Clinical trials: sponsored by Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Vasospasm After Subarachnoid Hemorrhage
Endovascular Therapy for Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Cerebral vasospasm is a common and serious complication after aneurysmal subarachnoid hemorrhage and is an important cause of delayed cerebral ischemia and poor neurological outcomes.
- Trial name
- RESCUE-CV (NCT07643922)
- Testing
- Intra-arterial and Intravenous Milrinone Therapy, Standardized Medical Management
- Where
- 2 sites in China
- Volunteers
- 306 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, TIA
Probucol for Symptomatic Intracranial and Extracranial Artery Stenosis
This study is a multicenter, double-blind, placebo-controlled, randomized clinical trial that aims to evaluate the efficacy of probucol on the reduction of the risk of recurrent stroke in patients with symptomatic intracranial or…
- Trial name
- NCT06225752
- Testing
- Probucol
- Where
- China
- Volunteers
- 5,452 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Ischemic Stroke Hospitalized, Impairment, Cognitive
A Study Testing How Well the Drug Extract of Ginkgo Biloba Leaves Tablets Works for People With Memory or Thinking Problems After a Stroke When Added to Standard Treatment
The goal of this clinical trial is to learn if Extract of Ginkgo Biloba Leaves Tablets help improve thinking and memory in people aged 55 years and older who had an ischemic stroke (a type of stroke caused by a blocked blood…
- Trial name
- GiCIIS (NCT07220538)
- Testing
- Extract of Ginkgo Biloba Leaves Tablets 240 mg (2 x 40 mg, t.i.d.), Standard of care (SoC) Group
- Where
- 34 sites in China
- Volunteers
- 400 people
- Sponsor
- Dr. Willmar Schwabe GmbH & Co. KG
Fibromyalgia, Pregabalin
The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalgia
Fibromyalgia is a chronic pain syndrome where current medications have limited efficacy and a slow onset of action. Esketamine shows potential as a rapid-acting analgesic, but previous low-dose studies failed to demonstrate…
- Conditions
- Fibromyalgia, Pregabalin, Esketamine
- Trial name
- NCT07230171
- Testing
- Pregabalin and venlafaxine concomitant therapy, Esketamine plus pregabalin and venlafaxine concomitant therapy
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Beijing Tiantan Hospital
Stroke Patients, Tracheostomy
A Speaking-Valve-Based Decannulation Protocol for Tracheostomized Stroke Patients
To evaluate the feasibility of a speaking-valve-based decannulation protocol in tracheostomized stroke patients
- Trial name
- SVBDP-TSP (NCT07904169)
- Testing
- Decannulation Protocol
- Volunteers
- 207 people
- Sponsor
- Hongying Jiang, MD
Stroke, Motor Dysfunction
Closed-Loop SCS-BCI for Post-Stroke Hemiplegia
This study evaluates a new closed-loop rehabilitation system for stroke survivors with arm weakness. The system combines a brain-computer interface (BCI, a special cap that reads brain signals), spinal cord stimulation (a…
- Conditions
- Stroke, Motor Dysfunction, Brain-computer Interface, Spinal Cord Stimulation (SCS)
- Trial name
- CL-SCS-BCI (NCT07903116)
- Testing
- Spinal Cord Stimulation, Non-invasive Brain-Computer Interface, Hand Exoskeleton
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Hypertension, Type 2 Diabetes Mellitus (T2DM)
Community-Empowerment and Environmental Enrichment-based Co-management (CEEEC) Model and Mechanisms for Improving Health of Older Stroke Patients With Multimorbidity
This study is a cluster randomized controlled trial with a 2×2 factorial design conducted in community health centers in Kunshan, Wuhan and Shanghai, China.
- Conditions
- Hypertension, Type 2 Diabetes Mellitus (T2DM), Multimorbidity, Stroke
- Trial name
- CEEEC (NCT06975501)
- Testing
- Exercise Intervention, Cognitive Intervention
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Duke Kunshan University
Brain Neoplasms, Sleep Initiation and Maintenance Disorders
Lemborexant on Perioperative Sleep Quality in Patients With Brain Tumor Undergoing Surgery
This study tests whether lemborexant can improve perioperative sleep quality in people with brain tumor undergoing surgery. Adults with brain tumor scheduled for surgery may join.
- Trial name
- NCT07903051
- Testing
- Lemborexant 5 mg
- Volunteers
- 112 people
- Sponsor
- Beijing Tiantan Hospital
Parkinson Disease (PD), Sleep Initiation and Maintenance Disorders
Lemborexant on Perioperative Sleep Quality in Patients With Parkinson's Disease Undergoing Deep Brain Stimulation
This study tests whether lemborexant, an approved sleep medicine, can improve sleep and recovery in people with Parkinson's disease undergoing deep brain stimulation (DBS) surgery.
- Conditions
- Parkinson Disease (PD), Sleep Initiation and Maintenance Disorders, Deep Brain Stimulation
- Trial name
- NCT07903038
- Testing
- Lemborexant 5 mg, Placabo
- Volunteers
- 128 people
- Sponsor
- Beijing Tiantan Hospital
Neurofibromatosis Type 2, NF2
Selumetinib for NF2-Related Schwannomatosis
The goal of this clinical trial is to evaluate the efficacy and safety of the MEK1/2 inhibitor selumetinib in treating patients with neurofibromatosis type 2-related schwannomatosis (NF2-SWN), including both adults and children…
- Conditions
- Neurofibromatosis Type 2, NF2, NF2-related Schwannomatosis, Meningioma
- Trial name
- ASSIST (NCT07707947)
- Testing
- Selumetinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tiantan Hospital
Prolonged Disorders of Consciousness, Tracheostomy
A Speaking-Valve-Based Decannulation Protoco for Patients With a Prolonged Disorders of Consciousness
To evaluate the feasibility of a standardized tracheostomy decannulation protocol for patients with prolonged Disorders of Consciousness (pDoC) .
- Trial name
- STEP-DoC (NCT07183670)
- Testing
- decannulation protocol
- Where
- 2 sites in China
- Volunteers
- 184 people
- Sponsor
- Hongying Jiang, MD
Moya Moya Disease, Moyamoya Syndrome
Efficacy and Safety of Ischemic Preconditioning Therapy Versus Optimal Medical Therapy in Reducing the Recurrence of Ischemic Events in Symptomatic Moyamoya Disease
This clinical trial aims to investigate whether remote ischemic conditioning (RIC) can reduce the risk of cerebral ischemic events, delay clinical progression, and improve long-term outcomes in patients with symptomatic Moyamoya…
- Trial name
- NCT07889531
- Testing
- Standard Remote Ischemic Preconditioning
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tiantan Hospital
Spinal Cord Injury
Recovery and Safety After Epidural Spinal Cord Stimulation in People With Spinal Cord Injury
Spinal cord injury can cause lasting difficulties with movement, sensation, bladder and bowel function, and daily activities. Epidural spinal cord stimulation delivers electrical pulses through implanted electrodes and may be…
- Trial name
- NCT07900490
- Testing
- Epidural Spinal Cord Stimulation
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Hainan University
Stellate Ganglion Block, Prolonged Disorders of Consciousness
Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness
This is a prospective, single-centre, single-arm, self-controlled, exploratory pilot study. The goal of this clinical trial is to learn about the effect of preoperative administration of stellate ganglion block on postoperative…
- Conditions
- Stellate Ganglion Block, Prolonged Disorders of Consciousness, Sleep
- Trial name
- NCT07274683
- Testing
- stellate ganglion block with 0.5% ropivacaine
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Beijing Tiantan Hospital
Crerbral Angiography
A Clinical Trial of Vascular Interventional Robotic System for Cerebral Angiography
This study aims to conduct a post-market, multicenter clinical trial utilizing an interventional robotic system for cerebral angiography.
- Trial name
- NCT07182188
- Testing
- Vascular Interventional Robotic System
- Where
- 2 sites in China
- Volunteers
- 660 people
- Sponsor
- Peking Union Medical College Hospital
Moyamoya Disease, Moyamoya Syndrome
Development and Validation of Risk Prediction Models for Stroke and Cognitive Impairment in Moyamoya Disease and Moyamoya Syndrome
This multicenter prospective observational cohort study aims to develop and validate individualized risk prediction models for stroke and cognitive decline in patients with moyamoya disease or moyamoya syndrome by integrating…
- Trial name
- NCT07894107
- Where
- 13 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tiantan Hospital
Glioblastoma
Safety and Efficacy Study of Anti-B7-H3 CAR-T Cell Therapy for Recurrent Glioblastoma
This is an open-label, single-arm, dose-escalation and multiple-dose study to evaluate the safety, tolerability, and preliminary efficacy of TX103-CAR-T Cell Injection, a B7-H3-targeting chimeric antigen receptor T-cell (CAR-T)…
- Trial name
- NCT05241392
- Testing
- B7-H3-targeting CAR-T cells/TX103-CAR-T Cell Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Vestibular Schwannoma, Facial Nerve Paralysis
Steroids for Facial Nerve Function Protection in Post-surgical Vestibular Schwannoma Patients
The purpose of this study is to evaluate the efficacy and safety of steroids treatment compared with placebo in preserving facial nerve function after craniotomy in patients with vestibular schwannoma who have not received…
- Trial name
- SAF-NRVS (NCT07116811)
- Testing
- Steroids therapy
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Beijing Tiantan Hospital
Unruptured Intracranial Aneurysms, Cerebrovascular Event
Efficacy and Safety of Methylprednisolone After Flow-Diverter Stent Implantation in Unruptured Intracranial Aneurysms
Study Title: Testing Methylprednisolone to Prevent Strokes After a Stent Procedure for Brain Aneurysms What is the purpose of this study? This study aims to find out if a short course of a steroid medicine called…
- Conditions
- Unruptured Intracranial Aneurysms, Cerebrovascular Event, Hemorrhagic Stroke, Methylprednisolone
- Trial name
- NCT07353749
- Testing
- Methylprednisolone (Injectable Form)
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Duan Chuanzhi
Unruptured Intracranial Aneurysm, Intracranial Aneurysm Rupture
Prospective Observational Cohort Study for Predicting Unruptured Intracranial Aneurysm Rupture Risk Using Blood Pressure Variability and 3D Structural Evolution
This is a single-center, prospective, longitudinal observational cohort study in adults with unruptured intracranial aneurysms (UIAs) who are managed by conservative observation rather than immediate surgery or endovascular…
- Trial name
- NCT07893574
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital