Clinical trials: Esomeprazole
Healthy
BE of Torrent's Esomeprazole Mg DR Capsules
Subjects to compare the single dose bioavailability of Torrent's Esomeprazole Mg DR Capsule 1×40 mg and Nexium 40 mg DR Capsule containing Esomeprazole 40 mg of AastraZeneca LP, USA.
- Trial name
- NCT02680119
- Testing
- Nexium 40 mg DR Capsules of AstraZeneca LP, USA., Torrent's Esomeprazole Magnesium DR Capsules 40 mg
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Torrent Pharmaceuticals Limited
Helicobacter Pylori Infection, Gut Microbiota
Effect of Probiotics on Gut Microbiota During the Helicobacter Pylori Eradication
Helicobacter pylori (H. pylori) is still infecting more than half of the population in many countries, although the prevalence is decreasing. As a main cause of chronic gastritis, peptic ulcer, and malignant gastric tumors, H.
- Trial name
- NCT05662514
- Testing
- Bifidobacterium animalis subsp. lactis BLa80
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Functional Dyspepsia, Probiotics
Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia
Objective: This study aims to evaluate the effectiveness of Clostridium butyricum in improving anxiety and depression in patients diagnosed with functional dyspepsia according to the Rome IV criteria.
- Conditions
- Functional Dyspepsia, Probiotics, Depression, Anxiety
- Trial name
- NCT07182890
- Testing
- Clostridium butyricum
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Larynx Disease
Effect of Acid Suppression With Esomeprazole on Vocal Cord Granulomas
The purpose of this research study is to measure the effects of the drug, esomeprazole 40 mg (Nexium) or placebo (inactive drug) on vocal cord granulomas.
- Trial name
- NCT00567658
- Testing
- Esomeprazole
- Where
- United States
- Sponsor
- Vanderbilt University
Stomach Diseases
PROGRESSive Withdrawal Esomeprazole and Acid-related Symptoms
Rebound acid hypersecretion (RAHS), defined as an increase in gastric acid secretion above pre-treatment levels after PPIs therapy is observed within two weeks after withdrawal of treatment and could theoretically lead to…
- Trial name
- PROGRESS (NCT02476097)
- Testing
- Esomeprazole: Nexium® 20mg, Astra Zeneca, CYP2C19 phenotypical analysis
- Where
- 2 sites in Switzerland
- Volunteers
- 58 people
- Sponsor
- Victoria Rollason
Helicobacter Infection
Comparison of Daily Single Dose Triple and Conventional Triple Therapies for Helicobacter Pylori Infection
This study is conducted to investigate whether the efficacy of single-dose triple therapy (Esomeprazole 40 mg, Tinidazole 1 g, and Levofluxacine 500 mg) for 14 days is superior to double-dose lansoprazole 30 mg, amoxicillin 1 g…
- Trial name
- NCT02711176
- Testing
- Nexium, Tinafas, Tavanex
- Where
- Iran
- Volunteers
- 212 people
- Sponsor
- Zahra Vahdat Shariatpanahi
Helicobacter Pylori Infection
The Effect of Time Intervals for Rescue Treatment on Eradication Effect of Helicobacter Pylori Infection
The researchers collect patients who accepted eradication program of the helicobacter pylori but failed to eradicate helicobacter pylor from the outpatient clinic.
- Trial name
- NCT05620589
- Testing
- Amoxicillin + Tetracycline + Bismuth + Esomeprazole, Amoxicillin + Tetracycline + Bismuth + Vonoprazan, Amoxicillin + Tetracycline + Bismuth + Tegoprazan
- Where
- China
- Volunteers
- 626 people
- Sponsor
- Shandong University
Functional Dyspepsia
Treatment Outcomes For Functional Dyspepsia Based On Current International Guidelines In Multi-Ethnic Asian Patients
Functional dyspepsia (FD) is among the most established and common functional gastrointestinal disorders (FGIDs). FD is subdivided into two subtypes based on symptoms: epigastric pain syndrome (EPS) and postprandial distress…
- Trial name
- NCT04918017
- Testing
- Treatment based on subtypes: Esomeprazole or Itopride, Treatment with proton pump inhibitor regardless of subtype: Esomeprazole
- Where
- Malaysia
- Volunteers
- 180 people
- Sponsor
- University of Malaya
Healthy
A Study of Food Effect and Esomeprazole on LY4064809 in Healthy Adult Participants
The purpose of this study is to evaluate the safety and effect of food on LY4064809 and the safety and effect of stomach changes by a proton pump inhibitor (PPI) esomeprazole, under fasted conditions in healthy adult…
- Trial name
- NCT06991179
- Testing
- LY4064809
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Scorpion Therapeutics, a wholly owned subsidiary of Eli Lilly and Company
Laryngopharyngeal Reflux
Comparison of Voice Therapy and Antireflex Therapy in LPR
This study will be a prospective, randomized, unblinded but controlled trial. Patients presenting to the Otolaryngology clinic who are diagnosed with laryngopharyngeal reflux disorder related dysphonia and meet inclusion criteria…
- Trial name
- NCT02530879
- Testing
- Omeprazole, Lansoprazole, Esomeprazole, Rantidine, Voice therapy, Combination of anti-reflux medication and voice therapy
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Temple University
Healthy
A Study in Healthy Men to Test Whether Esomeprazole Influences the Amount of BI 3000202 in the Blood
The main objective of this trial is to investigate the effect of the proton pump inhibitor esomeprazole on the pharmacokinetics of BI 3000202 in plasma.
- Trial name
- NCT06419660
- Testing
- BI 300202, esomeprazole
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Gastroesophageal Reflux
Validation of RDQ Questionnaire
The primary objective of this study is to determine the accuracy of the Reflux Disease Questionnaire (RDQ) as a diagnostic test for gastroesophageal reflux disease.
- Trial name
- NCT00291746
- Testing
- Esomeprazole, Bravo technique
- Where
- 30 sites in Canada, Denmark and 4 more
- Volunteers
- 350 people
- Sponsor
- AstraZeneca
Helicobacter
Comparison of the Levofloxacin Sequential Therapy and Quadruple Therapy in Second Line Treatment for HP
Objectives: Eradication of H. pylori infection could reduce the occurence or recurrence of gastric cancer and peptic ulcer diseases.
- Trial name
- NCT03148366
- Testing
- Levofloxacin based sequential therapy, bismuth quadruple therapy for 10 days (BQ)
- Where
- 2 sites in Taiwan
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy
Safety, Tolerability, PK, PD of Escalating Single and Multiple Oral Doses of CJ-12420 in Healthy Male Subjects
The objectives of this study are: To evaluate the safety and tolerability of single and multiple oral doses of CJ-12420 in healthy male subjects.
- Trial name
- NCT01473173
- Testing
- CJ-12420, Esomeprazole 40mg
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Gastritis, Dyspepsia
Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology
This study was conducted to investigate the effects of high-dose diphtherapy and bismuth quadruple therapy on H. pylori eradication on intestinal microecology, to clarify the changes in intestinal microbiota diversity and…
- Conditions
- Gastritis, Dyspepsia, Helicobacter Pylori Infection, Gastric Cancer
- Trial name
- NCT05742568
- Testing
- Esomeprazole, Amoxicillin, Bismuth
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Gastroesophageal Reflux Disease
Drug Interaction Study Between AZD3355 and Nexium
The purpose of the study is to evaluate if AZD3355 and Nexium interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.
- Trial name
- NCT00684190
- Testing
- AZD3355, Esomeprazole
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
A Study to Learn If the Study Medicine Esomeprazole Changes How the Body Processes the Other Study Medicine Vepdegestrant
The purpose of the study is to investigate the effect of multiple doses of a proton-pump inhibitor (PPI) esomeprazole on the PK of vepdegestrant under fed conditions in healthy adult participants.
- Trial name
- NCT06275841
- Testing
- vepdegestrant, esomeprazole
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Helicobacter Pylori Infection, Resistant Infection
One Sequencing Find All for Helicobacter Pylori Infection
The aim of this study is to Identify antibiotic resistance gene mutations in Helicobacter pylori (HP) and genetic diversity of drug metabolism for antibiotics and proton pump inhibitors (PPIs) in patients with HP infection using…
- Trial name
- NCT03837990
- Testing
- Helicobacter Pylori eradication therapy
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Gastroesophageal Reflux Disease
Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients
This study is designed to evaluate the efficacy and tolerability of ilaprazole relative to that of esomeprazole in healing erosive esophagitis and resolving accompanying symptoms of GERD.
- Trial name
- NCT02860624
- Testing
- 10 mg ilaprazole, 40mg esomeprazole
- Volunteers
- 550 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Erosive Esophagitis
A Multicenter, Randomized, Double Blind, Double Dummy, Parallel-Group Efficacy Study Comparing 8 Weeks of Treatment With Esomeprazole Magnesium (40mg qd) to Lansoprazole (30mg qd) for the Healing of Erosive Esophagitis in Patients With Moderate or Severe Erosive Esophagitis
This study looks at the healing rates in patients with Erosive Esophagitis (EE) when treated with either esomeprazole or lansoprazole
- Trial name
- NCT00641602
- Testing
- Esomeprazole, Lansoprazole
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca