Clinical trials: enrolling by invitation
Emotional Distress, Anhedonia
Positive Events Training to Enhance Positive Emotions in Adolescents With Elevated Depressive Symptoms: An N=1 Trial
Research shows that high positive emotionality is an essential ingredient in building resilience in youngsters, especially those with a vulnerability to develop depressive symptomatology.
- Trial name
- iPET N=1 (NCT07825285)
- Testing
- Positive Events Training (PET)
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- KU Leuven
Epilepsy Intractable
Neuronal Mechanisms of Human Episodic Memory
The purpose the research is to better understand how the human brain accomplishes the basic cognitive tasks of learning new information, recalling stored information, and making decisions or choices about presented information.
- Trial name
- NCT04500119
- Testing
- Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system; Blackrock Cerestim stimulator
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cedars-Sinai Medical Center
Autism Spectrum Disorder
Investigating the Relationship Between Motor Challenges and Postural Stability in ASD
condition and focus of study on Autism Spectrum Disorder
- Trial name
- ASD (NCT07825220)
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Management and Technology Sialkot Pakistan
Ankyloglossia
Long-term Follow-up of Infant Frenotomy/Frenectomy Through Early Childhood
Ankyloglossia (tongue tie) is an anatomically shortened lingual frenum that impairs appropriate tongue mobility. Initial clinical diagnosis of tongue tie usually begins during infancy with abnormal breastfeeding though not all…
- Trial name
- NCT07110948
- Testing
- Tongue tie release
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Alberta
Focal Epilepsy, Drug-resistant Focal Epilepsy
RNS System for Drug-Resistant Focal Epilepsy in Adolescents: A Real-World Study
The NeuroPace RNS System is FDA-approved for adults with drug-resistant focal epilepsy but is not yet approved for adolescents. This study uses real-world data to evaluate the RNS System's safety and effectiveness in adolescents…
- Trial name
- AURORA (NCT07823465)
- Testing
- NeuroPace RNS System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NeuroPace
Obesity
Cities for Better Health Childhood Obesity Prevention Initiative
This research project is part of the 'Cities for Better Health Childhood Obesity Prevention Initiative' (CBH COPI). The objective of the CBH COPI initiative is to develop, implement, and evaluate the effectiveness of a package of…
- Trial name
- CBH COPI (NCT06855563)
- Testing
- Community-based intervention packages
- Where
- 6 sites in Australia, Brazil and 4 more
- Volunteers
- 36,000 people
- Sponsor
- Novo Nordisk A/S
HSCT, Lung Transplant Recipient
Technical Development of Xe MRI
The goal of this study is to develop and optimize new proton (1H; conventional MRI) and Xe gas MRI techniques to assess regional cardiopulmonary structure and function in the clinical setting.
- Trial name
- NCT07823010
- Testing
- Hyperpolarized 129 Xenon
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Trigger Finger
A Comparison of Metacarpophalangeal Joint Blocking Splint With Relative Motion Extension Splint for Trigger Finger
The purpose of this research is to evaluate the effectiveness of two splint designs in conservative management of trigger finger.
- Trial name
- NCT06137404
- Testing
- Splint
- Where
- New Zealand
- Volunteers
- 30 people
- Sponsor
- Waikato Hospital
Cleft Lip, Nasal Surgical Procedures
Evaluation of a Novel Nasal Conformer in Pediatric Patients
This study compares the current commercially available nasal conformer available for use in cleft lip repair and nasal scar release to a novel, anatomically shaped conformer based upon typical nasal airspace shape.
- Trial name
- NCT06885801
- Testing
- use of an anatomically designed nasal conformer
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- East Tennessee Children's Hospital
Emotion Regulation Disorders
Virtual Reality Exposure Therapy for Emotion Regulation Difficulties in Adolescent Inpatients
The goal of this clinical trial is to evaluate whether a therapist-guided virtual reality (VR)-based intervention can improve emotion regulation in adolescents receiving inpatient psychiatric treatment.
- Trial name
- VRsafe (NCT07709468)
- Testing
- Virtual Reality Exposure Therapy
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Intestinal Failure
Spectral Lighting and Metabolism
The goal of this exploratory n-of-1-study is to compare markers of metabolism in infants in a Level IV Neonatal Intensive Care Unit (NICU) between two lighting environments.
- Trial name
- NCT06094504
- Testing
- Spectral Lighting
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Universal Behavioral Supports
Social and Emotional Learning in Norwegian Kindergarten
This project evaluates the effectiveness of the Norwegian version of Second Step Early Learning (Småsteg), a program of 28 weeks that emphasizes learning, friendship skills, and managing several strong feelings (e.g., scared…
- Trial name
- NCT06975267
- Testing
- Norwegian version of Second Step Early Learning, Free play
- Where
- Norway
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Ostfold University College
Congenital Heart Disease
International Multicenter Outcomes of Transcatheter Pulmonary Flow Restrictors in Congenital and Acquired Heart Disease
The international multicenter registry aims to collect real-world data on clinical outcomes and evaluate the net clinical success of transcatheter microvascular plug (MVP)-based pulmonary flow restrictors (PFRs) in patients with…
- Trial name
- RESTRICT (NCT07791069)
- Testing
- Transcatheter pulmonary flow restriction
- Where
- 5 sites in France, Germany and 3 more
- Volunteers
- 150 people
- Sponsor
- Fondation Hôpital Saint-Joseph
RETT Syndrome With Proven MECP2 Mutation
GCB-002 in Treatment of Patients With Rett Syndrome
Study Brief Summary overall design This study explored dose escalation of single-arm, open, single intrathecal injection in female RTT subjects with MECP2 gene mutations. The investigator plans to conduct 2-3 dose groups.
- Trial name
- GITFPWRS (NCT06739434)
- Testing
- GCB-002
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Genecombio Ltd.
Anterior Cruciate Ligament Injuries
Reduce Opiate Exposure With ACL Surgery
This is a randomized control trial to investigate the effectiveness of a multimodal opiate sparing analgesic regimen in controlling post-operative pain and potentially reduce post-operative opioid consumption in patients…
- Trial name
- NCT06561035
- Testing
- Opiate Sparing, Opiate Based
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Campbell Clinic
Anxiety, Cognition
Y Yoga Works: Effects of Acute Yoga on Anxiety, Affect, & Cognition
The goal of this research is to determine what components of an integrated yoga practice that influence anxiety, cognition, and affect among highly anxious college females.
- Conditions
- Anxiety, Cognition, Affect
- Trial name
- NCT07816861
- Testing
- Integrated Yoga, Yoga Postures, Breathwork/Meditation
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Spinal Cord Injuries
Neuromodulation of Spinal Locomotor Circuitry to Elicit Stepping After Pediatric Spinal Cord Injury
Spinal cord injury (SCI) results in damage to the descending neural pathways and leads to the immediate dysfunction of multiple physiological systems below the level of injury.
- Trial name
- NCT04077346
- Testing
- Biostim-5 transcutaneous spinal stimulator, Transcutaneous Spinal Stimulator + Activity Based Locomotor Training
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Louisville
Spinal Cord Injuries
Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury
Children who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and/or weakness of their arms and hand muscles.
- Trial name
- NCT04032990
- Testing
- Biostim-5 transcutaneous spinal stimulator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Louisville
Eccentric Cycling Exercise Training
Effectiveness of Eccentric Cycling Exercise in Ambulatory Rehabilitation for Patients With Cardiopulmonary Diseases: A Pragmatic Randomized Controlled Trial
In eccentric cycling exercise (ECC), the cyclist must oppose backwards moving pedals on a specialized motor-driven ergometer. Throughout this process, the force applied on the pedals exceeds the torque generated by the…
- Trial name
- NCT07815366
- Testing
- Eccentric cycling exercise
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Celiac Disease, Malabsorption Syndromes
Immune Responses to Gluten
This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.
- Conditions
- Celiac Disease, Malabsorption Syndromes, Digestive System Disease, Intestinal Disease
- Trial name
- NCT05209568
- Testing
- Gluten Powder
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
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