Clinical trials: Zonulin
Nephrotic Syndrome
Efficacy of a Gluten-free Diet in Difficult to Manage Nephrotic Syndrome: Utility of Plasma Zonulin Levels as a Predictive Biomarker
Elevated plasma zonulin levels, which are supportive of a diagnosis of CD (celiac disease) in children with gastrointestinal symptoms, may indicate patients with difficult-to-manage NS who will benefit from initiation of a GFD…
- Trial name
- NCT03387176
- Testing
- Implementation of a gluten-free diet
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- NYU Langone Health
Respiratory Failure
The Impact of Age-dependent Haptoglobin Deficiency on Plasma Free Hemoglobin Levels During Extracorporeal Membrane Oxygenation Support
Newborns and children with life-threatening heart and lung failure may require support with ECMO (extracorporeal membrane oxygenation).
- Trial name
- NCT03472768
- Testing
- Plasma Haptoglobin Concentration
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Colorado, Denver
Beta Thalassemia Major Anemia, Hemolysis
The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major
The accumulation of unpaired α-globin chains in β-thalassemia major patients may clinically create ineffective erythropoiesis, hemolysis, and chronic anemia.
- Conditions
- Beta Thalassemia Major Anemia, Hemolysis, Oxidative Stress
- Trial name
- NCT03948737
- Testing
- Alpha-Tocopherol
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Neonatal Sepsis
Distribution of Haptoglobin Phenotype in Septic and Non Septic Pre-term Neonates (PTSH)
The Haptoglobin (Hp) gene locus at chromosome 16q22 is polymorphic with two alleles denoted 1 and 2 .The gene product exists in three phenotypes: 1-1, 2-1, and 2-2.
- Trial name
- NCT00800449
- Where
- Israel
- Volunteers
- 133 people
- Sponsor
- Irina Kessel
Allergic Rhinitis (AR)
EFFECT OF AYURVEDA TREATMENT IN ALLERGIC RHINITIS
Background Allergic Rhinitis is a chronic Th2-mediated inflammatory disorder associated with significant disease burden and impaired quality of life.
- Trial name
- ARAM (NCT07626099)
- Testing
- AYURVEDA treatment protocol, Control(Citrizine 10mg)
- Volunteers
- 104 people
- Sponsor
- Amrita Vishwa Vidyapeetham
Cystic Fibrosis
Correlation Between Haptoglobin Phenotypes and Infectious and Other Complications in Cystic Fibrosis Patients
Cystic Fibrosis is a genetic disease with variable severity, and a predisposition for lung infection. Usually severity is determined by the class of CF mutations, but even among patients with the same severity of mutations there…
- Trial name
- Hp-in-CF (NCT01806025)
- Testing
- no intervention
- Where
- Israel
- Volunteers
- 142 people
- Sponsor
- Carmel Medical Center
Diabetes in Pregnancy
Haptoglobin and Diabetes Complications in Pregnancy
Pregnancies of patients with Diabetes are associated with increase adverse pregnancy outcome . The risk for vascular complications including: Intra uterine growth restriction (20%), hypertension (31%), preeclampsia (15%)…
- Trial name
- NCT01758016
- Where
- 3 sites in Israel
- Volunteers
- 400 people
- Sponsor
- Rambam Health Care Campus
Crohn's Disease
Effect of VSL#3 on Intestinal Permeability in Pediatric Crohn's Disease
The purpose of this study is to determine the effect of a probiotic formulation, VSL#3, on intestinal permeability in pediatric patients with Crohn's disease.
- Trial name
- NCT00944736
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's Mercy Hospital Kansas City
Preeclampsia
Haptoglobin and Preeclampsia
The purpose of this study is to show that a certain protein called haptoglobin protects against preeclampsia which is a common pregnancy complication.
- Trial name
- NCT01027130
- Where
- Israel
- Sponsor
- Bnai Zion Medical Center
Gastric Cancer
Glycans Bound to Serum Haptoglobin: a Novel Gastric Cancer Tumor Biomarker
The purpose of this study is to evaluate sensitivity and specificity of newly defined tumor biomarker with gastric cancer pts and cancer-free healthy volunteers.
- Trial name
- NCT02848066
- Testing
- Blood sample(10cc) collection
- Where
- South Korea
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Attention-deficit/Hyperactivity Disorder
Occludin and Zonulin in Attention-deficit/Hyperactivity Disorder
The association between levels of zonulin and occludin and behavioral/emotional problems in children with ADHD are investigated.
- Trial name
- NCT05502471
- Testing
- Zonulin, Occludin
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Autism Spectrum Disorder (ASD), Nutrition
Effect of Gluten-free Casein-free Diet on Serum Zonulin and Claudin-5 Levels and Some Clinical Symptoms in Children With Autism Spectrum Disorder
This study will investigate the effects of a gluten-free casein-free diet (GFCF) on serum zonulin and claudin-5 levels in children diagnosed with ASD, in relation to intestinal permeability and blood-brain barrier permeability…
- Trial name
- NCT07274930
- Testing
- Gluten Free Casein Free Diet, Normal Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Karadeniz Technical University
Impaired Wound Healing, Diabetes Mellitus
Wound Healing In Diabetes (WHy) Study
This observational study aims to identify risk factors and molecular mechanisms of impaired wound healing, to guide better foot care in the diabetic population.
- Trial name
- WHy (NCT01002521)
- Where
- Barbados
- Volunteers
- 605 people
- Sponsor
- The University of The West Indies
Functional Dyspepsia
Intestinal Permeability in Children/Adolescents With Functional Dyspepsia
The main purpose of this study is to evaluate whether intestinal permeability and/or serum zonulin concentration is increased in children/adolescents with functional dyspepsia (FD).
- Trial name
- NCT00363597
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City