Clinical trials: CPAP
Mechanical Ventilation, Sedation
Sedation and Ventilator Weaning Protocol in PICU
This research is a single-blinded, randomized controlled trial involving mechanically ventilated children in Pediatric Intensive Care Unit, Cipto Mangunkusumo Hospital, Indonesia.
- Trial name
- NCT04788589
- Testing
- Sedation and ventilator weaning protocol
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Neonatal Respiratory Distress
Effectiveness of Bubble Nasal Continuous Positive Airway Pressure (bCPAP) in Neonatal Respiratory Distress
The objective of study is to determine the effectiveness of bubble Continuous Positive Airway Pressure (bCPAP) in neonates presenting with respiratory distress as compared to the control group ( using oxygen via nasal cannula).
- Trial name
- bCPAP (NCT04401696)
- Testing
- Bubble CPAP, Nasal Oxygen
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- King Edward Medical University
Mechanical Ventilation, Retinal Disease
Cpap at Delivery Room for Preterm Infants
The objective of the study is to determine if CPAP applied within less than 15 min of life in the DR reduces the necessity of mechanical ventilation and surfactant during the first 5 days of life.
- Conditions
- Mechanical Ventilation, Retinal Disease, Death, Respiratory Tract Disease
- Trial name
- CPAP-DR (NCT01024361)
- Testing
- CPAP
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Asthma
Effects of Noninvasive Ventilation Compared to Salbutamol
Asthma is a chronic inflammatory disease characterized by recurrent and reversible episodes of airway obstruction. Drug treatment usually includes inhaled corticosteroids and bronchial dilators, which often do not have adequate…
- Trial name
- NCT03430505
- Testing
- Bilevel, Albuterol
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho
Respiratory Distress Syndrome
High Flow Nasal Cannula in Comparison With Nasal Continuous Positive Airway Pressure in the Management of Respiratory Distress Syndrome
To compare the primary outcome, failure of extubation defined by the need for re-intubation and mechanical ventilation within 5 days of initial extubation and secondary outcomes, morbidities and mortality after using of heated…
- Trial name
- NCT02587832
- Testing
- HHHFNC, NCPAP
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sidra Medicine
Neonates, Respiratory Distress
Non-invasive Secondary Respiratory Support in Late Preterm and Term Infants
The aim of the present work is to compare between various modes of non-invasive respiratory support (including NCPAP, NIPPV, and NHFOV) as secondary respiratory support modes in late preterm and term neonates as regards the need…
- Conditions
- Neonates, Respiratory Distress, Non- Invasive Ventilation
- Trial name
- NCT07000071
- Testing
- NCPAP, NIPPV, NHFOV
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Transient Tachypnea of the Newborn
Positive End Expiratory Pressure With A T-piece Resuscitator For Near-Term and Term Infants With Respiratory Distress
Evaluating the effect of early application of Continuous positive airway pressure (CPAP) via Neopuff in cases of transient tachypnea of the newborn(TTN) and its role in decreasing the duration and complication of TTN.
- Trial name
- NCT01859533
- Testing
- Neopuff
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Sleep Apnea, Pediatric Sleep Apnea
Use of a 3D Printer to Make Custom Sleep Masks for Positive Airway Pressure Treatment
This is a small pilot study to look at the feasibility of creating a customized sleep mask for use with Continuous Positive Airway Pressure (CPAP) or other similar treatments for sleep apnea.
- Trial name
- NCT02896751
- Testing
- 3D printed NIV mask
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Respiratory Distress Syndrome, Newborn, Chronic Lung Disease of Newborn (Diagnosis)
Diaphragmatic Electrical Activity in Preterm Infants on Non-Invasive Ventilation
Preterm babies have immature lungs and frequent pauses in their breathing which often necessitates breathing support. Nasal Continuous Positive Airway Pressure (CPAP) is one of the most commonly used tools but does not always…
- Trial name
- NCT03422549
- Testing
- Drager VN500 Ventilator
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Obstructive Sleep Apnea, Respiratory Insufficiency
Study of the Usability and Efficacy of a New Pediatric CPAP Mask
This study will evaluate a newly developed pediatric mask (known as Pixi) on children aged 2-7 using continuous positive airway pressure (CPAP), or Non-invasive ventilation (NIV) treatment.
- Trial name
- NCT01312948
- Testing
- Prototype mask (known as Pixi)
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- ResMed
Respiratory Insufficiency
Comparison of Humidified High Flow Nasal Cannula to Nasal CPAP in Neonates
We hypothesize that the success rate for keeping babies extubated (without a breathing tube for assisted mechanical ventilation), defined as the proportion of infants remaining extubated for a minimum of 72 hours, will be…
- Trial name
- HHFNC (NCT00609882)
- Testing
- Nasal CPAP, Humidified High Flow Nasal Cannula (HHFNC)
- Where
- 9 sites in United States, China
- Volunteers
- 420 people
- Sponsor
- University of Utah
Premature Neonate
Assessment of Ketamine and Propofol Sedation During LISA Method (Less Invasive Surfactant Administration)
Respiratory distress syndrome (RDS) caused by surfactant deficiency remains one of the major reasons of morbi-mortality in preterm infants and affects 85% of preterm babies born less than 32 week gestational age (wGA).
- Trial name
- ANALISA (NCT03705468)
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Montpellier
Continuous Positive Airway Pressure, Apnea of Prematurity
Randomized Trial Investigating Four Nasal CPAP Systems in the Management of Apnea of Prematurity
The purpose of this study is to evaluate four different nasal continuous pressure systems, which are usually applied on our neonatal intensive care unit, with regard of their effect on bradycardia and desaturations in preterm…
- Conditions
- Continuous Positive Airway Pressure, Apnea of Prematurity, CPAP
- Trial name
- NCT00482040
- Testing
- Stephanie (TM), Infant Flow (TM), Infant Flow advance (TM), Bubble CPAP
- Volunteers
- 16 people
- Sponsor
- University Hospital Tuebingen
Bronchopulmonary Dysplasia, Nasal High-frequency Oscillatory Ventilation
Nasal High-frequency Oscillatory Ventilation (NHFOV) for Ventilated Newborn Infants With BPD
Invasive ventilation(IV) remains one key cornerstone to reduce neonatal mortality for preterm infants with respiratory distress syndrome(RDS) and/or acute respiratory distress syndrome(ARDS).
- Conditions
- Bronchopulmonary Dysplasia, Nasal High-frequency Oscillatory Ventilation, Nasal Continuous Positive Airway Pressure, Neonate
- Trial name
- NCT04905732
- Testing
- NHFOV, NCPAP
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Infant,Premature
Effects of Closed-loop Automatic Control of FiO2 in Extremely Preterm Infants
Extremely low gestational age neonates (ELGANs), i.e. those born at <28 weeks, frequently experience intermittent hypoxemic/hyperoxemic episodes.
- Trial name
- FiO2-C (NCT03168516)
- Testing
- closed-loop automatic control of the inspiratory fraction of oxygen (FiO2-C)
- Where
- 32 sites in China, Germany and 2 more
- Volunteers
- 1,065 people
- Sponsor
- University Hospital Tuebingen
Continuous Positive Airway Pressure
Nasal Problems in Neonates and Infants Subjected to CPAP
The goal of this study is to Detect and Screen different nasal complications of using CPAP in neonates and infants and reach a consensus about minimizing nasal problems of CPAP in neonates and infants
- Trial name
- NCT06557915
- Testing
- screening
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Apnea, Infant, Premature
Randomized Trial of Nasal Continuous Positive Airway Pressure or Synchronized Nasal Ventilation in Premature Infants.
Very premature infants uniformly do not have mature functioning lungs to breathe well nor mature regulation mechanisms to breathe regularly. Assistance with a mechanical respirator is common.
- Conditions
- Apnea, Infant, Premature, Bronchopulmonary Dysplasia
- Trial name
- NCT00188968
- Testing
- Nasal Continuous Positive Airway Pressure, Synchronized Nasal Positive Pressure Ventilation
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
Respiratory Distress Syndrome, Cronic Lung Disease
Humidified High Flow Nasal Cannula as Compared to Nasal Continuous Positive Airway Pressure
The specific aims of this study are to evaluate the amount of high flow nasal cannula (HFNC) gas flow required to generate an equivalent positive distending pressure as that provided by nasal continuous positive airway pressure…
- Trial name
- NCT00356668
- Testing
- High Flow Nasal Cannula
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Apnea, Hypoxia
Effects of Automated Adjustment of Inspired Oxygen With Combined Adaptive Mechanical Backup Ventilation as Compared to Automated Oxygen Adjustment Alone in Preterm Infants With Intermittent Hypoxemic Events During Non-invasive Ventilatory Support
In this 2-phase cross-over study the investigators test the hypothesis that automated adjustment of the inspired oxygen with the combined use of synchronized noninvasive SpO2-sensitive and apnea-sensitive backup-ventilation…
- Trial name
- NCT02774408
- Testing
- Saturation sensitive backup ventilation
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Respiratory Distress Syndrome
Trial to Assess the Safety and Tolerability of Lucinactant for Inhalation in Premature Neonates
The primary objective of this study is to evaluate the safety and tolerability of aerosolized surfactant, specifically lucinactant for inhalation, administered in escalating inhaled doses to preterm neonates 29 to 34 weeks…
- Trial name
- NCT02074059
- Testing
- Lucinactant for Inhalation, nCPAP alone
- Where
- 11 sites in United States
- Volunteers
- 80 people
- Sponsor
- Windtree Therapeutics