Clinical trials: sponsored by Chulalongkorn University
Procedural Pain in Newborns
Leg and Foot Massage for Pain in Newborns Receiving Heel Stick
This study aims to evaluate the effect of a leg and foot massage program on pain in newborns receiving heel stick for monitoring serum bilirubin levels.
- Trial name
- NCT07893028
- Testing
- Leg and Foot Massage
- Where
- Thailand
- Volunteers
- 42 people
- Sponsor
- Chulalongkorn University
Brugada Syndrome
Southeast Asian Brugada Syndrome Cohort
Brugada syndrome (BrS) is the leading cause of sudden death in young Asian adults including Thailand. This syndrome may be hereditary and involve mutations in certain genes.
- Trial name
- SEA-BrS (NCT04232787)
- Where
- 11 sites in Thailand
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
E Cigarette Use
Circuit Breathing Exercise on Smoking Cessation Among Youth E-Cigarette Users
This study aims to investigate the acute effects of a circuit breathing intervention on nicotine withdrawal symptoms and respiratory parameters among youth who use e-cigarettes.
- Trial name
- NCT07886099
- Testing
- Circuit breathing, Diaphragmatic Breathing, Normal Breathing Condition
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
E Cigarette Use
A Behavioral Circuit Breathing Training Intervention on Smoking Cessation and Respiratory Function Among Youth Who Use E-cigarettes
This study aims to evaluate the effects of a six-week behavioral circuit breathing training intervention on smoking cessation and respiratory function compared with diaphragmatic breathing training and usual daily activities
- Trial name
- NCT07882407
- Testing
- Circuit Breathing Intervention, Diaphragmatic Breathing
- Where
- Thailand
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Cholestatic Liver Disease, Chronic Liver Disease (CLD)
Vitamin D2 vs Vitamin D2 Plus Calcitriol in Cholestatic Children With Vitamin D Deficiency
The goal of this clinical trial is to learn whether adding calcitriol to vitamin D2 can improve vitamin D deficiency in children with cholestasis and chronic liver disease.
- Conditions
- Cholestatic Liver Disease, Chronic Liver Disease (CLD), Vitamin D Deficiency, Children
- Trial name
- VITD-CHOL (NCT07670611)
- Testing
- Vitamin D2, Calcitriol
- Where
- Thailand
- Volunteers
- 54 people
- Sponsor
- Chulalongkorn University
Obesity
Impact of Dietary Fiber as Prebiotics on Intestinal Microbiota in Obese Thai Children
This study evaluates the changes in gut microbiota composition, body fat, children's eating behaviors, plasma amino acids, and satiety hormones (Peptide-YY and GLP-1) after a 6-month period in obese Thai children.
- Trial name
- NCT03968003
- Testing
- Inulin
- Where
- Thailand
- Volunteers
- 165 people
- Sponsor
- Chulalongkorn University
Severe Dengue
Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study)
The goal of this randomized double-blinded placebo-controlled trial is to learn about dexamethasone and the treatment of severe dengue population. The main question it aims to answer are steroid therapy may be effective in dengue.
- Trial name
- NCT05631405
- Testing
- Dexamethasone
- Where
- 2 sites in Thailand
- Volunteers
- 200 people
- Sponsor
- Chulalongkorn University
Actinic Prurigo
Multi-centred Clinico-genetic Study of Actinic Prurigo in Thailand
This research project investigates the clinical and genetic associations of Actinic Prurigo (AP) in the Thai population. As a rare chronic photodermatosis, AP has been observed to occur more frequently in individuals with certain…
- Trial name
- NCT07055009
- Testing
- Targeted long-read HLA sequencing, RNA extraction, Full Skin examination
- Where
- Thailand
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Functional Constipation
The Efficacy and Palatability of Developed Polyethylene Glycol-based Formula for Children With Functional Constipation
This study aims to evaluate the efficacy and palatability of a developed polyethylene glycol-based formula compared with the standard polyethylene glycol (PEG) in the treatment of children with functional constipation for 8…
- Trial name
- NCT06357897
- Testing
- Local PEG4000, Commercial PEG4000
- Where
- Thailand
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
CKD, ACS (Acute Coronary Syndrome)
Early Coronary Angiography in Advanced Chronic Kidney Disease With Acute Coronary Syndrome
This is the retrospective study regarding the association of invasive coronary angiography and time to renal replacement therapy initiation and mortality in patients with chronic kidney disease stage 4-5 who develop acute…
- Conditions
- CKD, ACS (Acute Coronary Syndrome), Coronary Angiography (CAG)
- Trial name
- CAG in CKD-ACS (NCT07474441)
- Testing
- coronary angiography
- Volunteers
- 139 people
- Sponsor
- Chulalongkorn University
Pediatric Cancers, Solid Tumor Pediatric
Safety and Efficacy of CMD03 CAR T Cell in Children With Relapse or Refractory Solid Tumors
A Phase 1 clinical trial to evaluate the safety and early efficacy of CAR T-cells with IL-7Ra signal targeting B7H3 in children with solid tumors patients after complete standard treatments.
- Trial name
- CMD03 (NCT06612645)
- Testing
- B7H3-IL7Ra CAR-T cells
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- Chulalongkorn University
Relapse B Acute Lymphoblastic Leukemia, Refactory Childhood Acute Lymphoblastic Leukemia
Clinical Trial of CMD63 Chimeric Antigen Receptor T-cell (CAR T-cell) in Children With Acute Lymphoblastic Leukemia (ALL)
A Phase 1 clinical trial to evaluate the safety and early efficacy of Chimeric Antigen Receptor T-cell (CAR T-cell) with IL-7Rα signaling targeting CD19 in children with relapsed and refractory B-cell Acute Lymphoblastic Leukemia…
- Trial name
- CMD63 (NCT07078929)
- Testing
- CD19-IL7Ra CAR-T cells
- Where
- 3 sites in Thailand
- Volunteers
- 16 people
- Sponsor
- Chulalongkorn University
Hemophilia A Patient
Real-World Joint Outcomes After Selective Transition to Low-Dose Emicizumab in Pediatric Hemophilia A
Recent studies have shown that pharmacokinetic (PK)-guided extended half-life (EHL) factor VIII can improve joint health in patients with hemophilia A.
- Trial name
- NCT07439055
- Testing
- Switching to low dose emicizumab
- Where
- Thailand
- Volunteers
- 18 people
- Sponsor
- Chulalongkorn University
ALS (Amyotrophic Lateral Sclerosis)
Amyotrophic Lateral Sclerosis Registry in Thailand
This is a prospective, observational, multicenter registry designed to collect comprehensive clinical, genetic, and outcome data from patients diagnosed with amyotrophic lateral sclerosis (ALS) across Thailand.
- Trial name
- Thai ALS Regis (NCT07175935)
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Chulalongkorn University
Functional Gastrointestinal Disorders, Infant Conditions
Prevalence of FGIDs and Probiotics Study
This is a study to evaluate the prevalence of FGIDs in infants using the Thai version of Rome IV diagnostic questionnaire for functional gastrointestinal disorders in infants and evaluate the efficacy of Limosilactobacillus…
- Trial name
- PROOF (NCT06309199)
- Testing
- Biogaia
- Where
- Thailand
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Undergraduate Health Professional Students, Dental Restorations
Sequential Practicing on Psychomotor Skill Acquisition in Undergraduate Dental Students
To determine the influence of hand practice sequence on psychomotor skill acquisition in a glass ceramic onlay preparation among undergraduate dental students.
- Conditions
- Undergraduate Health Professional Students, Dental Restorations, Education, Competency-Based, Dental Education and Special Care Dentistry
- Trial name
- Dentalpractice (NCT06862401)
- Testing
- Glass ceramic onlay preparation
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
DIPG Brain Tumor, Diffuse Intrinsic Pontine Glioma
Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG
A Phase 1 clinical trial to evaluate the safety and early efficacy of CAR T-cell with IL-7Ra signal targeting B7H3 in children with diffuse intrinsic pontine glioma (DIPG) patients after complete standard treatments.
- Trial name
- CMD03DIPG (NCT06221553)
- Testing
- B7H3 specific CAR T cell with IL-7Ra signaling domain
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- Chulalongkorn University
Neonatal Intensive Care Unit, PreTerm Neonate
Effects of a Structured Maternal Voice Program on Premature Infant Responses and Maternal-Infant Attachment in the Neonatal Intensive Care Unit
This study evaluates the effects of a Structured Maternal Voice Program (SMVP). on premature infant responses and maternal-infant attachment in the intensive care unit (NICU) .
- Conditions
- Neonatal Intensive Care Unit, PreTerm Neonate, Healthy
- Trial name
- SMVP-NICU (NCT06839534)
- Testing
- Structured Maternal Voice Program (SMVP)
- Where
- Thailand
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Hemophilia A
Cartilage Biomarkers and HEAD-US Score in Severe Hemophilia A Patients Receiving FVIII Prophylaxis
Patients with severe hemophilia A often develop joint complication requiring careful monitoring. This study aimed to compare the effectiveness of standard low dose weight-based FVIII concentrates (CFCs) prophylaxis with…
- Trial name
- HEADUS_SHA8 (NCT06816953)
- Testing
- HEAD-US, Urinary carboxy-terminal cross linked telopeptide of type II collagen, Inflammatory markers
- Where
- Thailand
- Volunteers
- 19 people
- Sponsor
- Chulalongkorn University
Obstructive Sleep Apnea of Child
The Effect of Self-care Emphasizing on Balloon-Blowing Exercise Program on Severity of Sleep Apnea and Respiratory Muscle Strength Among School Age Children With Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common condition in school-age children, often leading to sleep disturbances and associated health issues.
- Trial name
- "SEES" (NCT06780982)
- Testing
- Balloon-Blowing exercise program, Standard nursing care
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University