Clinical trials: Esomeprazole
Homeostasis, Bone and Bones
Effect of Dexlansoprazole on Bone Homeostasis
The purpose of this study is to evaluate the effect of dexlansoprazole modified release (MR), once daily (QD), on bone homeostasis.
- Trial name
- NCT01216293
- Testing
- Dexlansoprazole, Esomeprazole
- Where
- 12 sites in United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Takeda
Familial Hypercholesterolemia
PLUTO: Pediatric Lipid-redUction Trial of rOsuvastatin
The primary objective of this study is to determine the efficacy of once-daily rosuvastatin in reducing LDL-C in children and adolescents aged 10-17 years with HeFH from baseline (Day 0) to the end of the 12-week double-blind…
- Trial name
- NCT00355615
- Testing
- Rosuvastatin
- Where
- 20 sites in United States, Canada and 3 more
- Volunteers
- 173 people
- Sponsor
- AstraZeneca
Juvenile Idiopathic Arthritis (JIA)
A Safety Study of VIMOVO in Adolescents With Juvenile Idiopathic Arthritis (JIA)
A 6-month study of the safety of VIMOVO in adolescents aged 12 to 16 years with JIA.
- Trial name
- NCT01544114
- Testing
- VIMOVO 250/20, VIMOVO 375/20, VIMOVO 500/20
- Where
- 17 sites in United States
- Volunteers
- 46 people
- Sponsor
- Amgen
Upper Gastrointestinal Bleeding
Oral vs Intravenous and Proton Pump Inhibitor (PPI）for Peptic Ulcer Bleeding (PUB)
A bleeding peptic ulcer remains a serious medical problem with significant morbidity and mortality. Endoscopic therapy significantly reduces further bleeding, surgery, and mortality in patients with bleeding peptic ulcers and is…
- Trial name
- NCT01123031
- Testing
- lansoprazole, esomeprazole
- Sponsor
- Changhua Christian Hospital
Pharmacokinetics, Voriconazole
Development of Voriconazole Pharmacokinetics and Metabolism in Children and Adolescents
The death rate in children from the invasive fungal infection called aspergillosis is more than 50%. Voriconazole is the first-line therapy for this infection.
- Trial name
- NCT01976078
- Testing
- Midazolam/Ranitidine/Esomeprazole
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Children's Hospital Los Angeles
Death, Sudden, Cardiac
An Observational Study to Assess the Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Users of Proton Pump Inhibitors, and Users of Metoclopramide
The purpose of this observational study is to assess the risk of out-of-hospital Sudden Cardiac (heart) Death (SCD) associated with current use of domperidone compared to current use of a Proton Pump Inhibitor (PPI), current use…
- Trial name
- NCT01907633
- Testing
- No intervention
- Volunteers
- 15,000 people
- Sponsor
- Janssen Research & Development, LLC
Treatment Effectiveness
Vonoprazan for Helicobacter Pylori Eradication in Adolescents
The trial tends to evaluate the efficacy of vonoprazan-based triple therapy in eradicating H. Pylori infection in adolescent patients in Egypt, in comparison to standard treatment regimens to determine if it offers superior…
- Trial name
- NCT06162949
- Testing
- Vonoprazan, Amoxicillin, Clarithromycin
- Where
- Egypt
- Volunteers
- 242 people
- Sponsor
- Alexandria University
Pulmonary Aspiration of Gastric Contents
Prophylaxis for Aspiration of Gastric Contents.
Effect of orally administered two equal and consecutive doses of proton pump inhibitors, omeprazole, lansoprazole, esomeprazole , rabeprazole and pantoprazole and Histamine 2 receptor antagonists cimetidine…
- Trial name
- NCT02703896
- Testing
- Drug either PPIS or H2RA and prokinetics, orogastric intubation
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- King Saud University
Gastric Ulcer, Duodenal Ulcer, Anastomotic Ulcer, Reflux Oesophagitis,"Non-erosive Reflux Disease, Zollinger-Ellison Syndrome
Nexium Capsules Clinical Experience Investigation
The purpose of this study is to confirm the safety profile / factors which impact safety and efficacy of Nexium capsules in daily clinical usage for the patients who have been prescribed Nexium for "gastric ulcer", "duodenal…
- Trial name
- NCT01434485
- Where
- 47 sites in Japan
- Volunteers
- 3,691 people
- Sponsor
- AstraZeneca
Endoscopically-Proven GERD, Reflux
Pharmacokinetic Study of Esomeprazole Magnesium in Patients 1 to 11 Years-Old With Endoscopically-Proven Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to determine the area under the plasma concentration-time curve (AUC) of esomeprazole after single oral doses of 5 mg, 10 mg or 20 mg esomeprazole in pediatric patients 1 to 11 years-old inclusive…
- Trial name
- NCT00687245
- Testing
- esomeprazole magnesium
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Helicobacter Pylori Infection, Peptic Ulcer
Treatment Efficacy of Regimens With and Without Bismuth in Children With Helicobacter Pylori-Associated Peptic Ulcer Disease
The goal of this clinical trial is to learn if including bismuth in the treatment helps heal stomach and duodenal ulcers caused by Helicobacter pylori (H. pylori) in children.
- Trial name
- NCT07260006
- Testing
- Bismuth quadruple therapy, Triple therapy with PPI + Amoxicillin + Metronidazole
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori in Children
This study is designed to compare the eradication rates，safety and compliance of tailored therapy to those of standard triple therapy in children with H. pylori infection.
- Trial name
- NCT02635191
- Testing
- Tailored Group, Standard group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Children's Hospital
Epilepsy, Generalized, Helicobacter Pylori Infection
Helicobacter Pylori Eradication Therapy for Epileptic Children
Helicobacter pylori (H. pylori) infection is associated with several health problems. The role of H. pylori infection in epilepsy has been investigated in a few studies.
- Trial name
- NCT05297695
- Testing
- Triple therapy for H. pylori infection
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Sohag University
Gastric Ulcer, Duodenal Ulcer
Nexium Capsules Helicobacter Pylori Specific Clinical Experience Investigation
The purpose of this study is to confirm the safety profile / factors which impact safety and efficacy in patients given triple therapy for Helicobacter pylori eradication with Nexium + amoxicillin (AMPC) + clarithromycin (CAM)…
- Conditions
- Gastric Ulcer, Duodenal Ulcer, Gastric Mucosa-associated Lymphoid Tissue (MALT), Lymphoma Idiopathic Thrombocytopenic Purpura
- Trial name
- NCT01435525
- Where
- 36 sites in Japan
- Volunteers
- 369 people
- Sponsor
- AstraZeneca
Hematopoietic Stem Cell Transplantation (HSCT), aGVHD
GMPA Versus PPI for Gastric Protection and aGVHD Risk
The goal of this clinical trial is to observe whether different gastric protection strategies affect the incidence of acute graft-versus-host disease (aGVHD) in patients undergoing allogeneic hematopoietic stem cell…
- Conditions
- Hematopoietic Stem Cell Transplantation (HSCT), aGVHD, Infection, Mortality
- Trial name
- NCT07791849
- Testing
- Teprenone, Esomeprazole
- Where
- China
- Volunteers
- 198 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Response to Levodopa, Motor Outcomes
Effects of Helicobacter Pylori Infection Eradication in Patients With Parkinson's Disease
A higher prevalence of Helicobacter pylori infection rate has been demonstrated among PD patients compared to controls. As H. pylori infection is known to interfere with levodopa absorption, we embarked on this is a study to…
- Conditions
- Response to Levodopa, Motor Outcomes, Quality of Life Outcomes
- Trial name
- NCT02112812
- Testing
- Eradication therapy for H.pylori infection, Eradication of Helcobacter Pylori, Eradication therapy for Helicobacter pylori
- Where
- Malaysia
- Volunteers
- 82 people
- Sponsor
- National University of Malaysia
Gastroesophageal Reflux
The Gastrointestinal Microbiome of Infants With GERD and PPI Therapy: a Pilot Study
Proton Pump Inhibitors (PPI) are standard in the therapy of pediatric GERD. In the past it has been hypothesized, that either direct inhibition of bacterial ATPase or elevation of the pH may lead to changes in the intestinal…
- Trial name
- NCT02359604
- Testing
- PPI therapy, Stool sample
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Graz
Reflux Esophagitis
Nexium Capsules S-CEI for Justification of Esomeprazole in Acid Related Disease for Reflux Symptom Healing Based on Patient Clinical Outcomes
The objective of this investigation is to collect following data in patients given NEXIUM capsule (NEXIUM) in usual post-marketing use.
- Trial name
- NCT02477475
- Where
- 47 sites in Japan
- Volunteers
- 1,595 people
- Sponsor
- AstraZeneca
Helicobacter Pylori Infection
Bismuth Based Quadruple Therapy 10 Days in Children
Helicobacter pylori infection causes chronic gastritis, peptic ulcer disease and is involved in the development of gastric cancer.
- Trial name
- NCT03299725
- Testing
- colloidal bismuth sub-citrate
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Queen Fabiola Children's University Hospital
Upper Gastrointestinal Bleeding
A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy
A bleeding peptic ulcer remains a serious medical problem with significant morbidity and mortality. Endoscopic therapy significantly reduces further bleeding, surgery, and mortality in patients with bleeding peptic ulcers and is…
- Trial name
- NCT01275937
- Testing
- Esomeprazole
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Taipei Medical University