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Preoperative Anxiety
Effect of Animation-Assisted Preoperative Information on Anxiety in Adolescents Undergoing Elective Surgery
This study aims to find out whether adding a short educational animation to standard preoperative information can help reduce anxiety in adolescents aged 12-17 years who are scheduled for elective surgery.
- Trial name
- NCT07901231
- Testing
- Animation-Assisted Preoperative Information
- Volunteers
- 148 people
- Sponsor
- Ankara City Hospital Bilkent
Mydriasis, Dilation
Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis in Pediatric Subjects
The objectives of this study are: To evaluate the safety of Nyxol in pediatric subjects To evaluate the efficacy of Nyxol to expedite the reversal of pharmacologically induced mydriasis in pediatric subjects The Sponsor intends…
- Trial name
- MIRA-4 (NCT05223478)
- Testing
- Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Opus Genetics, Inc
Diffuse Midline Glioma, Diffuse Midline High-grade Glioma
PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma
This is a multisite, phase I/II clinical trial in children and young adults with newly-diagnosed high-grade glioma (HGG), diffuse midline glioma (DMG) and recurrent HGG/DMG, Medulloblastoma (MB), or ependymoma (EPN) to determine…
- Conditions
- Diffuse Midline Glioma, Diffuse Midline High-grade Glioma, Medulloblastoma, Ependymoma
- Trial name
- PRiME II (NCT06639607)
- Testing
- PEP-CMV vaccine, Tetanus booster, Nivolumab
- Where
- 3 sites in United States
- Volunteers
- 68 people
- Sponsor
- Washington University School of Medicine
Pediatric Dentistry, Premature Loss of Primary Molars
Evaluation of Polyetheretherketone and Monolithic Zirconia Versus Conventional Metal Band and Loop Space Maintainers in Children: A Randomized Split-Mouth Clinical Trial
Compare two tooth-colored CAD/CAM band and loop space maintainers, PEEK and monolithic zirconia (BruxZir), each against a conventional stainless-steel band and loop in children with premature loss of mandibular primary first…
- Conditions
- Pediatric Dentistry, Premature Loss of Primary Molars, Space Maintainer
- Trial name
- NCT06558968
- Testing
- PEEK band and loop space maintainer, BruxZir band and loop space maintainer, conventional stainless-steel band and loop space maintainer
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Aplastic Anemia
Long Term Follow-up Observational Study After Clinical Trials of AMG531 (Romiplostim) in Patients With Untreated Aplastic Anemia
To evaluate the long-term efficacy and safety after the end of romiplostim treatment by observation [up to 5 years] of patients who were registered for Study 531-003/531-004 in immunosuppressive therapy-naïve patients with…
- Trial name
- NCT04870346
- Where
- Japan
- Volunteers
- 36 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Down Syndrome, Trisomy 21
Executive Function Play Opportunities for Children With Down Syndrome
The Executive Function Play Opportunities (EXPO) study is a sequential, multiple assignment, randomized trial (SMART) evaluating adaptive caregiver-mediated intervention pathways for improving executive function (EF) in children…
- Trial name
- EXPO (NCT07792382)
- Testing
- EXPO, EXPO Extended, EXPO Foundations
- Where
- 2 sites in United States, Italy
- Volunteers
- 150 people
- Sponsor
- Colorado State University
Childhood Absence Epilepsy, Juvenile Absence Epilepsy
A Study to Evaluate the Efficacy, Safety, and Tolerability of Brivaracetam as Monotherapy in Patients 2 to 25 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy
The purpose of the study is to test the efficacy, safety and tolerability of brivaracetam monotherapy in study participants 2 to 25 years of age inclusive with childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE).
- Trial name
- EXPAND (NCT04666610)
- Testing
- Brivaracetam
- Where
- 35 sites in United States, Georgia and 5 more
- Volunteers
- 154 people
- Sponsor
- UCB Biopharma SRL
Acute Lymphatic Leukemia, Lymphoma
More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls.
- Trial name
- MaximALL (NCT07705178)
- Testing
- QOL assessment, Neuropsychological, Spirometry, DLCO measurement
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Iron Deficiency Anemia
Effect of Vitamin D Supplementation Added to Iron Therapy in Children With Iron Deficiency Anemia
This randomized controlled trial will evaluate the effect of two vitamin D3 supplementation regimens, administered in addition to oral iron therapy, on hematological and iron status in children aged 6-60 months with confirmed…
- Trial name
- NCT07892170
- Testing
- Elemental iron, Vitamin D3 2000 IU/day, Vitamin D3 400 IU/day
- Where
- Iraq
- Volunteers
- 120 people
- Sponsor
- AlFayhaa General Hospital
Health Literacy, Adolescent Health
MEST : A School- Based Health Literacy Intervention Trial
The purpose of this study is to evaluate the effectiveness of the MEST work strategy in upper secondary schools. MEST is a school based, health promoting intervention delivered by school health services and designed to strengthen…
- Trial name
- NCT07601815
- Testing
- MEST Work Strategy
- Where
- Norway
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Emergence Delirium in Pediatric Anesthesia
Predicting the Risk of Pediatric Emergence Delirium
The incidence of PED ranges from 2% to 50%, with a peak occurring 5-15 minutes after emergence from anesthesia. PED seriously endangers pediatric patient safety and impairs family experience.
- Trial name
- NCT07906977
- Testing
- Assessment of Pediatric Emergence Delirium
- Where
- China
- Volunteers
- 470 people
- Sponsor
- General Hospital of Ningxia Medical University
Sports Physical Therapy
Effects of Scapular Training on Adolescent Boxers
Boxing is a combat sport that requires repetitive, high-speed upper extremity movements, placing substantial demands on shoulder stability, scapular control, and neuromuscular coordination.
- Trial name
- NCT07899385
- Testing
- Scapular Stabilization Exercise Program, Standard Physiotherapy Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Istinye University
To Evaluate the Impact of a Basic Resuscitation Training Program on the Related Knowledge and Practices of CPR Among Private Home Nurses in Qatar
Impact of VAK & Kolb-Based Education on CPR Knowledge & Skills Among Private Home Nurses in Qatar
Out-of-hospital cardiac arrest (OHCA) is a significant global health challenge, responsible for a substantial proportion of deaths worldwide.
- Trial name
- NCT06865690
- Testing
- Eductional training program
- Where
- Qatar
- Volunteers
- 134 people
- Sponsor
- Assiut University
Solid Tumor
Indocyanine Green (ICG) Guided Sentinel Lymph Node Mapping for Pediatric Visceral Solid Tumors
The purpose of the study is to find out the usefulness and safety of a dye called Indocyanine Green (ICG for short). This dye will be used to help the surgeon find lymph nodes draining solid tumors inside the abdomen that need to…
- Trial name
- NCT05645523
- Testing
- Indocyanine Green
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- St. Jude Children's Research Hospital
Becker Muscular Dystrophy, Muscular Dystrophies
Defining Endpoints in Becker Muscular Dystrophy
This is a 24-month, observational study of 50 participants with Becker muscular dystrophy (BMD)
- Conditions
- Becker Muscular Dystrophy, Muscular Dystrophies, Muscular Dystrophy in Children, Muscular Dystrophy, Becker
- Trial name
- GRASP-01-002 (NCT05257473)
- Where
- 11 sites in United States, New Zealand and 1 more
- Volunteers
- 59 people
- Sponsor
- Virginia Commonwealth University
Epidermolysis Bullosa (EB), Chronic Wounds
Topical Insulin Versus Irradiated Amniotic Fluid Gel for Wound Healing in Epidermolysis Bullosa
This study aims to evaluate and compare the safety and efficacy of topical insulin and topical irradiated amniotic fluid gel in promoting wound healing in patients with epidermolysis bullosa (EB).
- Conditions
- Epidermolysis Bullosa (EB), Chronic Wounds, Wound Healing
- Trial name
- EB-INS-AFG (NCT07907523)
- Testing
- Topical Insulin (Actrapid®), Topical Irradiated Amniotic Fluid Gel, No active study treatment
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Ganglioneuroblastoma, Nodular, Neuroblastoma
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for…
- Trial name
- NCT06172296
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- 180 sites in United States, Australia and 3 more
- Volunteers
- 478 people
- Sponsor
- National Cancer Institute (NCI)
Malaria,Falciparum, Malaria in Pregnancy
Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics
The purpose of the INTREPiD study is to compare 1st trimester screening for malaria parasites with a high-sensitivity malaria rapid diagnostic test followed by treatment of test-positive women with artemether-lumefantrine (AL)…
- Conditions
- Malaria,Falciparum, Malaria in Pregnancy, Malaria in Childbirth, Pregnancy
- Trial name
- INTREPiD (NCT05757167)
- Testing
- Malaria High-Sensitivity Rapid Diagnostic Test (HS-RDT), Artemether-lumefantrine (AL)
- Where
- 2 sites in Democratic Republic of the Congo, Kenya
- Volunteers
- 2,174 people
- Sponsor
- Duke University
Patient Safety, Peripheral Intravenous Catheter-Related İnfiltration
Standardized Patient and In Situ Simulation for IV Infiltration Recognition
Peripheral intravenous catheters (PIVCs) are widely used invasive devices in hospital settings and are associated with a broad range of complications, among which infiltration is one of the most common and clinically significant.
- Trial name
- NCT07514247
- Testing
- Intervention: Standardized Patient Simulation, Intervention: In Situ Simulation
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Selçuk Görücü
Hypothalamic Obesity
A Study to Assess Efficacy and Safety of LB54640 in Patients With Hypothalamic Obesity
The goal of this study was to determine how well LB54640 (also known as bivamelagon) worked and how safe it was in participants with Hypothalamic Obesity (HO).
- Trial name
- NCT06046443
- Testing
- Bivamelagon
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 28 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
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