Clinical trials: Zonulin
Haptoglobin Type
The Type of Hepatoglobin in IUGR
Intra Uterine Growth Restriction is associated with increased oxidative stress. Haptoglobin (Hp) is an abundant plasma glycoprotein produced in the liver.
- Trial name
- NCT02127385
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Nephrotic Syndrome
Efficacy of a Gluten-free Diet in Difficult to Manage Nephrotic Syndrome: Utility of Plasma Zonulin Levels as a Predictive Biomarker
Elevated plasma zonulin levels, which are supportive of a diagnosis of CD (celiac disease) in children with gastrointestinal symptoms, may indicate patients with difficult-to-manage NS who will benefit from initiation of a GFD…
- Trial name
- NCT03387176
- Testing
- Implementation of a gluten-free diet
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- NYU Langone Health
Coronary Artery Disease
Haptoglobin Polymorphism as a Determinant of Adverse Outcome After Cardiac Surgery in Diabetic Patients
Specific aim 1a will test the hypothesis that diabetic patients with 2-2 haptoglobin genotype have higher indices of postoperative myocardial injury (creatine kinase MB isoenzyme , Troponin I ) and renal injury (as indicated by…
- Trial name
- NCT02771808
- Testing
- biomarker samples
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Virginia
Cardiovascular Diseases
Endothelial Function in a Sample Group of Patients From the ICARE Study
The ICARE study, clinicaltrials.gov ID number: NCT00220831 and protocol number KL-2004, is recruiting diabetic patients with haptoglobin phenotype 2-2, which are randomised to either Vitamin E 400IU per day or placebo.
- Trial name
- NCT00314379
- Testing
- Vitamin E 400IU/day
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Technion, Israel Institute of Technology
Respiratory Failure
The Impact of Age-dependent Haptoglobin Deficiency on Plasma Free Hemoglobin Levels During Extracorporeal Membrane Oxygenation Support
Newborns and children with life-threatening heart and lung failure may require support with ECMO (extracorporeal membrane oxygenation).
- Trial name
- NCT03472768
- Testing
- Plasma Haptoglobin Concentration
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Colorado, Denver
Duodenal Diseases, White Spot Lesion
İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin
With our study, we aimed to determine whether there is a correlation between zonulin, which plays a crucial role in intestinal barrier function and is implicated in the etiopathogenesis of many chronic and autoimmune diseases…
- Trial name
- NCT06200129
- Testing
- sws grade 1, sws grade 2, control
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation
Individualized Medical Nutrition Therapy in Adults With Type 2 Diabetes Mellitus
This study aims to investigate the effects of intensive medical nutrition therapy on blood sugar control, systemic inflammation, and gut barrier function in adults with type 2 diabetes mellitus.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation, Intestinal Permeability, Glycemic Control
- Trial name
- NCT07037212
- Testing
- Intensive Medical Nutrition Therapy (MNT), Standard Dietary Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Serap Balaban Barta
Ulcerative Colitis (UC), Steatotic Liver Disease
Ulcerative Colitis Permeability
Study aim: To investigate whether the values of zonulin and lipopolysaccharide-binding protein (LBP) as biomarkers of intestinal permeability are related to the degree of liver steatosis, steatohepatitis and fibrosis in patients…
- Conditions
- Ulcerative Colitis (UC), Steatotic Liver Disease, Intestinal Permeability
- Trial name
- UCP (NCT07662902)
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University Hospital Dubrava
Beta Thalassemia Major Anemia, Hemolysis
The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major
The accumulation of unpaired α-globin chains in β-thalassemia major patients may clinically create ineffective erythropoiesis, hemolysis, and chronic anemia.
- Conditions
- Beta Thalassemia Major Anemia, Hemolysis, Oxidative Stress
- Trial name
- NCT03948737
- Testing
- Alpha-Tocopherol
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Neonatal Sepsis
Distribution of Haptoglobin Phenotype in Septic and Non Septic Pre-term Neonates (PTSH)
The Haptoglobin (Hp) gene locus at chromosome 16q22 is polymorphic with two alleles denoted 1 and 2 .The gene product exists in three phenotypes: 1-1, 2-1, and 2-2.
- Trial name
- NCT00800449
- Where
- Israel
- Volunteers
- 133 people
- Sponsor
- Irina Kessel
Allergic Rhinitis (AR)
EFFECT OF AYURVEDA TREATMENT IN ALLERGIC RHINITIS
Background Allergic Rhinitis is a chronic Th2-mediated inflammatory disorder associated with significant disease burden and impaired quality of life.
- Trial name
- ARAM (NCT07626099)
- Testing
- AYURVEDA treatment protocol, Control(Citrizine 10mg)
- Volunteers
- 104 people
- Sponsor
- Amrita Vishwa Vidyapeetham
Diabetes, Cardiovascular Disease
Haptoglobin Phenotype and Cardiovascular Complications in Diabetic Patients
3054 diabetic patients were screened for Haptoglobin Phenotype as part of the ICARE study (NCT00220831) and composite the I CARE Registry, 1434 Hp 2-2 patients were treated as part of the I CARE study with vitamin E vs.
- Conditions
- Diabetes, Cardiovascular Disease, Myocardial Infarction
- Trial name
- ICARER (NCT00448487)
- Where
- Israel
- Volunteers
- 3,054 people
- Sponsor
- Dr. Shany Blum
Intraabdominal Hypertension, Multi-Organ Disorder
Correlation Between Intra-abdominal Pressure, Biomarkers of Bacterial Translocation and Intestinal Wall Damage
Main scientific hypotheses of the project: 1. The level of intestinal microflora translocation markers and biomarkers of intestinal wall damage the in the blood serum correlates with the level of intra-abdominal pressure…
- Conditions
- Intraabdominal Hypertension, Multi-Organ Disorder, Translocation Syndrome
- Trial name
- NCT06221293
- Testing
- immunoenzyme analysis
- Where
- 5 sites in Kazakhstan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Karaganda Medical University
Cystic Fibrosis
Correlation Between Haptoglobin Phenotypes and Infectious and Other Complications in Cystic Fibrosis Patients
Cystic Fibrosis is a genetic disease with variable severity, and a predisposition for lung infection. Usually severity is determined by the class of CF mutations, but even among patients with the same severity of mutations there…
- Trial name
- Hp-in-CF (NCT01806025)
- Testing
- no intervention
- Where
- Israel
- Volunteers
- 142 people
- Sponsor
- Carmel Medical Center
Diabetes in Pregnancy
Haptoglobin and Diabetes Complications in Pregnancy
Pregnancies of patients with Diabetes are associated with increase adverse pregnancy outcome . The risk for vascular complications including: Intra uterine growth restriction (20%), hypertension (31%), preeclampsia (15%)…
- Trial name
- NCT01758016
- Where
- 3 sites in Israel
- Volunteers
- 400 people
- Sponsor
- Rambam Health Care Campus
Critical Illness, Surgery
Diluted and Undiluted Enteral Nutrition
Adult patients after elective major abdominal surgeries who are planned to be admitted to the Intensive Care Unit (ICU) can be included in the trial. Each patient will be fed via the gastrointestinal tract.
- Conditions
- Critical Illness, Surgery, Enteral Feeding Intolerance, Gastro-Intestinal Disorder
- Trial name
- NCT06516835
- Testing
- Enteral fluid, Intravenous fluid
- Where
- 5 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lublin
Reproductive Age, PCOS (Polycystic Ovary Syndrome)
Functional Proteins in Polycystic Ovary Syndrome
The concentration of functional proteins: kisspeptin, ghrelin, zonulin will be measured and compared in women with polycystic ovary syndrome (PCOS) and insulin resistance (IR), in women with PCOS without IR, and in women without…
- Trial name
- NCT06793098
- Testing
- Measurement of kisspeptin concentration, Measurement of ghrelin concentration, Measurement of zonulin concentration
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Type 1 Diabetes, Heart Disease
Haptoglobin Phenotype, Vitamin E and High-density Lipoprotein (HDL) Function in Type 1 Diabetes
The purpose of the study is to determine whether the function of the good cholesterol (HDL cholesterol) as well as its subfractions (via NMR spectroscopy) is altered among people with type 1 diabetes and a variation in the…
- Trial name
- HAP-E (NCT01098994)
- Testing
- Vitamin E, Dummy pills
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Pittsburgh
Chronic Kidney Disease 5D
Effect of Inulin on Gut Microbiota and Gut Barrier in Chronic Kidney Disease
An adequate fiber intake is crucial for a well-balanced diet and reduces the risk of chronic diseases. However, nutritional recommendations for chronic kidney disease patients lead to an insufficient fiber intake with possible…
- Trial name
- RESTORE (NCT05071131)
- Testing
- Inulin
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Diabetes Mellitus
Relationship of Haptoglobin Phenotype to Vascular Function and Response to Vitamin E Supplementation in Patients With Diabetes Mellitus Type 2: The EVAS Trial
Relationship of haptoglobin phenotype to vascular function and response to Vitamin E supplementation in Patients with Diabetes Mellitus Type 2: The EVAS Trial Specific Aims: The phenotype haptoglobin 2-2 (Hp 2-2) is associated…
- Trial name
- EVAS (NCT02776397)
- Testing
- Vitamin E
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- Tan Tock Seng Hospital