Clinical trials: Metronidazole
C. Difficile Infection
Prospective Study of Clostridium Difficile in Children Undergoing Colonoscopy
The investigators found that community acquired C. diff occurs in children undergoing a colonoscopy. When they were treated their symptoms got better. But, the investigators do not know if the treatment for the C.
- Trial name
- c diff (NCT01472978)
- Testing
- metronidazole
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Perforated Appendicitis
Intravenous Versus Intravenous/Oral Antibiotics for Perforated Appendicitis
The objective of this study is to scientifically evaluate two different management strategies for perforated appendicitis. The hypothesis is that early discharge with oral antibiotic therapy may result in a dramatic decrease in…
- Trial name
- NCT00462020
- Testing
- 5 days of IV antibiotics (ceftriaxone and metronidazole), Home with oral antibiotics when eating (ampicillin/clavulanic acid)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Children's Mercy Hospital Kansas City
Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation
Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that frequently alters oxygen delivery to the brain.
- Conditions
- Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation, CCHS, CCHS With Hirschsprung Disease
- Trial name
- NCT03568669
- Testing
- NIH Toolbox Cognition Battery
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin
Diarrhea
Effects of Probiotic in Treatment of Persistent Diarrhea in Children
Persistent diarrhea is a common health problem worldwide, particularly in low-income countries. Approximately 3% to 20% of acute diarrhea episodes in children under 5 years of age become persistent diarrhea.
- Trial name
- NCT05812820
- Testing
- LiveSpo DIA30, LiveSpo CLAUSY, RO
- Where
- Vietnam
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National Children's Hospital, Vietnam
Acute Focal Appendicitis, Appendicitis
Non-operative Management for Appendicitis in Children
This study is designed to determine the safety and efficacy of non-operative antibiotic management of clinically diagnosed acute uncomplicated appendicitis in children.
- Trial name
- APRES (NCT02795793)
- Testing
- Non-operative management group (NOM), Appendectomy group (Operative management, OM)
- Where
- 2 sites in Australia
- Volunteers
- 226 people
- Sponsor
- Sydney Children's Hospitals Network
Visual Field Defect Following Cerebrovascular Accident, Hemianopia
Multisensory Telerehabilitation for Visual Field Defects
Brain injuries may cause the loss of the ability to see portions of the visual field, the so-called visual field defects (VFDs).
- Conditions
- Visual Field Defect Following Cerebrovascular Accident, Hemianopia, Brain Injuries
- Trial name
- MUST (NCT06341777)
- Testing
- Audio-visual training (AVT) telerehabilitation
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Istituto Auxologico Italiano
Blood Transfusion Complication, Wrong Blood in Tube
Proficiency Based Training to Investigate Blood Sampling Errors Including WBIT
The objective of this study is to determine the effectiveness of a Proficiency Based Progression training programme, together with evidence based individual feedback for any residual errors, which has been specifically developed…
- Conditions
- Blood Transfusion Complication, Wrong Blood in Tube, Pre Analytical Blood Sample Errors
- Trial name
- NCT03577561
- Testing
- Proficiency Based Progression Training in Phlebotomy
- Where
- Ireland
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Patrick Henn
Infection
Preoperative Dose of Co-amoxiclav for Prevention of Postoperative Complications in Dentoalveolar Surgery
There was no evidence to judge the effects of preventative antibiotics for extractions of severely decayed teeth, teeth in diseased gums, or extractions in patients who are sick or have low immunity to infection.
- Trial name
- NCT03844776
- Testing
- Co-Amoxiclav, Paracetamol, Chlorhexidine mouthwash
- Where
- Saudi Arabia
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Taibah University
Bladder Adenocarcinoma, Bladder Squamous Cell Carcinoma
Neoadjuvant Intravesical Vaccine Therapy in Treating Patients With Bladder Carcinoma Who Are Undergoing Cystectomy
This phase I trial studies the side effects and best dose of vaccine therapy given directly into the bladder in treating patients who are undergoing surgery to remove all or part of the bladder.
- Conditions
- Bladder Adenocarcinoma, Bladder Squamous Cell Carcinoma, Bladder Urothelial Carcinoma, Recurrent Bladder Carcinoma
- Trial name
- NCT00072137
- Testing
- Recombinant Fowlpox-TRICOM Vaccine, Recombinant Fowlpox GM-CSF Vaccine Adjuvant, Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Obstructive Sleep Apnea (OSA)
Evaluation of the Diagnostic Capacity of a Smart Mattress Versus Conventional Polysomnography
This project aims to develop and evaluate an innovative, non-invasive diagnostic system based on a smart mattress for detecting obstructive sleep apnea (OSA), as well as assessing overall sleep quality and identifying periodic…
- Trial name
- NCT07432919
- Testing
- Integrated polysomnographic assessment with smart mattress.
- Where
- 2 sites in Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospital San Pedro de Logroño
Autism Spectrum Disorders
Cortical Metrics Assessment Outcome Measure Development in Autism With Memantine Treatment
Specific Aim 1: Obtain proof of concept evidence that cortical metrics will change in response to treatment with Memantine extended release (XR)®, an agent that modulates n-methyl d-asptartate (NMDA) receptor activation, in…
- Trial name
- NCT02353130
- Testing
- Memantine-XR
- Sponsor
- University of North Carolina, Chapel Hill
Generalized Aggressive Periodontitis
Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment
This study is designed as a parallel, masked, randomized, placebo-controlled clinical trial to assess the clinical, microbiological, and immunological outcomes of scaling and root planning (SRP) or full-mouth ultrasonic…
- Trial name
- NCT03933501
- Testing
- amoxicillin and metronidazole
- Volunteers
- 48 people
- Sponsor
- University of Campinas, Brazil
Neurofibromatosis Type 1
Gait in Young Children With NF1
The objective of this study is to develop office-based tools to quantify gait in young children with NF1 that reflect overall gross motor impairment and predict future gross motor difficulties.
- Trial name
- NCT07564622
- Volunteers
- 56 people
- Sponsor
- NYU Langone Health
Vaginal Infection
Multi-Center Study of New Medications to Treat Vaginal Infections
The purpose of this study is to evaluate the safety and efficacy of terconazole/metronidazole gel in the treatment of vaginal infections
- Trial name
- SMART GIVES (NCT02308007)
- Testing
- Terconazole, Metronidazole, Terconazole/metronidazole
- Where
- 51 sites in United States
- Volunteers
- 475 people
- Sponsor
- Curatek Pharmaceuticals, LLC
Cystic Echincoccosis, Hydatid Disease
MR Assessment of Hepatic Hydatid Disease
Hydatid disease is a major healthcare problem worldwide caused by infection that commonly affects the liver. Treatments for hydatid disease depend on how advanced the disease is and if the infection is active or not.
- Trial name
- NCT03289884
- Testing
- MRI scan (not involving ionising radiation), Ultrasound scan (not involving ionising radiation), Ex vivo MRI scan of cyst fluid sample
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London
Very Preterm and Extremely Preterm Birth
Sodium and Milk Fortification Evaluation of Body Composition Among Very Preterm Infants
The goal of the trial is to learn if targeted sodium supplementation (including blood and urine sodium testing) versus standard milk fortification (including blood sodium testing) improves growth and body composition in very…
- Trial name
- SAFE (NCT07562997)
- Testing
- Urine sodium testing, Serum sodium testing, Milk fortification
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Washington
Pancreatic Cancer
Gut Microbiome Modulation to Enable Efficacy of Checkpoint-based Immunotherapy in Pancreatic Adenocarcinoma
A multi-institutional, single arm pilot study of antibiotics and pembrolizumab for the treatment of surgically resectable pancreatic cancer.
- Trial name
- NCT03891979
- Testing
- Pembrolizumab, Ciprofloxacin 500mg PO BID days 1-29, Metronidazole 500mg PO TID days 1-29
- Where
- United States
- Sponsor
- NYU Langone Health
Bacterial Vaginosis (BV), Menopause
Probiotic Efficacy in Postmenopausal Women with Bacterial Vaginosis
This study is a double-blind, randomized, controlled trial (RCT) aimed at evaluating the effects of Lactobacillus sp. probiotic administration on the vaginal microbiota changes in postmenopausal women with bacterial vaginosis and…
- Trial name
- NCT06659380
- Testing
- Metronidazole + Floragyn® probiotic tablets (Lapi, Indonesia), Metronidazole + Cal95, Floragyn® probiotic tablets (Lapi, Indonesia)
- Where
- Indonesia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Pulp Necrosis
Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth
This study aims to compare regenerative endodontics for necrotic young permanent anterior teeth using oral photo-activated disinfection versus triple antibiotic paste in terms of: 1.
- Trial name
- NCT03763110
- Testing
- Photo Activated Disinfection, antibiotic paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vaginal Infection
Multi-Center Study of New Medications to Treat Vaginal Infections
The purpose of this study is to evaluate the safety and efficacy of terconazole gel in the treatment of vaginal infections
- Trial name
- SMART GIVES (NCT02308046)
- Testing
- Terconazole
- Where
- 41 sites in United States
- Volunteers
- 212 people
- Sponsor
- Curatek Pharmaceuticals, LLC