Clinical trials: sponsored by Changhai Hospital
Chronic Pancreatitis, Complication
The Natural History of Chronic Pancreatitis
Chronic pancreatitis (CP) is a disease characterized by inflammation and their replacement by fibrotic tissue. The destruction of pancreatic function and structure are the main complications.
- Conditions
- Chronic Pancreatitis, Complication, Risk Factors
- Trial name
- NCT03324698
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Changhai Hospital
Atrial Fibrillation (AF)
Research on Post-Stroke Anticoagulation Strategies for Atrial Fibrillation Based on Left Atrial Appendage Flow Velocity Measured by Intracardiac Echocardiography (ICE)
1. Study Purpose The primary aim of this research was to systematically describe and characterize a novel, thrombus-mimicking artifact observed during Intracardiac Echocardiography (ICE), termed the "Floating Lotus" sign.
- Trial name
- NCT07439731
- Testing
- Intracardiac Echocardiography (ICE) for Differential Diagnosis
- Where
- 2 sites in China
- Volunteers
- 172 people
- Sponsor
- Changhai Hospital
Lumbar Spinal Stenosis (LSS), Degenerative Spondylolisthesis G1
Multicenter Clinical Randomized Controlled Trial of Unilateral Biportal Endoscopic Spinal Surgery for Degenerative Grade 1 Spondylolisthesis Complicated With Lumbar Spinal Stenosis
The research objective of this project is to clarify and compare the efficacy of the unilateral biportal endoscopy (UBE) technique and traditional open decompression, fusion and internal fixation surgery in the treatment of…
- Trial name
- NCT07303348
- Testing
- UBE, PLIF
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatic Neoplasm
Prediction Model of Pancreatic Neoplasms in CP Patients With Focal Pancreatic Lesions
This study aims to develop XGBoost machine learning model to predict pancreatic neoplasms in CP patients with focal pancreatic lesions.
- Conditions
- Chronic Pancreatitis, Pancreatic Neoplasm, Machine Learning
- Trial name
- NCT07045181
- Testing
- XGBoost machine learning
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Benign Biliary Strictures
Long-Term Outcomes of Different Stents for Benign Biliary Strictures Caused by Chronic Pancreatitis
This observational study aims to observe and compare the long-term effectiveness and safety of different types of stents for benign biliary strictures secondary to chronic pancreatitis.
- Conditions
- Chronic Pancreatitis, Benign Biliary Strictures, Stenting Treatment, ERCP
- Trial name
- SOLID (NCT06981975)
- Testing
- single plastic stent, Multiple plastic stents, Fully covered self-expanding metal stents
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatic Exocrine Insufficiency
Investigation on the Current Situation and Risk Factors Analysis of Exocrine Insufficiency in Chronic Pancreatitis
Pancreatic exocrine insufficiency (PEI) is one of the common complications of chronic pancreatitis (CP). Mild to moderate PEI may present with atypical digestive tract symptoms such as abdominal distension and abdominal pain…
- Trial name
- CP-ESRF (NCT06946108)
- Testing
- Detection of Pancreatic Exocrine Function in Patients with Chronic Pancreatitis (CP)
- Where
- China
- Volunteers
- 1,101 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis
Natural Course and Therapeutic Effect of Chronic Pancreatitis
The goal of this observational study is to establish a prospective cohort of chronic pancreatitis (CP) patients to provide evidence-based guidance for clinical practice and comprehensively optimize diagnostic and treatment…
- Trial name
- NCT06925204
- Testing
- Observation
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Changhai Hospital
Resectable Simultaneous Colorectal Cancer Liver Metastasis
The Outcomes of Laparoscopic Hybrid Surgery Versus Totally Open Surgery
Simultaneous colorectal cancer liver metastasis (SCRLM) is one of the risk factors for poor prognosis in colorectal cancer. Surgical resection of primary and metastatic lesions is the first choice of treatment for patients with…
- Trial name
- NCT06550700
- Testing
- laparoscopic hybrid surgery (LHS)
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Changhai Hospital
Acute Ischemic Stroke, Large Vessel Occlusion
Acute Ischemic Stroke EndoVascular Therapy: a Multicenter REGISTRY Study
A Multicenter Registry of Endovascular Treatment for Acute Ischemic Stroke.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Thrombosis
- Trial name
- NCT05864638
- Testing
- Endovascular treatment
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Changhai Hospital
Localized Prostate Cancer
Hypofractionated Post-prostatectomy Radiotherapy (HYPORT)for Localized Prostate Cancer
The aim of this trial is to compare the safety outcomes of Hypofractionated postprostatectomy radiotherapy (HYPORT) and Conventionally fractionated postprostatectomy radiotherapy(COPORT) in treating patients with localized…
- Trial name
- NCT06325995
- Testing
- Conventional radiation therapy, Hypofractionated radiation therapy
- Where
- China
- Volunteers
- 428 people
- Sponsor
- Changhai Hospital
Radiotherapy
Chemoradiotherapy After Surgery Versus Preoperative Chemoradiotherapy for Stage II/III Mid-low Rectal Cancer With or Without High-risk Factors
The purpose of this observational study is to understand the effect of different timing of chemoradiotherapy on overall survival in patients with stage II/III low- and medium-level rectal cancer with or without high-risk factors
- Trial name
- NCT06566222
- Testing
- chemoradiotherapy after surgery, High-risk Factors
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Chronic Pancreatitis
Exercise Inhibit Innate Immune Response and Ameliorate Chronic Pancreatitis
The goal of this observational study is to learn about the effects of different physical exercise on disease progression in patients with chronic pancreatitis.
- Trial name
- NCT06534138
- Testing
- Physical exercise
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Changhai Hospital
Early Esophageal Cancer
China Early Esophageal Cancer Cohort
With the development of endoscopy, more and more patients with superficial esophageal squamous cell carcinoma (ESCC) receive endoscopic resection rather than traditional surgery.
- Trial name
- NCT06515964
- Testing
- observational study
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Changhai Hospital
Pancreatic Duct Stone
Safety and Efficacy of P-ESWL and ERCP
To determine the types, incidence and risk factors of adverse events after pancreatic extracorporeal shock wave lithotripsy (P-ESWL) and endoscopic retrograde cholangiopancreatography (ERCP), define the grading criteria of…
- Trial name
- NCT05916547
- Testing
- pancreatic extracorporeal shock wave lithotripsy
- Where
- China
- Volunteers
- 2,071 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer, Chronic Pancreatitis
Gastrointestinal Microflora and Serum Metabolomics in Patients With Pancreatic Cancer and Chronic Pancreatitis
The investigators plan to collect throat swabs, saliva, feces and serum samples from pancreatic cancer patients, chronic pancreatitis patients and healthy people and clarify the characteristics of oral flora and serum metabolome…
- Trial name
- NCT06411470
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Cohort Study, Recurrent Acute Pancreatitis
Natural Course and Therapeutic Effect of Recurrent Acute Pancreatitis
The goal of this observational cohort study is to learn about the etiology, natural course, therapeutic effect and outcome of recurrent acute pancreatitis patients.
- Trial name
- NACRE (NCT06355206)
- Testing
- endoscopic intervention, surgery or conservative treatment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Exocrine Pancreatic Insufficiency
AI Evaluation of Pancreatic Exocrine Insufficiency in CP Patients
Early assessment of pancreatic exocrine insufficiency (PEI) is crucial for determining appropriate chronic pancreatitis (CP) treatment plans, thereby avoiding unnecessary suffering and further complications in patients.
- Conditions
- Chronic Pancreatitis, Exocrine Pancreatic Insufficiency, Machine Learning, Deep Learning
- Trial name
- NCT06278272
- Where
- China
- Volunteers
- 504 people
- Sponsor
- Changhai Hospital
Colorectal Cancer, Colorectal Adenoma
A Study on a Blood-based Dual-target Test for CRC Detection
To evaluate the effectiveness and accuracy of the ctDNA dual-target test kit in a large case-control cohort for the detection of colorectal cancer and advanced adenomas.
- Trial name
- NCT05508503
- Testing
- Test of methylated NTMT1 and MAP3K14-AS1, FIT
- Where
- China
- Volunteers
- 1,378 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Second-degree Burn Wounds, Skin Graft Wounds
Efficacy of a Transparent Silicone Membrane With Physical Microstructure for Second-degree Burn Wounds and Skin Graft Wounds
The goal of this clinical trial is to comparison of physical microstructure-modified transparent silicone films and current conventional trauma dressings for second-degree burn wounds and post-skin graft wounds.The main question…
- Trial name
- NCT06170008
- Testing
- Physical microstructure-modified transparent silicone film sheet, Decellularized pig skin, Vaseline gauze
- Volunteers
- 40 people
- Sponsor
- Changhai Hospital
Esophageal Cancer
Endoscopic Submucosal Dissection Versus Esophagectomy for Early Esophageal Carcinoma
Endoscopic submucosal dissection (ESD) is a minimally invasive alternative to esophagectomy for early esophageal squamous cell carcinoma (EESCC), The data of EESCC patients who received ESD or esophagectomy were retrospectively…
- Trial name
- NCT06060106
- Testing
- Endoscopic submucosal dissection, Esophagectomy
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Changhai Hospital