Clinical trials: sponsored by CHU de Reims
Juvenile Idiopathic Arthritis
Sarcopenia and Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is a rare chronic inflammatory rheumatic disease that begins during childhood and may persist into adulthood in many patients.
- Trial name
- SAJI (NCT07634354)
- Testing
- Sarcopenia screening assessment
- Where
- France
- Volunteers
- 200 people
- Sponsor
- CHU de Reims
Catheter Related Complication
Difficult Intravenous Access in Pediatric Patients: Paramedical Care Using Ultrasound Guidance
Obtaining intravenous access is difficult in the pediatric population. Ultrasound-guidance allows real-time visualization of target veins which are invisible and impalpable.
- Trial name
- VVParamECHO (NCT06465121)
- Testing
- peripheral intravenous catheterization performed with ultrasound guidance by a trained nurse
- Where
- France
- Volunteers
- 120 people
- Sponsor
- CHU de Reims
Very Preterm Birth
Evaluation of a Sensory-tonic Stimulation on Development of Parent-infant Interactions and Social Cognition in Very Premature Children
Attachment is built primarily on the first interactions of the first 9 months of a baby's life. These first interactions and their effects of stress, pleasure and displeasure are retained to establish some of the baby's…
- Trial name
- CALIN (NCT04380051)
- Testing
- sensory-tonic stimulation, skin-to-skin contact
- Where
- France
- Volunteers
- 120 people
- Sponsor
- CHU de Reims
Alzheimer Disease
Amyloid Beta-peptide 1-40 and Alzheimer's Disease
The combined measurement of Ab42 and tau protein (total and phosphorylated) in the spinal fluid has been shown to be promising in the diagnosis of Alzheimer's disease (AD), and has justified its inclusion new diagnostic criteria.
- Trial name
- ADAB40 (NCT02770482)
- Testing
- spinal fluid collection
- Where
- France
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Neurogenic Vesical Hyperactivity Syndrom
Children Toxine Botulinum Detrusor Injection in Neurogenic Vesical Hyperactivity Syndrom: Non Inferiority Multicenter Controlled Therapeutic Study Between Two Reported Weight's Doses
Detrusor hyperactivity is an urodynamic observation defined by involuntary detrusor contractions during the vesical filling. Within neurological bladders childs, especially related to spinal dysraphisms, this hyperactivity…
- Trial name
- TBIDE (NCT02816151)
- Testing
- full dose at 16 UI/kg for Dysport or 6,5 UA/kg for Botox, half dose at 8 UI/kg for Dysport or 3,25 UA/kg for Botox
- Where
- France
- Volunteers
- 29 people
- Sponsor
- CHU de Reims
Preterm Children
Preterm Birth and Social Cognition
The study aims at investigating social cognition outcomes of children born prematurely. Social cognition can be briefly defined as a process which underlines people's social and emotional behaviors.
- Trial name
- TERM-COG (NCT03007095)
- Testing
- Evaluation of the children's social cognitive development
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Acute Lymphoblastic Leukemia
Role of the Microparticles and of Tissue Factor in the Pro-thrombotic Phenotype and the Thromboembolic Complications During the Acute Lymphoblastic Leukemia in Children.
Acute lymphoblastic leukemia is the most common malignancy of the child. Current therapeutic strategies allow healing of over 80% of children. However these treatments are associated with toxicity, with a mortality of 1-2%.
- Trial name
- THROMBLEUKEMIA (NCT02862652)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 24 people
- Sponsor
- CHU de Reims
Sickle Cells Patients
Study of Vitamin B12 Metabolism in Children With Sickle Cell Disease Exposed to MEOPA
Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis (Limit : 5000 characters) The sickle cells anemia is a monogenic disease linked to the presence of Hemoglobin S due…
- Trial name
- DREPAM (NCT06581900)
- Testing
- Vitamin B12
- Where
- France
- Volunteers
- 29 people
- Sponsor
- CHU de Reims
Pediatric Epilepsy
Social Cognition in Pediatric Epilepsy
The purpose of this study is to investigate the development of social cognition skills in pediatric epilepsy compared to healthy children.
- Trial name
- TOMEPI (NCT04253379)
- Testing
- Neuropsychological evaluation , Evaluation of theory of mind, Evaluation of executive functions, Evaluation of verbal skills
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Reduction in DMFT Index and Plaque Index in Patients at the Treatment Completion, an Average of 4 Years, DMFT Index, ICDAS Score, Dental Plaque Index, Communication, Prevention, Dentist, Orthodontist
A New Digital Communication Tool Between Dentist and Orthodontist to Improve Dental Prevention
Dentists and orthodontists of the oral medicine department of Reims University Hospital noted that many children presented white spots around orthodontic brackets, or decays at the end of their multi-brackets orthodontic…
- Trial name
- ComDentODFPrev (NCT06517238)
- Testing
- There is no intervention
- Where
- France
- Volunteers
- 30 people
- Sponsor
- CHU de Reims
Adolescent Idiopathic Scoliosis
Effect of a Brace on the Adolescent Idiopathic Scoliosis Breathing
This study intends to investigate the effect of bracing on respiratory function in the treatment of adolescent idiopathic scoliosis (AIS).
- Trial name
- CTM biomec (NCT05749562)
- Testing
- Cheneau-Toulouse-Munster brace
- Where
- France
- Volunteers
- 12 people
- Sponsor
- CHU de Reims
Anorexia Nervosa
Efficiency of Virtual Reality Exposure Therapy in the Management of Body Dysmorphic Disorders in Female Adolescents With Anorexia Nervosa
Anorexia nervosa is defined in DSM V as a quantitative and qualitative dietary restriction resulting in significant weight loss, intense fear of weight gain, altered weight and body shape perception (body dysmorphic disorder) and…
- Trial name
- ANO-TERV (NCT04107870)
- Testing
- Virtual Reality Exposure Therapy sessions, Psychomotor therapy sessions
- Where
- France
- Volunteers
- 40 people
- Sponsor
- CHU de Reims
Coronavirus Infections
CoViD-19 Patient in Reims University Hospital in March to April 2020
Medical context: Follow-up of a retrospective cohort of 499 cases of CoViD-19, hospitalized at the University Hospital of Reims during the health crisis, prospectively up to two years of follow-up.
- Trial name
- COVID-Reims (NCT04553575)
- Testing
- serology
- Where
- France
- Volunteers
- 127 people
- Sponsor
- CHU de Reims
Diabetes Mellitus, Type 1
Interest of SmartGuard Technology (Predictive System for Stopping Insulin Before Hypoglycemia) in Children With Type 1 Diabetes Treated With Insulin Pump
Management of children and adolescents with type 1 diabetes is essentially insulin therapy using insulin pump, allowing the improvement of the glycemic balance.
- Trial name
- NCT03882463
- Testing
- Continuous glucose monitoring with the stop insulin pump function
- Where
- France
- Volunteers
- 34 people
- Sponsor
- CHU de Reims
Premature Newborns
Dosage of Serum Tryptase Levels in a Population of Premature Newborns to Evaluate Mast Cell Activity
Compare serum tryptase levels of premature babies (<37 weeks of amenorrhea) to children born at full term. Study the evolution of serum tryptase levels in premature babies(<37 weeks of amenorrhea).
- Trial name
- NCT02787980
- Testing
- Additional taking blood
- Where
- France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Pregnancy
Relevance of Ultrasound Screening for Foetal Macrosomia
Management of fetal macrosomia is based on a suspicion of macrosomia (no certainty before birth). This management is an artificial induction of labour for an earlier delivery and therefore a lower fetal weight gain.
- Trial name
- USmacro (NCT04443205)
- Testing
- Data record
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- CHU de Reims
Slow Language Impairment
Better Understanding Slow Language Impairment
This study was designed to examine the development of children aged 6 to 10 with slow language impairment (SLI). The aim was threefold: (1) to investigate language skills of children with SLI at different levels - formal…
- Trial name
- SLI:COGGEN (NCT03660995)
- Testing
- Evaluation of language skills and procedural learning of children with SLI and their controls. DNA sampling.
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Sudden Death in Children
Impact of Information Campaign's Alongside Maternity Staff About Bedding Infant
It is now well established that infants should be placed on the back only in a SleepSack without coverage or plush or pillow on a firm mattress in a bedroom.
- Trial name
- NCT03934242
- Testing
- Questionnaire on new born's bedding
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Odontology
Physiological and Oral Dental Parameters of Young Child
The aim of this study is to measure some oral and maxillofacial physiological parameters, with a view to creating a modular prototype articulator from young children to adolescents by 3D printing.
- Trial name
- PhyDentchild (NCT03620214)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- CHU de Reims
Healthy Infants
Age-dependency of Thrombin Generation Using a New Standardized Assay
The aim of this study is to establish normal values of thrombin generation assay parameters in pediatrics, according to different age groups. The standardized thrombin generation assay "Genesia™" will be used.
- Trial name
- TGT (NCT03007108)
- Testing
- blood withdrawal
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- CHU de Reims