Clinical trials: sponsored by Chinese PLA General Hospital
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)
Safety and Efficacy of Secukinumab Versus Mycophenolate Mofetil in Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (SMART)
The goal of this clinical trial is to evaluate the safety and efficacy of secukinumab versus mycophenolate mofetil in relapsing myelin oligodendrocyte glycoprotein antibody-associated disease.
- Trial name
- SMART (NCT07917247)
- Testing
- Secukinumab, Mycophenolate mofetil (MMF)
- Volunteers
- 130 people
- Sponsor
- Chinese PLA General Hospital
Cochlear Implant, Severe to Very Severe Sensorineural Hearing Loss
Epidemiological Survey on the Current Status of Cochlear Implantation in China
Cochlear implantation is an effective intervention for patients with severe to very severe sensorineural hearing loss. By the beginning of 2026, the total number of cochlear implants in China was about 180000.
- Trial name
- NCT07821281
- Testing
- Cochlear Implant
- Volunteers
- 180,000 people
- Sponsor
- Chinese PLA General Hospital
Hepatocellular Carcinoma
Combination Therapy of Microwave Ablation and Cellular Immunotherapy for Hepatocellular Carcinoma
The study is to observe safety, survival effect and peripheral T-lymphocyte subsets of combination therapy with percutaneous microwave ablation (MWA) and adoptive immunotherapy in hepatocellular carcinoma(HCC).
- Trial name
- NCT02851784
- Testing
- adoptive immunotherapy, MWA
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Acute Gastrointestinal Graft-versus-host Disease
Prospective Randomized Controlled Study: Amimaitosai Injection Combined With Corticosteroids for Gastrointestinal aGVHD
This study focuses on patients with gastrointestinal-dominant acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation.
- Trial name
- NCT07803978
- Testing
- Amimaitosai injection, Methylprednisolone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Hematopoietic Stem Cell Transplantation
Population PK-guided ATG Dosing in Haplo-HSCT
To evaluate the safety and efficacy of a population pharmacokinetics (PK)-guided targeted ATG dosing strategy in haploidentical stem cell transplantation and to observe the GVHD-free, relapse-free survival (GRFS) in the cohort…
- Trial name
- NCT07791576
- Testing
- Anti Thymocyte Globulin
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Chinese PLA General Hospital
Carotid Artery Stenosis, Carotid Atherosclerosis
Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis
This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of…
- Conditions
- Carotid Artery Stenosis, Carotid Atherosclerosis, Carotid Atherosclerotic Plaque
- Trial name
- NCT07762664
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Severe Aplastic Anemia (SAA), Severe Aplastic Anemia, Refractory
Phase I Clinical Study of Haplo-HSCT Combined With Hypoxic 3D-Cultured Umbilical Cord MSC for the Treatment of SAA
Efficacy and Safety of Sequential Infusion of Hypoxic 3D-Cultured Umbilical Cord Mesenchymal Stem Cells in Haploidentical Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia: A Multicenter, Randomized, Phase 1 Trial
- Conditions
- Severe Aplastic Anemia (SAA), Severe Aplastic Anemia, Refractory, Severe Aplastic Anemia
- Trial name
- NCT07299123
- Testing
- 3D hypoxia-preconditioned UC-MSC group, 2D UC-MSC group
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital
Acute Myeloid Leukemia, First Line Therapy
A Multicenter RCT of "3+7" vs Venetoclax + CACAG in Newly Diagnosed Mid/High-Risk AML Patients
The purpose of this study is to compare the efficacy and safety of venetoclax combined with the CACAG regimen with the traditional "3+7" regimen in the treatment of newly diagnosed intermediate- or high-risk acute myeloid…
- Trial name
- NCT06928376
- Testing
- Azacytidine;Cytarabine;Aclacinomycin;Chidamide;Venetoclax;Granulocyte colony-stimulating factor, "3+7"
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Chinese PLA General Hospital
Acute Lymphocytic Leukemia
TCR Reserved and Power3 (SPPL3) Gene Knock-out Allogeneic CD19-targeting CAR-T Cell Therapy in r/r B-ALL
The safety and efficacy of the chimeric antigen receptor (CAR)-T, a CD19-targeting, TRAC and Power3 (SPPL3) double gene deleted allogeneic CAR-T cell product, are undergoing rigorous evaluation in non-Hodgkin's lymphoma (NHL)…
- Trial name
- NCT06481735
- Testing
- TCR reserved and Power3 (SPPL3) Gene Knock-out Allogeneic CD19-targeting CAR-T cell, Fludarabine, Cyclophosphamide
- Where
- 6 sites in China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
GVHD,Acute, Biomarker
Role of aGVHD Biomarkers on aGVHD Risks
To establish risk rating criteria of biological protein marker, determine the role and consistency of aGVHD biomarkers in aGVHD diagnosis and aGVHD prognosis, and evaluate the the impact on non-relapse mortality and relapse and…
- Trial name
- GVHD (NCT04284904)
- Testing
- aGVHD biomarker
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Complication Rate, Efficacy and Safety
Efficacy of Thermal Ablation Combined With Antithyroid Drugs in the Treatment of Primary Hyperthyroidism
Hyperthyroidism is a clinical syndrome caused by excessive production of thyroid hormones, leading to accelerated metabolism and increased excitability of multiple organ systems.
- Conditions
- Complication Rate, Efficacy and Safety, Hyperthyroidism/Thyrotoxicosis, Cure Rate
- Trial name
- NCT07557810
- Testing
- thermal ablation combined with antithyroid drug therapy
- Where
- China
- Volunteers
- 454 people
- Sponsor
- Chinese PLA General Hospital
Peripheral Blood Stem Cell Transplantation
Ruxolitinib and Chidamide Intensified Bu/CY Conditioning Regimen
The purpose of this study is to determine the efficacy and safety of Ruxolitinib and Chidamide intensified conditioning regimen in patients with Acute B cell Lymphoblast leukemia Underwenting Haploidenticl Peripheral blood Stem…
- Trial name
- NCT05088226
- Testing
- Ruxolitinib combined with Chidamide.
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese PLA General Hospital
Obesity Type 2 Diabetes Mellitus
Chinese, Overweight or Obesity, Real-World Registry Study
This study will enroll 10,000 patients with obesity, with the participation of approximately 50 medical institutions nationwide.
- Trial name
- NCT07525037
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Chinese PLA General Hospital
Acute Monocytic Leukemia
Venetoclax Combined With CACAG Regimen Versus "3+7" Regimen in the Treatment of Acute Monocytic Leukemia
This study is a multicenter, randomized, prospective Phase II clinical trial designed to compare the effectiveness of two treatment approaches for patients with acute monocytic leukemia.
- Trial name
- NCT07512700
- Testing
- CACAG+VEN, 3+7
- Where
- 3 sites in China
- Volunteers
- 204 people
- Sponsor
- Chinese PLA General Hospital
EBV Infection After Allogenic HSCT
Clinical Study of EBV-TCR-T Cells for EBV Infection After Allogenic HSCT
This is a multi-center, single arm, open-label, phase I study to determine the safety and effectiveness of EBV-TCR-T cell immunotherapy in treating EBV virus infection after allogenic HSCT.
- Trial name
- NCT06119256
- Testing
- EBV-TCR-T cells
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Chinese PLA General Hospital
Relapsed/Refractory Acute Myeloid Leukemia
Clinical Study of Venetoclax Combined With CACAG Regimen in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia
The purpose of this study is to compare the efficacy and safety of venetoclax combined with CACAG regimen with BAT regimen in the treatment of relapsed/refractory acute myeloid leukemia.
- Trial name
- NCT06084819
- Testing
- Azacytidine;Cytarabine;Aclacinomycin;Chidamide;Venetoclax;Granulocyte colony-stimulating factor, Best-Available Therapy(BAT) Regimen
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Ruxolitinib-Decitabine Intensified Conditioning Regimen for AML: A Randomized Trial
This study aims to determine whether the recurrence rate of high-risk acute myeloid leukemia CR1 patients who received allogeneic hematopoietic stem cell transplantation with the Ruxolitinib, Decitabine combined with Bu/Cy or BuF…
- Trial name
- NCT07101588
- Testing
- Ruxolitinib, Decitabine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Haploidentical Hematopoietic Stem Cell Transplantation
Targeted Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation
The purpose of this study is to determine the response and toxicity rate of two different dosages (Individualized dosage VS. fixed dosage) of ATG as a prophylaxis for acute GVHD in haploidentical peripheral blood stem cell…
- Trial name
- NCT05166967
- Testing
- Individual Antithymocyte globulin, Antithymocyte globulin
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Chinese PLA General Hospital
Acute Myeloid Leukemia
Venetoclax Plus CACAG Regimen for Newly Diagnosed Acute Myeloid Leukemia
The purpose of this study is to compare the efficacy and safety of venetoclax combined with CACAG regimen with the traditional "3+7" regimen in the treatment of newly diagnosed acute myeloid leukemia.
- Trial name
- NCT06068621
- Testing
- Azacytidine;Cytarabine;Aclacinomycin;Chidamide;Venetoclax;Granulocyte colony-stimulating factor, "3+7"
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Benign Prostate Hypertrophy(BPH)
Evaluation of the Application Effect of a Surgical Navigation System in HoLEP Surgery
3D imaging-assisted surgical navigation system was established using the following specific procedures: 1) Prostate MRI Acquisition and 3D Reconstruction: patient prostate MRI images are acquired, and professional engineers…
- Trial name
- NCT07251621
- Testing
- use the 3D imaging-assisted surgical navigation system during surgery
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital