Find a clinical trial
Sickle Cell Disease
A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)
The main purpose of this study is to compare the effect of tebapivat versus placebo on anemia and to detect a dose-response for hemoglobin (Hb) response in participants with SCD.
- Trial name
- NCT06924970
- Testing
- Tebapivat
- Where
- 20 sites in United States, Belgium and 5 more
- Volunteers
- 59 people
- Sponsor
- Agios Pharmaceuticals, Inc.
Duchenne Muscular Dystrophy
A Study to Investigate the Safety and Biodistribution of a Single Intrathecal (IT) Injection of INS1201 in Ambulatory Males With Duchenne Muscular Dystrophy (DMD)
The primary objective of this study is to evaluate the safety and tolerability of a single dose of INS1201 via IT administration in ambulatory male participants with DMD.
- Trial name
- ASCEND (NCT06817382)
- Testing
- INS1201
- Where
- 10 sites in United States
- Volunteers
- 12 people
- Sponsor
- Insmed Gene Therapy LLC
Milk Allergy
Performance of the Basophil Activation Test in the Diagnosis of IgE-mediated Cow's Milk Allergy in Infants and Evaluation of Hydrolysate Allergenicity.
The goal of this clinical trial is to investigate if the basophil activation test (BAT) represents a safer, faster, and more cost-effective diagnostic modality than the state-of-the art diagnostic work-up (specifik IgE and oral…
- Trial name
- MilkBAT (NCT07900594)
- Testing
- Basophil activation test, quality of life questionnaire
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Physical Fitness, Health
Effects of the 11 for Health Program on Physical Fitness and Health-Related Outcomes in Schoolchildren
This study aims to examine the effects of the 11 for Health program on physical fitness and health-related outcomes in fifth-grade students. The study will use a quasi-experimental pretest-posttest design with a control group.
- Conditions
- Physical Fitness, Health, Body Composition
- Trial name
- NCT07900399
- Testing
- 11 for Health Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Prostate Cancer, Prostate Cancer Locally Advanced
Hypofractionated Radiotherapy With MRI-Guided Focal Boost and Pelvic Irradiation in High-Risk Prostate Cancer
This prospective phase II study evaluated long-term disease control and side effects of a moderately hypofractionated radiotherapy protocol for men with high-risk prostate cancer.
- Conditions
- Prostate Cancer, Prostate Cancer Locally Advanced, Prostatic Neoplams
- Trial name
- NCT07900555
- Testing
- Hypofractionated IMRT with focal simultaneous integrated boost and elective pelvic irradiation, Androgen Deprivation Therapy (ADT)
- Where
- Norway
- Volunteers
- 191 people
- Sponsor
- Haukeland University Hospital
Preterm Birth
Adolescents Born Preterm; Nurtured Beginnings
This research study is a long-term follow-up to an earlier study of developmental care. For that study, high risk preterm newborns were randomly assigned to a standard care group, which received the standard care offered in the…
- Trial name
- NCT00310869
- Testing
- Individualized Developmental Care in the NICU
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Boston Children's Hospital
Acquired Brain Injury
Exercise and Physical Activity in Children With Pediatric Acquired Brain Injury
Exercise and physical activity in children with pediatric acquired brain injury
- Trial name
- DIScover_Ped (NCT06804486)
- Testing
- Exercise, Recommendation to Deprescribe
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Universidade da Coruña
Walking Mesh
Smart Sock for Monitoring Walking and Supporting Physical Activity in Older Adults: A Family-Supported Feasibility Study
The goal of this randomized feasibility clinical trial is to learn whether a low-cost smart sock and mobile application can be used safely, reliably, and comfortably to support gradual walking activity in adults aged 60 years and…
- Trial name
- NCT07902102
- Testing
- Low-Cost Smart Sock and Older-Adult Mobile Application, Standard Individual Walking Plan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Pediatric
Optimal Defaults Grocery Shopping Intervention to Promote Healthy Diets for Pediatric Cancer Survivors and Their Families
This clinical trial tests the feasibility, acceptability and effect of an optimal defaults grocery shopping intervention to promote healthy diets for pediatric cancer survivors and their families.
- Trial name
- NCT07901816
- Testing
- Dietary Intervention - meal recipes, Informational Intervention, Educational Intervention
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Patient Safety, Peripheral Intravenous Catheter-Related İnfiltration
Standardized Patient and In Situ Simulation for IV Infiltration Recognition
Peripheral intravenous catheters (PIVCs) are widely used invasive devices in hospital settings and are associated with a broad range of complications, among which infiltration is one of the most common and clinically significant.
- Trial name
- NCT07514247
- Testing
- Intervention: Standardized Patient Simulation, Intervention: In Situ Simulation
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Selçuk Görücü
Engagement, Patient
Developing a mHealth Simulation Platform for Youth
The investigators will conduct a 12-week single group feasibility pilot field study among youth who will use a diabetes technology education application in their natural home environment.
- Trial name
- NCT05953532
- Testing
- A1Control
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Ohio State University
Complex Congenital Heart Disease
Impact of Surgical Timing on the Neurodevelopmental Prognosis of Newborns With Complex Congenital Heart Disease
We propose a prospective observational study whose main objective will be to determine whether there is an association between age at surgery (days of life) and neurodevelopmental outcome in patients with CCHD.
- Trial name
- CINC (NCT04733378)
- Testing
- Peri-operative neurological monitoring
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Neurofibromatosis Type 2, NF2
Selumetinib for NF2-Related Schwannomatosis
The goal of this clinical trial is to evaluate the efficacy and safety of the MEK1/2 inhibitor selumetinib in treating patients with neurofibromatosis type 2-related schwannomatosis (NF2-SWN), including both adults and children…
- Conditions
- Neurofibromatosis Type 2, NF2, NF2-related Schwannomatosis, Meningioma
- Trial name
- ASSIST (NCT07707947)
- Testing
- Selumetinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tiantan Hospital
Comparative Effectiveness
Equivalence of Oral Melatonin and Oral Midazolam in Preoperative Anxiolysis for Pediatric Fast-Track Cardiac Surgery
Equivalence of Oral Melatonin and Oral Midazolam in Preoperative Anxiolysis for Pediatric Fast-Track Cardiac Surgery
- Trial name
- NCT07900321
- Testing
- Melatonin, Midazolam
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Myelodysplastic Syndromes
Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms
Background: Myelodysplastic syndrome (MDS) and myelodysplastic/myeloproliferative neoplasm (MDS/MPN) are blood disorders that can cause serious complications in children and adults.
- Trial name
- NCT06303193
- Testing
- pacritinib
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Cancer Institute (NCI)
Stargardt Disease, Stargardt Macular Dystrophy
A Study About the Safety of a Single ASP2020 Eye Injection and if it Helps People With Vision Loss From Stargardt-type Eye Conditions
Macular dystrophies are a group of inherited eye conditions that affect the macula. The macula is in the center of the retina, the light sensitive part at the back of the eye.
- Conditions
- Stargardt Disease, Stargardt Macular Dystrophy, Stargardt-like Macular Dystrophy
- Trial name
- DEVOTE (NCT07734064)
- Testing
- ASP2020
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Astellas Institute for Regenerative Medicine
Rare Genetic Muscle Diseases, Muscular Dystrophy, Duchenne
Transcriptomic Analysis to Put an End to Misdiagnosis in Patients With Rare Muscle Diseases
Since 2017, more than 250 analyses performed at the Molecular Genetics Laboratory of the Timone Enfant Hospital have yielded negative results in patients with rare genetic muscle diseases.
- Conditions
- Rare Genetic Muscle Diseases, Muscular Dystrophy, Duchenne, Muscular Dystrophy, Becker, Congenital Myopathy
- Trial name
- ARNseq-Musc (NCT06833489)
- Testing
- ARN extraction from muscle biopsies
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Advanced Lung Carcinoma, Malignant Female Reproductive System Neoplasm
Conquer Fear SUPPORT Intervention in Supporting Patients With Stage III-IV Lung or Gynecologic Cancer
This trial will pilot a psychosocial intervention called Conquer Fear Support (CFS) in patients with stage III-IV lung or gynecologic cancer who are experiencing fear of cancer progression.
- Conditions
- Advanced Lung Carcinoma, Malignant Female Reproductive System Neoplasm, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8
- Trial name
- NCT03776253
- Testing
- Psychosocial Care Conquer Fear Support intervention (psychoeducation, attention training, worry management, and detached mindfulness components), Questionnaire Administration
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- City of Hope Medical Center
Healthy Eating, Nutrition Literacy
Screen-Based Simulation for Adolescents' Healthy Eating Attitudes and Nutrition Literacy: A Randomized Controlled Trial
This randomized controlled trial aimed to evaluate the effect of healthy eating education delivered through screen-based simulation on healthy eating attitudes and nutrition literacy in adolescents attending a high school.
- Conditions
- Healthy Eating, Nutrition Literacy, Adolescent Nutrition
- Trial name
- NCT07901361
- Testing
- Screen-Based Simulation Healthy Eating Education, Slide Presentation Healthy Eating Education
- Where
- Turkey (Türkiye)
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Extubation
Modified Deep Extubation vs. Standard Awake Extubation
The proposed study is to compare a modified DE technique, which is regularly used for low-risk patients by staff anesthesiologists at our institution, to a standard awake extubation.
- Trial name
- mDE (NCT06318715)
- Testing
- modified deep extubation (mDE), standard awake extubation
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital