Clinical trials: Weaning
Cardiac Valve Disease
Ultrafiltration on Coagulation Function in Cardiac Surgery
To determine the effect of modified ultrafiltration, which is usually employed for reducing free water at the end of cardiopulmonary bypass (CPB), on coagulation profile in patients undergoing cardiac surgery
- Trial name
- NCT04031144
- Testing
- Ultrafiltration
- Where
- South Korea
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Neurologic Disorder, Respiratory Insufficiency
Weaning Success in Different Weaning Strategies in Early Neurological Rehabilitation Patients - a Matched-pair Analysis
To enable weaning from mechanical ventilation, two different strategies may be distinguished: continuous weaning and discontinuous weaning.
- Trial name
- NCT05483244
- Testing
- discontinuous weaning, continuous weaning
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Respiratory Distress Syndrome, Newborn
Comparison of Methods of Weaning From Nasal CPAP in Preterm Infants: A Randomized Controlled Trial
This study aimed to determine the efficacy of different NCPAP weaning strategies in pre-term infants presenting with respiratory distress, and ultimately establishing the best method to withdraw from NCPAP.
- Trial name
- NCT07009366
- Testing
- Sudden weaning of NCPAP, Gradual weaning with increasing the time off NCPAP, Pressure weaning of NCPAP
- Where
- Pakistan
- Volunteers
- 75 people
- Sponsor
- RESnTEC, Institute of Research
Respiratory Distress Syndrome, Hyaline Membrane Disease
Weaning Preterm Neonates From Nasal Continuous Positive Airway Pressure
There is little data published concerning the best approach to nasal continuous positive airway pressure (nCPAP) weaning. Potential complications associated with prolonged nCPAP therapy include gastric distension, nasal…
- Conditions
- Respiratory Distress Syndrome, Hyaline Membrane Disease, Preterm Infants, Premature Infants
- Trial name
- NCT01093495
- Testing
- CPAP, Nasal Cannula
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Mechanical Ventilation
Work of Breathing Assessment During Weaning From Mechanical Ventilation
Introduction In patients assisted by mechanical ventilation, the Work Of Breathing (WOB) is shared between the patient and the ventilator.
- Trial name
- WOAW (NCT02762292)
- Testing
- Measurement of work of breathing using indirect calorimeter
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital
Mechanical Ventilation
The Ratio of Diaphragmatic Movement Between the Midaxillary Line and the Midclavicular Line Predicts the Success Rate of Weaning From Mechanical Ventilation
This study will provide individualized objective indicators for patients undergoing invasive mechanical ventilation. It will set specific assessment parameters for weaning and extubation for different patients, increase the…
- Trial name
- NCT07235956
- Testing
- Observe the ratio of diaphragmatic excursion between the midaxillary line and the midclavicular line in the successful group of invasive mechanical ventilation weaning.
- Volunteers
- 100 people
- Sponsor
- Zheng Qingjiang
Neonatal Respiratory Failure
Flow and Grow - The Ideal Time to Wean CPAP Off In Extremely Low Birth Weight Infants
Preterm neonates born at less than 30 weeks' gestation are commonly maintained on invasive or non-invasive respiratory support to facilitate gas exchange.
- Trial name
- Flow&Grow (NCT06123143)
- Testing
- Standardized/structured CPAP weaning protocol
- Where
- 5 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of California, San Diego
Congenital Heart Disease
Use of a Predictive Analytics Algorithm to Optimize Weaning of Inotropes Following Pediatric Cardiac Surgery
The objective of this study is to determine the effectiveness of a real time continuous risk analytics algorithm in the successful de-escalation of vasoactive and inotropic support in pediatric patients following cardiac surgery.
- Trial name
- NCT04600700
- Testing
- Clinical Decision support system (CDSS) for inotrope weaning
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston Children's Hospital
Eczema, Allergy
Probiotics in Prevention of Allergies, Obesity and Caries
During the period of 2000-2003, 179 healthy, term infants with no previous signs of allergic disease were recruited and randomized to daily intake of cereals with or without the addition of Lactobacillus paracasei subspecies…
- Conditions
- Eczema, Allergy, Asthma, Obesity
- Trial name
- ELEFANT (NCT00894816)
- Testing
- Lactobacillus F19
- Where
- Sweden
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Umeå University
Growth Failure, Atopy
The PREWEAN Study. Weaning of Preterm Infants During the First Year of Life.
In this Austrian observational study preterm infants born with a birth weight <1500 g and a gestational age <32 weeks will be investigated at the neonatal outpatient clinic.
- Conditions
- Growth Failure, Atopy, Adiposity, Cognitive Impairment
- Trial name
- PREWEAN (NCT02936219)
- Where
- Austria
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Vegetable Intake After Weaning With Vegetables or Fruits, Fruit Intake After Weaning With Vegetables or Fruits
Mum Can I Have Vegetables Again? Development of Vegetable Preferences
Rationale: Despite the health benefits, children's consumption of vegetables is below the recommendations. Most human food preferences are learned through mere exposure, imitation, and conditioning principles.
- Trial name
- VaVo (NCT01858337)
- Testing
- green beans group, Artichoke group, Apple group
- Where
- Netherlands
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Adolescent Idiopathic Scoliosis
Brace Weaning Protocol Comparing Gradual and Immediate Weaning
This is a non-blinded, randomized controlled trial for testing two brace weaning protocols namely immediate removal of brace or gradual weaning of brace over a course of 6 months for adolescent idiopathic scoliosis (AIS)…
- Trial name
- NCT03329716
- Testing
- Brace weaning
- Where
- Hong Kong
- Volunteers
- 369 people
- Sponsor
- The University of Hong Kong
ICU Acquired Weakness, Weaning Failure
Predictors of Prognosis in Patients With Critical Illness.
Recently, intensive care unit acquired weakness (ICUAW) has become a hotspot issue in the patients with critical illness. The symptoms of ICUAW, including sensory impairment and muscle atrophy, may lead to poor quality of life…
- Conditions
- ICU Acquired Weakness, Weaning Failure, Quality of Life
- Trial name
- NCT04914065
- Testing
- Regular care in the surgery intensive care unit
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taoyuan General Hospital
Ventilator Weaning, Child
The Role of Chest Electrical Impedance Tomography in the Pediatric Ventilator Weaning
To correlate the data obtained by Electrical impedance tomography (EIT) during the spontaneous breathing trials (SBT) on a T-piece, in children, with failure in the trial and Extubation failure.
- Conditions
- Ventilator Weaning, Child, Spontaneous Breathing Trial, Electrical Impedance Tomography
- Trial name
- NCT04011852
- Testing
- Electrical Impedance tomography
- Where
- Brazil
- Volunteers
- 83 people
- Sponsor
- University of Sao Paulo General Hospital
Critically Ill
Screening Frequency Trial to Identify Weaning Candidates
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- RELEASE (NCT02001220)
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 53 people
- Sponsor
- Unity Health Toronto
Intensive Care Medicine, Mechanical Ventilation
The Classification of Difficult Weaning and the Predictive Value of Relative Factors for Difficult Weaning
To evaluate the distribution of different types of difficult weaning and the predictive value of weaning relative factors.
- Conditions
- Intensive Care Medicine, Mechanical Ventilation, Weaning
- Trial name
- NCT02487927
- Testing
- weaning
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Jianfeng Xie
Feeding Disorders
CHAMP For the Feeder: Tube Feeding Study
Single site evidence-based implementation of a mHealth application for remote patient monitoring for pediatric patients ready to wean from tube feedings (TFs).
- Trial name
- NCT06052891
- Testing
- CHAMP Application
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Lori Erickson
Development of Eating Behavior
Comparison of Effect of Repeated Exposure, Flavor-Flavor and Flavor-Nutrient Learning on Vegetable Acceptance in Infants
This study aims at comparing learning mechanisms to increase vegetable acceptance in infants at complementary feeding, namely repeated exposure (RE), flavor-flavor learning (FFL) and flavor-nutrient learning (FNL); measuring the…
- Trial name
- T221_HabEat (NCT01790191)
- Testing
- Repeated consumption of basic artichoke purée., Repeated consumption of sweet artichoke purée., Repeated exposure to fat artichoke purée.
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Critically Ill
Frequency of Screening and SBT Technique Trial
The requirement for invasive mechanical ventilation is a defining feature of critical illness. Liberation or weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Trial name
- FAST (NCT02399267)
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 10 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Myasthenia Gravis, Guillain-Barre Syndrome
Ventilator Weaning Practices in Patients Intubated for Guillain-Barré Syndrome or Myasthenia Gravis
Guillain-Barré syndrome and myasthenia gravis are two neuromuscular diseases that are commonly managed in ICUs that may require different weaning protocols.
- Trial name
- GUIMAUVE (NCT07022028)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Poitiers University Hospital