Find a clinical trial
Cytomegalovirus Prophylaxis
A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)
Researchers are looking for a way to prevent cytomegalovirus (CMV) in children and adolescents who receive a kidney transplant (KT) and weigh less than 40 kilograms (88.2 pounds).
- Trial name
- NCT07199465
- Testing
- Letermovir
- Where
- 22 sites in United States
- Volunteers
- 40 people
- Sponsor
- Merck Sharp & Dohme LLC
High-Risk Neuroblastoma
A Safety and Efficacy Study of hu14 in High-Risk Neuroblastoma Patients
Neuroblastoma is the most common type of solid cancer found outside the brain in young children. Generally, it affects children younger than 5 years old, with the average age when it is found being just 2 years.
- Trial name
- SHINE (NCT07549321)
- Testing
- hu1418K322A + Temozolomide + Irinotecan
- Where
- 19 sites in United States, Canada and 5 more
- Volunteers
- 144 people
- Sponsor
- Renaissance Pharma Ltd.
Becker Muscular Dystrophy, Muscular Dystrophies
Defining Endpoints in Becker Muscular Dystrophy
This is a 24-month, observational study of 50 participants with Becker muscular dystrophy (BMD)
- Conditions
- Becker Muscular Dystrophy, Muscular Dystrophies, Muscular Dystrophy in Children, Muscular Dystrophy, Becker
- Trial name
- GRASP-01-002 (NCT05257473)
- Where
- 11 sites in United States, New Zealand and 1 more
- Volunteers
- 59 people
- Sponsor
- Virginia Commonwealth University
Neuroblastoma
4SCAR-T Therapy Targeting GD2, PSMA and CD276 for Treating Neuroblastoma
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of multiple 4SCAR-T cell therapy which targets GD2, PSMA and CD276 surface antigens in patients with relapsed and refractory neuroblastoma (NB).
- Trial name
- NCT04637503
- Testing
- GD2, PSMA and CD276 CAR-T cells
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Epidermolysis Bullosa (EB), Chronic Wounds
Topical Insulin Versus Irradiated Amniotic Fluid Gel for Wound Healing in Epidermolysis Bullosa
This study aims to evaluate and compare the safety and efficacy of topical insulin and topical irradiated amniotic fluid gel in promoting wound healing in patients with epidermolysis bullosa (EB).
- Conditions
- Epidermolysis Bullosa (EB), Chronic Wounds, Wound Healing
- Trial name
- EB-INS-AFG (NCT07907523)
- Testing
- Topical Insulin (Actrapid®), Topical Irradiated Amniotic Fluid Gel, No active study treatment
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Type 1 Diabetes
Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that causes a deficit of pancreatic islet beta cells. Millions of individuals worldwide have T1D, and incidence increases annually.
- Trial name
- NCT04011020
- Testing
- Stem Cell Educator therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yong Zhao, MD, PhD
Behavior Problem, Parenting
Chicago Parent Program for Foster and Kinship Caregivers
The primary objective of this study is to test the effects of an evidence-based prevention intervention (CPP) adapted for foster and kinship caregivers of young children (FC; foster care) on caregiver competence and child…
- Trial name
- NCT06170047
- Testing
- Chicago Parent Program for Foster Care, Usual Care
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hepatitis C,Chronic Children, Only
Twelve Weeks Sofosbuvir/Daclatasvir in HCV Infected Children Aged 6-18 Years
Recently the era of direct-acting antiviral drugs for hepatitis C treatment has changed the world map of HCV. Results in adults are promising. FDA approved only two drugs in the pediatric age group 12 to 17 years.
- Trial name
- NCT07905989
- Testing
- Sofosbuvir/Daclatasvir
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- National Liver Institute, Egypt
Acute Lymphatic Leukemia, Lymphoma
More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls.
- Trial name
- MaximALL (NCT07705178)
- Testing
- QOL assessment, Neuropsychological, Spirometry, DLCO measurement
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Healthy Eating, Nutrition Literacy
Screen-Based Simulation for Adolescents' Healthy Eating Attitudes and Nutrition Literacy
This randomized controlled trial aimed to evaluate the effect of healthy eating education delivered through screen-based simulation on healthy eating attitudes and nutrition literacy in adolescents attending a high school.
- Conditions
- Healthy Eating, Nutrition Literacy, Adolescent Nutrition
- Trial name
- NCT07901361
- Testing
- Screen-Based Simulation Healthy Eating Education, Slide Presentation Healthy Eating Education
- Where
- Turkey (Türkiye)
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Eosinophilic Esophagitis
Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis
A randomized, double-blind, placebo-controlled multicenter, phase 3 study to evaluate the efficacy and safety of tezepelumab administered subcutaneously (SC) using an accessorized pre-filled syringe (APFS) versus placebo in adult…
- Trial name
- CROSSING (NCT05583227)
- Testing
- Tezepelumab
- Where
- 124 sites in United States, Australia and 20 more
- Volunteers
- 368 people
- Sponsor
- AstraZeneca
Avulsion Fracture
Lateral Ankle Treatment
This is a randomized control trial of pediatric patients with acute lateral ankle avulsion fractures. Patients will be randomized into two groups: Standard of care treatment which includes booting with early range of motion and…
- Trial name
- NCT07751068
- Testing
- Prolonged Immobilization (Casting), Standard of Care (SOC)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Texas Scottish Rite Hospital for Children
B-cell Malignancies
A Phase I/II Multiple Center Trial of 4SCAR19 Cells in the Treatment of Relapsed and Refractory B Cell Malignancies
The study will evaluate safety and efficacy of a 4th generation chimeric antigen receptor gene-modified T cells targeting CD19 (4SCAR19) for patients with B cell malignancies.
- Trial name
- NCT03050190
- Testing
- Therapeutic 4SCAR19 cells
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Irreversible Pulpitis
Effect of Temperature Elevation on the Antimicrobial Efficacy of Two Root Canal Irrigants in Primary Root Canal Infections: A Randomized Controlled Clinical Trial
evaluate the antimicrobial efficacy of preheated sodium hypochlorite and dexamethasone sodium phosphate and at room temperature in patients with primary root canal infection.
- Trial name
- NCT07906925
- Testing
- Dexamethasone Sodium Phosphate 10 MG/ML, Sodium Hypochlorite 2,5%
- Volunteers
- 40 people
- Sponsor
- Tanta University
B Cell Malignancies
4SCAR19U T Cells Targeting B Cell Malignancies
The purpose of this study is to assess the feasibility, safety and efficacy of universal CAR T cell therapy against CD19-positive hematological malignancies using a novel CD19-specific CAR T cell product, 4SCAR19U T cells.
- Trial name
- NCT05995015
- Testing
- Universal CD19-specific CAR gene-engineered T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Atypical Hemolytic Uremic Syndrome
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
This study aims to evaluate the efficacy and safety of crovalimab in adult and adolescent participants with aHUS.
- Trial name
- COMMUTE-a (NCT04861259)
- Testing
- Crovalimab
- Where
- 41 sites in United States, Belgium and 14 more
- Volunteers
- 83 people
- Sponsor
- Hoffmann-La Roche
Behavioral Insomnia of Childhood
Development of Sleep Intervention for Parent and Child
This study aims to develop and test the intervention program to help manage parental thoughts in parents with child sleep problems.
- Trial name
- NCT05806450
- Testing
- Intervention, Active control condition
- Where
- South Korea
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Sungshin Women's University
Myelodysplastic Syndromes
Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms
Background: Myelodysplastic syndrome (MDS) and myelodysplastic/myeloproliferative neoplasm (MDS/MPN) are blood disorders that can cause serious complications in children and adults.
- Trial name
- NCT06303193
- Testing
- pacritinib
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Cancer Institute (NCI)
Conductive Hearing Loss, Mixed Hearing Loss
Post-Market Registry Study for Vibrant Hearing Solutions
This observational registry collects retrospective and prospective, data from children and adults who use CE-marked MED-EL implantable (PMEI, BCI, or AMEI) or non-implantable (BCD) hearing solutions as part of routine care.
- Conditions
- Conductive Hearing Loss, Mixed Hearing Loss, Sensorineural Hearing Loss, Single Sided Deafness
- Trial name
- NCT07906314
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Absent Pulmonary Artery
A Study Of Surgical Repair Of Discontinuous Branching Pulmonary Arteries
The purpose of this study is to test the safety and performance of a new blood vessel graft, called the ATEV. The graft is designed to reconnect the heart to the lungs and to grow as the child grows, which may eliminate the need…
- Trial name
- NCT07785661
- Testing
- Acellular Tissue Engineered Vessel (ATEV) Conduit
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Joseph Dearani