Clinical trials: Pioglitazone, completed
Type 2 Diabetes
Pioglitazone/Glimepiride (Sonias) Combination Tablets Special Drug Use Surveillance Survey in Patients With Type 2 Diabetes Mellitus Who Respond Poorly to Pioglitazone
The purpose of this study is to evaluate the safety and efficacy of long-term use of pioglitazone/glimepiride combination tablets (Sonias Combination Tablets LD) in patients with type 2 diabetes mellitus who respond poorly to…
- Trial name
- NCT02098746
- Testing
- Pioglitazone/glimepiride
- Volunteers
- 294 people
- Sponsor
- Takeda
Type 1 Diabetes Mellitus
Effect of Pioglitazone on the Course of New Onset Type 1 Diabetes Mellitus
A study to examine the effect of pioglitazone on the course of new onset type 1 diabetes mellitus.
- Trial name
- NCT00545857
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stony Brook University
PCOS
Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress in Patients With Poly Cystic Ovary Syndrome
The investigators aim is to conduct a double blind randomized clinical trial, to study the effects of triple drug cocktail (metformin, pioglitazone and acetyl L-Carnitine) therapy on metabolic, endocrine alterations and perceived…
- Trial name
- PCOS (NCT04113889)
- Testing
- Metformin (1000 mg daily), Pioglitazone (30 mg daily), Acetyl-L-carnitine (3 gm daily)
- Where
- Pakistan
- Volunteers
- 147 people
- Sponsor
- Khyber Medical University Peshawar
Autism Spectrum Disorders
Dose Finding Study of Pioglitazone in Children With Autism Spectrum Disorders (ASD) (PIO)
The investigators propose a pilot, single blind, placebo run-in, dose finding study of pioglitazone in children with autism with the ultimate goal of identifying appropriate dosing and outcome measures for a larger follow-up…
- Trial name
- NCT01205282
- Testing
- Pioglitazone
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Evdokia Anagnostou
Type 2 Diabetes
Pioglitazone and Metformin in Diabetic Children
HYPOTHESIS: Treatment with pioglitazone is more effective in reducing resistin concentrations and insulin resistance than metformin in children with Type 2 Diabetes (T2D).
- Trial name
- NCT01396564
- Testing
- Metformin, Pioglitazone
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Insulin Resistance, Diabetes Mellitus
A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)
The goal of this study is to aggressively treat insulin resistance and its clinical manifestations when they first appear in childhood, and to prevent the subsequent progression towards impaired glucose tolerance and type-2…
- Trial name
- NCT00015626
- Testing
- Metformin, skin biopsy, diet and exercise
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Center for Research Resources (NCRR)
Type 2 Diabetes
Long-term Use of Sonias Combination Tablets in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the safety and efficacy of long-term use of Sonias Combination Tablets in patients with type 2 diabetes mellitus in the routine clinical setting.
- Trial name
- NCT02098733
- Testing
- Pioglitazone/glimepiride
- Volunteers
- 1,168 people
- Sponsor
- Takeda
Type 2 Diabetes Mellitus
Pioglitazone Tablets Special Drug Use Surveillance "Combined Use of Biguanides / Long-term Treatment"
To investigate the safety and efficacy of long-term treatment with pioglitazone (Actos tablets) in combination with biguanides (for 12 months after the start of pioglitazone tablets treatment) in patients with type 2 diabetes…
- Trial name
- NCT02003014
- Testing
- Pioglitazone
- Volunteers
- 899 people
- Sponsor
- Takeda
Diabetic, Myocardial Infarction
The Effect of Sitagliptin, Pioglitazone and Dapagliflozine on Myocardial Infarction in Diabetic Rats
The aim of the present study is to evaluate the prophylactic effect of Sitagliptin, Pioglitazone and Dapagliflozine on Isoprenaline induced myocardial infarction in type II diabetic rats.
- Trial name
- NCT07083232
- Testing
- standard normal diet, low dose Streptozotocin, Sitagliptin (Novartis, USA)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Diabetes
Pioglitazone on Cardiac Function and Large Arteries (PICCOLA Study)
This study aims to use a novel, sensitive, non-invasive scanning technique to investigate the effects of insulin-sensitizing agent pioglitazone, on heart and artery function.
- Trial name
- PICCOLA (NCT00485056)
- Testing
- Pioglitazone
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Imperial College London
Fatty Liver, Nonalcoholic Steatohepatitis
Treatment of Nonalcoholic Steatohepatitis With Pioglitazone
This study will evaluate the effectiveness of pioglitazone, a new diabetes medicine, on decreasing insulin resistance and improving liver disease in patients with nonalcoholic steatohepatitis (NASH).
- Trial name
- NCT00013598
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Severe Sepsis, Septic Shock
Pharmacokinetic and Biomarker Study of Pioglitazone in Adolescents With Severe Sepsis and Septic Shock
The purpose of this study is to evaluate the pharmacokinetics of pioglitazone and to determine the effect on inflammatory biomarkers for pioglitazone in patients with severe sepsis and septic shock.
- Trial name
- NCT01352182
- Testing
- Pioglitazone hydrochloride
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Peritoneal Dialysis, Pioglitazone
Pioglitazone Attenuates Dysmetabolism in Peritoneal Dialysis (PD) Patients
1. Background:Cardiovascular disease (CVD) is the major cause of mortality in peritoneal dialysis (PD) patients, in whom it is partly attributable to a higher prevalence of dysmetabolism.
- Conditions
- Peritoneal Dialysis, Pioglitazone, Hypertriglyceridemia, Insulin Resistance
- Trial name
- NCT01258322
- Testing
- Pioglitazone
- Volunteers
- 70 people
- Sponsor
- Huashan Hospital
Type 2 Diabetes Mellitus
Weight Trajectory in New Users of Sulfonylureas as Add on Therapy Next to Metformin.
Next to HbA1c, body weight is regarded as an important surrogate end-point in trials investigating glucose-lowering agents. An increase in weight could contribute to worsening insulin resistance.
- Trial name
- ZODIAC-39 (NCT02133118)
- Testing
- individual SUs, insulin, pioglitazone
- Where
- Netherlands
- Volunteers
- 16,293 people
- Sponsor
- Medical Research Foundation, The Netherlands
Type 2 Diabetes Mellitus
Alogliptin/Pioglitazone (Liovel) Combination Tablets Survey on Long-term Use in Patients With Type 2 Diabetes Mellitus
The purpose of this survey is to examine the safety and efficacy of long-term use of alogliptin/pioglitazone(Liovel) combination tablets in patients with type 2 diabetes mellitus determined as warranting combination therapy with…
- Trial name
- NCT01990300
- Testing
- Alogliptin/Pioglitazone
- Where
- Japan
- Volunteers
- 3,281 people
- Sponsor
- Takeda
Bone Metabolism
Efficacy of Pioglitazone on Bone Metabolism in Postmenopausal Women With Impaired Fasting Glucose.
The purpose of this study is to evaluate the effect of pioglitazone on bone metabolism in postmenopausal women with impaired fasting glucose.
- Trial name
- NCT00708175
- Testing
- Pioglitazone
- Where
- 34 sites in United States
- Volunteers
- 156 people
- Sponsor
- Takeda
Friedreich's Ataxia
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept
Friedreich's ataxia (FA) is a rare progressive neurological disorder affecting approximately 1/30, 000 individuals. No treatment is presently available to counteract the neurodegeneration of this extremely severe disease.
- Trial name
- ACTFRIE (NCT00811681)
- Testing
- pioglitazone
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes Mellitus
Pioglitazone Tablets Special Drug Use Surveillance "Combined Use of Insulin Products / Long-term Treatment"
The purpose of this study is to investigate the safety and efficacy of long-term treatment with pioglitazone (Actos Tablets) in the routine clinical setting in combination with an insulin product in patients with type 2 diabetes…
- Trial name
- NCT02068508
- Testing
- Pioglitazone
- Volunteers
- 1,067 people
- Sponsor
- Takeda
Type 2 Diabetes Mellitus
Special Drug Use Surveillance of Pioglitazone/Metformin Hydrochloride Combination Tablets Survey on Long-term Use for Type 2 Diabetes Mellitus
The purpose of this study is to investigate the safety and efficacy of long-term use of pioglitazone/metformin hydrochloride combination tablets in the routine clinical setting in patients with type 2 diabetes mellitus for whom…
- Trial name
- NCT02024971
- Testing
- Pioglitazone/metformin hydrochloride
- Volunteers
- 1,103 people
- Sponsor
- Takeda
Diabetes Mellitus, Type 2, Cardiovascular Diseases
A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease
The primary purpose of study is to estimate the incidence and comparative effect on health outcomes: 1) hospitalization for heart failure, 2) below knee lower extremity amputation.
- Trial name
- NCT03492580
- Testing
- Canagliflozin, Empagliflozin, Dapagliflozin
- Where
- United States
- Volunteers
- 714,582 people
- Sponsor
- Janssen Research & Development, LLC