Clinical trials: sponsored by Case Comprehensive Cancer Center
Acute Leukemia, Acute Lymphoblastic Leukemia, Pediatric
Brain MRF in Children, Adolescents and Young Adults With Acute Leukemia
The survival of children, adolescents and young adults (AYA) with acute leukemia has improved dramatically over the last two decades.
- Conditions
- Acute Leukemia, Acute Lymphoblastic Leukemia, Pediatric, Acute Myeloid Leukemia in Children, Myeloproliferative Neoplasm
- Trial name
- NCT06421155
- Testing
- MRF with neurocognative studies
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Case Comprehensive Cancer Center
Marker; Structural
Fatty Acid Binding Proteins and Markers of Cellular Senescence in Cancer Survivors
The purpose of this research study is to investigate whether cancer survivors have higher levels of proteins called Fatty Acid Binding Proteins as well as 12 different markers of cellular senescence than people who have never had…
- Trial name
- NCT07114614
- Testing
- Specimen #1, Specimen #2
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Case Comprehensive Cancer Center
Treatment With Proton Beam Radiation Therapy
Proton Therapy Patient Registry
The purpose of this study is to establish a database (or "registry") of patients treated with proton beam therapy at the University Hospitals (UH) Proton Therapy Center.
- Trial name
- NCT02986048
- Testing
- Proton Beam Therapy
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- Case Comprehensive Cancer Center
Depression, Cancer
Mindfulness-based Intervention for Depressive Symptoms Sent Via Text (MINDSET)
The purpose of this study is to develop and test a new intervention to reduce depressive symptoms in post-treatment cancer participants.
- Conditions
- Depression, Cancer, Stage III Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT06811454
- Testing
- MINDSET, Enhanced Usual Care (EUC)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Case Comprehensive Cancer Center
Leukemia
Thiotepa Plus Fludarabine+ Melphalan as the Preparative Regime for Alternative Donor Transplantation
In the United States, thiotepa has been utilized in reduced intensity conditioning regimens for alternative donor courses (double umbilical cord blood transplant (dUCBT) and haplo-identical transplants).
- Trial name
- NCT03342196
- Testing
- Melphalan, Thiotepa, Fludarabine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center
Stem Cell Transplant Complications, Myeloma
Transplant Wellness Clinic for Elderly or High Risk Patients Undergoing BMT
As the average age of individuals undergoing stem cell transplant continues to increase, challenges associated with balancing the side effects of cancer treatments while also managing other medical conditions develop.
- Conditions
- Stem Cell Transplant Complications, Myeloma, Lymphoma, Allogeneic and Autologous Stem Cell Transplant
- Trial name
- NCT04194840
- Testing
- physical therapy consult, Cognitive Assessment, Cancer Aging Research Group (CARG) assessment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Case Comprehensive Cancer Center
Cancer Prevention
Getting Ahead for Cancer Control
A new, practical program, entitled Getting Ahead in a Just-Gettin'-By World, provides a novel approach to addressing this previously intractable problem.
- Trial name
- NCT03247634
- Testing
- Getting Ahead in a Just-Gettin'-By World
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Pulmonary Metastatic Osteosarcoma (pOS)
Natalizumab in Recurrent, Refractory or Progressive Pulmonary Metastatic Osteosarcoma
The purpose of this study is to evaluate the safety and tolerability of Natalizumab in children, adolescent and young adult patients with pulmonary metastatic osteosarcoma (pOS) and to assess clinical response associated with…
- Trial name
- NCT03811886
- Testing
- Natalizumab
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Basal Cell Carcinoma, Basal Cell Nevus Syndrome
Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma
The purpose of this study is to study 50 patients with multiple Basal Cell Carcinoma (BCC) who will be receiving Photodynamic Therapy (PDT) as treatment for their tumors.
- Trial name
- NCT03467789
- Testing
- Dietary Vitamin D3 pre-treatment, Photodynamic therapy, Serum Maintenance Vitamin D3
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Case Comprehensive Cancer Center
Smoking Behaviors
C-FLASH (Cigarillo Flavor and Abuse Liability, Attention, and Substitution in youtH)
The purpose of this research is to understand how flavor affects young adult's perceptions of little cigar or cigarillo use.
- Trial name
- NCT04358705
- Testing
- Aim 1: Online survey, Eye Tracking Activity, Eye tracking survey
- Where
- United States
- Volunteers
- 658 people
- Sponsor
- Case Comprehensive Cancer Center
Adolescent and Young Adult Cancers
CyberCycling to Reduce Therapeutic Side Effects and Improve Quality of Life in AYA Cancers
Only a few clinical trials evaluating the potential benefits of exercise have been conducted in adolescents and young adults (AYA) with cancer and, no prior studies have evaluated the potential effects of 'cybercycling'…
- Trial name
- NCT02916472
- Testing
- CyberCycling, Stretching, Resistance Bands
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Case Comprehensive Cancer Center
Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia
Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD Prevention
This randomized clinical trial studies standard GVHD prophylaxis with tacrolimus and methotrexate compared to tacrolimus, mycophenolate mofetil and a reduced-dose methotrexate in patients with hematologic malignancies undergoing…
- Conditions
- Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Acute Biphenotypic Leukemia
- Trial name
- NCT01951885
- Testing
- tacrolimus, methotrexate, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Assessment of Candidate Protein Expression in Breast Cancer Specimens
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00918892
- Testing
- gene expression analysis, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Case Comprehensive Cancer Center
Stage I Breast Cancer, Stage II Breast Cancer
Comparison of Use of Indocyanine Green and 99mTc-labeled Radiotracer for Axillary Lymphatic Mapping in Patients With Breast Cancer
This clinical trial will enroll up to 130 adult women with a confirmed diagnosis of clinical stage 1 or 2 breast cancer who are undergoing breast cancer surgery with lumpectomy or mastectomy and planned axillary sentinel node…
- Trial name
- NCT02419807
- Testing
- Indocyanine Green Solution, Technetium Tc-99m Sulfur Colloid, Lymphoscintigraphy
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Virtual Prostate Biopsy Protocol for Patients on Active Surveillance and at Risk of Prostate Cancer
The purpose of this study is to examine the use of MRI surveillance for patients with no prostate cancer, potential prostate cancer, or diagnosed low-grade prostate cancer.
- Trial name
- NCT03823001
- Testing
- virtual biopsy (VB) monitoring protocol
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Neurofibromatosis Type 1, Brain Tumor
Feasibility and Clinically Application of Magnetic Resonance Fingerprinting
This study will look at the feasibility of using magnetic resonance fingerprinting (MRF) in children, adolescents and young adults (AYA) with and without brain tumors.
- Conditions
- Neurofibromatosis Type 1, Brain Tumor, Glioma
- Trial name
- NCT02387840
- Testing
- Magnetic Resonance Imaging, Magnetic Resonance Fingerprinting
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Stage I Endometrial Carcinoma, Stage II Endometrial Carcinoma
Lymph Node Mapping in Patients With Newly Diagnosed Endometrial Cancer Undergoing Surgery
This clinical trial studies lymph node mapping in patients with newly diagnosed endometrial cancer undergoing surgery. Lymph node mapping may help in planning surgery to remove endometrial cancer and affected lymph nodes.
- Conditions
- Stage I Endometrial Carcinoma, Stage II Endometrial Carcinoma, Stage III Endometrial Carcinoma, Stage IV Endometrial Carcinoma
- Trial name
- NCT01939028
- Testing
- lymph node mapping, sentinel lymph node biopsy, isosulfan blue
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Case Comprehensive Cancer Center
Chronic Myeloproliferative Disorders, Leukemia
Combination Chemotherapy Followed By Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Severe Aplastic Anemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Umbilical cord blood transplantation may be able to replace cells destroyed by chemotherapy.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00054236
- Testing
- anti-thymocyte globulin, filgrastim, cyclophosphamide
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Case Comprehensive Cancer Center
Healthy, no Evidence of Disease
Web-Based Tailored Educational Program in Improving Nurse Communication With Patients About Clinical Trials
This pilot, randomized clinical trial studies a web-based tailored educational program in improving nurse communication with patients about clinical trial treatment options.
- Trial name
- NCT02129517
- Testing
- IMPACT intervention, Online education materials, survey administration
- Where
- United States
- Volunteers
- 1,262 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Pediatric Cancer
Can Making Video Narratives Benefit Adolescents With Cancer
The purpose of this study is to learn more about the content of and benefits of making video testimonials in adolescents with cancer.
- Trial name
- NCT03127254
- Testing
- Video narrative, PedsQL, Ten Item Personality Inventory
- Sponsor
- Case Comprehensive Cancer Center