Clinical trials: Fentanyl
Respiratory Distress Syndrome, Newborn
Premedication for Less Invasive Surfactant Administration Study (PRELISA)
The purpose of this study is to conduct a double blinded randomized control trial to determine the safety and efficacy of using IV fentanyl and atropine prior to Less Invasive Surfactant Administration (LISA) procedure in preterm…
- Trial name
- PRELISA (NCT05065424)
- Testing
- IV Atropine and Fentanyl Premedication Arm
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Texas Southwestern Medical Center
Opioid Use Disorder
Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine
This is a single center, double-blind, randomized trial to compare the effects of intrathecal hydromorphone versus intrathecal morphine to treat post cesarean pain in patients with OUD taking buprenorphine.
- Trial name
- NCT06784180
- Testing
- Morphine, Bupivacaine, Fentanyl
- Where
- United States
- Sponsor
- University of North Carolina, Chapel Hill
Adenotonsillectomy, Obstructive Sleep Apnea (OSA)
Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstructive Sleep Apnea
Emphasize that the usage of multimodal analgesia in managing perioperative pain in children with mild to moderate Obstructive Sleep Apnea undergoing adenotonsillectomy may achieve the same efficacy of fentanyl with less…
- Conditions
- Adenotonsillectomy, Obstructive Sleep Apnea (OSA), Fentanyl, Opioid
- Trial name
- NCT07435493
- Testing
- Group A: Fentanyl-Based Analgesia, Group B: Opioid-Free Multimodal Analgesia
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Opioid Free Anesthesia
Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis
Opioid-free anesthesia (OFA) is a multimodal analgesic approach designed to eliminate the intraoperative use of systemic, neuraxial, or intracavitary opioids.
- Trial name
- NCT07389096
- Testing
- Dexmedetomidine, Fentanyl (IV)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Nashwa Ahmed
Staphylococcus Aureus Bacterial Contamination
Investigation of Antibacterial Effect of Levobupivacaine on Staphylococcus Aureus
This experimental in vitro study aimed to investigate the antibacterial effect of levobupivacaine on Staphylococcus aureus in a patient-controlled analgesia (PCA) model at concentrations commonly used for postoperative pain…
- Trial name
- NCT07285759
- Testing
- Levobupivacaine, Fentanyl, Saline
- Volunteers
- 40 people
- Sponsor
- Dokuz Eylul University
Postoperative Pain
Comparing Intramuscular Fentanyl and Ketorolac With Nerve of Arnold (NOA) Block for Bilateral Myringotomy
Background: Bilateral myringotomy with tympanostomy tube (BMT) placement is one of the most common pediatric surgical procedures. Despite its brief duration, many children experience significant postoperative pain.
- Trial name
- NOA (NCT07276906)
- Testing
- Fentanyl, Ketorolac, Nerve of Arnold Block
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of South Alabama
Pain, Postoperative, Tonsillar Hypertrophy
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea
- Trial name
- OPTIMAL (NCT06576830)
- Testing
- Methadone, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Duke University
Analgesia, Sedation and Analgesia
Dexmedetomidine as an Adjunct to Fentanyl for Term Neonates on Mechanical Ventilation
Despite well conducted studies on pain management in mechanically ventilated neonates, there is still a need for exploration of appropriate and accurate pharmacological management strategies for this ongoing pain, and assessment…
- Conditions
- Analgesia, Sedation and Analgesia, Neonatal, Mechanical Ventilation in Neonates
- Trial name
- NCT07241351
- Testing
- Dexmedetomidine, fentanyl 1mcg/kg/hr, fentanyl 0.5 mcg/kg/hr
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Spine Surgery, Hemodynamic Stability During Anesthesia
Hemodynamic Effects of Fentanyl Vs Dexmedetomidine in Spine Surgery
Researchers will compare dexmedetomidine to fentanyl to see which drug provides better hemodynamic stability during spinal surgery.
- Trial name
- NCT07238101
- Testing
- Dexmedetomidine, fentanyl
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Sumatera Utara
Distal Radius Fracture Reduction, Pain Control
Pain Control Alternatives in Pediatric Patients With Distal Radius Fractures
The aim of this study is to evaluate the efficacy of a hematoma block and minimal ketamine pain control or hematoma block and intranasal fentanyl in pediatric patients presenting with distal radius fractures requiring reduction…
- Conditions
- Distal Radius Fracture Reduction, Pain Control, Pediatric Fractures
- Trial name
- NCT07120763
- Testing
- Ketamine + Lidocaine, Ketamine group, Fentanyl (Nasalfent, Fentanyl Citrate Nasal Spray)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- State University of New York at Buffalo
Procedural Pain
Intranasal Versus Intravenous Fentanyl For Procedural Analgesia in Preterm Neonates
Pain in neonatal life has profound long-term developmental impacts, so pain control is crucial. The intranasal (IN) route is a minimally invasive method for rapidly delivering fentanyl to provide short-term analgesia and sedation…
- Trial name
- NCT07190625
- Testing
- fentanyl intravenous, Fentanyl intranasal using atomizer, fentanyl intranasal direct
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Acute Stress Disorder, Anxiety
Safety & Efficacy of Intranasal Dexmedetomidine, Fentanyl & Midazolam in the Pediatric Emergency Room
The hypothesis is that intranasal dexmedetomidine will provide significantly more effective analgesia and anxiolysis for subjects undergoing a simple laceration repair when compared to either intranasal fentanyl or intranasal…
- Conditions
- Acute Stress Disorder, Anxiety, Pain
- Trial name
- NCT05057689
- Testing
- Intranasal Dexmedetomidine (4 mcg/kg), Intranasal Fentanyl (2 mcg/kg), Intranasal Midazolam (5 mg/kg)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Epilepsy, Brain Tumor
Effect of Different Anesthetic Drugs on Electrocorticography (ECOG).
Prospective, double-blind, randomized-controlled study for pediatric cases scheduled for brain tumor excision with the aid of electrocorticography (ECOG).
- Trial name
- ECOG-Anaes (NCT07165262)
- Testing
- Fentanyl (IV), Ketamine (0.5 mg/kg)
- Where
- 2 sites in Egypt
- Volunteers
- 88 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Sedation, Analgesia Assessment
Study Comparing Atomizerd Midazolam & Fentanyl and Dexmedomidine for Procedural Sedation in Adult and Pediatric Patient (2 to 60 Years Old)
To evaluate the depth of sedation, as well as onset, and recovery times, satisfaction of sedation , adverse events associated with Atomized Midazolam \& Fentanyl and Dexmedetomidine during procedural sedation in a diverse…
- Trial name
- NCT07166666
- Testing
- atomizer, rescue medication, Midazolam
- Where
- Oman
- Volunteers
- 128 people
- Sponsor
- Oman Medical Speciality Board
Preterm Neonates Pain Managment, PreTerm Neonate
Pain Managment in Preterm Neonates
To compare the effect of Intranasal versus Intravenous Fentanyl on oxidative stress by measuring MDA level just before and after 30 minutes from painful procedure and comparing the results.
- Trial name
- NCT07148882
- Testing
- fentanyl
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Vaginal Delivery, Normal Labor
Comparative Analysis of Analgesic Efficacy: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor
the goal of this randomized control trial is to compare the effect of adding fentanyl v.s dexmedetomidine to bupivacaine in single shot spinal analgesia in achievement of analgesia by decreasing visual analogue scale, onset and…
- Trial name
- SSSA (NCT06823349)
- Testing
- Dexmedetomidine, fentanyl, Saline 0.9%
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Jehan George Sadek
Etomidate, Esketamine
Etomidate and Esketamine on Postoperative Pain After Tonsillectomy Undergoing Children
Objective: To explore the effect of etomidate and esketamine on postoperative pain after tonsillectomy in children. Methods: Investigators enrolled 64 children with American Society of Anesthesiologists (ASA) physical status I…
- Conditions
- Etomidate, Esketamine, Tonsillectomy, Children
- Trial name
- NCT07062601
- Testing
- Etomidate and fentanyl group, Etomidate and esketamine group
- Volunteers
- 64 people
- Sponsor
- Anqing Municipal Hospital
Ultrasound, Pectoral Nerve Block
Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median Sternotomy
This randomized, double-blinded, study aims to compare the efficacy of intraoperative and postoperative pain control while using bilateral ultrasound guided the pectoral nerves (PECS) versus transversus thoracic muscle plane…
- Conditions
- Ultrasound, Pectoral Nerve Block, Transverse Thoracic Plane Block, Pediatric Patients
- Trial name
- NCT06984276
- Testing
- Control, Pectoral nerves (PECS), Transversus thoracic muscle plane block (TTPB)
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Cairo University
Analgesic, Sedative
Analgesic and Sedative Effect of Fentanyl Versus Dexmedetomidine Infusion in Post-Operative Mechanically Ventilated Children After Open Abdominal Surgeries
This study aimed to compare the efficacy and safety of fentanyl versus dexmedetomidine infusion in this population.
- Conditions
- Analgesic, Sedative, Fentanyl, Dexmedetomidine
- Trial name
- NCT06994273
- Testing
- Fentanyl, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Tanta University
Postoperative Pain, Pediatric Open Heart Surgery
A Combination of Intrathecal Fentanyl and Pecto-Intercostal Fascial Block in Paediatric Cardiac Surgery.
Cardiac surgery is commonly performed via median sternotomy. Patients undergoing cardiac surgical procedures frequently experience intense acute pain in the post-sternotomy wound, which can potentially transition into persistent…
- Trial name
- NCT06882655
- Testing
- PIFB group, Intrathecal fentanyl(IT fentanyl), IT + PIFB
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Alexandria University