Clinical trials: sponsored by Chinese PLA General Hospital
Chronic Non-specific Low Back Pain, Lumbar Multifidus Muscle Injury
The Intervention Effect of Exercise on Lumbar Multifidus Muscle Injuries
This is a single-center, prospective interventional study. The main purpose is to use ultrasound radiomics to analyze changes in multifidus muscle ultrasound imaging features before and after rehabilitation therapy in patients…
- Trial name
- NCT07892846
- Testing
- Lumbar multifidus muscle rehabilitation exercise
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital
Non-Hodgkin's Lymphoma
BEX101 in B-cell Non-Hodgkin's Lymphoma
BEX101 injection is an extracorporeal anti-CD19 Chimeric Antigen Receptor T-Cell (CAR-T cell) therapy product. This single-arm, open-label, phase I/II clinical study is designed to evaluate the safety and efficacy of BEX101…
- Trial name
- NCT07882641
- Testing
- BEX101 injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Depression, Anxiety
Postoperative Anxiety and Depression Among Chinese Elderly Patients
The goal of this observational study is to learn about the prevalence of postoperative anxiety and depression symptoms and identify the related risk factors in elderly patients aged 65 and older who undergo non-cardiac surgery in…
- Trial name
- NCT07532122
- Where
- China
- Volunteers
- 7,568 people
- Sponsor
- Chinese PLA General Hospital
Gastric Adenocarcinoma
Different Cycles of Neoadjuvant PD-1 Blockades + Chemotherapy for Advanced Gastric Cancer
The goal of this observational study is to analyze the impact of different durations of neoadjuvant PD-1 inhibitor combined with chemotherapy on tumor regression and safety in patients with advanced gastric cancer.
- Trial name
- NCT06798376
- Testing
- 2-4 cycles of neoadjuvant PD-1 Inhibitors combined with chemotherapy, 5-8 cycles of neoadjuvant PD-1 Inhibitors combined with chemotherapy, Gastrectomy
- Where
- China
- Volunteers
- 409 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Pain Control, Coronary Artery Disease
Serratus Anterior Plane Block for Recovery After Minimally Invasive CABG
Coronary artery bypass surgery is an important treatment method for severe coronary heart disease. Among them, minimally invasive bypass surgery, although having less trauma, requires a small incision on the left chest.
- Trial name
- NCT07877532
- Testing
- Ultrasound-guided Serratus Anterior Plane Block with Ropivacaine, Ultrasound-guided Serratus Anterior Plane Block with Normal Saline
- Volunteers
- 168 people
- Sponsor
- Chinese PLA General Hospital
Gastric Cancer, Tumor Microenvironment
Tumor Microenvironment in Gastric Cancer Patients Treated With Combined Immunotherapy and Chemotherapy
The goal of this study is to analyze the tumor microenvironment (TME) in gastric cancer patients treated with combined immunotherapy and chemotherapy.
- Conditions
- Gastric Cancer, Tumor Microenvironment, Immunotherapy, Chemotherapy
- Trial name
- NCT06202781
- Testing
- SOX plus PD-1 inhibitor, Gastroscopic biopsy
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Chinese PLA General Hospital
Chronic Migraine Headache
Low-Intensity Focused Ultrasound Targeting the Dorsolateral Prefrontal Cortex for Preventive Treatment of Chronic Migraine
Chronic migraine is a disabling neurological disorder characterized by frequent headache attacks and significant impairment of quality of life.
- Trial name
- NCT07857109
- Testing
- Low-Intensity Focused Ultrasound Stimulation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chinese PLA General Hospital
Cochlear Implant, Severe to Very Severe Sensorineural Hearing Loss
Epidemiological Survey on the Current Status of Cochlear Implantation in China
Cochlear implantation is an effective intervention for patients with severe to very severe sensorineural hearing loss. By the beginning of 2026, the total number of cochlear implants in China was about 180000.
- Trial name
- NCT07821281
- Testing
- Cochlear Implant
- Volunteers
- 180,000 people
- Sponsor
- Chinese PLA General Hospital
Hepatocellular Carcinoma
Combination Therapy of Microwave Ablation and Cellular Immunotherapy for Hepatocellular Carcinoma
The study is to observe safety, survival effect and peripheral T-lymphocyte subsets of combination therapy with percutaneous microwave ablation (MWA) and adoptive immunotherapy in hepatocellular carcinoma(HCC).
- Trial name
- NCT02851784
- Testing
- adoptive immunotherapy, MWA
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Ovarian Cancer
A Phase 3 Study of Manganese-primed Immunochemotherapy in Patients With Advanced Ovarian Cancer
Epithelial ovarian cancer is the most lethal gynecologic malignancy, and most patients eventually relapse and develop resistance to available therapies.
- Trial name
- NCT07822646
- Testing
- Manganese Chloride, Nab-paclitaxel, Platinum chemotherapy
- Where
- 6 sites in China
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
Multiple Myeloma
Safety and Efficacy of KSVCBD Injection in Multiple Myeloma Expressing CD19 and/or BCMA
KSVCBD injection is an in vivo Chimeric Antigen Receptor T-Cell (CAR-T cell) therapy product. This multicenter, single-arm, open-label, early exploratory clinical study is designed to evaluate the preliminary safety and efficacy…
- Trial name
- NCT07620275
- Testing
- KSVCBD injection
- Where
- 3 sites in China
- Volunteers
- 9 people
- Sponsor
- Chinese PLA General Hospital
Ceftobiprole
Individualized Precision Therapy With Ceftobiprole Guided by PK/PD in Geriatric Populations
Ceftobiprole, a fifth-generation cephalosporin, exhibits potent antibacterial activity against MRSA, penicillin-resistant Streptococcus pneumoniae (PRSP), and certain Gram-negative bacteria (e.g., Pseudomonas aeruginosa).
- Trial name
- NCT07127185
- Testing
- LS/MS
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
ANCA-Associated Glomerulonephritis (AAGN), ANCA-Associated Vasculitis (AAV)
Obinutuzumab Beta Combined With Low-dose Glucocorticoid in New-onset ANCA-Associated Glomerulonephritis
This study is an open-label, single-arm, exploratory study designed to evaluate the efficacy and safety of Obinutuzumab beta combined with a rapid-tapering glucocorticoid regimen in patients with new-onset ANCA-associated…
- Trial name
- NCT07746180
- Testing
- Obinutuzumab beta, Glucocorticoids
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Non Hodgkin's Lymphoma
Allogenic CD19-targeting CAR-γδT Cell Therapy in R/R NHL
This is a single center, prospective, open-label, single-arm, phase 1/2 study for patients with r/r B-cell NHL to evaluate the safety and efficacy of gene edited allogenic CD19 CAR-γδT cells.
- Trial name
- NCT05554939
- Testing
- Allogenic CD19 CAR-γδT cell, Fludarabine, Cyclophosphamide
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Depressive Disorder
Validity of the 3-item Patient Health Questionnaire (PHQ-3) for Identifying Moderate-to-Severe Depressive Symptoms Among Elderly Perioperative Patients: A Secondary Analysis of a National Prospective Cohort
This is a retrospective observational study based on our hospital's prospective peri-operative elderly patient database. We aim to evaluate the correlation between the 9-item Patient Health Questionnaire (PHQ-9) and the brief…
- Trial name
- NCT07818057
- Testing
- Retrospective data analysis
- Where
- China
- Volunteers
- 10,536 people
- Sponsor
- Chinese PLA General Hospital
Acute Kidney Injury, Hepatectomy
Renal Oxygenation-Guided AKI Reduction Trial
Acute kidney injury (AKI) is a common complication after major liver surgery. This study will evaluate whether intraoperative management guided by renal regional oxygen saturation (RrSO₂), measured using near-infrared…
- Trial name
- ROGAR (NCT07816640)
- Testing
- INVOS 5100C regional oxygen saturation monitoring system, RrSO2-guided perioperative management, Usual perioperative management
- Where
- 20 sites in China
- Volunteers
- 1,200 people
- Sponsor
- Chinese PLA General Hospital
Acute Gastrointestinal Graft-versus-host Disease
Prospective Randomized Controlled Study: Amimaitosai Injection Combined With Corticosteroids for Gastrointestinal aGVHD
This study focuses on patients with gastrointestinal-dominant acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation.
- Trial name
- NCT07803978
- Testing
- Amimaitosai injection, Methylprednisolone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Delirium, Anxiety
Intraoperative Midazolam on Delirium Outcome of Elderly Patients
This study was a multicenter, randomized, double-blind, placebo-controlled trial to treat elderly surgical patients with low-dose midazolam or placebo for anesthesia induction.
- Trial name
- IMODE (NCT06963112)
- Testing
- Midazolam, Saline
- Where
- 5 sites in China
- Volunteers
- 612 people
- Sponsor
- Chinese PLA General Hospital
Lipoma
Ultrasound-Guided Emulsification Therapy in the Clinical Treatment of Subcutaneous Lipomas
Background:Lipomas are the most common benign soft tissue tumors, traditionally treated by open surgical excision. However, open surgery is associated with relatively large incisions, prolonged recovery, and visible scarring.
- Trial name
- NCT07797270
- Testing
- CUSA Minimally Invasive Resection
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Benign Breast Nodules
Ultrasound-Guided Emulsification Therapy in the Clinical Treatment of Benign Breast Nodules
Background： Benign breast nodules are common breast diseases in women, including fibroadenomas, hyperplastic nodules, and other benign lesions.
- Trial name
- NCT07797257
- Testing
- CUSA Minimally Invasive Resection
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital