Clinical trials: sponsored by Amsterdam UMC, location VUmc
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Parkinson Disease
Cue2Walk, Cost-effectiveness of Automated Freezing Detection and Provision of External Cues in Comparison to Usual Care in People With Parkinson's Disease
The majority of people with Parkinson's disease incur Freezing of Gait (FoG), which is not addressed adequately by medication. Cueing is a proven strategy to overcome FoG.
- Trial name
- NCT06416345
- Testing
- Cue2Walk, Usual Care
- Where
- 2 sites in Netherlands
- Volunteers
- 84 people
- Sponsor
- Amsterdam UMC, location VUmc
Cerebral Palsy, Spastic
Power2Walk: The Impact of Functional Power Training on Participation and Activity in Children With Cerebral Palsy.
Rationale: Children with cerebral palsy (CP) experience limitations in walking ability due to functional motor impairments caused by neurodevelopmental damage during fetal or early child development.
- Trial name
- Power2Walk (NCT06640894)
- Testing
- MegaPower training, Usual Care
- Where
- 10 sites in Netherlands
- Volunteers
- 66 people
- Sponsor
- Amsterdam UMC, location VUmc
Physical Activity, Health Promotion
YoPA - A Youth-centred Participatory Action
Background A vast majority of adolescents do not meet guidelines for healthy physical activity, sedentary behaviour, and sleep, posing major risks for developing multiple non-communicable diseases.
- Conditions
- Physical Activity, Health Promotion, Sleep, Screen Use
- Trial name
- YoPA (NCT06181162)
- Testing
- Social and/or physical environmental interventions
- Where
- 4 sites in Denmark, Netherlands and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Active Outdoor Play and Related Healthy Dietary Behaviours
B-challenged: Co-creating Physical and Social Environments to Promote Children's Active Outdoor Play
BACKGROUND An alarmingly low number of children meet public health guidelines for physical activity and healthy dietary behaviours, and are at increased risk of developing lifestyle-related diseases.
- Trial name
- B-challenged (NCT07136376)
- Testing
- Physical and social environmental interventions.
- Where
- 5 sites in Denmark, Germany and 3 more
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Cerebral Palsy, Spastic
Effect of Functional Power Training on Calf Muscle Length and Strength in Children With Spastic Paresis
Spastic paresis (SP) is a common motor condition in children and is often caused by cerebral palsy. Skeletal muscles develop differently in children with SP due to brain damage in early development; muscle strength and muscle…
- Trial name
- MegaMuscle (NCT05649930)
- Testing
- Functional power training
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- Amsterdam UMC, location VUmc
Parkinson Disease, Impaired Cognition
Cognitive Training in Parkinson Study
This study evaluates the efficacy of an eight-week online cognitive training program on objective and subjective cognitive functions in Parkinson's disease.
- Conditions
- Parkinson Disease, Impaired Cognition, Alteration in Cognition
- Trial name
- cogtips (NCT02920632)
- Testing
- Online cognitive training 1, Online cognitive training 2
- Where
- Netherlands
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Emotion Regulation, Emotional Neglect
How do You Feelee? Emotion-based Smartphone App in the Forensic Outpatient Setting
This intervention study aims to explore the addition of the Feelee app (using active emoji data with passive behavioral data through phone sensing) in treatment as usual for adolescents in the forensic outpatient setting.
- Trial name
- NCT06509360
- Testing
- Feelee app
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people
- Sponsor
- Amsterdam UMC, location VUmc
Gender Dysphoria, Adolescent
Fertility Preservation for Transfeminine Adolescents Via Semen Cryopreservation or Testicular Sperm Extraction
The goal of this observational cohort study is to identify and predict parameters for successful testicular sperm extraction (TESE) procedures or semen cryopreservation more accurately and to evaluate the decision making process…
- Trial name
- TESE (NCT06400199)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Trilateral Retinoblastoma, Retinoblastoma
Trilateral Retinoblastoma: Incidence and Outcomes
Patients with heritable retinoblastoma are at risk to develop an intracranial brain tumor, which is often fatal. The investigators intend to look at the incidence and survival of trilateral retinoblastoma (which is a brain tumor…
- Trial name
- GS-TRIO (NCT06367530)
- Testing
- Incidence and survival of trilateral retinoblastoma and the differences globally
- Where
- Netherlands
- Volunteers
- 4,351 people
- Sponsor
- Amsterdam UMC, location VUmc
Retinoblastoma
Evaluation of MRI of the Pineal Gland in Retinoblastoma
Rationale: Currently baseline brain MRI (magnetic resonance imaging) with extended follow-up of pineal cysts is systematically performed in all new retinoblastoma (Rb) patients, because children with hereditary retinoblastoma…
- Trial name
- TRbFU (NCT06367569)
- Testing
- Screening for trilateral retinoblastoma with MRI
- Where
- Netherlands
- Volunteers
- 607 people
- Sponsor
- Amsterdam UMC, location VUmc
Retinoblastoma, Secondary Primary Malignancies After Retinoblastoma
New Strategies to Detect Cancers in Carriers of Mutations in RB1
Rationale: Individuals with a cancer predisposition due to a mutation in the paradigm tumor suppressor gene RB1, have a high risk to develop the childhood cancer retinoblastoma (Rb).
- Trial name
- NIRBTEST (NCT04164134)
- Testing
- blood draw
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Inguinal Hernia
Hernia Exploration oR Not In Infants Analysis
This study evaluates the effectiveness and cost-effectiveness of contralateral surgical exploration during unilateral inguinal hernia repair in children younger than six months with a unilateral inguinal hernia.
- Trial name
- HERNIIA (NCT03623893)
- Testing
- Contralateral exploration
- Where
- 7 sites in Netherlands
- Volunteers
- 416 people
- Sponsor
- Amsterdam UMC, location VUmc
Cerebral Palsy, Intrathecal Baclofen
Predictive Factors for Succes of ITB in CP
For children with severe cerebral palsy (CP) in whom other options are insufficient, intrathecal baclofen (ITB) treatment could be an option.
- Trial name
- NCT05817409
- Testing
- Intrathecal Baclofen Pump
- Volunteers
- 75 people
- Sponsor
- Amsterdam UMC, location VUmc
Endometriosis
The Effect of Dietary Interventions, or no Intervention, on Pain and Quality of Life in Women Diagnosed With Endometriosis
This prospective pilot study was performed to explore the influence of a dietary intervention, the Low FODMAP diet or endometriosis diet, on endometriosis-related pain and Quality of Life (QoL).
- Trial name
- Dieetstudie (NCT05714189)
- Testing
- Low FODMAP diet, Endometriosis diet
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Amsterdam UMC, location VUmc
Behavior Problem
Effectiveness of the MY LIFE Treatment for Adolescents With Behavioral Problems
Objective This study examines the effects of the MY LIFE treatment, a group intervention aiming to increase hope, self-worth and social support seeking in adolescents with behavioral problems in mental health care.
- Trial name
- NCT05581914
- Testing
- MY LIFE treatment, Care as Usual
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Anastomotic Leak Small Intestine, Anastomotic Leak Large Intestine
Enhanced Perioperative Care for the Prevention of Colorectal Anastomotic Leakage
This multicenter open-label trial is designed to evaluate if the implementation of an enhanced peri-operative care protocol results in an optimal intraoperative condition of the patient and in a decrease in incidence of…
- Conditions
- Anastomotic Leak Small Intestine, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum, Intraoperative Awareness
- Trial name
- DOUBLE CHECK (NCT05250882)
- Testing
- Enhanced perioperative care protocol
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 1,600 people
- Sponsor
- Amsterdam UMC, location VUmc
Neurocognitive Disorders
Evaluating the Long-term Neurocognitive Effects of Preconceptional Exposure to Iodinated Contrast on the Offspring
Iodinated contrast is commonly used in hysterosalpingography (HSG), a diagnostic tool in fertility work-up. This study aims to investigate the safety of contrast media used during HSG by evaluating the long-term effects on the…
- Trial name
- Neuro-H2Oil (NCT05168228)
- Testing
- Oil- versus waterbased contrast in hysterosalpingography (HSG)
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Amsterdam UMC, location VUmc
Parkinson's Disease, Depression
Effect of Bright Light on Mood and Sleep in Parkinson's Disease
The purpose of this clinical trial is to investigate whether light therapy is a suitable treatment option for depression and insomnia in Parkinson's disease.
- Trial name
- LightPD (NCT01604876)
- Testing
- light therapy 30 min morning and evening, three months
- Where
- Netherlands
- Volunteers
- 83 people
- Sponsor
- Amsterdam UMC, location VUmc
Wilms Tumour
Collaborative Wilms Tumour Africa Project
Significant progress has been made in the treatment of Wilms tumor in high income countries, where survival is now around 85% - 90%.
- Trial name
- NCT01991652
- Where
- 3 sites in Cameroon, Ghana and 1 more
- Volunteers
- 400 people
- Sponsor
- Amsterdam UMC, location VUmc