Clinical trials: Simvastatin
Necrotic Pulp, Postoperative Pain
Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy
The aim of the current study is to compare a newly introduced material which is a combination of triple mix antibiotics paste and anti-hyperlipidemia drug simvastatin, the new material is named 3MIX-TATIN \& will be compared to…
- Trial name
- 3-mixtatin (NCT03084601)
- Testing
- Calcium Hydroxide, Iodoform, paste, 3-mixtatin
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mahmoud M Saadoon
Necrotic Primary Molars
3Mixtatin Versus Modified 3Mix-MP in Lesion Sterilization and Tissue Repair for Treatment of Necrotic Primary Molars
This randomized clinical study aims to assess the clinical and radiographic success rate of the 3Mixtatin versus the 3Mix in LSTR in necrotic primary molars.
- Trial name
- LSTR (NCT05677945)
- Testing
- 3Mixtatin paste: Simvastatin mixed with modified triple antibiotic, 3Mix: Modified triple antibiotic mix in propylene glycol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp, Primary Teeth
Clinical and Radiographic Evaluation of Zinc Oxide Modified 3Mixtatin Versus Zical in Root Canal Treatment of Necrotic Primary Molars.
Primary molars with necrotic pulp or abscess are common unfortunate event faced in pediatric dentistry .The traditional treatment is either pulpectomy or extraction.
- Trial name
- NCT06752889
- Testing
- Group( 1): Control Group (pulpectomy using zic oxide eugenol based sealer Zical):, Group ( 2) Experimental group modified 3-MIX-TATIN):
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Healthy Volunteers
Effects of Statins on the Pharmacokinetics for Midazolam in Healthy Volunteers
The purpose of this study is to investigate whether statins have any influence on cytochrome P450 (CYP) 3A4 enzyme activity using a probe drug midazolam.
- Trial name
- H-17-21 (NCT00716846)
- Testing
- simvastatin, atorvastatin, pitavastatin
- Where
- Japan
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Hamamatsu University
Pain
Effects of Simvastatin in the Prevention of Pain Experienced After Tooth Extraction
Atraumatic extraction of maxillary premolar teeth (on the Right, left side) was done; Subsequently, the patients were randomly divided into two equal groups: A group (Extraction + filled with a Simvastatin solution impregnated…
- Trial name
- NCT04406883
- Testing
- Extraction + filled with Simvastatin solution impregnated gelatin sponge
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Hypertension, Hyperlipidemia
The Effect of Providing Free Samples of Generic Cardiovascular Medications to Physicians
In this randomized controlled trial, we will provide primary care physicians with free samples of highly effective generic cardiovascular medications.
- Trial name
- SAMPLES (NCT00761904)
- Testing
- Free Generic Samples (hydrochlorothiazide, simvastatin)
- Where
- United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Irreversible Pulpitis, Primary Teeth
Comparison of 3Mixtatin Pulpotomy and Metapex Pulpectomy in Primary Molars With Irreversible Pulpitis
The present study aims to evaluate the clinical and radiographic success of pulpotomy using 3Mixtatin versus pulpectomy using Metapex in primary molars with irreversible pulpitis in children aged 4 to 9 years.
- Conditions
- Irreversible Pulpitis, Primary Teeth, Pulp Disease, Dental
- Trial name
- NCT06925490
- Testing
- Metapex, 3Mixtatin
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Reversible Pulpitis
Effect of Simvastatin as Pulpotomy Agent in Cariously Exposed Permanent Molars
The study will compare the outcome of complete pulpotomy in mature permanent mandibular molars with deep carious lesions by using Mineral Trioxide Aggregate and Simvastatin -alpha tricalcium phosphate as medicament agent
- Trial name
- NCT04374214
- Testing
- Complete Pulpotomy using Mineral Trioxide Aggregate, Complete Pulpotomy using Simvastain -alphatricalcium phosphate
- Where
- India
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulp Disease, Dental, Deciduous Teeth
3Mixtatin and MTA Vital Pulpotomy in Primary Molars
The aim of the study is to evaluate clinical and radiographic success of using 3Mixtain versus mineral trioxide aggregate in pulpotomy of deeply carious Primary molars.
- Trial name
- NCT06478940
- Testing
- 3 mixtatin pulpotomy, MTA pulpotomy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tooth, Deciduous
3Mixstatin ,Tri-Antibiotic Mix & Simvastatin in the Treatment of Primary Molars
The aim of this study is to determine whether the success rate of pulp therapy undergone on primary molars with signs and symptoms of odontogenic infection that may render them indicated for extraction will improve with the use…
- Trial name
- NCT03585751
- Testing
- Pulpectomy for primary molars + triple antibiotic mix, Pulpectomy for primary molars + 3mixstatin, Pulpectomy for primary molars + simvastatin
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Drug Distribution
Statin Distribution
Anticipating an increased use of statins in children and adolescents, it is imperative that we understand the genetic and developmental characteristics affecting the pharmacokinetics and pharmacodynamics of statins in childhood…
- Trial name
- NCT02360826
- Testing
- Pravastatin, Simvastatin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City