Clinical trials: Oxycodone
Surgery, Pain, Post Operative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll.
- Trial name
- CARES for Kids (NCT06671002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 9 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Pregnancy Related, Opioid Use
Opioid Prescription After Cesarean Trial
Non-inferiority randomized trial of 5,500 women with a cesarean delivery randomized prior to discharge to either an individualized opioid prescription protocol (IOPP) that includes shared decision making or to a fixed opioid…
- Conditions
- Pregnancy Related, Opioid Use, Pain
- Trial name
- PACT (NCT04296396)
- Testing
- 0 to 20 tablets of oxycodone 5mg, Fixed opioid prescription
- Where
- 12 sites in United States
- Volunteers
- 5,521 people
- Sponsor
- The George Washington University Biostatistics Center
ACL - Anterior Cruciate Ligament Rupture, ACL Injuries
Non-Narcotic Pain Control After ACL Reconstruction
This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses…
- Trial name
- NCT06973785
- Testing
- dispense of study drug, Ketorolac
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Opioid Related Disorders, Opiate Addiction
Evaluation of Changes in Prescribing Behavior of ER/LA Opioid Prescribers
A study will be performed to evaluate changes in prescribing behavior of prescribers of ER/LA opioids
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02920762
- Testing
- on-interventional study - retrospective database review
- Volunteers
- 5,575,834 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Supracondylar Humerus Fracture
NSAIDs vs Opioids for Post-op Pain in Supracondylar Humerus Fractures
The purpose of this study is to determine if using the combination of acetaminophen (also known as Tylenol) and ibuprofen (also known as Motrin or Advil) will provide equal or better pain control as compared to…
- Trial name
- NCT04905563
- Testing
- Acetaminophen-Hydrocodone, Acetaminophen and Ibuprofen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Le Bonheur Children's Hospital
Liquid Oxycodone
The Effect of General Anesthesia on Pharmacokinetics of Oxycodone in Pediatric
Oxycodone is an oral opioid analgesic that is most commonly prescribed for the management of pain in post-operative patients at Boston Children's Hospital.
- Trial name
- NCT03054831
- Testing
- liquid oxycodone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain
Evaluate The Pharmacokinetics and Safety Of Oxycodone Oral Solution In Pediatric and Adolescent Subjects
The objective of this study is to characterize the pharmacokinetics and to evaluate the safety of single and multiple doses of Oxycodone Oral Solution in pediatric and adolescent subjects for postoperative pain.
- Trial name
- NCT01959204
- Testing
- Oxycodone
- Where
- 9 sites in United States
- Volunteers
- 97 people
- Sponsor
- VistaPharm, Inc.
Supracondylar Humerus Fracture
Supracondylar Humerus Fracture (SCHF) Post-Op Study Between Opioid and Non-Opioid Pain Management
This purpose of this study is to determine the efficacy of nonopioid versus opioid analgesic regimens following surgical fixation of Gartland Type III Supracondylar Humoral Fractures (SCHFs) to assist in the development of a…
- Trial name
- NCT06187584
- Testing
- Hydrocodone/acetaminophen, Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Children's Mercy Hospital Kansas City
Postoperative Pain, Opioid Dependence
PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in Children
Each year, in the U.S. alone, >6 million children undergo painful surgery; up to 50% of them experience significant and serious side effects with opioids and inadequate pain relief.
- Trial name
- NCT03495388
- Testing
- Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 129 people
- Sponsor
- Senthil Sadhasivam
Children, Lacerations
Pain and Anxiety Management With Oral Narcotic for Pediatric Suture Repair
The purpose of this study is: To determine whether oral narcotic medication versus placebo improves the pain and anxiety scores for pediatric patients requiring laceration repair in the pediatric emergency department and…
- Conditions
- Children, Lacerations, Procedures, Child
- Trial name
- NCT01053637
- Testing
- hydrocodone/acetaminophen, Sugar water
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Baylor College of Medicine
Anterior Cruciate Ligament Reconstruction
Anterior Cruciate Ligament Pain Study
The objective of this study is to compare the pain control benefit of two different types of nerve blocks in patients undergoing anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT02604550
- Testing
- Ropivacaine 0.5%, Percocet 7.5/325, Naprosyn 500 mg
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Emory University
Periacetabular Osteotomy, Opiates
Open-label Placebo for Pain Management in Adolescents and Young Adults Undergoing Bernese Periacetabular Osteotomy
In this randomized controlled trial, 64 participants undergoing PAO at UCSF will be enrolled and randomized to receive either COLP plus treatment as usual (TAU) or TAU alone.
- Trial name
- COLP PAO (NCT07373210)
- Testing
- Treatment as usual
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of California, San Francisco
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Pain
Fixed-dose Combination of Oxycodone [OXIcodona] + IbuproFEN in Pain Relief After Third Molar Extraction
A clinical, multicenter, randomized, parallel-group, double-blind, double-dummy, comparative study of non-inferiority. ⚠️Study will only be conducted in research centers in Brazil (please do not send e-mail if your center is…
- Trial name
- OXIFEN (NCT05081102)
- Testing
- FDC of oxycodone 5 mg/ibuprofen 400 mg, Tylex
- Where
- Brazil
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Eurofarma Laboratorios S.A.
Limb Fracture
Ethnicity and Analgesic Practice in a Pediatric Emergency Department
Early and appropriate pain management in the emergency department (ED) is an important aspect of child care. Studies in the adult population revealed that ethnicity might be associated with disparities in analgesia and opioid…
- Trial name
- NCT02322463
- Testing
- Arab children
- Where
- Israel
- Volunteers
- 5,000 people
- Sponsor
- Rambam Health Care Campus
Pain
Population Pharmacokinetic-Pharmacodynamic Study of Intravenous Oxycodone in Malaysian Population
Oxycodone has been in clinical use for decades. It is an effective alternative to morphine for moderate to severe acute or chronic pain and has been found to improve quality of life.
- Trial name
- NCT02728648
- Testing
- Oxycodone
- Where
- Malaysia
- Volunteers
- 33 people
- Sponsor
- University of Malaya
Opioid Use, Unspecified
Observational Study on the Incorporation of Opioids and Their Metabolites Into Hair of Pediatric Patients
Hair analysis is a well-established and important tool in both forensic and clinical context. When it comes to the interpretation of positive hair analysis results, reliable and comprehensive reference data is essential.
- Trial name
- NCT05740657
- Testing
- Fentanyl
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Opioid Use, Unspecified
Investigating Interventions to Reduce Residual Opioids in the Home Following Legitimate Opioid Prescribing in Children.
The overall objective of this study is to evaluate strategies to reduce unused opioids prescribed for pediatric acute post-surgical pain management.
- Trial name
- NCT04219397
- Testing
- Medication take back, Medication home disposal
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Indiana University
Anterior Cruciate Ligament Injuries
Reduce Opiate Exposure With ACL Surgery
This is a randomized control trial to investigate the effectiveness of a multimodal opiate sparing analgesic regimen in controlling post-operative pain and potentially reduce post-operative opioid consumption in patients…
- Trial name
- NCT06561035
- Testing
- Opiate Sparing, Opiate Based
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Campbell Clinic