Clinical trials: sponsored by CHU de Reims
Neuromuscular Disease in Post-Intensive Care Syndrome
Feasibility Study on the Use of a Walking Exoskeleton in the Intensive Care Unit
The purpose of this study is to evaluate the feasibility of using a lower-limb exoskeleton in the intensive care unit for early mobilization of participants with intensive care neuromyopathy.
- Trial name
- ExoRea (NCT07907237)
- Testing
- rehabilitation session assisted by an exoskeleton
- Volunteers
- 30 people
- Sponsor
- CHU de Reims
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Exercise Order During Pulmonary Rehabilitation on Muscle Strength in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) is a chronic multisystem disease frequently associated with peripheral muscle dysfunction, which is strongly linked to prognosis and survival.
- Trial name
- ISTOR-COPD (NCT07655011)
- Testing
- Pulmonary Rehabilitation - Strength First, Pulmonary Rehabilitation - Endurance First
- Where
- France
- Volunteers
- 138 people
- Sponsor
- CHU de Reims
Ventilator Associated Pneumonia
Ventilator Associated Pneumonia Multiplex PCR for Anti-Infective Regimens
Ventilator-associated pneumonia (VAP) remains one of the main nosocomial infections acquired in the intensive care unit (ICU). VAP is pneumonia occurring 48 hours after intubation.
- Trial name
- VAMPAIR (NCT06554327)
- Testing
- Multiplex PCR
- Where
- France
- Volunteers
- 265 people
- Sponsor
- CHU de Reims
Adhesive Capsulitis
Evaluation of the Efficacy of Suprascapular Nerve Block in Adhesive Capsulitis
This is a double-blind interventional superiority study evaluating the efficacy of suprascapular nerve block in addition to conventional therapies for adhesive capsulitis.
- Trial name
- BAC-Reims (NCT06176248)
- Testing
- Triamcinolone Acetonide, saline solution
- Where
- France
- Volunteers
- 62 people
- Sponsor
- CHU de Reims
Unruptured Intracranial Aneurysm
MRI Analysis in the Growth of Cerebral Aneurysms
An intracranial aneurysm is defined as a localized dilatation of the cerebral arteries, which can potentially lead to rupture and subsequent hemorrhagic stroke. The mechanisms by which aneurysms develop and grow remain unknown.
- Trial name
- EPICAVC (NCT06705452)
- Testing
- Additional 4D Flow MRI or additional 4D Flow sequence
- Where
- France
- Volunteers
- 281 people
- Sponsor
- CHU de Reims
Alcohol Use Disorder
Self-Concept and Autobiographical Memory in Alcohol Use Disorder
This study has two objectives. First, to evaluate the effectiveness of psychotherapy sessions based on self-concept and autobiographical memory in patients suffering from alcohol use disorders (AUD).
- Trial name
- CoSMA (NCT06985927)
- Testing
- psychotherapeutic sessions
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Chronic Renal Insufficiency
Creation and Validation of a Questionnaire to Measure the Feelings of a Chronic Renal Insufficiency Person During His Hemodialysis
Chronic Hemodialysis is a treatment for kidney failure. It involves the construction of three treatment sessions per week extrarenal lasting 4 hours each.
- Trial name
- VecuHD (NCT02791828)
- Where
- France
- Volunteers
- 297 people
- Sponsor
- CHU de Reims
Urinary Bladder Tumour
Urinary Markers by SpectrosCopy: Diagnostic Aid in oncologY - Application to Urological Cancers
This study aims to evaluate the performance of vibrational spectroscopy (Infrared and Raman spectroscopy techniques) in bladder cancer diagnosis using urine samples.
- Trial name
- MUSCADE (NCT06087016)
- Testing
- Urine vibrational analysis
- Where
- France
- Volunteers
- 899 people
- Sponsor
- CHU de Reims
Periodontitis, Gingivitis
Intraoral Scanners as Periodontal and Dental Pathologies Diagnosis Tools
Periodontal diseases and dental pathologies are highly prevalent oral diseases. Thirty-three to fifty percent of adult population presented at least one untreated caries and more than 50% of French population are affected by…
- Conditions
- Periodontitis, Gingivitis, Dental Caries, Diagnosis
- Trial name
- Odonto3D (NCT06006429)
- Testing
- Numerical dental impression by intraoral scanner
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Shock, Right Ventricular Dysfunction
Right Ventriculo-Arterial Coupling During Fluid Loading in ICU Patients
Preload responsiveness and venous congestion have largely been investigated independently in recent literature. However, recent data report a similar incidence of venous congestion regardless of fluid responsiveness status…
- Conditions
- Shock, Right Ventricular Dysfunction, Venous Congestion
- Trial name
- RVPA-FLICU (NCT07537621)
- Testing
- Echography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Juvenile Idiopathic Arthritis
Sarcopenia and Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is a rare chronic inflammatory rheumatic disease that begins during childhood and may persist into adulthood in many patients.
- Trial name
- SAJI (NCT07634354)
- Testing
- Sarcopenia screening assessment
- Where
- France
- Volunteers
- 200 people
- Sponsor
- CHU de Reims
Alcohol Use Disorder
Social Cognition in Severe Alcohol Use Disorder
With 41,000 deaths per year, alcohol consumption is the second leading cause of preventable mortality in France. Nearly 3.4% of adults engage in excessive and chronic alcohol use, meeting criteria for Severe Alcohol Use Disorder…
- Trial name
- COSMO (NCT07464613)
- Testing
- Analysis of social functioning and social cognition processes
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Diabetic Retinopathy, Retinal Vein Occlusion
Soluble Cluster of Differentiation 160 (sCD160) in Sera and Intra-ocular Fluids: Association With Ischaemic Retinopathies
CD160 represents a new angiogenic factor as its specific engagement by an agonist monoclonal antibody directed against human CD160 reduced angiogenesis of endothelial cells with a distinct mechanism from current angiogenic…
- Trial name
- NCT03680794
- Testing
- sampling of ophthalmic liquid
- Where
- France
- Volunteers
- 120 people
- Sponsor
- CHU de Reims
Colorectal Adenocarcinoma
Measurement of MMP-14 Protein, a Potential New Marker for Colorectal Cancer Detection, in Plasma Vesicles Named Exosomes
Colorectal cancer is the third most common cancer in men, and the second most common in women. Screening for colorectal cancer is based on the search for blood in the stool using fecal immunochemical test (FIT).
- Trial name
- EXOSCOL02 (NCT06955767)
- Testing
- Blood will be drawn from 2 additional tubes of 5 ml each
- Where
- France
- Volunteers
- 650 people
- Sponsor
- CHU de Reims
Bipolar Disorder, Major Depressive Disorder
Functional Magnetic Resonance Imaging Study of Inhibitory Control in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder and unipolar depressive disorder are two chronic mood disorders associated with a significant social impact, even during euthymic phases.
- Trial name
- COLIBRI (NCT07503275)
- Testing
- Analysis of inhibitory control
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Bipolar Disorder and Major Depressive Disorder
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their…
- Trial name
- COMET (NCT06740331)
- Testing
- Analysis of social cognition, memory functioning, and executive functioning processes
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Stress Disorder, Post-traumatic
Sensory Stimulation Program Delivered by Family Members of Brain-injured Patients in Critical Care: Effect on Relatives' Post-traumatic Stress
Severe traumatic brain injuries are common and can lead to major long-term disability. Patients with severe brain injury often require admission to critical care.
- Trial name
- StimulSensRea (NCT07456384)
- Testing
- Standardized family-delivered neurosensory stimulation protocol
- Where
- France
- Volunteers
- 200 people
- Sponsor
- CHU de Reims
Postnatal Depression
New Cognitive Treatment for Peripartum Depression
The peripartum period is the period between the last month of pregnancy and up to a year after childbirth. It can be considered a difficult time for women, as it is a period of transition during which vulnerability to psychiatric…
- Trial name
- MCT-DPP (NCT06253390)
- Testing
- Metacognitive training, control
- Where
- France
- Volunteers
- 96 people
- Sponsor
- CHU de Reims
Catheter Related Complication
Difficult Intravenous Access in Pediatric Patients: Paramedical Care Using Ultrasound Guidance
Obtaining intravenous access is difficult in the pediatric population. Ultrasound-guidance allows real-time visualization of target veins which are invisible and impalpable.
- Trial name
- VVParamECHO (NCT06465121)
- Testing
- peripheral intravenous catheterization performed with ultrasound guidance by a trained nurse
- Where
- France
- Volunteers
- 120 people
- Sponsor
- CHU de Reims
Ankle Sprains
Osteopathic Consultation in the Emergency Department for Fresh Lateral Ligament Sprain
The study consists in recruiting patients with ankle sprains who visit the emergency department (ED). Each patient will be tested by an osteopath who we will measure pain, swelling and/or edema, and mobility of the ankle.
- Trial name
- OASED (NCT04999254)
- Testing
- Medical treatment, osteopathic treatment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims