coverage of treatment for severe wasting (SAM) by leveraging existing community groups to deliver an integrated package focused on prevention, screening, referral, and treatment…
- Conditions
- Acute Malnutrition, Severe, Malnutrition, Child, Wasting
- Trial name
- R-SWITCH (NCT06380504)
- Testing
- R-SWITCH integrated intervention package
- Where
- Ethiopia
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Chronic Kidney Diseases
Ghrelin and Obestatin in CKD Children
Protein energy wasting (PEW) is a complex syndrome associated with different underlying illnesses and characterized by loss of muscle, with or without loss of fat.
- Trial name
- NCT03171116
- Testing
- none intervention
- Volunteers
- 154 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Malnutrition, Infant, Malnutrition
Hospital-Based Prospective Cohort of Malnutrition Under 6-Month Study (HOSPIC-6-Study)
This study is a hospital-based, prospective, multicentre cohort study (the HOSPIC-6 Study) that will follow infants under 6 months of age who are admitted to pediatric or perinatology wards with acute malnutrition, diagnosed…
- Trial name
- HOSPIC-6 (NCT07831343)
- Testing
- Not applicable- observational study
- Where
- 16 sites in Indonesia
- Volunteers
- 1,780 people
- Sponsor
- Universitas Indonesia
Diarrhea, Wasting
Lactoferrin and Lysozyme Supplementation for Long-term Diarrhea Sequelae
Children in low- and middle-income countries who are hospitalized for diarrhea and also have malnutrition are at high risk for illness and death in the 6 months period following treatment for diarrhoea despite receiving current…
- Conditions
- Diarrhea, Wasting, Malnutrition, Child
- Trial name
- NCT05519254
- Testing
- Lactoferrin, Lysozyme, Lactoferrin + Lysozyme
- Where
- 4 sites in Kenya
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Washington
Nutrition Poor, Aflatoxins Toxicity
One Nutrition in Complex Environments (ONCE)
This study asks the research question "Does enabling families (particularly mothers and other caregivers) to 'assess and act' on drivers of malnutrition through a targeted SBC+ package succeed in a sustained reduction of risk…
- Conditions
- Nutrition Poor, Aflatoxins Toxicity, Water-Related Diseases
- Trial name
- ONCE (NCT04209569)
- Testing
- Nutrition Impact and Positive Practice Circle (NIPP)
- Where
- Uganda
- Volunteers
- 1,834 people, healthy volunteers welcome
- Sponsor
- Tufts University
HIV Infections, HIV Wasting Syndrome
A Comparison of Two Caloric Supplements in the Prevention of Weight Loss in Patients With AIDS Who Take Daily Multivitamin and Mineral Supplements
To compare a caloric supplement containing peptides and medium-chain triglycerides, a caloric supplement containing whole protein and long-chain triglycerides, and no caloric supplement for the prevention of weight loss in…
- Trial name
- NCT00001077
- Testing
- Multivitamin and mineral supplements, Peptamen, NuBasics
- Where
- 17 sites in United States
- Volunteers
- 536 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nutrition, Growth
Impact of Diet and Nutrition on Growth and Development in Young Children
The association between nutrition in early life and its long-term health consequences has long been known. However, there is a scarcity of scientific evidence on how nutritional status affects child growth and development in…
- Conditions
- Nutrition, Growth, Development, Stunting
- Trial name
- DIGEST (NCT06018636)
- Where
- Pakistan
- Volunteers
- 832 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Malnutrition, Wasting
Nutritional Impact of Moringa Oleifera Leaf Supplementation in Mothers and Children
Studies to date on the effects of Moringa oleifera in diabetes and anemia and animal studies that examine the utility of moringa for increased milk and litter yield are of small scale, however high-quality large-scale placebo or…
- Conditions
- Malnutrition, Wasting, Growth Failure
- Trial name
- NCT04587271
- Testing
- Moringa oleifera (high dose), Moringa oleifera (low dose)
- Where
- 2 sites in Kenya
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Suzanna L Attia
Underweight, Stunted Growth
Effects of Multiple-micronutrients Supplementation on Growth and Iron Status of Indigenous Children in Malaysia
Child undernutrition is largely attributed to inadequate nutrition including micronutrient deficiency. Undernutrition is prevalent among indigenous children as compared to the general population.
- Conditions
- Underweight, Stunted Growth, Wasting, Anemia
- Trial name
- NCT04561635
- Testing
- Multiple-micronutrients supplement
- Where
- Malaysia
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Cachexia
Study of GTx-024 on Muscle Wasting (Cachexia) Cancer.
The purpose of this study is to assess if Gtx-024 is effective in increasing lean body mass in subjects with muscle wasting related to cancer.
- Trial name
- NCT00467844
- Testing
- GTx-024
- Where
- 52 sites in United States, Canada
- Volunteers
- 159 people
- Sponsor
- GTx
Nutrition Disorders, Life-threatening Infection
Cotrimoxazole Prophylaxis in Severely Malnourished Children
This trial aims to test the hypothesis that mortality among Kenyan children with severe malnutrition following initial stabilisation is due to ongoing vulnerability to infectious disease, and that long term daily co-trimoxazole…
- Trial name
- CTX (NCT00934492)
- Testing
- Cotrimoxazole dispersible tablet
- Where
- 4 sites in Kenya
- Volunteers
- 1,781 people
- Sponsor
- University of Oxford
Malnutrition
Stunting Prevention Project in Thatta and Sujawal Districts, Sindh Province, Pakistan
Widespread food insecurity and malnutrition are largely the main impairing factors for human capital development in Pakistan. Rates of chronic malnutrition are very high, and acute malnutrition is critical: 44% of children under…
- Trial name
- NCT02422953
- Testing
- Wheat Soya Blend (WSB), Wawa Mum, Micronutrient Powders (MNP)
- Where
- Pakistan
- Volunteers
- 4,020 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Undernutrition
Effectiveness of Small-Quantity vs Medium-Quantity Lipid-Based Nutrient Supplements for Prevention of Undernutrition in Young Children
Nutrition is essential for a child's growth, brain development, and protection from disease. While breastmilk provides the best nutrition for young infants, children older than six months may not get all the nutrients they need…
- Trial name
- NCT07451951
- Testing
- Medium-quantity lipid-based nutrient supplement (MQ-LNS), Small-quantity lipid-based nutrient supplement (SQ-LNS)
- Where
- 2 sites in Pakistan
- Volunteers
- 1,568 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Stunting, Wasting
Weight Patterns in the Month After Birth
This is a prospective cohort study that will be conducted in four low income countries to describe newborn weight patterns in the first month after birth and their association with clinical and demographic factors including…
- Conditions
- Stunting, Wasting, Undernutrition, Feeding Patterns
- Trial name
- NCT04025827
- Testing
- Dietary intake
- Where
- 5 sites in United States, Guinea-Bissau and 3 more
- Volunteers
- 741 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV Infections, HIV Wasting Syndrome
A Study to Evaluate the Effect of Nandrolone Decanoate in Women With HIV-Associated Weight Loss
The purpose of this study is to see if giving nandrolone decanoate (a hormonal drug) will cause weight gain in HIV-positive women who have HIV-associated weight loss (wasting). Wasting has become an AIDS-defining condition.
- Trial name
- NCT00000854
- Testing
- Nandrolone decanoate
- Where
- 22 sites in United States, Puerto Rico
- Volunteers
- 38 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, HIV Wasting Syndrome
The Effect of Anti-HIV Treatment on Body Characteristics of HIV-Infected Children
The purpose of this study is to see how beginning or changing anti-HIV medications affects the body composition (weight, height, growth, body fat, and muscle mass, or fat and muscle distribution) of HIV-infected children.
- Conditions
- HIV Infections, HIV Wasting Syndrome, Lipodystrophy
- Trial name
- NCT00006064
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Severe Acute Malnutrition, Cognitive Impairment
Choline to Improve Malnutrition and Enhance Cognition
The goal of this clinical trial is to test adding choline to ready-to-use therapeutic food (RUTF) in children with severe acute malnutrition (SAM) in Malawi.
- Conditions
- Severe Acute Malnutrition, Cognitive Impairment, Wasting, Kwashiorkor
- Trial name
- CHIME-SAM (NCT06154174)
- Testing
- C-RUTF (Ready-to-Use Therapeutic Food with added choline), S-RUTF (Ready-to-Use Therapeutic Food without added choline), Amoxicillin
- Where
- 10 sites in Malawi
- Volunteers
- 1,500 people
- Sponsor
- Washington University School of Medicine
Spinal Muscular Atrophy
Phase IIIb, Open-label, Multi-center Study to Evaluate Safety, Tolerability and Efficacy of OAV101 Administered Intrathecally to Participants With SMA Who Discontinued Treatment With Nusinersen or Risdiplam
This was a Phase IIIb open-label, single arm, multi-center study to evaluate the safety, tolerability and efficacy of OAV101B in participants with SMA aged 2 to <18 years after the discontinuation of treatment with nusinersen or…
- Trial name
- STRENGTH (NCT05386680)
- Testing
- OAV101
- Where
- 13 sites in United States, Australia and 7 more
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Undernutrition, Eating Disorders
Genetic Correlates of Wasting: a Pilot Study With Children Attending a Tertiary Feeding Clinic
This is a pilot study of children attending the Glasgow feeding clinic (GFC) which looks after a range of children with severe feeding problems who commonly have low appetite and extreme thinness.
- Conditions
- Undernutrition, Eating Disorders, Underweight
- Trial name
- NCT04848129
- Testing
- Feeding clinic
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Glasgow
Rheumatoid Arthritis, Muscle Atrophy
Muscle Wasting and Rheumatoid Arthritis Flares
People living with Rheumatoid Arthritis (RA) often present with low muscle mass compared to their healthy counterparts. This affects their mobility, overall health and quality of life.
- Trial name
- NCT06400316
- Testing
- Amino Acid Supplement
- Volunteers
- 40 people
- Sponsor
- Leeds Beckett University