Clinical trials: sponsored by Beijing Tiantan Hospital
Neurofibromatosis Type 2, NF2
Selumetinib for NF2-Related Schwannomatosis
The goal of this clinical trial is to evaluate the efficacy and safety of the MEK1/2 inhibitor selumetinib in treating patients with neurofibromatosis type 2-related schwannomatosis (NF2-SWN), including both adults and children…
- Conditions
- Neurofibromatosis Type 2, NF2, NF2-related Schwannomatosis, Meningioma
- Trial name
- ASSIST (NCT07707947)
- Testing
- Selumetinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tiantan Hospital
Spinal Cord Injury
Recovery and Safety After Epidural Spinal Cord Stimulation in People With Spinal Cord Injury
Spinal cord injury can cause lasting difficulties with movement, sensation, bladder and bowel function, and daily activities. Epidural spinal cord stimulation delivers electrical pulses through implanted electrodes and may be…
- Trial name
- NCT07900490
- Testing
- Epidural Spinal Cord Stimulation
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Hainan University
Moyamoya Disease, Moyamoya Syndrome
Development and Validation of Risk Prediction Models for Stroke and Cognitive Impairment in Moyamoya Disease and Moyamoya Syndrome
This multicenter prospective observational cohort study aims to develop and validate individualized risk prediction models for stroke and cognitive decline in patients with moyamoya disease or moyamoya syndrome by integrating…
- Trial name
- NCT07894107
- Where
- 13 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tiantan Hospital
Pituitary Neuroendocrine Tumors
A Comparative Study of Patients Undergoing Surgery for Pituitary Neuroendocrine Tumors Detected by Different Ways
This multicenter cohort study is based on the National Brain Tumor Registry of China (NBTRC). It will compare patients who underwent surgery for Pituitary Neuroendocrine Tumors (PitNETs) detected through health screening versus…
- Trial name
- NCT07835412
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Tiantan Hospital
Focal Epilepsy, Intraoperative Monitoring
High-density Flexible μECoG for Epilepsy Surgery - A Single-Arm ECT
What's the clinical value of high-density flexible microelectrocorticography (μECoG) for guiding the resection of epileptogenic zone (EZ) in epilepsy surgery?
- Trial name
- Epi-PRECISE (NCT07656857)
- Testing
- Using High-density Flexible microElectrocorticography for intraoperative monitoring
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
Intelligent Microcatheter Shaping for Intracranial Aneurysm Coil Embolization
This prospective, multicenter, observational registry study will evaluate the real-world safety, effectiveness, and clinical value of artificial intelligence (AI)-assisted microcatheter shaping during coil embolization of…
- Trial name
- NCT07749404
- Testing
- Physician-Experience Microcatheter Shaping, AI-Assisted Microcatheter Shaping Simulation Technology
- Where
- China
- Volunteers
- 1,438 people
- Sponsor
- Xuanwu Hospital, Beijing
Neurofibromatosis Type 2, Vestibular Schwannoma
Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2)
This is an adaptive platform-basket trial that aims to evaluate the safety and efficacy of multiple novel agents and combination therapies in patients with NF2-related schwannomatosis (NF2-SWN).
- Conditions
- Neurofibromatosis Type 2, Vestibular Schwannoma, Non-vestibular Schwannoma, Meningioma
- Trial name
- PRIME-NF2 (NCT07713745)
- Testing
- Selumetinib 25mg/m2, Luvometinib, Serplulimab
- Where
- 5 sites in China
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Headache Disorders, Primary, Migraine
China HeadAche DIsorders RegiStry
It is planned to include 10000 patients. In the China HeadAche DIsorders RegiStry CHAIRS）, patients aged over 12 years with primary headache and medication-overuse headache(MOH) were collected.
- Conditions
- Headache Disorders, Primary, Migraine, New Daily Persistent Headache, Medication Overuse Headache
- Trial name
- CHAIRS (NCT05334927)
- Testing
- Medicine Overuse Headache/New Daily Persistent Headache, Episodic Migraine and Chronic Migraine, Patients with other types of primary headache
- Where
- 61 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Tiantan Hospital
NMO Spectrum Disorder, MRI
Clinical and Imaging Cohort of Neuroinflammation Diseases in China (CLUE)
CLUE is a prospective study to assess structural and functional changes of the brain, spinal cord, and optic nerve, as well as the inflammatory environment in patients with neuroinflammatory and demyelinating diseases.
- Conditions
- NMO Spectrum Disorder, MRI, Multiple Sclerosis, MOGAD
- Trial name
- NCT04106830
- Testing
- Intravenous steroid
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
Real-World Study of Woven EndoBridge for Intracranial Aneurysm Treatment
We designed the Real-World Study of Woven EndoBridge for Intracranial Aneurysm Treatment (WEB-RWS), an ambidirectional, multicenter, post-market real-world study with a prospective active surveillance component.
- Trial name
- WEB-RWS (NCT07620626)
- Testing
- Intrasaccular Flow Disruption Device
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Spontaneous Intracranial Hypotension
Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to leaks of cerebrospinal fluid (CSF).
- Trial name
- NCT07602556
- Testing
- PRP Patch group, Whole Blood Patch Group
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease
Family-Based Moyamoya Susceptibility and Early Detection
This single-center, prospective, family-based observational cohort study aims to investigate susceptibility to moyamoya disease (MMD) and to develop strategies for early screening in individuals at increased familial risk.
- Trial name
- FAMES (NCT07517354)
- Testing
- 5T High-Resolution MRI
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Central Nervous System Disease, MRI
Validation on Clinical Adaptability of the Foundation Model Specific to Neuroimaging Diagnosis
This clinic trial aims to investigate whether artificial intelligence (AI) diagnostic tools at neurological diseases diagnosis on brain CT/MRI can improve the work efficiency of specialized neuroimaging physicians, with a…
- Conditions
- Central Nervous System Disease, MRI, CT, AI (Artificial Intelligence)
- Trial name
- NCT07471984
- Testing
- Foundation Model Specific to Neurological Diagnosis
- Where
- China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Yaou Liu
Parkinson's Disease, Progressive Supranuclear Palsy(PSP)
Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital Biomarkers
This research employs AI to analyze facial expressions and speech patterns, aiming to develop new digital tools for diagnosing and differentiating Parkinson's disease and similar disorders.
- Conditions
- Parkinson's Disease, Progressive Supranuclear Palsy(PSP), Multiple System Atrophy, Healthy Control
- Trial name
- NCT07392411
- Testing
- video recording
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Temporal Lobe Epilepsy (TLE)
MRgLITT for mTLE: A PROBE Trial
How does magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) impact clinical prognosis in mesial temporal lobe epilepsy (mTLE)?
- Trial name
- MINE (NCT06720922)
- Testing
- Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT), Open Surgery
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Arteriovenous Malformation, Intracranial Arterial Diseases
Cerebral Arteriovenous Malformation With Aneurysm: Epidemiology, Clinical Features, and Prognosis
The study is a multicenter, prospective cohort study designed to assess the natural history, clinical safety and efficacy of various treatment strategies in patients with cerebral arteriovenous malformations (AVMs) and…
- Conditions
- Cerebral Arteriovenous Malformation, Intracranial Arterial Diseases, Intra Cerebral Hemorrhage, Intracranial Aneurysm
- Trial name
- NCT07353736
- Where
- China
- Volunteers
- 630 people
- Sponsor
- Duan Chuanzhi
Healthy, Multiple Sclerosis
Normal Chinese Lifespan Brain Charts Initiative (NCLBCI)
Major brain diseases (including neuroimmune diseases, neurodegenerative diseases, and cerebrovascular diseases) are leading causes of death and disability in humans.
- Conditions
- Healthy, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Neurodegenerative Diseases
- Trial name
- NCT06643858
- Testing
- No intervention
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Craniopharyngioma
ImmunoPET Targeting Trophoblast Cell-surface Antigen 2 (Trop-2) in Craniopharyngioma Patients
This study aims to investigate 68Ga-MY6349, an immune-PET tracer targeting trophoblast cell surface antigen 2 (Trop2), for the noninvasive diagnosis of craniopharyngioma in vivo.
- Trial name
- NCT07177482
- Testing
- 68Ga-MY6349 PET/CT
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Deling Li
Central Nervous System Disease, MRI
An Explainable Neuroradiologist Artificial Intelligence Assistance System for Brain CT and MRI
This clinic trial aims to validate the working performance of radiologists with or without artificial intelligence (AI) diagnostic tool at neurological diseases diagnosis on brain CT/MRI.
- Conditions
- Central Nervous System Disease, MRI, CT, AI (Artificial Intelligence)
- Trial name
- NCT07167043
- Testing
- AI-assisted diagnostic systems
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Yaou Liu
Hemangioma, Cavernous, Central Nervous System
Study on Treatment Decision-Making and Prognostic Follow-Up for Untreated Cerebral Cavernous Malformations
The goal of this observational study is to evaluate and predict the risk associated with cerebral cavernous malformations (CCMs) using advanced artificial intelligence and radiomics analysis technology.
- Trial name
- NCT06214767
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Beijing Tiantan Hospital