Clinical trials: Pemetrexed
Vital Pulp Therapy
Vital Pulp Therapy With Different Materials for Young Permanent Teeth
This study will be conducted to: Evaluate clinically and radiographically apexogenesis in immature permanent molars using: 1. Calcium Hydroxide. 2. MTA. 3. Laser. 4. Laser combined with MTA.
- Trial name
- NCT05498337
- Testing
- calcium hydroxide, MTA, Diode Laser
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pulp Exposure, Dental
Pulpotomy Technique Preserving Vitality of Traumatized Anterior Permanent Immature Teeth
Aim of the study: To compare the clinical and radiographic outcomes of mineral trioxide aggregate (MTA) and Biodentine as vital pulp therapy materials (pulpotomy) preserving the vitality of traumatized immature anterior permanent…
- Trial name
- NCT03838068
- Testing
- Biodentine, mineral trioxide aggregate, cervical pulpotomy
- Where
- Egypt
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gihan M Abuelniel ,PhD
Extensively Decayed Primary Molars
Efficacy of Totalfill® and ProRoot MTA® as Pulpotomy Agent in Primary Molars
An experimental prospective double-blind, randomized clinical trial (RCT) with parallel design. To evaluate the outcome of using 2 pulpotomy agents: Totalfill® as study group and mineral trioxide aggregate (MTA®) as a control.
- Trial name
- NCT05149651
- Testing
- Totalfill, MTA
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Ghent
Pulp Necrosis, Apexification
Evaluation the Effect of Using of Apical Matrix With Apexification Procedure on Apical Healing of Necrotic Immature Teeth
This study was conducted to evaluate the effect of the use of apical matrix, with Mineral Trioxide Aggregate (MTA) or calcium hydroxide Ca(OH)2 Apexification on apical healing and calcific barrier formation of immature teeth with…
- Trial name
- NCT03849222
- Testing
- Apexification, MTA, Ca(OH)2
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Deep Caries, Reversible Pulpitis
Similar Outcomes of Vital Pulp Therapy Using Mineral Trioxide Aggregate or Biodentine™
This study aimed to evaluate the clinical performance of White MTA (MTA, Angelus, Londrina, Brazil) and Biodentine™ in pulp capping of cariously exposed mature permanent teeth.
- Conditions
- Deep Caries, Reversible Pulpitis, Irreversible Pulpitis
- Trial name
- NCT03186690
- Testing
- Biodentine, Mineral Trioxide Aggregate
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Direct Pulp Capping in Primary Teeth
DPC in Primary Molars.
To evaluate clinical and radiographical outcomes of direct pulp capping using calcium hydroxide (CH), mineral trioxide aggregate (MTA), and premedicated direct pulp capping (PDPC) with formocresol (FC) in primary teeth.
- Trial name
- NCT05222243
- Testing
- Direct pulp capping with calcium hydroxide, Direct pulp capping with MTA, Direct pulp capping with Formocresol
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Decayed Primary Molars
Partial Versus Complete Pulpotomy Using Three Different Materials in Primary Molars: a Clinical Study
The purposes of the study to compare partial pulpotomy versus complete pulpotomy in primary molars using three different materials (Formocresol, MTA, Theracal LC) .
- Trial name
- NCT05190783
- Testing
- Formocresol, MTA, TheraCal
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Caries in Children, Vital Pulp Therapy
Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study
The process of dental caries is dynamic and can be either reversible or irreversible depending on the balance between protective and pathologic factors in the oral cavity.
- Trial name
- NCT06372561
- Testing
- Mineral trioxide aggregate (dressing material), Melatonin (dressing material)
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Endometrial Cancer
Pemetrexed Disodium in Treating Patients With Persistent or Recurrent Endometrial Cancer
RATIONALE: Drugs used in chemotherapy such as pemetrexed disodium work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00087100
- Testing
- pemetrexed disodium
- Where
- 23 sites in United States
- Volunteers
- 51 people
- Sponsor
- Gynecologic Oncology Group
Malignant Mesothelioma
Pemetrexed Disodium and Cisplatin Followed By Surgery and Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma
RATIONALE: Drugs used in chemotherapy, such as pemetrexed disodium and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00227630
- Testing
- cisplatin, pemetrexed disodium, adjuvant therapy
- Where
- 8 sites in Belgium, Italy and 2 more
- Volunteers
- 59 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Osteosarcoma, Medulloblastoma
A Study of Pemetrexed in Children With Recurrent Cancer
To determine the response rate of pemetrexed given every 21 days for the treatment of children with relapsed or refractory osteosarcoma, Ewing's sarcoma/peripheral primitive neuroectodermal tumors (PNET), rhabdomyosarcoma…
- Conditions
- Osteosarcoma, Medulloblastoma, Sarcoma, Ewing's, Neuroblastoma (Measurable Disease)
- Trial name
- NCT00520936
- Testing
- pemetrexed
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Eli Lilly and Company
Reversible Pulpitis, Extremely Deep Caries
Outcome of Direct Pulp Capping and Partial Pulpotomy in Reversible Pulpitis
AIM: -The aim of the study is to compare the outcome of Direct Pulp Capping and Partial Pulpotomy in mature permanent teeth with Reversible Pulpitis OBJECTIVES: - Primary Objective: to compare the difference in clinical and…
- Trial name
- NCT07300124
- Testing
- Partial Pulpotomy in Reversible Pulpitis, Direct pulp capping with MTA
- Where
- India
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulp Disease, Dental
Sodiumhexametaphosphate Versus MTA as Pulp Capping Material for Immature Permanent Teeth
Sodiumhexametaphosphate will be used as capping material for dental pulp of immature permanent teeth
- Trial name
- NCT06170762
- Testing
- Pulp capping, Sodiumhexametaphosphate, MTA
- Volunteers
- 100 people
- Sponsor
- Minia University
Cervical Intraepithelial Neoplasia, Uterine Neoplasms
A Trial for Patients With Advanced/Recurrent Cervical Cancer
This phase II trial is studying the antitumor activity of single agent pemetrexed 900mg/m2 IV over 10 minutes in patients with recurrent cervical cancer.
- Conditions
- Cervical Intraepithelial Neoplasia, Uterine Neoplasms, Genital Neoplasms, Female
- Trial name
- NCT00190983
- Testing
- Pemetrexed
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Eli Lilly and Company
Advanced Solid Tumors
An Extension Protocol for Subjects Who Were Previously Enrolled in Other Tivantinib (ARQ 197) Protocols
This is an extension study that will allow participants to continue to receive study therapy when the original studies into which they were enrolled have reached their designated end-dates.
- Trial name
- NCT01178411
- Testing
- Tivantinib, Anti-Cancer Combination Therapy
- Volunteers
- 60 people
- Sponsor
- ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
Neoplasms, Neoplasms by Site
A Trial for Patients With Advanced/Recurrent Endometrial Cancer
The intent of this protocol is to screen a new agent for activity in patients with advanced or recurrent endometrial carcinoma. This phase II trial is studying how well pemetrexed disodium works in treating patients with advanced…
- Conditions
- Neoplasms, Neoplasms by Site, Urogenital Neoplasms, Genital Neoplasms, Female
- Trial name
- NCT00377520
- Testing
- pemetrexed
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Eli Lilly and Company
Medulloblastoma
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
Historically, medulloblastoma treatment has been determined by the amount of leftover disease present after surgery, also known as clinical risk (standard vs. high risk).
- Trial name
- NCT01878617
- Testing
- Craniospinal Irradiation with boost to the primary tumor site, Cyclophosphamide, Cisplatin
- Where
- 23 sites in United States, Australia and 2 more
- Volunteers
- 660 people
- Sponsor
- St. Jude Children's Research Hospital
Tooth Injuries
Comparison of Sealing Ability of MTA and Biodentine for Repairing of Furcal Perforation in Primary Molars
Preservation of the primary teeth is a mandatory issue for maintaining the integrity of the normal dentition and functioning till the eruption of the successors.
- Trial name
- NCT05006755
- Testing
- Mineral Trioxide Aggregate, Biodentine
- Volunteers
- 42 people
- Sponsor
- Amany hasanean Abd El sadek
Non-small Cell Lung Cancer, Metastatic Lung Cancer
Emulation of the KEYNOTE-189 Trial Using Electronic Health Records
Investigators are building an empirical evidence base supporting the utility of real-world data through the emulation of randomized controlled trials in the oncology setting.
- Trial name
- NCT05908799
- Testing
- Pembrolizumab + Pemetrexed-Platinum, Pemetrexed-Platinum
- Where
- United States
- Volunteers
- 1,854 people, healthy volunteers welcome
- Sponsor
- Aetion, Inc.
Carcinoma, Non-Small-Cell Lung
Study Of Use Of Pemetrexed In Patients With Non-Small Lung Cancer Metastatic In Andalusian Public Health System
STUDY OF USE OF PEMETREXED IN PATIENTS WITH NON-SMALL LUNG CANCER METASTATIC IN ANDALUSIAN PUBLIC HEALTH SYSTEM
- Trial name
- NCT01877902
- Where
- 18 sites in Spain
- Volunteers
- 190 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud