Clinical trials: sponsored by University Health Network, Toronto
- Sponsor University Health Network, Toronto
- Age group Children (under 18)
- Accepts healthy volunteers yes
Healthy Controls
Intranasal Insulin and Olanzapine Study in Healthy Volunteers
Antipsychotic (AP) medications are considered to be the gold standard treatment for psychotic disorders including schizophrenia.
- Trial name
- INI/OLA (NCT03741478)
- Testing
- OLANZapine 2.5 MG, Insulin Lispro 100 UNT/ML, Saline
- Where
- 2 sites in Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Mood Disorders, Depressive Disorder
An Innovative Master Platform for Clinical Trials in Mood Disorders
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person.
- Conditions
- Mood Disorders, Depressive Disorder, Bipolar and Related Disorders
- Trial name
- ENABLE (NCT06408012)
- Where
- 9 sites in Canada
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Myocardial Injury, Myocarditis
Myocardial Injury and Outcomes Following COVID-19 Vaccination (MYOVAX Study)
The study will focus on cardiac blood and imaging biomarkers to facilitate early recognition of patients at risk for myocardial injury after COVID-19 vaccination.
- Conditions
- Myocardial Injury, Myocarditis, COVID-19 Vaccination, SARS-CoV-2
- Trial name
- MYOVAX (NCT04967807)
- Testing
- Cardiac PET/MRI, Blood Biomarkers
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cerebral Palsy (CP)
FES Implementation Pediatrics
Physical rehabilitation interventions that promote activity-dependent neuroplasticity are desired for children with CP as this will result in improved motor skill and function.
- Trial name
- NCT06689007
- Testing
- Implementation Intervention
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Asthma
Magnetic Resonance (MR) in Asthmatic Patients
Asthma is a disease of small airways. Affected areas have reduced lung ventilation causing reflex vasoconstriction. MR perfusion imaging of the lungs is a sensitive method of imaging zonal lung perfusion.
- Trial name
- NCT00188487
- Testing
- magnetic resonance imaging (MRI) of the thorax
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Impostor Phenomenon
IMPROV-ing The Impostor Phenomenon
The impostor phenomenon refers to feelings of self-doubt and fraudulence in one's own abilities, despite the presence of external evidence to suggest otherwise.
- Trial name
- NCT05230030
- Testing
- Improvisation Workshop
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Stroke
Development and Evaluation of iWalk: A Guide to Facilitate Evidence-informed Assessment of Walking After Stroke
Stroke remains a major health concern and the second highest cause of disability worldwide. After experiencing a stroke, many people lose the ability to walk independently.
- Trial name
- NCT04184843
- Testing
- iWalk Toolkit
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Education, Surgery
Video-based Coaching (VBC) in Gynecologic Surgery
This multi-centre, randomized controlled trial aims to assess the role of video-based coaching (VBC) in residency education in gynecologic and gynecologic oncology surgery.
- Conditions
- Education, Surgery, Gynecologic Cancer
- Trial name
- NCT05086783
- Testing
- Video-based coaching, Standard surgical teaching (master-apprentice model - (MAM))
- Where
- 3 sites in Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Hypertension
Use of a Hypertension Tool to Manage Blood Pressure in Hemodialysis
The objective of this project is to develop, validate, and implement a tool to help manager hypertension in patients on hemodialysis.
- Trial name
- NCT03089385
- Testing
- Hypertension tool
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Flap Necrosis
Near Infrared Imaging and Flap Necrosis
Skin flaps following mastectomy breast surgery that do not have enough oxygen are at risk for necrosis which can increase wound healing problems, postoperative recovery time and be costly to the hospital systems and affect the…
- Trial name
- NCT03476499
- Testing
- Near Infrared Imaging (NIR) device
- Where
- 2 sites in Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
External Causes of Morbidity and Mortality, Stillbirth
Linking Facility-based Mortality Audits With Community Engagement in Gilgit-Baltistan, Pakistan
Pakistan is one of the countries in South Asia where neonatal mortality rates remain stagnant. Babies born in Pakistan encounter the highest risk of dying; of every 1,000 babies born, 46 die before the end of their first month…
- Conditions
- External Causes of Morbidity and Mortality, Stillbirth, Neonatal Death
- Trial name
- NCT03904706
- Testing
- Audits only, Audits with community feedback
- Where
- Pakistan
- Volunteers
- 1,871 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Vision, Low
eSight Eyewear Quality of Life and Efficacy Study
The "eSight Quality of Life and Efficacy Study" (eQUEST) is a prospective cohort study intended to demonstrate the functional vision and Quality of Life (QoL) improvement provided by eSight Eyewear to persons with significant…
- Trial name
- eQUEST (NCT02616900)
- Testing
- eSight Eyewear
- Where
- 6 sites in United States, Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- eSight Corporation
Fontan Physiology
Feasibility and Efficacy of Portable Non-invasive Negative Pressure Ventilation in Fontan Patients
The human heart has 4 chambers: 2 collecting chambers (atria) and 2 pumping chambers (ventricles) to allow blood flow within two distinct circuits: "pulmonary" and "systemic".
- Trial name
- FONTAN-CMR (NCT03251742)
- Testing
- Hayek RTX ventilator
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Education, Training
Assessment of a Web-Based Simulation in Transesophageal Echocardiography (TEE) Views
Transesophageal echocardiography (TEE) is often used by anesthesiologists during cardiac surgery, as a monitoring tool in non-cardiac surgery, and as a point of care diagnostic tool in the intensive care unit (ICU).
- Trial name
- Web-SimTEE (NCT03262532)
- Testing
- Web-base simulator, No web-base simulator
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Patient Simulation
Virtual Reality Simulation for Teaching and Assessment of Anesthesia Crisis Management
In this study, Investigators are going to develop and test a device to apply virtual reality simulation to improve and help for teaching and assessment of anesthesia crisis management.
- Trial name
- NCT03434002
- Testing
- Training by Virtual Reality Simulation, Training by Mannequin Based Simulation
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Asthma in Children, Allergy in Children
Project 500 CHILD Study
This proposal relates to the testing of several specific hypotheses in a subset of 500 participants in the Canadian Healthy Infant Longitudinal Development (CHILD) Study.
- Conditions
- Asthma in Children, Allergy in Children, Environmental Exposure, Genetic Predisposition
- Trial name
- NCT03225534
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- McMaster University
CARDIOVASCULAR DISEASES
A Multi-centered Feedback and Education Intervention Designed to Reduce Inappropriate Transthoracic Echocardiograms
This study is an international, prospective, multi-centred, investigator blinded, randomized control trial of an educational and feedback-based intervention vs.
- Trial name
- NCT02038101
- Testing
- Education and Feedback
- Where
- 6 sites in United States, Canada
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Effects of Photographic Aids (Photos of Faces) on Patient Recall of Their Clinical Care Team, Effects of Photographic Aids (Photos of Faces) on Clinician-patient Communication
Put a Face to a Name (Part A): The Effects of Photographic Aids on Patient Satisfaction, Clinician Communication, and Quality of Care
Communication is critical within healthcare, and is the root cause of most errors. With increased adoption and use of new information technologies and mediated communication systems, such as Electronic Health Records (EHR), that…
- Conditions
- Effects of Photographic Aids (Photos of Faces) on Patient Recall of Their Clinical Care Team, Effects of Photographic Aids (Photos of Faces) on Clinician-patient Communication, Effects of Photographic Aids (Photos of Faces) on Overall Patient Satisfaction
- Trial name
- Face2Name (NCT01658644)
- Testing
- Provision of Clinical Care Handout
- Where
- Canada
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Deglutition Disorders, Dysphagia
Development of a Web-Based Course to Maintain Skills in Nurses Trained to Screen for Dysphagia
This research aims to facilitate the successful implementation of the new Heart and Stroke Foundation of Ontario dysphagia screening model for acute stroke patients.
- Conditions
- Deglutition Disorders, Dysphagia, Stroke
- Trial name
- NCT00570557
- Testing
- TOR-BSST© Refresher Training
- Where
- 5 sites in United States, Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Bone Density, Osteopenia
The Influence of Vibration on Bone Mineral Density in Women Who Have Weak Bones After Menopause
This study will examine whether whole-body vibration slows down bone loss in healthy postmenopausal women with osteopenia. Whole-body vibration is a promising novel therapy that involves standing on a platform which produces…
- Conditions
- Bone Density, Osteopenia, Osteoporosis, Post-Menopause
- Trial name
- NCT00420940
- Testing
- Juvent 1000 Dynamic Motion Therapy (DMT) Platform
- Where
- Canada
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto